LOCUS       NM_017399                512 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus fatty acid binding protein 1, liver (Fabp1), mRNA.
ACCESSION   NM_017399
VERSION     NM_017399.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Newberry,E.P., Molitor,E.A., Liu,A., Chong,K., Liu,X., Alonso,C.,
            Mato,J.M. and Davidson,N.O.
  TITLE     Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes
            Tumorigenesis and Is Accelerated with Fabp1 Deletion
  JOURNAL   Am J Pathol 194 (6), 958-974 (2024)
   PUBMED   38417694
  REMARK    GeneRIF: Impaired Hepatic Very Low-Density Lipoprotein Secretion
            Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion.
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 512)
  AUTHORS   Tang,W., Sun,G., Ji,G.W., Feng,T., Zhang,Q., Cao,H., Wu,W.,
            Zhang,X., Liu,C., Liu,H., Huang,T., Liu,L., Xia,Y. and Wang,X.
  TITLE     Single-cell RNA-sequencing atlas reveals an FABP1-dependent
            immunosuppressive environment in hepatocellular carcinoma
  JOURNAL   J Immunother Cancer 11 (11), e007030 (2023)
   PUBMED   38007237
  REMARK    GeneRIF: Single-cell RNA-sequencing atlas reveals an
            FABP1-dependent immunosuppressive environment in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 512)
  AUTHORS   You,H., Wen,X., Wang,X., Zhu,C., Chen,H., Bu,L., Zhang,J. and Qu,S.
  TITLE     Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting
            ubiquitylation and degradation of FABP1
  JOURNAL   Free Radic Biol Med 207, 260-271 (2023)
   PUBMED   37499886
  REMARK    GeneRIF: Derlin-1 ameliorates nonalcoholic hepatic steatosis by
            promoting ubiquitylation and degradation of FABP1.
REFERENCE   5  (bases 1 to 512)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 512)
  AUTHORS   Mallordy,A., Poirier,H., Besnard,P., Niot,I. and Carlier,H.
  TITLE     Evidence for transcriptional induction of the liver
            fatty-acid-binding-protein gene by bezafibrate in the small
            intestine
  JOURNAL   Eur J Biochem 227 (3), 801-807 (1995)
   PUBMED   7867641
REFERENCE   7  (bases 1 to 512)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 512)
  AUTHORS   Norman,D.J., Fletcher,C. and Heintz,N.
  TITLE     Genetic mapping of the lurcher locus on mouse chromosome 6 using an
            intersubspecific backcross
  JOURNAL   Genomics 9 (1), 147-153 (1991)
   PUBMED   1672287
REFERENCE   9  (bases 1 to 512)
  AUTHORS   Bansal,M.P., Cook,R.G., Danielson,K.G. and Medina,D.
  TITLE     A 14-kilodalton selenium-binding protein in mouse liver is fatty
            acid-binding protein
  JOURNAL   J Biol Chem 264 (23), 13780-13784 (1989)
   PUBMED   2760043
REFERENCE   10 (bases 1 to 512)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131868.1 and AW113370.1.
            
            On Feb 21, 2018 this sequence version replaced NM_017399.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY105254.1, CD297710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AK131868.1         2-434
            434-512             AW113370.1         1-79                c
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     gene            1..512
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /note="fatty acid binding protein 1, liver"
                     /db_xref="GeneID:14080"
                     /db_xref="MGI:MGI:95479"
     exon            1..115
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..432
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /note="fatty acid-binding protein 1; 14 kDa
                     selenium-binding protein; liver-type fatty acid-binding
                     protein"
                     /codon_start=1
                     /product="fatty acid-binding protein, liver"
                     /protein_id="NP_059095.1"
                     /db_xref="CCDS:CCDS20226.1"
                     /db_xref="GeneID:14080"
                     /db_xref="MGI:MGI:95479"
                     /translation="MNFSGKYQLQSQENFEPFMKAIGLPEDLIQKGKDIKGVSEIVHE
                     GKKIKLTITYGPKVVRNEFTLGEECELETMTGEKVKAVVKLEGDNKMVTTFKGIKSVT
                     ELNGDTITNTMTLGDIVYKRVSKRI"
     exon            116..288
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            289..381
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            382..512
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      476..481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      499
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /note="major polyA site"
ORIGIN      
        1 aggcagagct gttgtggtca gctgtggaaa ggaagcctcg ttgccaccat gaacttctcc
       61 ggcaagtacc aattgcagag ccaggagaac tttgagccat tcatgaaggc aataggtctg
      121 cccgaggacc tcatccagaa agggaaggac atcaaggggg tgtcagaaat cgtgcatgaa
      181 gggaagaaaa tcaaactcac catcacctat ggacccaaag tggtccgcaa tgagttcacc
      241 ctgggggagg agtgcgaact ggagaccatg actggggaaa aagtcaaggc agtcgtcaag
      301 ctggaaggtg acaataaaat ggtgacaact ttcaaaggca taaagtccgt gactgaactc
      361 aatggagaca caatcaccaa taccatgaca ttgggcgaca ttgtctacaa gagagtcagc
      421 aagagaattt agacaaggct atatttcata ttcttttaca gtgtaaaatt aatacaataa
      481 agttaccttt cttttggaat aacttctcct tg
//
