LOCUS       NM_010175               2876 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus Fas associated via death domain (Fadd), mRNA.
ACCESSION   NM_010175
VERSION     NM_010175.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Rodriguez,D.A., Tummers,B., Shaw,J.J.P., Quarato,G., Weinlich,R.,
            Cripps,J., Fitzgerald,P., Janke,L.J., Pelletier,S., Crawford,J.C.
            and Green,D.R.
  TITLE     The interaction between RIPK1 and FADD controls perinatal lethality
            and inflammation
  JOURNAL   Cell Rep 43 (6), 114335 (2024)
   PUBMED   38850531
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 2876)
  AUTHORS   Deng,X., Wang,L., Zhai,Y., Liu,Q., Du,F., Zhang,Y., Zhao,W., Wu,T.,
            Tao,Y., Deng,J., Cao,Y., Hao,P., Ren,J., Shen,Y., Yu,Z., Zheng,Y.,
            Zhang,H. and Wang,H.
  TITLE     RIPK1 plays a crucial role in maintaining regulatory T-Cell
            homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
  JOURNAL   Cell Mol Immunol 21 (1), 80-90 (2024)
   PUBMED   38082146
  REMARK    GeneRIF: RIPK1 plays a crucial role in maintaining regulatory
            T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell
            death.
REFERENCE   6  (bases 1 to 2876)
  AUTHORS   Yeh,W.C., de la Pompa,J.L., McCurrach,M.E., Shu,H.B., Elia,A.J.,
            Shahinian,A., Ng,M., Wakeham,A., Khoo,W., Mitchell,K.,
            El-Deiry,W.S., Lowe,S.W., Goeddel,D.V. and Mak,T.W.
  TITLE     FADD: essential for embryo development and signaling from some, but
            not all, inducers of apoptosis
  JOURNAL   Science 279 (5358), 1954-1958 (1998)
   PUBMED   9506948
REFERENCE   7  (bases 1 to 2876)
  AUTHORS   Zhang,J., Cado,D., Chen,A., Kabra,N.H. and Winoto,A.
  TITLE     Fas-mediated apoptosis and activation-induced T-cell proliferation
            are defective in mice lacking FADD/Mort1
  JOURNAL   Nature 392 (6673), 296-300 (1998)
   PUBMED   9521326
REFERENCE   8  (bases 1 to 2876)
  AUTHORS   Zhang,J. and Winoto,A.
  TITLE     A mouse Fas-associated protein with homology to the human
            Mort1/FADD protein is essential for Fas-induced apoptosis
  JOURNAL   Mol Cell Biol 16 (6), 2756-2763 (1996)
   PUBMED   8649383
REFERENCE   9  (bases 1 to 2876)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   10 (bases 1 to 2876)
  AUTHORS   Boldin,M.P., Varfolomeev,E.E., Pancer,Z., Mett,I.L., Camonis,J.H.
            and Wallach,D.
  TITLE     A novel protein that interacts with the death domain of Fas/APO1
            contains a sequence motif related to the death domain
  JOURNAL   J Biol Chem 270 (14), 7795-7798 (1995)
   PUBMED   7536190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153792.4.
            
            On Jun 3, 2018 this sequence version replaced NM_010175.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169798.1, AK084808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC153792.4         95486-95823         c
            339-2876            AC153792.4         91705-94242         c
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.85 cM"
     gene            1..2876
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /note="Fas associated via death domain"
                     /db_xref="GeneID:14082"
                     /db_xref="MGI:MGI:109324"
     exon            1..338
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..670
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /note="Fas-associating protein with death domain; protein
                     FADD; mediator of receptor induced toxicity;
                     FAS-associating death domain-containing protein; Fas
                     (TNFRSF6)-associated via death domain"
                     /codon_start=1
                     /product="FAS-associated death domain protein"
                     /protein_id="NP_034305.1"
                     /db_xref="CCDS:CCDS22050.1"
                     /db_xref="GeneID:14082"
                     /db_xref="MGI:MGI:109324"
                     /translation="MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLD
                     LFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFD
                     IVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAG
                     LVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP"
     exon            339..2876
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /note="hexamer: AATAAA"
     polyA_site      1507
                     /gene="Fadd"
                     /gene_synonym="Mort1/FADD"
                     /note="major polyA site"
ORIGIN      
        1 aaggtgattt cctatgtggg atcgctgagg ggcagcccgg cgtaccactg ccatggaccc
       61 attcctggtg ctgctgcact cgctgtccgg cagcctgtcg ggcaacgatc tgatggagct
      121 caagttcttg tgccgcgagc gcgtgagcaa acgaaagctg gagcgcgtgc agagtggcct
      181 ggacctgttc acggtgctgc tggagcagaa cgacctggag cgcgggcaca ccgggctgct
      241 gcgcgagttg ctggcctcgc tgcgccgaca cgatctactg cagcgcctgg acgacttcga
      301 ggcggggacg gcgaccgctg cgcccccggg ggaggcagat ctgcaggtgg catttgacat
      361 tgtgtgtgac aatgtgggga gagactggaa aagactggcc cgcgagctga aggtgtctga
      421 ggccaagatg gatgggattg aggagaagta cccccgaagt ctgagtgagc gggtaaggga
      481 gagtctgaaa gtctggaaga atgctgagaa gaagaacgcc tcggtggccg gactggttaa
      541 ggcgctgcgg acctgcaggc tgaatctggt ggctgacctg gtggaagaag cccaggaatc
      601 tgtgagcaag agtgagaata tgtccccagt actaagggat tcaactgtgt cttcctcaga
      661 aacaccctga caagcctaca gctcctctca ggagtcactg tggacttgat cacaccatga
      721 tgtagcacca agtgcctttt gtgcccagtg ccaaaaagac cttgctgatc cagggcgggt
      781 cccctcccac cagctcctgg agtatatctg tatctacgga acctctgctc cctgggcttt
      841 cggaacacat gaaggttccc cgtcgtgttc tccaccactg ctcctccccc ccaccccccc
      901 aagaggtctc tggtcttgca agaaggaagt tgaagctgat ggcacatgtg ctgactgcag
      961 tttgagagcc ttcttcttgt tccttggggg aagacaccat ctcagttaag atcacttggt
     1021 tgccttacag ttggccaaga ggacatctgt ctcacatcct tggaggccat cagacagcag
     1081 ctcctgaccc cccaccctca aacaagtgca agacccctgt gaggactgtg gtttaaaggg
     1141 tagcaccttg cctccatggt ggtctgtaag caagtgccct gggcctacct acatatagtg
     1201 gctcactctg aaatcctagc acttgagagt tgagaactgc actttacagc agcctgagct
     1261 acaaatgaga tgttctcccc aaacacacaa aagcaagtgc ctttacctgg agataacttg
     1321 tgtcaccaag aatttctatt atattaagaa cccttctaac ctcagaaatc cctcccatca
     1381 ggctgactga ggtgtgctta cagccctggg tgctagttgt gaatggagtg atgtgatttc
     1441 cttcacacca gcaggggccc tgactgccac acttggagcc caataaacca ttgtctcagc
     1501 tttctaacct ttggctgggt gtgataatac atacctttga tcctagcttt ttagggaggt
     1561 ggaagcaggt ggatctctgt gatctatgag ttcaaggaca gcctagccta catagagaac
     1621 actaagtaga aagaccatat ctcaaataaa taaaagttca tgtctggaga agaggatctt
     1681 agccacaggt tctcctgaca gagtgaagag ctgtacctca ctgtcctaac ctaatgtgga
     1741 cttcaagtga ccagcctggg gcctgtactc aaacacagat cagtcatttc ctggcactta
     1801 ggttctatgc cctcatttcc tgctccctgc tccacctatc caccagacag ctgacccctc
     1861 agcacacttg aactctcctc aatcgccttc cgcattgttg gtccctcctg cattccttgg
     1921 gttgcaccct cctccacagc ctcaagccta ccatgttctt cagctcagca ttgctccatc
     1981 tggctgtttg ttcaaattct tggccattga ggcctcctga ctactctggg gactcatcct
     2041 gttttctctg accccatttc tcacctggct gtagccacaa tgctcttgac tccccagact
     2101 atgcataggc ctgtataagg tgtctggtgg gtgttctctg tcattctcta cccctccccc
     2161 tttctccagt ttgaagggtt taagacacgg tttcttgtag cccagatgta acctaggttg
     2221 gcctcaagct gagtgtaact gaagtgacct tgaactcctt tctgatcatc ctatgcgcta
     2281 ggaagcctgg gcaaccctac tgctcttgct gatgcctttt aactgtcctg tggcaagtca
     2341 caggtcgatg ggcttagatg tcactttttt tttttttttt ttttttggtt tttccagaca
     2401 gggtttctct gtatagccct ggctgtcctg gaactcactt tgtagaccag gctggccttg
     2461 aactcagaaa tccgcctgcc tctgcctccc cagtgctggg atcaaaggcg tgcgtcacca
     2521 cgcccggcgt gtcacatttt ttgtacagct caggaatcca aaatggctct ccagagttca
     2581 gctcagatat gagcaagctg gtttccttct agatttaaga gaatgtcact tgctgtattc
     2641 ccctctttaa gtggcagtat tgagttacta ctgttgcagg gcttttgggc caccaaagaa
     2701 acttatccct ttgtacagag tcccttcaac cacgttgggg attaaaacgc ggtcatcatc
     2761 agggtgagca ccccacacat ctctgcatct ccccaacttg tgcccagttt tgccctgaac
     2821 acctcagcat caattcctcc tgctgctaat aaaggcttgt cagagctgca cagctc
//
