LOCUS       NM_010634                969 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus fatty acid binding protein 5, epidermal (Fabp5),
            transcript variant 1, mRNA.
ACCESSION   NM_010634
VERSION     NM_010634.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Liu,J., Li,J., Wu,X., Zhang,M., Yan,G., Sun,H. and Li,D.
  TITLE     High levels of fatty acid-binding protein 5 excessively enhances
            fatty acid synthesis and proliferation of granulosa cells in
            polycystic ovary syndrome
  JOURNAL   J Ovarian Res 17 (1), 44 (2024)
   PUBMED   38373971
  REMARK    GeneRIF: High levels of fatty acid-binding protein 5 excessively
            enhances fatty acid synthesis and proliferation of granulosa cells
            in polycystic ovary syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Hao,J., Yu,J., Yorek,M.S., Yu,C.L., Pope,R.M., Chimenti,M.S.,
            Xiong,Y., Klingelhutz,A., Jabbari,A. and Li,B.
  TITLE     Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils
            in psoriasis
  JOURNAL   Cell Rep 42 (11), 113449 (2023)
   PUBMED   37967009
  REMARK    GeneRIF: Keratinocyte FABP5-VCP complex mediates recruitment of
            neutrophils in psoriasis.
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Penman,S.L., Roeder,N.M., Berthold,E.C., Senetra,A.S., Marion,M.,
            Richardson,B.J., White,O., Fearby,N.L., McCurdy,C.R., Hamilton,J.,
            Sharma,A. and Thanos,P.K.
  TITLE     FABP5 is important for cognitive function and is an important
            regulator of the physiological effects and pharmacokinetics of
            acute Delta9 tetrahydrocannabinol inhalation in mice
  JOURNAL   Pharmacol Biochem Behav 231, 173633 (2023)
   PUBMED   37716413
  REMARK    GeneRIF: FABP5 is important for cognitive function and is an
            important regulator of the physiological effects and
            pharmacokinetics of acute Delta9 tetrahydrocannabinol inhalation in
            mice.
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Reynolds,J.M., Liu,Q., Brittingham,K.C., Liu,Y., Gruenthal,M.,
            Gorgun,C.Z., Hotamisligil,G.S., Stout,R.D. and Suttles,J.
  TITLE     Deficiency of fatty acid-binding proteins in mice confers
            protection from development of experimental autoimmune
            encephalomyelitis
  JOURNAL   J Immunol 179 (1), 313-321 (2007)
   PUBMED   17579051
  REMARK    GeneRIF: Metabolic-inflammatory pathway cross-regulation by
            epidermal-type FABP contributes to adaptive immune responses and
            subsequent autoimmune inflammation.
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Maeda,K., Cao,H., Kono,K., Gorgun,C.Z., Furuhashi,M., Uysal,K.T.,
            Cao,Q., Atsumi,G., Malone,H., Krishnan,B., Minokoshi,Y., Kahn,B.B.,
            Parker,R.A. and Hotamisligil,G.S.
  TITLE     Adipocyte/macrophage fatty acid binding proteins control integrated
            metabolic responses in obesity and diabetes
  JOURNAL   Cell Metab 1 (2), 107-119 (2005)
   PUBMED   16054052
REFERENCE   6  (bases 1 to 969)
  AUTHORS   Owada,Y., Suzuki,R., Iwasa,H., Spener,F. and Kondo,H.
  TITLE     Localization of epidermal-type fatty acid binding protein in the
            thymic epithelial cells of mice
  JOURNAL   Histochem Cell Biol 117 (1), 55-60 (2002)
   PUBMED   11819097
REFERENCE   7  (bases 1 to 969)
  AUTHORS   Yanase,H., Shimizu,H., Kanda,T., Fujii,H. and Iwanaga,T.
  TITLE     Cellular localization of the diazepam binding inhibitor (DBI) in
            the gastrointestinal tract of mice and its coexistence with the
            fatty acid binding protein (FABP)
  JOURNAL   Arch Histol Cytol 64 (4), 449-460 (2001)
   PUBMED   11757913
REFERENCE   8  (bases 1 to 969)
  AUTHORS   Hertzel,A.V. and Bernlohr,D.A.
  TITLE     Cloning and chromosomal location of the murine keratinocyte
            lipid-binding protein gene
  JOURNAL   Gene 221 (2), 235-243 (1998)
   PUBMED   9795232
REFERENCE   9  (bases 1 to 969)
  AUTHORS   Bleck,B., Hohoff,C., Binas,B., Rustow,B., Dixkens,C., Hameister,H.,
            Borchers,T. and Spener,F.
  TITLE     Cloning and chromosomal localisation of the murine epidermal-type
            fatty acid binding protein gene (Fabpe)
  JOURNAL   Gene 215 (1), 123-130 (1998)
   PUBMED   9666100
REFERENCE   10 (bases 1 to 969)
  AUTHORS   Krieg,P., Feil,S., Furstenberger,G. and Bowden,G.T.
  TITLE     Tumor-specific overexpression of a novel keratinocyte lipid-binding
            protein. Identification and characterization of a cloned sequence
            activated during multistage carcinogenesis in mouse skin
  JOURNAL   J Biol Chem 268 (23), 17362-17369 (1993)
   PUBMED   8349619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157379.7, AK011551.1 and
            BE987062.1.
            
            On Jan 15, 2013 this sequence version replaced NM_010634.2.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. In humans this gene has been associated
            with psoriasis and type 2 diabetes. In mouse deficiency of this
            gene in combination with a deficiency in Fabp4 confers protection
            against atherosclerosis, diet-induced obesity, insulin resistance
            and experimental autoimmune encephalomyelitis (the mouse model for
            multiple sclerosis). Alternative splicing results in multiple
            transcript variants that encode different protein isoforms. The
            mouse genome contains many pseudogenes similar to this locus.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70100.1, CK792559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC157379.7         67142-67145         c
            5-950               AK011551.1         1-946
            951-969             BE987062.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.47 cM"
     gene            1..969
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="fatty acid binding protein 5, epidermal"
                     /db_xref="GeneID:16592"
                     /db_xref="MGI:MGI:101790"
     exon            1..134
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..463
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="isoform 1 is encoded by transcript variant 1; fatty
                     acid-binding protein, epidermal; epithelial fatty
                     acid-binding protein; keratinocyte lipid-binding protein;
                     epidermal-type fatty acid-binding protein;
                     psoriasis-associated fatty acid-binding protein homolog"
                     /codon_start=1
                     /product="fatty acid-binding protein 5 isoform 1"
                     /protein_id="NP_034764.1"
                     /db_xref="CCDS:CCDS38388.1"
                     /db_xref="GeneID:16592"
                     /db_xref="MGI:MGI:101790"
                     /translation="MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCI
                     ITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDG
                     KESTITRKLKDGKMIVECVMNNATCTRVYEKVQ"
     exon            135..307
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            308..409
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            410..953
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      659..664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      685
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="major polyA site"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      953
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /note="major polyA site"
ORIGIN      
        1 cggaacagcg ccctcgccac cgcgtctctg ctgcttttgt gctctccctc ccaccatggc
       61 cagtcttaag gatctcgaag ggaagtggcg cctgatggaa agccacggct ttgaggagta
      121 catgaaagag ctaggagtag gactggctct taggaagatg gctgccatgg ccaagccaga
      181 ctgtatcatt acgtgtgatg gcaacaacat cacggtcaaa accgagagca cagtgaagac
      241 gactgtgttc tcttgtaacc tgggagagaa gtttgatgaa acgacagctg atggcagaaa
      301 aactgagacg gtctgcacct tccaagacgg tgccctggtc cagcaccagc aatgggacgg
      361 gaaggagagc acgataacaa gaaaactgaa ggatgggaag atgatcgtgg agtgtgtcat
      421 gaacaatgcc acctgcactc gggtctatga gaaggtgcaa tgagggcttc ctcgtcatcc
      481 tggacaggag ttagctgcca gagtgaatat gctcaattca gtgagcggtc aaatgcaaca
      541 aacagcttca cttctttggt tttatttttc atgactgttg agttctcttt atcacaaaca
      601 ctttacatgg accttcatgt caaacttggt ttacccagga tcattccttt ggttagtaaa
      661 taaacgtgtt agtgctaatt tatgatatgt gtgtgggttc ttcaaggaat tgaaaattgg
      721 tgatacatta taacacttag aaattgaaaa gctctctggt attcttcagg atcccttatg
      781 actgatatat cctagcaact tgtagacgtg gccagcttct tttgcagtga atacatgccc
      841 cgtcatttaa gcttgcctta aatcgtttga actttgtcaa ctcaataatt gagactattc
      901 ctatcgaatg atagctacat aaattttata gaataaaggg agatccaagc ttaaaaaaaa
      961 aaaaaaaaa
//
