LOCUS       NM_021890               3269 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fatty acid desaturase 3 (Fads3), mRNA.
ACCESSION   NM_021890 XM_207007
VERSION     NM_021890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Karsai,G., Lone,M., Kutalik,Z., Brenna,J.T., Li,H., Pan,D., von
            Eckardstein,A. and Hornemann,T.
  TITLE     FADS3 is a Delta14Z sphingoid base desaturase that contributes to
            gender differences in the human plasma sphingolipidome
  JOURNAL   J Biol Chem 295 (7), 1889-1897 (2020)
   PUBMED   31862735
  REMARK    GeneRIF: FADS3 is a Delta14Z sphingoid base desaturase that
            contributes to gender differences in the human plasma
            sphingolipidome.
REFERENCE   3  (bases 1 to 3269)
  AUTHORS   Jojima,K., Edagawa,M., Sawai,M., Ohno,Y. and Kihara,A.
  TITLE     Biosynthesis of the anti-lipid-microdomain sphingoid base
            4,14-sphingadiene by the ceramide desaturase FADS3
  JOURNAL   FASEB J 34 (2), 3318-3335 (2020)
   PUBMED   31916624
REFERENCE   4  (bases 1 to 3269)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3269)
  AUTHORS   Lin,S., Zhu,Y.Y., Hu,W., Yang,Y., Luo,J.M., Hu,S.J. and Yang,Z.M.
  TITLE     Decidual expression and regulation of fatty acid desaturase 3
            during mouse decidualization
  JOURNAL   Reproduction 156 (5), 429-437 (2018)
   PUBMED   30400035
  REMARK    GeneRIF: strongly expressed in the decidual cells at implantation
            sites
REFERENCE   6  (bases 1 to 3269)
  AUTHORS   Zhang,J.Y., Qin,X., Park,H.G., Kim,E., Liu,G., Kothapalli,K.S.D.
            and Brenna,J.T.
  TITLE     Alternative splicing generates novel Fads3 transcript in mice
  JOURNAL   Mol Biol Rep 43 (8), 761-766 (2016)
   PUBMED   27216536
  REMARK    GeneRIF: Changes in expression patterns and fatty acid profiles
            suggest that Fads3AT9 may play a role in the regulation and/or
            biosynthesis of long chain polyunsaturated fatty acids from
            precursors.
REFERENCE   7  (bases 1 to 3269)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   8  (bases 1 to 3269)
  AUTHORS   Pedrono,F., Blanchard,H., Kloareg,M., D'andrea,S., Daval,S.,
            Rioux,V. and Legrand,P.
  TITLE     The fatty acid desaturase 3 gene encodes for different FADS3
            protein isoforms in mammalian tissues
  JOURNAL   J Lipid Res 51 (3), 472-479 (2010)
   PUBMED   19752397
  REMARK    GeneRIF: FADS3 does exist under multiple protein isoforms depending
            on the mammalian tissues.
REFERENCE   9  (bases 1 to 3269)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   10 (bases 1 to 3269)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY227181.1, AK029318.1, AK080414.1 and AA981959.1.
            
            On Jul 15, 2005 this sequence version replaced NM_021890.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029318.1, AK090042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               BY227181.1         2-143
            143-1282            AK029318.1         2-1141
            1283-1837           AK080414.1         1135-1689
            1838-2979           AK029318.1         1697-2838
            2980-3127           AA981959.1         390-537
            3128-3269           AK029318.1         2987-3128
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.33 cM"
     gene            1..3269
                     /gene="Fads3"
                     /note="fatty acid desaturase 3"
                     /db_xref="GeneID:60527"
                     /db_xref="MGI:MGI:1928740"
     exon            1..409
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1534
                     /gene="Fads3"
                     /EC_number="1.14.19.-"
                     /note="delta(13) desaturase; delta(13) fatty acid
                     desaturase"
                     /codon_start=1
                     /product="fatty acid desaturase 3"
                     /protein_id="NP_068690.3"
                     /db_xref="CCDS:CCDS29570.1"
                     /db_xref="GeneID:60527"
                     /db_xref="MGI:MGI:1928740"
                     /translation="MGGVGEPGGGPGPREGPAPLGAPLPIFRWEQIRQHDLPGDKWLV
                     IERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFHAFHQDLHFVRKFLKPLLIGELAP
                     EEPSQDGAQNAQLIEDFRALRQAAEDMKLFEADTTFFALLLGHILAMELLAWLIIYLL
                     GPGWVSSILAALILAISQAQCWCLQHDLGHASIFTKSRWNHVAQQFVMGQLKGFSAHW
                     WNFRHFQHHAKPNIFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNHQHLYFFLIGP
                     PLLTLVNFEVENLAYMLVCMQWTDLLWAASFYSRFFLSYSPFYGATGTLLLFVAVRVL
                     ESHWFVWITQMNHIPKEIGHEKHRDWASSQLAATCNVEPSLFIDWFSGHLNFQIEHHL
                     FPTMPRHNYRRVAPLVKAFCAKHGLHYEVKPFLTALVDIIGSLKKSGDIWLDAYLHQ"
     exon            410..520
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..718
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..820
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..943
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1004
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1081
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1179
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1276
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1356
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1482
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..3269
                     /gene="Fads3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fads3"
                     /note="hexamer: TATAAA"
     polyA_site      1842
                     /gene="Fads3"
                     /note="major polyA site"
     regulatory      3243..3248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fads3"
                     /note="hexamer: AATAAA"
     polyA_site      3244
                     /gene="Fads3"
ORIGIN      
        1 aagggaggga aaagttccct gcgcggagag ccgggcaggc gcacgctctt acggcggccg
       61 cagcggcagg gcggggccgg tggggcgggc ggaggaagac ccctgattgc cacctcgcct
      121 ccctcagtgt ctctcttaga ccttggtcac gtaccggggt ccggaggact tgtgtacagc
      181 ggcaatgggc ggtgtcgggg agcccggagg gggacccggg ccgcgggagg ggcccgcacc
      241 gctgggggcg cccctaccca tcttccgctg ggagcagatc cgccagcatg acctaccagg
      301 cgacaagtgg ctggtcatcg agcgccgtgt ctacgacatc agccgctggg cacagcggca
      361 cccagggggt agccgcctca tcggccacca cggtgcggag gacgccacgg atgccttcca
      421 cgccttccac caagatctcc attttgtgcg caagttcctg aaacccctgt tgattggaga
      481 gctagcccca gaggaaccca gccaggatgg agctcagaat gcccagctga tcgaggactt
      541 ccgagccttg cgccaggcag ctgaagacat gaagctgttt gaagctgata ccactttctt
      601 tgcactcctg ctgggccaca tcctggctat ggagttgttg gcctggctta tcatctacct
      661 cttgggccct ggctgggtgt ccagtatcct tgctgccctg atcctggcca tctctcaggc
      721 ccagtgctgg tgtctgcaac atgatctagg tcatgcttcc atcttcacta agtccaggtg
      781 gaaccatgtg gcccagcagt tcgtgatggg gcagttgaaa ggcttttccg cccactggtg
      841 gaatttccgc cacttccagc accatgccaa acccaacatc ttccacaaag acccagatgt
      901 gactgtcgca cctgtcttcc tcctggggga gtcatctgtg gagtatggca agaagaaacg
      961 cagatacctg ccctacaacc accagcatct atacttcttc ctgattggcc ctccgctgct
     1021 caccttggtg aactttgaag ttgaaaatct ggcgtacatg ctggtgtgca tgcagtggac
     1081 ggacttgctg tgggctgcca gtttctactc ccgctttttc ttgtcctact ctcccttcta
     1141 tggtgccact gggacactgc tcctctttgt tgctgtcagg gtgctggaga gccactggtt
     1201 cgtgtggatc acgcagatga accacatccc caaggagatt ggccatgaaa agcatcggga
     1261 ctgggcaagc tctcagctgg cagccacctg caatgtggaa ccttcgctct tcattgactg
     1321 gttcagcggg cacctcaatt tccagattga gcaccacctc ttccccacga tgccaaggca
     1381 caactaccgg agggtggccc ccctggtcaa ggcgttctgc gccaagcacg gcctacacta
     1441 cgaggtgaag cctttcctca ccgctctggt ggatatcatc gggtccctga agaagtctgg
     1501 cgacatctgg ctggatgcat acctccatca atgaaggcag cacccttatg ggtggtgaag
     1561 gggtaagggt ccagactcca gcagtcaccg agtcactggg caagattgac agtcatcctc
     1621 accccctgct ggggcagcct gtctgcccgc ctggtcctgc tggctttcct cagtcctcag
     1681 cattttctgg tcagcaatcc tatggccatg gcacatgtcc aacaggacca gggtggaggg
     1741 aacatactta aaatgacacg gtgagcatag catgttttcc tagagcaaga actggaagga
     1801 aaacttgtta tttttatata aaaagcaacc cagacacatg gagccaagtg ttggactttc
     1861 atgaattttg gagccaaatc tgcttcagac ttggtggaag ggccatcatt gtggagctgg
     1921 gatggaatgt aaggagttcc tctccaccct gggtgctctg ggtcatggag gcaacagcta
     1981 ctctacccca tggtttgttc ctacactgag cagcatcccg gggggagtta tgtactcaag
     2041 agcctatggt taaggatcac atctgcagga gcctctggat tatgggatgg gaaagcctat
     2101 atatctatac tggctttcta cagccctcta tgcaggagag cccagtagtg ggagctctgc
     2161 tacactgggt attgcataac agttgtgctg aatatgcagt gactcaagtg tggccattct
     2221 gtccctaagt cctttaaata taaggactat ttcttgagca ggaactaacc tctcacttgg
     2281 cctcaggatc ttcatctgga caatgggtac agttgacagt tgactgcact atcaaccttt
     2341 gaacagctca aggcagaagt tttgctttat cttgattctc tccccaaagt gttaaggatg
     2401 ctcccttcaa gctaagcact gcaatctggg aaggcacccc ttccctagtg ctttacatcc
     2461 aactcagtgc tgtaggcatg ctaggcaagt actctactac tgtcctaaac ccaagtttgg
     2521 tgagagagga gaggggacag tggactctgt cagccccagc accgacaccc catggctcca
     2581 agctgggcta cagatcttta aagaggtctc agaagcttta ggctgtagca atcccagcag
     2641 aaatgctaaa ctgggcatct cctgtaggag ctgaggcctc atcaccagct gtggggacta
     2701 ccccaccctc tctccactcc ctgtggcctc cttgcctagg ggagtaccag tgaagcctcc
     2761 tggataaagc gagggaagga gaggtcccat cgcgtctggg tacctccctt gctctgttcc
     2821 attcagctct cccttccctg ggattaggtg gatggggcta agtcacgtgt ctgctaggac
     2881 ttaaggctgc ttgacctcaa ggaaggaatt caagctctta aatccaaagt aaatccaaag
     2941 tgtcgctttc aacgcgatga gaaataaaaa ggatgcccta gaaaggcttg cgccaaaagg
     3001 cagaaatgta tttaaaagct ttatgcgtat gaccccatgc ctctgggcta aactgttttg
     3061 ttctctgaga caagcccttt gctttctctg gactttattt tcttcctcag gtaagggctg
     3121 aagatccctt gaaagctact tctaagccct gttatatata cttgtagtcc aaggtactta
     3181 acagaaggat cacaagttca aaggcagcca aggcgactta ttaaaatcct gtttgagatg
     3241 ataataaata ttttaagggt ctggggatg
//
