LOCUS       NM_007983               4380 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Fas-associated factor 1 (Faf1), transcript variant 1,
            mRNA.
ACCESSION   NM_007983
VERSION     NM_007983.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4380)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4380)
  AUTHORS   Chen,C.H., Lin,H.W., Huang,M.F., Chiang,C.W., Lee,K.H.,
            Phuong,N.T., Cai,Z.Y., Chang,W.C. and Lin,D.Y.
  TITLE     Sumoylation of SAP130 regulates its interaction with FAF1 as well
            as its protein stability and transcriptional repressor function
  JOURNAL   BMC Mol Cell Biol 25 (1), 2 (2024)
   PUBMED   38172660
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4380)
  AUTHORS   Cui,S., Simmons,G. Jr., Vale,G., Deng,Y., Kim,J., Kim,H., Zhang,R.,
            McDonald,J.G. and Ye,J.
  TITLE     FAF1 blocks ferroptosis by inhibiting peroxidation of
            polyunsaturated fatty acids
  JOURNAL   Proc Natl Acad Sci U S A 119 (17), e2107189119 (2022)
   PUBMED   35467977
REFERENCE   4  (bases 1 to 4380)
  AUTHORS   Kim,T.H., Lee,H.C., Kim,J.H., Hewawaduge,C.Y., Chathuranga,K.,
            Chathuranga,W.A.G., Ekanayaka,P., Wijerathne,H.M.S.M., Kim,C.J.,
            Kim,E. and Lee,J.S.
  TITLE     Fas-associated factor 1 mediates NADPH oxidase-induced reactive
            oxygen species production and proinflammatory responses in
            macrophages against Listeria infection
  JOURNAL   PLoS Pathog 15 (8), e1008004 (2019)
   PUBMED   31412082
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4380)
  AUTHORS   Yu,C., Kim,B.S., Park,M., Do,Y.J., Kong,Y.Y. and Kim,E.
  TITLE     FAF1 mediates necrosis through JNK1-mediated mitochondrial
            dysfunction leading to retinal degeneration in the ganglion cell
            layer upon ischemic insult
  JOURNAL   Cell Commun Signal 16 (1), 56 (2018)
   PUBMED   30200976
  REMARK    GeneRIF: FAF1 plays a key role in ischemic retinal damage and may
            be implicated in the pathogenesis of retinal ischemic disease
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4380)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 4380)
  AUTHORS   Brown,G.M., Furlong,R.A., Sargent,C.A., Erickson,R.P.,
            Longepied,G., Mitchell,M., Jones,M.H., Hargreave,T.B., Cooke,H.J.
            and Affara,N.A.
  TITLE     Characterisation of the coding sequence and fine mapping of the
            human DFFRY gene and comparative expression analysis and mapping to
            the Sxrb interval of the mouse Y chromosome of the Dffry gene
  JOURNAL   Hum Mol Genet 7 (1), 97-107 (1998)
   PUBMED   9384609
REFERENCE   8  (bases 1 to 4380)
  AUTHORS   Wood,S.A., Pascoe,W.S., Ru,K., Yamada,T., Hirchenhain,J., Kemler,R.
            and Mattick,J.S.
  TITLE     Cloning and expression analysis of a novel mouse gene with sequence
            similarity to the Drosophila fat facets gene
  JOURNAL   Mech Dev 63 (1), 29-38 (1997)
   PUBMED   9178254
REFERENCE   9  (bases 1 to 4380)
  AUTHORS   Kikyo,N., Rideout,W.M. 3rd, Tada,T., Tada,M. and Surani,M.A.
  TITLE     Mapping of the Fas-associated factor 1 gene, Faf1, to mouse
            chromosome 4C6 by FISH
  JOURNAL   Mamm Genome 8 (3), 224-225 (1997)
   PUBMED   9069128
REFERENCE   10 (bases 1 to 4380)
  AUTHORS   Chu,K., Niu,X. and Williams,L.T.
  TITLE     A Fas-associated protein factor, FAF1, potentiates Fas-mediated
            apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11894-11898 (1995)
   PUBMED   8524870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627392.12 and AL627188.18.
            
            On Mar 23, 2023 this sequence version replaced NM_007983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065098.1, SRR7652917.598087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AL627392.12        16226-16622
            398-466             AL627392.12        50340-50408
            467-513             AL627392.12        60306-60352
            514-716             AL627392.12        66940-67142
            717-808             AL627392.12        76141-76232
            809-900             AL627392.12        82416-82507
            901-1006            AL627392.12        97130-97235
            1007-1093           AL627392.12        134318-134404
            1094-1189           AL627392.12        169356-169451
            1190-1316           AL627392.12        179866-179992
            1317-1380           AL627392.12        180859-180922
            1381-1462           AL627392.12        181838-181919
            1463-1617           AL627188.18        20839-20993
            1618-1754           AL627188.18        42666-42802
            1755-1843           AL627188.18        49932-50020
            1844-1924           AL627188.18        84328-84408
            1925-2002           AL627188.18        84915-84992
            2003-2218           AL627188.18        94513-94728
            2219-4380           AL627188.18        120829-122990
FEATURES             Location/Qualifiers
     source          1..4380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.33 cM"
     gene            1..4380
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="Fas-associated factor 1"
                     /db_xref="GeneID:14084"
                     /db_xref="MGI:MGI:109419"
     exon            1..397
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2302
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="FAS-associated factor 1 isoform 1"
                     /protein_id="NP_032009.2"
                     /db_xref="CCDS:CCDS18468.1"
                     /db_xref="GeneID:14084"
                     /db_xref="MGI:MGI:109419"
                     /translation="MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGV
                     IPQENGILQSDFGGETMPGPTFDPASHPAPASTPSSSAFRPVMPSRQIVERQPRMLDF
                     RVEYRDRNVDVVLEDSCTVGEIKQILENELQIPVPKMLLKGWKTGDVEDSTVLKSLHL
                     PKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTVQE
                     VKRNVYDLTSIPVRHQLWEGWPASATDDSMCLAESGLSYPCHRLTVGRRTSPVQTREQ
                     SEEQSTDVHMVSDSDGDDFEDASEFGVDDGEVFGMASSTLRKSPMMPENAENEGDALL
                     QFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQ
                     MLCAESIVSYLSQNFITWAWDLTKDTNRARFLTMCNRHFGSVIAQTIRTQKTDQFPLF
                     LIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFSAQQQEDIKDEDEREARENVKR
                     EQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKE
                     ENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEFKLLSTFPRRDVT
                     QLDPNKSLLEVNLFPQETLFLQAKE"
     exon            398..466
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            467..513
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            514..716
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            717..808
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            809..900
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1006
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1093
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1189
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1316
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1380
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1462
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1617
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1754
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1843
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1924
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2002
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2218
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..4380
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="hexamer: AATAAA"
     polyA_site      2467
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="major polyA site"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="hexamer: AATAAA"
     polyA_site      3516
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
     regulatory      3666..3671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="hexamer: AATATA"
     polyA_site      3689
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
     regulatory      4360..4365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
                     /note="hexamer: ATTAAA"
     polyA_site      4380
                     /gene="Faf1"
                     /gene_synonym="Dffrx; Fam"
ORIGIN      
        1 gcccccgtcg ggtttgccgt ggctggaggg agccgggcgc gcgctgtcgc aacctgtcct
       61 cctcccaggc ggcgacggaa ggaccggccc ggcatcgaga ccagcctccc cgtcccggca
      121 gctgcggcga gggctccgcg gggcgcaggc gggctcaggg cggctgaagg ttaccgagtg
      181 catgagcacc tagtctcccg cgctgccccg cccgccggtc cgccggccct cccgccggct
      241 cgcccgccag cccttcgcca cccggcggcg gccgcagctt cggccgcagg aggcgccgtc
      301 tcgctcccag gtgcgcgctt cgttcccgga gccgcggagc tcggcggccg ccatggcgtc
      361 caacatggac cgggagatga tccttgcgga ttttcaggca tgtactggta ttgaaaacat
      421 cgatgaagct attacactgc ttgagcaaaa taactgggac ttggtggcag ctattaatgg
      481 tgtaatacca caggaaaatg gcattctaca aagtgacttt ggaggtgaga ccatgccagg
      541 acccacattt gatccagcaa gtcaccctgc tccagcttca actccctctt cttcagcgtt
      601 tcgacctgta atgccatcca ggcagattgt agaaaggcag cctcgaatgc tagacttcag
      661 agttgaatac agagacagaa atgttgatgt ggtacttgaa gacagctgta ctgttggaga
      721 gatcaaacag attctagaaa atgagcttca gatacctgtg cctaaaatgc tgttaaaagg
      781 ctggaagact ggagacgtgg aagacagtac ggtcttaaaa tcactacact tgccaaaaaa
      841 caacagtctt tatgtcctta caccagactt gccaccgcct tcatcatcca gccatgctgg
      901 tgccctgcag gaatcattaa atcaaaactt catgctgatc atcacccacc gagaggtcca
      961 gcgggagtac aacctgaact tctcaggaag cagtaccgtt caagaggtaa agagaaatgt
     1021 gtatgacctt acaagcatac ctgttcgaca tcagttatgg gagggctggc cagcttctgc
     1081 caccgatgac tcaatgtgtc ttgctgaatc aggcctctct tatccctgcc atcgattaac
     1141 tgtgggaaga agaacttcac ctgtacagac ccgtgagcaa tcagaagagc aaagcacgga
     1201 tgttcatatg gttagtgata gtgatggcga tgactttgaa gatgcttcag aatttggagt
     1261 ggatgacgga gaagtatttg gcatggcatc atctaccctg agaaaatctc caatgatgcc
     1321 agaaaacgca gaaaatgaag gagatgcctt attacaattt acagcagagt tttcttcaag
     1381 atatggtgac tgccatcctg tattttttat tggctcatta gaagctgctt tccaagaggc
     1441 cttctatgtg aaagcccgag acagaaaact tcttgctatc tacctccacc atgatgaaag
     1501 tgtactaacc aacgtgttct gctcacaaat gctttgtgct gaatccattg tttcctatct
     1561 gagtcaaaat tttataacct gggcttggga tctgacaaag gacaccaaca gagcaagatt
     1621 tctgacaatg tgcaatagac actttggcag cgttattgca caaactattc ggactcaaaa
     1681 gacagatcag tttccacttt tcctgattat catgggaaag cgatcatcta atgaagtgtt
     1741 aaatgtgata caaggtaata caacagtgga tgagttaatg atgagactca tggctgcaat
     1801 ggagattttc tcagctcaac aacaggaaga cattaaggat gaggatgaac gtgaagccag
     1861 agaaaatgtg aagagagagc aagatgaggc ctatcgcctt tccctcgaag ccgacagggc
     1921 aaagagagaa gctcatgaga gagagatggc agaacagttt cgtttggagc agattcgcaa
     1981 agaacaagaa gaagaacgtg aggccatcag actctcctta gaacaagccc ttcctccaga
     2041 gccgaaggaa gaaaatgctg agcctgttag caagcttcgg attcgaaccc ccagtggcga
     2101 gttcctggaa cggcgtttcc tggccagcaa taagctccag attgtctttg atttcgtggc
     2161 ttccaaggga tttccatggg atgaattcaa gttactgagc acctttccta ggagagatgt
     2221 aactcagcta gaccccaata agtcattatt ggaggtaaac ttgttccctc aagaaaccct
     2281 tttccttcaa gcaaaagagt aaacatgact gagaggtgga agcagccact cctgacgagc
     2341 cagcggcacg tgtcaagaga tgggctcctc accaacccac ctacctgctc gtgtcactca
     2401 gttcaatgtc acacttctgc ctcttgcaag attgctggaa aaaagtaata aacatagcta
     2461 cttaaaattt cccatccatg agtatatgtt ccccgctcct catgacggag tgccacaacc
     2521 ccattgccct ctcctgatgc ctgactagtg ttctgttgtg tgtgagtggc cccaggggaa
     2581 cttaacctct gtgctaccca tctttccctc attgtccaag acagttctct ctgtcctaga
     2641 catcaggatg ctgtgtatct gatatgtctc attgagccag ggctcatacc ctctgccttt
     2701 acctttctat aactgcagtt taagtttatc acctaatttt aaaaggcaaa gtgaaaaaaa
     2761 gtcaaatggg acattttggg tctgaacatc agacattttg gggtagaggg tagaggagtg
     2821 tatcatacat ctgactcctt tactaagatg taagattttt gttagtagac tgatttgata
     2881 tgtatgcaag gtatttatat acttctgtca tgcgctgcat attccatctt ggaggggttt
     2941 gtttgtttgt ttgtttgttt gtttgtttca ttgcagcttg ggaaactatt caagtacaca
     3001 gtgtgttgag atcacgaaga gaatgctggt accattgtag gccagctgtg gcaagctgct
     3061 cttcaacttt ttgaggcact aggaacttcc tagatacctg ctcccacact gctagtgtct
     3121 ctgtggacac gacacacagt tttcctgccc tttcttcctc aacagcttta tacatctgga
     3181 cctagtcatg tggtggggtg tctgtttgtt tgtttgtttg tttttgtttt cactttaggc
     3241 tttggagacc agagctcatt atgtagctca ggggtgtggc ctcaaacctt cagtaatctg
     3301 ctttactctc caagtgccaa gatttcaggc atgccccacg atacctggcc agtgtctggt
     3361 gttttaaaca ccttgtccgt tgccaaaatc taatcagctg tcccttgggc tttcctgcat
     3421 taagggactt gctctatgat tttatttctg aatattttaa tattagatat tgaatttata
     3481 tcccaaataa aaggaatctc attctttggc taaaaattca gacttcatat atttaagaga
     3541 gcaaatgtgg gggcttagcc tataatacat gtgttgccag aattgataca tagtaatctt
     3601 gggtttgatt tagtagaagt gcattttgtt aatctgtggg tttaaggttt aaggtagttc
     3661 atgagaatat aatttatatc ttcacagcct attttagtcc tgaaatgttc tttatggtgt
     3721 ttttgtgtca tctccagtct ttatcctaag agctgaccta ccagtctggt tattttgtaa
     3781 gtgtgttagg tgtgtttccc tgggaccatc ttggggctct aagaagactt acccaaagct
     3841 ggaggtgtgt ctggtcactt tttcctctac tcagaaagta ttgcccaaga aagttcacct
     3901 gttttcctct gatgctcagc catgaacatc ccctgaaaac ttctctaaga gattgttccc
     3961 aataccactg cgctttatct gccaactgac tgaaaaggga gctcactgtg aggggagttt
     4021 ctcctaagca attcctctcc agcgctgttc cttccttccc aatgagtggc accacaagat
     4081 gtcatttctg aagctgcagc tgtactaggg caccagctct tctttttcca gccagacttt
     4141 gttctatagc tgctgtgaga agccacagtc ctgaacttaa accacagtca aaaacagcag
     4201 ccagggtgtg ggcagaggct tgagagagct ctccgagttc tcatgtctaa cctgtccctc
     4261 tgagtggaat ttggcttcac tacagggttt cctaccattc ctgtttactt ctgtatacca
     4321 acatataacc tttactctga aaccaatttc ataacagtta ttaaatgtta tttgaatgtg
//
