LOCUS       NM_146094               3474 bp    mRNA    linear   ROD 20-FEB-2025
DEFINITION  Mus musculus fatty acid desaturase 1 (Fads1), mRNA.
ACCESSION   NM_146094
VERSION     NM_146094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3474)
  AUTHORS   Lorito,N., Subbiani,A., Smiriglia,A., Bacci,M., Bonechi,F.,
            Tronci,L., Romano,E., Corrado,A., Longo,D.L., Iozzo,M.,
            Ippolito,L., Comito,G., Giannoni,E., Meattini,I., Avgustinova,A.,
            Chiarugi,P., Bachi,A. and Morandi,A.
  TITLE     FADS1/2 control lipid metabolism and ferroptosis susceptibility in
            triple-negative breast cancer
  JOURNAL   EMBO Mol Med 16 (7), 1533-1559 (2024)
   PUBMED   38926633
  REMARK    GeneRIF: FADS1/2 control lipid metabolism and ferroptosis
            susceptibility in triple-negative breast cancer.
REFERENCE   2  (bases 1 to 3474)
  AUTHORS   Liu,Q., Wang,P., Yang,Z., Dai,Y. and Wang,S.
  TITLE     Targeted Knockdown of Hepatic Delta-5 Fatty Acid Desaturase FADS1
            Aggravates Atherosclerosis in ApoE-/- Mice
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 131 (2024)
   PUBMED   38682200
  REMARK    GeneRIF: Targeted Knockdown of Hepatic Delta-5 Fatty Acid
            Desaturase FADS1 Aggravates Atherosclerosis in ApoE[-/-] Mice.
REFERENCE   3  (bases 1 to 3474)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3474)
  AUTHORS   Yamamoto,H., Lee-Okada,H.C., Ikeda,M., Nakamura,T., Saito,T.,
            Takata,A., Yokomizo,T., Iwata,N., Kato,T. and Kasahara,T.
  TITLE     GWAS-identified bipolar disorder risk allele in the FADS1/2 gene
            region links mood episodes and unsaturated fatty acid metabolism in
            mutant mice
  JOURNAL   Mol Psychiatry 28 (7), 2848-2856 (2023)
   PUBMED   36806390
REFERENCE   6  (bases 1 to 3474)
  AUTHORS   Stroud,C.K., Nara,T.Y., Roqueta-Rivera,M., Radlowski,E.C.,
            Lawrence,P., Zhang,Y., Cho,B.H., Segre,M., Hess,R.A., Brenna,J.T.,
            Haschek,W.M. and Nakamura,M.T.
  TITLE     Disruption of FADS2 gene in mice impairs male reproduction and
            causes dermal and intestinal ulceration
  JOURNAL   J Lipid Res 50 (9), 1870-1880 (2009)
   PUBMED   19351970
REFERENCE   7  (bases 1 to 3474)
  AUTHORS   Jia,Q., Lupton,J.R., Smith,R., Weeks,B.R., Callaway,E.,
            Davidson,L.A., Kim,W., Fan,Y.Y., Yang,P., Newman,R.A., Kang,J.X.,
            McMurray,D.N. and Chapkin,R.S.
  TITLE     Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid
            desaturase) transgenic mice
  JOURNAL   Cancer Res 68 (10), 3985-3991 (2008)
   PUBMED   18483285
  REMARK    GeneRIF: n-3 fatty acid desaturase may have a role in
            colitis-associated colon cancer in mice
REFERENCE   8  (bases 1 to 3474)
  AUTHORS   Dreesen,T.D., Adamson,A.W., Tekle,M., Tang,C., Cho,H.P.,
            Clarke,S.D. and Gettys,T.W.
  TITLE     A newly discovered member of the fatty acid desaturase gene family:
            a non-coding, antisense RNA gene to delta5-desaturase
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 75 (2), 97-106 (2006)
   PUBMED   16846730
  REMARK    GeneRIF: support a significant role for reverse Delta5-desaturase
            as a natural antisense regulator of Delta5-desaturase
REFERENCE   9  (bases 1 to 3474)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3474)
  AUTHORS   Fujiwara,Y., Ishibashi,T. and Imai,Y.
  TITLE     Cytoplasmic location of linoleoyl-CoA desaturase in microsomal
            membranes of rat liver
  JOURNAL   Arch Biochem Biophys 233 (2), 402-407 (1984)
   PUBMED   6207773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132148.3, AK083959.1 and BC063053.1.
            
            On Aug 16, 2009 this sequence version replaced NM_146094.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063053.1, AB072976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC132148.3         38057-38196
            141-3451            AK083959.1         3-3313
            3452-3474           BC063053.1         3312-3334
FEATURES             Location/Qualifiers
     source          1..3474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.54 cM"
     gene            1..3474
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /note="fatty acid desaturase 1"
                     /db_xref="GeneID:76267"
                     /db_xref="MGI:MGI:1923517"
     exon            1..377
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1508
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /EC_number="1.14.19.44"
                     /note="D5D; delta(5) desaturase; delta(5) fatty acid
                     desaturase"
                     /codon_start=1
                     /product="acyl-CoA (8-3)-desaturase"
                     /protein_id="NP_666206.1"
                     /db_xref="CCDS:CCDS29572.1"
                     /db_xref="GeneID:76267"
                     /db_xref="MGI:MGI:1923517"
                     /translation="MAPDPVPTPGPASAQLRQTRYFTWEEVAQRSGREKERWLVIDRK
                     VYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPS
                     FEPTKNKALTDEFRELRATVERMGLMKANHLFFLVYLLHILLLDVAAWLTLWIFGTSL
                     VPFILCAVLLSTVQAQAGWLQHDFGHLSVFGTSTWNHLLHHFVIGHLKGAPASWWNHM
                     HFQHHAKPNCFRKDPDINMHPLFFALGKVLPVELGREKKKHMPYNHQHKYFFLIGPPA
                     LLPLYFQWYIFYFVVQRKKWVDLAWMLSFYARIFFTYMPLLGLKGFLGLFFIVRFLES
                     NWFVWVTQMNHIPMHIDHDRNVDWVSTQLQATCNVHQSAFNNWFSGHLNFQIEHHLFP
                     TMPRHNYHKVAPLVQSLCAKYGIKYESKPLLTAFADIVYSLKESGQLWLDAYLHQ"
     exon            378..488
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            489..686
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            687..788
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            789..917
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            918..978
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1055
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1153
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1250
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1330
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1456
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..3460
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /note="hexamer: AATAAA"
     polyA_site      3460
                     /gene="Fads1"
                     /gene_synonym="0710001O03Rik; A930006B21Rik; DSD"
                     /note="major polyA site"
ORIGIN      
        1 ggcggtccgc gccaagggtg ctgaaaaccc tgcgcgcgaa cggcggtctc cgggcgcgcg
       61 ctcgaggcag cccgacgctc ccctagttcg cgagcctggc gtgcgctgcc ccgcggcccg
      121 gagcgcgcac ctctcagact ccagcttccc ccgccaagct tgctatggct cccgacccgg
      181 tgccgacccc tggcccggcc tccgcccagc tccgccaaac gcgctacttt acttgggagg
      241 aggtggcgca gcgctccggg cgggagaagg agcgatggct cgtgatcgac cggaaggtgt
      301 acaacatcag cgacttcagc cgccgccacc cggggggctc ccgggtcatc agccactacg
      361 cgggtcagga tgccacggat ccttttgtgg cattccacat caacaagggt cttgtgagaa
      421 agtatatgaa ctctcttctg attggagagc tggctccgga gcaacccagc tttgaaccca
      481 ccaagaataa agcgctaact gatgaattcc gggagctgcg ggccacagta gagcgaatgg
      541 gcctcatgaa ggccaaccac ctcttcttcc tggtctacct gcttcacatc ctgctgctgg
      601 atgtggctgc ctggctcacc ctttggatct ttggaacttc cttggtgccc ttcatcctct
      661 gtgcagtact gctcagtaca gttcaggctc aggcaggttg gctacagcat gactttgggc
      721 acctgtcagt ctttggcacc tcgacatgga atcacctgct acatcatttt gtgattggcc
      781 acctgaaggg ggcccccgcc agctggtgga accacatgca tttccagcac catgccaagc
      841 ctaactgctt ccgcaaggac cccgatatca acatgcaccc cctcttcttc gccctgggga
      901 aggtccttcc tgtggagctc gggagggaaa agaagaagca catgccatac aaccatcagc
      961 acaagtactt cttcctcatc ggacccccag ccttgctgcc tctatacttc cagtggtata
     1021 ttttctattt tgtggttcag cggaaaaaat gggtggactt ggcctggatg ctcagcttct
     1081 atgcccgcat cttcttcact tacatgccgc tgctggggct gaaaggcttc ctgggccttt
     1141 tcttcattgt caggttcctg gaaagcaact ggtttgtgtg ggtgacacag atgaaccata
     1201 tccccatgca cattgatcac gaccggaatg tggactgggt ctccacccag ctgcaggcaa
     1261 cctgcaacgt tcaccaatca gccttcaaca actggttcag tggccaccta aatttccaga
     1321 ttgaacacca cctcttcccc accatgccgc ggcacaacta ccacaaggtg gcacccctag
     1381 tacaatccct gtgcgccaag tacggcatca agtatgagtc caagcccctg ctcacagcct
     1441 tcgcggacat tgtttactcc ctgaaggagt cagggcaact ctggttggac gcttaccttc
     1501 accaatagca gcagcagacc tccatatgga ggaggaagag gacacctgga gccaaagcag
     1561 gagttggagg gacaatgcca ctatgaatct aatgtttaaa aggttaggga acatggatat
     1621 tcgtactcac atctgcgccc ctcccccttg ccttctgggt accaaacttg agggagggga
     1681 gagctgttga agcaggaatt caaaactgtt atttcttcta ctttggcagg ggagggggac
     1741 aaatggtggt acctacagag ctctgcatga agtagggacc ccacactaga taacccctct
     1801 tgtaaagtat gagcccatct cactgggcta tctgactctc caccctcctt gttagtctct
     1861 gaggaacagt gcaactcctt cgaacatgat ttagaaagag ggcattcatg catagaattc
     1921 tgaggcctgg cacaactccc tgcccaggag cacagcttgc tgctgagggc tgggtgtgac
     1981 cgtgtctgcc tctggctgct gggagaagct gtttttcagt ttcagaagca ggcaggacaa
     2041 aggccaggac tgtggtttgg gaggcatttg gccctggaag gtcctggcac acgcaattct
     2101 tgggtctcat tccatccagg ttccagagag aacattagat cttagctctt gacaaaacgg
     2161 atggcagata ctggcctttg aaactctgtt gattcatctc ttctaatcgg tccccaagga
     2221 gaaagaacat aaacaaagag tgaggtcttc cctcccactg aacactattc ccatagtttc
     2281 cttttgctcc ccagcctgta attctaagtt caacaaaaca gttgtcaaca aaagtgactg
     2341 aggcttccac cagagtgcca gggctctgtg cagactcaga atccctgttc cctatgtcac
     2401 gttccagcat tgtatagcac agttccatgt cacaaacagg aaggttagaa acactaaggt
     2461 ctgtgaacat cactgctgca gcgaggcagc tcctctgtct actcgttcaa gtgtcttact
     2521 ctactggatg ctggatagaa atttagggta acttctgaca aagtgtgccg gtctaacaat
     2581 aaaatagggt tttgtaatct tctggttggt aaaagatatg ttccggagaa tataggaaca
     2641 tgcccggaga gacctaacct gtatgtccac tttcatgctc ttgttcccca aacccctggg
     2701 cattgttgtc tgctcaagag attctactgg aagcatgatg acccacctgt ctgggaagag
     2761 aaaacctcaa gaaggcaaag tgcagtgcgt gtttgtggtc aagatgaggg tgttaaggga
     2821 tgttggagtc tggtgtagag acaggcaggt tgcagaaaag cacagatctt tgccagtggt
     2881 tggccctgat tgaaaacctg tttgaaacag actgtgtagg aaaaatcagg attaaagagt
     2941 gctgccttta tggctccttc ttcagaatag gtgcagaccc ctccccgtgc ccgttccctg
     3001 ccacccgggg taaggaggtg gcactaccag tctgtctaac ccactcactg gctttgacct
     3061 tcaactgcca gtctgggcaa ataccagtga gctctgttgt accaagacca ggtcttcaga
     3121 gcatctgaac cactgtggcc ttctcttctc agccttcact gtgacacggg ggacattgag
     3181 tgacaagcct cagaatgtta cagaggtaaa gtgaggcatc tcaaatccac tgacagataa
     3241 gaaaaccgcg ttagagggaa agtcacctct gctattgtag aaagtggcag aatatccaaa
     3301 cttaactcta gcttccatgt ctgtctttat taccttcatc ttcctacttc ctgtcccacc
     3361 ggcatctcac ttaattgagc ctaatgtcag tatctgtgtg tgccaatgct gttaccacat
     3421 cctggtgaag ctaaaaaata aaatttaatt tggaccaaaa aaaaaaaaaa aaaa
//
