LOCUS       NM_008375                510 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus fatty acid binding protein 6 (Fabp6), mRNA.
ACCESSION   NM_008375
VERSION     NM_008375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Habib,S.M., Zwicker,B.L., Wykes,L. and Agellon,L.B.
  TITLE     Sexually dimorphic response of mice to the Western-style diet
            caused by deficiency of fatty acid binding protein 6 (Fabp6)
  JOURNAL   Physiol Rep 9 (3), e14733 (2021)
   PUBMED   33527741
  REMARK    GeneRIF: Sexually dimorphic response of mice to the Western-style
            diet caused by deficiency of fatty acid binding protein 6 (Fabp6).
REFERENCE   3  (bases 1 to 510)
  AUTHORS   Srivillibhuthur,M., Warder,B.N., Toke,N.H., Shah,P.P., Feng,Q.,
            Gao,N., Bonder,E.M. and Verzi,M.P.
  TITLE     TFAM is required for maturation of the fetal and adult intestinal
            epithelium
  JOURNAL   Dev Biol 439 (2), 92-101 (2018)
   PUBMED   29684311
REFERENCE   4  (bases 1 to 510)
  AUTHORS   Duggavathi,R., Siddappa,D., Schuermann,Y., Pansera,M., Menard,I.J.,
            Praslickova,D. and Agellon,L.B.
  TITLE     The fatty acid binding protein 6 gene (Fabp6) is expressed in
            murine granulosa cells and is involved in ovulatory response to
            superstimulation
  JOURNAL   J Reprod Dev 61 (3), 237-240 (2015)
   PUBMED   25754072
  REMARK    GeneRIF: expression of the Fabp6 gene in granulosa cells serves an
            important and previously unrecognized function in fertility
REFERENCE   5  (bases 1 to 510)
  AUTHORS   Praslickova,D., Torchia,E.C., Sugiyama,M.G., Magrane,E.J.,
            Zwicker,B.L., Kolodzieyski,L. and Agellon,L.B.
  TITLE     The ileal lipid binding protein is required for efficient
            absorption and transport of bile acids in the distal portion of the
            murine small intestine
  JOURNAL   PLoS One 7 (12), e50810 (2012)
   PUBMED   23251388
  REMARK    GeneRIF: The results demonstrate that ilbp is involved in the
            apical to basolateral transport of bile acids in ileal enterocytes,
            and is vital for the maintenance of bile acid homeostasis in the
            enterohepatic circulation (EHC) in mice.
REFERENCE   6  (bases 1 to 510)
  AUTHORS   Labonte,E.D., Li,Q., Kay,C.M. and Agellon,L.B.
  TITLE     The relative ligand binding preference of the murine ileal lipid
            binding protein
  JOURNAL   Protein Expr Purif 28 (1), 25-33 (2003)
   PUBMED   12651103
  REMARK    GeneRIF: The ligand binding activity of purified recombinant murine
            ILBP (mILBP) in vitro; mILBP exhibits a preference for certain
            species of bile and fatty acids.
REFERENCE   7  (bases 1 to 510)
  AUTHORS   Grober,J., Zaghini,I., Fujii,H., Jones,S.A., Kliewer,S.A.,
            Willson,T.M., Ono,T. and Besnard,P.
  TITLE     Identification of a bile acid-responsive element in the human ileal
            bile acid-binding protein gene. Involvement of the farnesoid X
            receptor/9-cis-retinoic acid receptor heterodimer
  JOURNAL   J Biol Chem 274 (42), 29749-29754 (1999)
   PUBMED   10514450
REFERENCE   8  (bases 1 to 510)
  AUTHORS   Stengelin,S., Apel,S., Becker,W., Maier,M., Rosenberger,J.,
            Bewersdorf,U., Girbig,F., Weyland,C., Wess,G. and Kramer,W.
  TITLE     The rabbit ileal lipid-binding protein. Gene cloning and functional
            expression of the recombinant protein
  JOURNAL   Eur J Biochem 239 (3), 887-896 (1996)
   PUBMED   8774740
REFERENCE   9  (bases 1 to 510)
  AUTHORS   Birkenmeier,E.H., Rowe,L.B., Crossman,M.W. and Gordon,J.I.
  TITLE     Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 5 (12), 805-806 (1994)
   PUBMED   7894165
REFERENCE   10 (bases 1 to 510)
  AUTHORS   Crossman,M.W., Hauft,S.M. and Gordon,J.I.
  TITLE     The mouse ileal lipid-binding protein gene: a model for studying
            axial patterning during gut morphogenesis
  JOURNAL   J Cell Biol 126 (6), 1547-1564 (1994)
   PUBMED   8089185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ043022.1 and BC119289.1.
            
            On Jan 12, 2013 this sequence version replaced NM_008375.1.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. This protein functions within the ileum,
            the distal 25-30% of the small intestine, and plays a role in
            enterohepatic circulation of bile acids and cholesterol
            homeostasis. In humans, it has been reported that polymorphisms in
            FABP6 confer a protective effect in obese individuals from
            developing type 2 diabetes. In mice deficiency of this gene affects
            bile acid metabolism in a gender-specific manner and was reported
            to be required for efficient apical to basolateral transport of
            conjugated bile acids. [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ043022.1, BX633352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CJ043022.1         1-30
            31-510              BC119289.1         1-480
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.81 cM"
     gene            1..510
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /note="fatty acid binding protein 6"
                     /db_xref="GeneID:16204"
                     /db_xref="MGI:MGI:96565"
     exon            1..118
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..438
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /note="ileal lipid-binding protein; ileal bile
                     acid-binding protein"
                     /codon_start=1
                     /product="gastrotropin"
                     /protein_id="NP_032401.1"
                     /db_xref="CCDS:CCDS24560.1"
                     /db_xref="GeneID:16204"
                     /db_xref="MGI:MGI:96565"
                     /translation="MAFSGKYEFESEKNYDEFMKRLGLPGDVIERGRNFKIITEVQQD
                     GQDFTWSQSYSGGNIMSNKFTIGKECEMQTMGGKKFKATVKMEGGKVVAEFPNYHQTS
                     EVVGDKLVEISTIGDVTYERVSKRLA"
     exon            119..294
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /inference="alignment:Splign:2.1.0"
     exon            295..384
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /inference="alignment:Splign:2.1.0"
     exon            385..510
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      475..480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /note="hexamer: AATAAA"
     polyA_site      497
                     /gene="Fabp6"
                     /gene_synonym="GT; I-15P; I-BABP; ILBP; ILBP3; Illbp"
                     /note="major polyA site"
ORIGIN      
        1 gaccaacctt cttccttagc tgctcgctgc tgccagctct cttccagcac catggccttc
       61 agtggcaaat atgaatttga gagtgagaag aattacgatg agttcatgaa gcgcctgggt
      121 cttccaggag acgtgattga aaggggacgt aacttcaaga tcatcacaga ggtccagcag
      181 gacggacagg acttcacctg gtcccagtct tactctgggg gcaacattat gagcaacaag
      241 ttcaccattg gcaaagaatg tgaaatgcag accatggggg gcaagaagtt caaggctacc
      301 gtgaagatgg agggtggcaa ggtggtggca gagttcccca actatcacca gacttcggag
      361 gtcgtgggtg acaagttggt ggagatctcc accatcgggg atgtgaccta tgagcgcgta
      421 agcaagaggc tggcttgagc taccaggctg ggcttggagg ggctacgacc caccaataaa
      481 agtgtttcat ggatcaccac tgctagcccc
//
