LOCUS       NM_178035               5994 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fatty acid desaturase domain family, member 6 (Fads6),
            mRNA.
ACCESSION   NM_178035
VERSION     NM_178035.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5994)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603828.9.
            
            On Dec 6, 2019 this sequence version replaced NM_178035.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB087503.1, BC132067.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AL603828.9         98230-98478         c
            250-416             AL603828.9         97454-97620         c
            417-597             AL603828.9         87034-87214         c
            598-785             AL603828.9         86215-86402         c
            786-965             AL603828.9         85116-85295         c
            966-5994            AL603828.9         79543-84571         c
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..5994
                     /gene="Fads6"
                     /note="fatty acid desaturase domain family, member 6"
                     /db_xref="GeneID:328035"
                     /db_xref="MGI:MGI:3039592"
     exon            1..249
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1115
                     /gene="Fads6"
                     /EC_number="1.14.19.-"
                     /codon_start=1
                     /product="fatty acid desaturase 6"
                     /protein_id="NP_828874.3"
                     /db_xref="CCDS:CCDS25626.1"
                     /db_xref="GeneID:328035"
                     /db_xref="MGI:MGI:3039592"
                     /translation="METVRSAPPGDGAAEALLKELERQVQDVVRASSWWERHGVDCAI
                     LALSLLALPAGFLCLRAHNILAFATGITILGVCHYTLTVKGSHLATHSALTESKRWSK
                     ILMIFFLEVCTAFSAEFAKFNHVNLHHVYTNVVGLGDSSTWKVPLLNRYVYMFLGPLL
                     VPIITPLVALEHLRKEEPRTALRTLGFICLGLYSQYWLFMNVSGFKNPSSALACMLLT
                     RSLLAHPYLHVNIFQHIGLPMFSPDKKPRRIHMMTLGVLNLPRQLVLDWAFGHSLISC
                     HVEHHLFPWLSDHMCLKVKPLVSKFLHEKQLPYNEDSYLARFQLFLSRYEEFMVHVPP
                     ITELVGVQ"
     exon            250..416
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..597
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     exon            598..785
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     exon            786..965
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     exon            966..5994
                     /gene="Fads6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fads6"
                     /note="hexamer: AATATA"
     polyA_site      4999
                     /gene="Fads6"
                     /note="major polyA site"
     regulatory      5974..5979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fads6"
                     /note="hexamer: ACTAAA"
     polyA_site      5994
                     /gene="Fads6"
                     /note="major polyA site"
ORIGIN      
        1 gtgttctctc cggcgcagca accgagctca cacccgaatc ccgggtcctc ctcgcttgtc
       61 cccagctcgg tgagtccagg gaacccatgg agaccgttcg tagtgcgcct ccgggggacg
      121 gcgctgctga ggcgctgctg aaagagctgg agcgtcaggt gcaggatgtg gtgcgggcga
      181 gctcgtggtg ggagcgccac ggtgtggact gcgccatcct cgctctcagc ctgctcgcct
      241 tgccggcagg gttcctgtgc ctacgcgccc ataatatcct ggcctttgcc acgggcatca
      301 caatcttggg tgtgtgccat tatacactca ccgtcaaggg cagccacctg gccactcaca
      361 gtgccctcac agagtccaaa cgctggagca agatcttgat gattttcttt ttggaggtgt
      421 gcacagcctt ttctgcagag ttcgccaaat tcaaccacgt gaatctgcac cacgtttaca
      481 ccaacgtggt gggtctgggc gattcaagca cgtggaaggt gcctctcctc aaccgctacg
      541 tttacatgtt ccttgggccg cttttggtcc ccatcataac gccgctggta gctcttgagc
      601 atttgaggaa ggaagagccg aggactgcac tgcggacttt gggcttcatc tgcctgggcc
      661 tttactctca gtactggctg ttcatgaatg tgtcaggctt caagaacccc agttcagcac
      721 tggcctgcat gctgctcacc agatccctgc tggcccaccc ttatctccat gtcaatatct
      781 tccagcacat cggactgcct atgttctccc cggacaagaa gcccaggagg atccacatga
      841 tgaccctggg ggttctgaac ctgccacggc agctggtgtt ggactgggca ttcggccact
      901 ccctcatcag ctgccacgtg gagcaccacc tcttcccttg gctctctgac cacatgtgct
      961 tgaaggtgaa gcccttggtg tcgaagtttc tccacgagaa gcagctgcct tacaatgaag
     1021 actcatacct ggctcgattc cagctgttcc tcagccgcta tgaggagttc atggtgcatg
     1081 tcccgcccat cactgagctg gtgggggtgc aatgaaggct ggaccccctc cctcgcccag
     1141 tcctggccct cctgtactgc tggcccttgg ggagggggtg cggactggtg gacctggcac
     1201 cgtcctggga tttgagttaa gggagactgt tgggagaaga aatggaatca gttcagaggc
     1261 tgtgcatcct gatccaccta ggcctcagct gactccatct cagcatccct ccttctgctg
     1321 cctctgagcc aggggggagg gctaaggggg ctggtgacag gtgaggtggc atcctatgtc
     1381 cagaaggagg gggctcagag ccagagccag cctcctccgc tcggctctcc tcagtgccca
     1441 ggctgctgct tcctcctgta ccatcagtgg ttctagtccc cagggccctc tccctagggt
     1501 aaacagggtg aacggggtga ggtcattatt atttttttta gcagaccccc tcccctgttc
     1561 ttcacctgaa ggagcctgtg ccacactggg ctcagctcta ggacccacag agtcagtgag
     1621 atgaaaggga gtgtatttcc agagaagtgc tccagaaggg agcatgcgca ggcgtaaaac
     1681 tgtagaaggc actgccagct ttgagcatga ccttggctag ctctgtacaa ctctgctttg
     1741 ttccatgttc ggaaggctcc aacctggggg gggagggggg gagggcagag tcactgggag
     1801 gtggatgagg ctggaggagg gcagagagga atggagtggg ggggtggggt aaggggtggg
     1861 agggggtagg ggaaggagat aggaaagctg aagagaaggg ctcggtttgg ctctgggagg
     1921 aaggattgca agctgggtgg gaatataatg gagccactga taccaacact aggaggaagc
     1981 caagctgggg aacaacactg agaaccagcc aagccagcaa ccgagagagg ctgggcagtg
     2041 cttcagccag atggcagagc agagaggttt atggaagggc ccagtggaga ctgaaggagg
     2101 gacagatgag gttagacctg catgcatcag gacgccaggg ccgctgttag gtcataacct
     2161 agctcctcgc ctccccgctg ctgacatttt ctttggctga tttgtggcag gctgtgctga
     2221 gcgctggctt ctactgacta gatgttggga gcccaaatca tgacagtcaa aaatgactcc
     2281 cgggatagcc aactgtctcc caagtgacga aactgtcctt gattaagaac acgaggctgt
     2341 tcttctagct gactcactgg gtggaagggt gtactgctct ggtgatggga gggtacacgg
     2401 ggatgggccg accagcctgc tagaacccat ctctgggggc tgatgtggcc tagacagatg
     2461 cagccgccac tggcctgaca acccttcctg tcttctccca gcacccctcc ttcttccggg
     2521 gccctttcct ccagctatgg ctcttgggca gcctctcccc tgggctcctt ctgggctggg
     2581 taaaggcttc tagctgctgc tggcttctta tctctgctga ggaatctcta cactcctcac
     2641 tcatccccgt tgactgtgtg cctcctgttc actgccaagg ggctcgctca cagcagtttc
     2701 agatccaagc cccccaccac caccccaccc ccctgccgcc ctcctgctta gctgtaggct
     2761 attgctgctc gttttgaaat gcattagcag ctcagaagag gccttaaggt ctgagggcgg
     2821 ttcatcaatt ctccctctga aaaatccaat gacagaaaag ggtcctggca gtgtattgta
     2881 agctagtgat caaaccatcc aaatatacag ccagtgactc actgctattg atctgggcct
     2941 gagtggggtt cattccgggg cagccgctgg aggccctggt atcagacctg actagacatg
     3001 actatacata tgtatgtatg actagacata ccatggccat gggtgcacca ggaacaaatc
     3061 acttaggttc tctgcaatgt gccctgtctg tcagtctaac catgtgagct agggatacag
     3121 aagtaaggga gccagcgggg gtgcctgaag taccaccagg gctctgcagt ccgtggtcta
     3181 acagaccagc caaggggacc gcactgccgg tgagcagtca cggctgtttt cttaccacaa
     3241 acgcagactt gcttggctct ggttgtgttg ttttctggaa ctcaattggt gggtggctgg
     3301 cctcaaactc gcagaaatcc acttgcttcc acctcagtgg atctcagcct tcctaatggt
     3361 tcatgcctgt actttgctat gcttatgagt cctaatgtga atatcttcta ctcaggacat
     3421 ctgatatgtg accgacccct gggaaagggt cgctcgaccc ccaaagggtc acaacccacg
     3481 ggttgggaat ctttgctctt cctctccctc caaagtgctg ggtttaaagg tttccctctg
     3541 ggccaggcta gacgtttgta tgccatctaa ttttaatcct tacaagttag attctttcta
     3601 ctcatattat aaatggggga aaaagaagct gagattaaac ctctcaacat catgactgtg
     3661 aagtccagca tagggatttg aactcagcaa ctccagaacc caggttggtg accctcagag
     3721 atgctgtttc ggaatgggaa gccctgtaga cattttgggt gtttgcgtct gatttgctat
     3781 ctccttcttc tacatgacag gatatctggt ggttttatta ttaagatttt ttttccctga
     3841 gacatggttt ctctgtgtag ccctggctgt cctggaactg cctgtgtgga ccaggctggt
     3901 ctcaaactta gagatccacc tgtttctatc tctgcctcct gagtgttggg ctacatgaga
     3961 ccttgtctaa gagaagaaaa aaaaaaaaaa aaggaaaagg aaaaagaagt tccttatgac
     4021 cagccattgg atgctaggta ctgtgtgatg ctctggggat gagtgaatga gatggcctct
     4081 atatcccacc acattcatga agcctgctgc ccagtgcagg gtgtcaaatt ttgtgaaaag
     4141 ggccagataa atatttcagg tgttgtgaac aatatgatgt ctgtcacaac ttctcaactg
     4201 ccatcaaagt gtcacagcca gatgaacatg cccccaaggc tcagggacca ctgtggaaga
     4261 gggagcagga agcctgccag agccagaggc cagggtacag caaagcagag cccagatttc
     4321 tggacatgac aggactcctg cactaataaa ctcacagcag ccagtggctg cccacacaag
     4381 atcaagccag tgatggttac agaatagagg ggcgtctcag ctagggtttc tattgctgtg
     4441 aagaaacact atggccactc ttacaaagga aaacatttaa ttggggctgg cttacagttc
     4501 agacatttag tccattacca tcagggtggg aagcatggtg gtgtgcaggc agacatggtg
     4561 caggagagga gctgagagtt ctactggatc ctcagagagt aggaagagtg acactaggcc
     4621 tgaagtccac ccccagtgac acacttcctc catcaaggtc acacctccta acagtgccac
     4681 gccccataag cctatgggaa ctattttcat tcaaaccacc acaaggggaa aagagtttac
     4741 aagtccctgt ggctaactga ggttctactg acaactggtg ttttctgggg agggtgactc
     4801 agttttcttt aagggtgtgg cccctgataa gtccaccttg ccatgactat atgtaagtgg
     4861 gttattgaaa aaaaaaaaac atttagttgc agatgtgagg tggatttagg agggattggg
     4921 gaagaaatag ggagtgaata gaatcaaaat acattatata aaattttcaa aaattaataa
     4981 aaatatattt aaaaatgaac atggtattgt cccaataaaa cttgacttac aaagcaagta
     5041 attttcacgt cacaaaatat aaactatgtt accatttaag atggctccgt agttaagagc
     5101 acttgcaggg gctcagagtt caatccccag cacccatgac agatgttcac cgaagccctc
     5161 tgatctccaa ggcagcagca cagggcagag agacgggtgt atataaaaat agagagagaa
     5221 actgggcaat gatggttcac acttttaatc ccagaacttg ggaggcagag gcaggagaat
     5281 ctctgggagt tcaagaccag cctggtctac cgagtgagtt ccagaacagc cagggctaca
     5341 cagagaaact ctgtcttgaa aagcaaaaca aaacagtaca tgtgtaaata aattattgtt
     5401 ggagagatgg ctcagtggtt aagagtatgc aaaggtcctg agttcaattc ccagcacaca
     5461 cacagcagct cacaaccgtc tgacaccaaa ttctagtgtg cagatgtaca tgcagacaaa
     5521 atattcacat acataagcta catacgtaaa taatttatgt ataggcttgt gggcagcatt
     5581 tatcttacct actagtcttc tggggcaggc gtaaaacaca atgacatgtt agagaatcat
     5641 atttacctct caataagaaa gtggtggagc caatcaatgg tggtgcacac ctttgatccc
     5701 agcactaggg aggcagaggc aggcagatct ctaccagttc aaggctggcc tggtctatag
     5761 agtgagttcc aggactgcca gggttacaca gagaaacact gtcttgaaaa acaaaacaaa
     5821 caaacaaagt ggggagtgat tagttgagca gaggattctg ggatactgag ttttggttct
     5881 cagtctggtt gtaggtcaca ttattacacc tacagtctca taacccatca actatggtgg
     5941 gaatgaatgc acttctctgt atgtcaaact tcaactaaaa ataaccttca tttt
//
