LOCUS       NM_024406                638 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fatty acid binding protein 4, adipocyte (Fabp4),
            transcript variant 1, mRNA.
ACCESSION   NM_024406
VERSION     NM_024406.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Allen,R.S., Biswas,S.K. and Seifert,A.W.
  TITLE     Ear pinna growth and differentiation is conserved in murids and
            requires BMP signaling for chondrocyte proliferation
  JOURNAL   Development 152 (3) (2025)
   PUBMED   39846506
REFERENCE   2  (bases 1 to 638)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   3  (bases 1 to 638)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   4  (bases 1 to 638)
  AUTHORS   Couselo-Seijas,M., Vazquez-Abuin,X., Gomez-Lazaro,M., Pereira,L.,
            Gomez,A.M., Caballero,R., Delpon,E., Bravo,S.,
            Gonzalez-Juanatey,J.R. and Eiras,S.
  TITLE     FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca2+
            Dynamic Changes
  JOURNAL   Circ Arrhythm Electrophysiol 17 (9), e012683 (2024)
   PUBMED   39212041
  REMARK    GeneRIF: FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and
            Ca[2+] Dynamic Changes.
REFERENCE   5  (bases 1 to 638)
  AUTHORS   Farley,A., Gao,Y., Sun,Y., Zohrabian,S., Pu,W.T. and Lin,Z.
  TITLE     Activation of VGLL4 Suppresses Cardiomyocyte Maturational
            Hypertrophic Growth
  JOURNAL   Cells 13 (16), 1342 (2024)
   PUBMED   39195232
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 638)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   7  (bases 1 to 638)
  AUTHORS   Xu,Z., Bernlohr,D.A. and Banaszak,L.J.
  TITLE     Crystal structure of recombinant murine adipocyte lipid-binding
            protein
  JOURNAL   Biochemistry 31 (13), 3484-3492 (1992)
   PUBMED   1554730
REFERENCE   8  (bases 1 to 638)
  AUTHORS   Serikawa,T., Montagutelli,X., Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Polymorphisms revealed by PCR with single, short-sized, arbitrary
            primers are reliable markers for mouse and rat gene mapping
  JOURNAL   Mamm Genome 3 (2), 65-72 (1992)
   PUBMED   1617216
REFERENCE   9  (bases 1 to 638)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   10 (bases 1 to 638)
  AUTHORS   Cook,J.S., Lucas,J.J., Sibley,E., Bolanowski,M.A., Christy,R.J.,
            Kelly,T.J. and Lane,M.D.
  TITLE     Expression of the differentiation-induced gene for fatty
            acid-binding protein is activated by glucocorticoid and cAMP
  JOURNAL   Proc Natl Acad Sci U S A 85 (9), 2949-2953 (1988)
   PUBMED   2452440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113990.10.
            
            On Mar 14, 2022 this sequence version replaced NM_024406.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054426.1, CB587478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC113990.10        167211-167348       c
            139-311             AC113990.10        164722-164894       c
            312-413             AC113990.10        164013-164114       c
            414-638             AC113990.10        163118-163342       c
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.56 cM"
     gene            1..638
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /note="fatty acid binding protein 4, adipocyte"
                     /db_xref="GeneID:11770"
                     /db_xref="MGI:MGI:88038"
     exon            1..138
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..464
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /note="isoform 1 is encoded by transcript variant 1; fatty
                     acid-binding protein, adipocyte; protein 422; P2 adipocyte
                     protein; myelin P2 protein homolog; 3T3-L1 lipid-binding
                     protein; fatty acid-binding protein 4; adipocyte
                     lipid-binding protein; adipocyte-type fatty acid-binding
                     protein; adipocyte protein aP2"
                     /codon_start=1
                     /product="fatty acid-binding protein, adipocyte isoform 1"
                     /protein_id="NP_077717.1"
                     /db_xref="CCDS:CCDS17238.1"
                     /db_xref="GeneID:11770"
                     /db_xref="MGI:MGI:88038"
                     /translation="MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIIS
                     VNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKS
                     TTIKRKRDGDKLVVECVMKGVTSTRVYERA"
     exon            139..311
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /inference="alignment:Splign:2.1.0"
     exon            312..413
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /inference="alignment:Splign:2.1.0"
     exon            414..638
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      618..623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /note="hexamer: AATAAA"
     polyA_site      638
                     /gene="Fabp4"
                     /gene_synonym="422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl;
                     P15"
                     /note="major polyA site"
ORIGIN      
        1 atagcaccct cctgtgctgc agcctttctc acctggaaga cagctcctcc tcgaaggttt
       61 acaaaatgtg tgatgccttt gtgggaacct ggaagcttgt ctccagtgaa aacttcgatg
      121 attacatgaa agaagtggga gtgggctttg ccacaaggaa agtggcaggc atggccaagc
      181 ccaacatgat catcagcgta aatggggatt tggtcaccat ccggtcagag agtactttta
      241 aaaacaccga gatttccttc aaactgggcg tggaattcga tgaaatcacc gcagacgaca
      301 ggaaggtgaa gagcatcata accctagatg gcggggccct ggtgcaggtg cagaagtggg
      361 atggaaagtc gaccacaata aagagaaaac gagatggtga caagctggtg gtggaatgtg
      421 ttatgaaagg cgtgacttcc acaagagttt atgaaagggc atgagccaaa ggaagaggcc
      481 tggatggaaa tttgcatcaa acactacaat agtcagtcgg atttattgtt tttttttaaa
      541 gatatgattt tccactaata agcaagcaat taattttttc tgaagatgca ttttattgga
      601 tatggttatg ttgattaaat aaaacctttt tagactta
//
