LOCUS       NM_007980                977 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fatty acid binding protein 2, intestinal (Fabp2),
            mRNA.
ACCESSION   NM_007980
VERSION     NM_007980.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Sekimori,T., Fukunaga,K., Oizumi,H., Baba,T., Totsune,T.,
            Takeda,A., Sasaki,T. and Kawahata,I.
  TITLE     FABP2 is Involved in Intestinal alpha-Synuclein Pathologies
  JOURNAL   J Integr Neurosci 23 (2), 44 (2024)
   PUBMED   38419457
  REMARK    GeneRIF: FABP2 is Involved in Intestinal alpha-Synuclein
            Pathologies.
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Agellon,L.B., Drozdowski,L., Li,L., Iordache,C., Luong,L.,
            Clandinin,M.T., Uwiera,R.R., Toth,M.J. and Thomson,A.B.
  TITLE     Loss of intestinal fatty acid binding protein increases the
            susceptibility of male mice to high fat diet-induced fatty liver
  JOURNAL   Biochim Biophys Acta 1771 (10), 1283-1288 (2007)
   PUBMED   17905650
  REMARK    GeneRIF: loss of I-FABP renders male mice sensitive to high fat
            diet-induced fatty liver, and this effect is independent of hepatic
            L-FABP
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Vassileva,G., Huwyler,L., Poirier,K., Agellon,L.B. and Toth,M.J.
  TITLE     The intestinal fatty acid binding protein is not essential for
            dietary fat absorption in mice
  JOURNAL   FASEB J 14 (13), 2040-2046 (2000)
   PUBMED   11023988
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Oesterreicher,T.J., Leeper,L.L., Finegold,M.J., Darlington,G.J. and
            Henning,S.J.
  TITLE     Intestinal maturation in mice lacking CCAAT/enhancer-binding
            protein alpha (C/EPBalpha)
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1165-1171 (1998)
   PUBMED   9494081
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Poirier,H., Niot,I., Degrace,P., Monnot,M.C., Bernard,A. and
            Besnard,P.
  TITLE     Fatty acid regulation of fatty acid-binding protein expression in
            the small intestine
  JOURNAL   Am J Physiol 273 (2 Pt 1), G289-G295 (1997)
   PUBMED   9277406
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Kaestner,K.H., Silberg,D.G., Traber,P.G. and Schutz,G.
  TITLE     The mesenchymal winged helix transcription factor Fkh6 is required
            for the control of gastrointestinal proliferation and
            differentiation
  JOURNAL   Genes Dev 11 (12), 1583-1595 (1997)
   PUBMED   9203584
REFERENCE   8  (bases 1 to 977)
  AUTHORS   Cohn,S.M., Simon,T.C., Roth,K.A., Birkenmeier,E.H. and Gordon,J.I.
  TITLE     Use of transgenic mice to map cis-acting elements in the intestinal
            fatty acid binding protein gene (Fabpi) that control its cell
            lineage-specific and regional patterns of expression along the
            duodenal-colonic and crypt-villus axes of the gut epithelium
  JOURNAL   J Cell Biol 119 (1), 27-44 (1992)
   PUBMED   1527171
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Green,R.P., Cohn,S.M., Sacchettini,J.C., Jackson,K.E. and
            Gordon,J.I.
  TITLE     The mouse intestinal fatty acid binding protein gene: nucleotide
            sequence, pattern of developmental and regional expression, and
            proposed structure of its protein product
  JOURNAL   DNA Cell Biol 11 (1), 31-41 (1992)
   PUBMED   1739433
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA245078.1, AK007995.1 and
            BY707992.1.
            
            On Jan 11, 2013 this sequence version replaced NM_007980.2.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. This protein functions within
            enterocytes, possibly to sense lipids as part of energy
            homeostasis. In humans polymorphisms are associated with increased
            fat oxidation and insulin resistance. In mice deficiency of this
            gene alters body weight in a gender-specific manner and causes
            hyperinsulinemia. [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY707992.1, BB610447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AA245078.1         1-304
            305-962             AK007995.1         3-660
            963-977             BY707992.1         659-673
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.74 cM"
     gene            1..977
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /note="fatty acid binding protein 2, intestinal"
                     /db_xref="GeneID:14079"
                     /db_xref="MGI:MGI:95478"
     exon            1..408
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..740
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /note="intestinal fatty acid binding protein 2;
                     intestinal-type fatty acid-binding protein"
                     /codon_start=1
                     /product="fatty acid-binding protein, intestinal"
                     /protein_id="NP_032006.1"
                     /db_xref="CCDS:CCDS17813.1"
                     /db_xref="GeneID:14079"
                     /db_xref="MGI:MGI:95478"
                     /translation="MAFDGTWKVDRNENYEKFMEKMGINVMKRKLGAHDNLKLTITQD
                     GNKFTVKESSNFRNIDVVFELGVNFPYSLADGTELTGAWTIEGNKLIGKFTRVDNGKE
                     LIAVREVSGNELIQTYTYEGVEAKRFFKKE"
     exon            409..581
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            582..689
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            690..965
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      945..950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      965
                     /gene="Fabp2"
                     /gene_synonym="Fabpi; I-FABP"
                     /note="major polyA site"
ORIGIN      
        1 cttagaactg gctgcctctg cctccggaga gcagcgatta aaagtgtcag ccatcattac
       61 ctggccctaa ttcttgaaat aaaaatgccc acatgctgta gttgaaggca gagtaggaat
      121 gattatcaga ttttaattca gttgaatccc agcagtagat tcaaagaaag catgggaaga
      181 gaaaccaaag gggcctggca tgtgaggcgg ttaggttatc tcctgaactt cgaacttcca
      241 catcacagta tgaattggtt cgaagataag aaatagaata aattctctct agtggacagg
      301 actggacctc tgctttccta gagacacaca cagctgagat catggcattc gacggcacgt
      361 ggaaagtaga ccggaacgag aactatgaaa agttcatgga gaaaatgggc attaatgtga
      421 tgaagaggaa gcttggagct catgacaatc tgaaactgac aatcacacag gatggaaata
      481 aattcacagt caaagaatca agcaacttca gaaacattga tgttgtgttt gagctcggtg
      541 taaactttcc ctacagtcta gcagacggaa cggagctcac tggggcctgg accattgagg
      601 gaaataaact tattgggaaa ttcacacgtg tagacaatgg aaaggagctg attgctgtcc
      661 gagaggtttc tggtaatgaa ctaatccaga cctacacata tgaaggagtt gaggccaagc
      721 gattctttaa gaaggaataa gtcaacttct cagagcctgg agcaacgctg aagagctaag
      781 ctgatgtcag atttctttct ccatcatgct aatgccaggc tcattcgtca tcctatcagc
      841 actggtctcc agccttgtca aagctaaaga agtaaaagct aattaaaaga acttcatttg
      901 ttttatgatc cttaagctat acatgaacta gtcttttaaa agaaaataaa tcctgttctc
      961 acacaaaaaa aaaaaaa
//
