LOCUS       NM_023480               1407 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus fumarylacetoacetate hydrolase domain containing 1
            (Fahd1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_023480
VERSION     NM_023480.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1407)
  AUTHORS   Salti A, Etemad S, Cubero MS, Albertini E, Kovacs-Szalka B,
            Holzknecht M, Cappuccio E, Cavinato M, Edenhofer F and Jansen Durr
            P.
  TITLE     High Glycolytic Activity Enhances Stem Cell Reprogramming of
            Fahd1-KO Mouse Embryonic Fibroblasts
  JOURNAL   Cells 10 (8), 2040 (2021)
   PUBMED   34440809
  REMARK    GeneRIF: High Glycolytic Activity Enhances Stem Cell Reprogramming
            of Fahd1-KO Mouse Embryonic Fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1407)
  AUTHORS   Weiss AKH, Naschberger A, Cappuccio E, Metzger C, Mottes L,
            Holzknecht M, von Velsen J, Bowler MW, Rupp B and Jansen-Durr P.
  TITLE     Structural and functional comparison of fumarylacetoacetate domain
            containing protein 1 in human and mouse
  JOURNAL   Biosci Rep 40 (3) (2020)
   PUBMED   32068790
  REMARK    GeneRIF: Structural and functional comparison of
            fumarylacetoacetate domain containing protein 1 in human and mouse.
REFERENCE   3  (bases 1 to 1407)
  AUTHORS   Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E,
            Taferner A, Unterluggauer H, Kramer C, Liedl KR and Jansen-Durr P.
  TITLE     Identification of FAH domain-containing protein 1 (FAHD1) as
            oxaloacetate decarboxylase
  JOURNAL   J Biol Chem 290 (11), 6755-6762 (2015)
   PUBMED   25575590
  REMARK    GeneRIF: Based on molecular modeling and subsequent biochemical
            investigations, the study identified FAHD1 as a eukaryotic
            oxaloacetate decarboxylase enzyme.
REFERENCE   4  (bases 1 to 1407)
  AUTHORS   Pircher H, Straganz GD, Ehehalt D, Morrow G, Tanguay RM and
            Jansen-Durr P.
  TITLE     Identification of human fumarylacetoacetate hydrolase
            domain-containing protein 1 (FAHD1) as a novel mitochondrial
            acylpyruvase
  JOURNAL   J Biol Chem 286 (42), 36500-36508 (2011)
   PUBMED   21878618
  REMARK    GeneRIF: identified mammalian FAHD1 as a novel mitochondrial enzyme
            with acylpyruvate hydrolase activity.
REFERENCE   5  (bases 1 to 1407)
  AUTHORS   Hong S, Choi I, Woo JM, Oh J, Kim T, Choi E, Kim TW, Jung YK, Kim
            DH, Sun CH, Yi GS, Eddy EM and Cho C.
  TITLE     Identification and integrative analysis of 28 novel genes
            specifically expressed and developmentally regulated in murine
            spermatogenic cells
  JOURNAL   J Biol Chem 280 (9), 7685-7693 (2005)
   PUBMED   15613475
REFERENCE   6  (bases 1 to 1407)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1407)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2.
            
            [WARNING] On Nov 13, 2023 this sequence was replaced by
            NM_023480.4.
            
            On Aug 15, 2018 this sequence version replaced NM_023480.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK141973.1, AK157292.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1407              AC166102.2         92036-93442
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1407
                     /gene="Fahd1"
                     /gene_synonym="1110025H10Rik"
                     /note="fumarylacetoacetate hydrolase domain containing 1"
                     /db_xref="GeneID:68636"
                     /db_xref="MGI:MGI:1915886"
     exon            1..1407
                     /gene="Fahd1"
                     /gene_synonym="1110025H10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..885
                     /gene="Fahd1"
                     /gene_synonym="1110025H10Rik"
                     /EC_number="3.7.1.5"
                     /EC_number="4.1.1.112"
                     /note="fumarylacetoacetate hydrolase domain-containing
                     protein 1; OAA decarboxylase; oxaloacetate decarboxylase"
                     /codon_start=1
                     /product="acylpyruvase FAHD1, mitochondrial"
                     /protein_id="NP_075969.1"
                     /db_xref="CCDS:CCDS37496.1"
                     /db_xref="GeneID:68636"
                     /db_xref="MGI:MGI:1915886"
                     /translation="MTQSCTMASTKPLSRFWEWGKNIVCVGRNYADHVKEMRSTVLSE
                     PVLFLKPSTAYAPEGSPVLMPAYCRNLHHEVELGVLLGKRGEAIPEAAAMDYVAGYAL
                     CLDMTARDVQEECKKKGLPWTLAKSFTSSCPVSAFVPKEKIPDPHALRLWLKVNGELR
                     QEGKTSSMIFSIPYIISYVSKIITLEEGDLILTGTPKGVGPIKENDEIEAGIDGVVSM
                     RFKVKRSEY"
ORIGIN      
        1 agactcggtc tgcaagtggg tgttggagga ggctgagcgt gagcctcctc gtctctctgg
       61 ggcagtcgcc tgcacgcaga gacctttcgc tgacctcagc gtcccgctgc tgcgcaagga
      121 agggcggggc cgctccgacc tggacagcgt ccgaagccag tcctctggag gccgccgtag
      181 tccgggggag tcggtggtca catgacccaa agctgtacta tggcttccac caaaccgctg
      241 tctcgtttct gggagtgggg caagaatatc gtctgcgtgg ggaggaacta tgcagatcac
      301 gtcaaagaga tgcgcagcac cgtgctgagt gagcctgtgc ttttcctgaa gccgtccacc
      361 gcgtacgctc ccgagggctc accggtgtta atgcccgctt actgccgcaa cctccaccac
      421 gaggtggagt tgggagtgct tctgggcaag cgtggtgaag cgatcccgga ggctgcagcc
      481 atggactacg tggccggcta tgccctgtgc ctggacatga ctgccagaga tgtgcaggag
      541 gagtgcaaga agaaggggct gccgtggacc ctggctaaga gctttacgtc ctcctgcccg
      601 gtcagtgcct tcgtgcccaa ggagaagatt cctgaccctc atgccctaag actgtggctc
      661 aaggtcaacg gagagctcag gcaggagggc aaaacatcat ctatgatctt ttccatcccc
      721 tacatcatca gctatgtttc taagataata accttggaag aaggagatct tatcttgacc
      781 gggactccaa agggagttgg gccaattaaa gaaaacgatg agatcgaggc cggcatagat
      841 ggggtggtta gtatgaggtt caaggtgaaa agatcagaat actgagagta gagtgccaaa
      901 ggggaaggga gacagaagca agggaaataa atgacactaa taatgaaaat ctaaaaatta
      961 tgctagacat gtcaaaaaag atgaatcctt aaaaaataac gtgatctaaa agacctggga
     1021 ctgaaataga aacaggaaca acgaagctaa aggatataga atgcttccca agagggcaat
     1081 gttaaactaa actttgagaa gttgtagttt tcttttctaa aactgaactg aatagacttt
     1141 tcaataaatc attctgaagt ctatacctcc agacttaaaa gtgcaaagga agtaactcat
     1201 taatgctgtt ggcctttagg aaagctgttt gtacagagca ctccagttga tttttacttg
     1261 ggaaagtcct ccacctcaaa gccagataag aattttgtta agtgagctct tgctgcagcc
     1321 ctgccttgtt tactttgggt gtggcttctg agtttggaag ataattttga aattgttttc
     1381 caaataaaga ccatttctgt gtgactg
//
