LOCUS       NM_010173               3826 bp    mRNA    linear   ROD 26-MAR-2023
DEFINITION  Mus musculus fatty acid amide hydrolase (Faah), transcript variant
            1, mRNA.
ACCESSION   NM_010173
VERSION     NM_010173.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Chen C, Wang W, Raymond M, Ahmadinejad F, Poklis JL, Em B, Gewirtz
            DA, Lichtman AH and Li N.
  TITLE     Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates
            Cisplatin-Induced Nephropathy in Mice
  JOURNAL   Mol Pharmacol 103 (4), 230-240 (2023)
   PUBMED   36702548
  REMARK    GeneRIF: Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates
            Cisplatin-Induced Nephropathy in Mice.
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Simon A, von Einem T, Seidinger A, Matthey M, Bindila L and Wenzel
            D.
  TITLE     The endocannabinoid anandamide is an airway relaxant in health and
            disease
  JOURNAL   Nat Commun 13 (1), 6941 (2022)
   PUBMED   36396957
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Genovese T, Duranti A, D'Amico R, Fusco R, Impellizzeri D, Peritore
            AF, Crupi R, Gugliandolo E, Cuzzocrea S, Di Paola R, Siracusa R and
            Cordaro M.
  TITLE     Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in
            Counteracting Acute Lung Injury
  JOURNAL   Int J Mol Sci 23 (5), 2781 (2022)
   PUBMED   35269926
  REMARK    GeneRIF: Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key
            Role in Counteracting Acute Lung Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Yaghootfam C, Gehrig B, Sylvester M, Gieselmann V and Matzner U.
  TITLE     Deletion of fatty acid amide hydrolase reduces lyso-sulfatide
            levels but exacerbates metachromatic leukodystrophy in mice
  JOURNAL   J Biol Chem 297 (3), 101064 (2021)
   PUBMED   34375644
  REMARK    GeneRIF: Deletion of fatty acid amide hydrolase reduces
            lyso-sulfatide levels but exacerbates metachromatic leukodystrophy
            in mice.
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Kim JT, Terrell SM, Li VL, Wei W, Fischer CR and Long JZ.
  TITLE     Cooperative enzymatic control of N-acyl amino acids by PM20D1 and
            FAAH
  JOURNAL   Elife 9, e55211 (2020)
   PUBMED   32271712
  REMARK    GeneRIF: Cooperative enzymatic control of N-acyl amino acids by
            PM20D1 and FAAH.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Ye TZ, Gordon CT, Lai YH, Fujiwara Y, Peters LL, Perkins AC and
            Chui DH.
  TITLE     Ermap, a gene coding for a novel erythroid specific
            adhesion/receptor membrane protein
  JOURNAL   Gene 242 (1-2), 337-345 (2000)
   PUBMED   10721728
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Goparaju SK, Kurahashi Y, Suzuki H, Ueda N and Yamamoto S.
  TITLE     Anandamide amidohydrolase of porcine brain: cDNA cloning,
            functional expression and site-directed mutagenesis(1)
  JOURNAL   Biochim Biophys Acta 1441 (1), 77-84 (1999)
   PUBMED   10526230
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Paria BC, Zhao X, Wang J, Das SK and Dey SK.
  TITLE     Fatty-acid amide hydrolase is expressed in the mouse uterus and
            embryo during the periimplantation period
  JOURNAL   Biol Reprod 60 (5), 1151-1157 (1999)
   PUBMED   10208977
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Wan M, Cravatt BF, Ring HZ, Zhang X and Francke U.
  TITLE     Conserved chromosomal location and genomic structure of human and
            mouse fatty-acid amide hydrolase genes and evaluation of clasper as
            a candidate neurological mutation
  JOURNAL   Genomics 54 (3), 408-414 (1998)
   PUBMED   9878243
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Giang DK and Cravatt BF.
  TITLE     Molecular characterization of human and mouse fatty acid amide
            hydrolases
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2238-2242 (1997)
   PUBMED   9122178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627105.13, AK079598.1 and AK080603.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_010173.6.
            
            On Nov 4, 2017 this sequence version replaced NM_010173.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079598.1, BC052321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL627105.13        106841-106862       c
            23-1713             AK079598.1         2-1692
            1714-1714           AK080603.1         1525-1525
            1715-3826           AK079598.1         1694-3805
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.08 cM"
     gene            1..3826
                     /gene="Faah"
                     /note="fatty acid amide hydrolase"
                     /db_xref="GeneID:14073"
                     /db_xref="MGI:MGI:109609"
     exon            1..462
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2007
                     /gene="Faah"
                     /EC_number="3.5.1.99"
                     /note="amide hydrolase; fatty acid amide hydrolase
                     protein; oleamide hydrolase 1; anandamide amidohydrolase
                     1; fatty acid ester hydrolase"
                     /codon_start=1
                     /product="fatty-acid amide hydrolase 1"
                     /protein_id="NP_034303.3"
                     /db_xref="CCDS:CCDS18501.1"
                     /db_xref="GeneID:14073"
                     /db_xref="MGI:MGI:109609"
                     /translation="MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRA
                     RQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLG
                     KAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNE
                     GVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSS
                     GGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAV
                     QLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDN
                     YTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNF
                     KGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHE
                     IEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVP
                     VTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMR
                     EVERLMTPEKRPS"
     exon            463..576
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            577..711
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            712..845
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1052
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1093
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1218
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1344
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1442
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1542
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1583
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1623
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1732
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1878
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..3826
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcccacg cggagctcgt ctgttccgcc tgccttaaaa cgctggcacg ccaggaaccg
       61 ggccagaagg ggtctaggct tgaccttgac cgttggagct gctagcttgg ctctcgctgc
      121 cgggcaacgg cgcgctcccc gcgggcccgc ggctgcgcct gcccctccct caagcggaat
      181 cgcgggcgat ccaggccggg ttttgcagcg gagctgttgg tgtgcgcgtg ccgagtcctc
      241 tcgggtggcg gtcggctgca ggagatcatg gtgctgagcg aagtgtggac cgcgctgtct
      301 ggactctccg gggtttgcct agcctgcagc ttgctgtcgg cggcggtggt cctgcgatgg
      361 accaggagcc agaccgcccg gggcgcggtg accagggcgc ggcagaagca gcgagccggc
      421 ctggagacca tggacaaggc ggtgcagcgc ttccggctgc agaatcctga cctggattca
      481 gaggccttgc tggctctgcc cctgctccaa ctggtacaga agttacagag tggggaactg
      541 tccccagaag ctgtgctctt tacctacctg ggaaaggcct gggaagtgaa caaagggacc
      601 aactgtgtga cctcctatct gactgactgt gagactcagc tgtcccaggc cccacggcag
      661 ggcctgctct atggcgtccc cgtgagcctc aaggaatgct tcagctacaa gggccatgct
      721 tccacactgg gcttaagttt gaacgagggt gtgacatcgg agagtgactg tgtggtggtg
      781 caggtactga agctgcaggg agctgtgccc tttgtgcaca ccaacgtccc ccagtccatg
      841 ctaagctatg actgcagtaa ccccctcttt ggccagacca tgaacccgtg gaagccctcc
      901 aagagtccag gaggttcctc agggggtgag ggggctctca ttggatctgg aggctcccct
      961 ctgggtttag gcactgacat cggcggcagc atccggttcc cttctgcctt ctgtggcatc
     1021 tgtggcctca agcctactgg gaaccgcctc agcaagagtg gcctgaagag ctgtgtttat
     1081 ggacagacag cagtgcagct ttctgttggc cccatggcac gggatgtgga tagcctggca
     1141 ttgtgcatga aagccctact ttgtgaggat ttgttccgct tggactccac catccccccc
     1201 ttgcccttca gggaggagat ctacagaagt tctcgacccc ttcgtgtggg atactatgaa
     1261 actgacaact acaccatgcc cactccagcc atgaggaggg ctgtgatgga gaccaagcag
     1321 agtctcgagg ctgctggcca cacgctggtc cccttcttac caaacaacat accttatgcc
     1381 ctggaggtcc tgtcggcagg tgggctgttc agtgatggtg gctgctcttt tctccaaaac
     1441 ttcaaaggcg actttgtgga tccctgcttg ggggacctgg tcttagtgct gaagctgccc
     1501 aggtggttta aaaaactgct gagcttcctg ctgaagcctc tgtttcctcg gctggcagcc
     1561 tttctcaaca gtatgtgtcc tcggtcagcc gaaaagctgt gggaactgca gcatgagatt
     1621 gagatgtatc gccagtccgt cattgcccag tggaaggcaa tgaacttgga cgtggtgcta
     1681 acccccatgc tgggtcctgc tctggatttg aacacaccgg gcagagccac aggggctatc
     1741 agctacactg ttctctataa ctgcctggac ttccctgcgg gggtggtgcc tgtcaccact
     1801 gtgaccgctg aggacgatgc ccagatggaa cactacaaag gctactttgg ggatatgtgg
     1861 gacaacattc tgaagaaggg catgaaaaag ggtataggcc tgcctgtggc tgtgcagtgc
     1921 gtggctctgc cctggcagga agagctgtgt ctgcggttca tgcgggaggt ggaacggctg
     1981 atgacccctg aaaagcggcc atcttgaggg tcattcatct gcccagctct ggaggaccta
     2041 aggcccatgc gctctgcact gcagccccat ctattcagga tcctgccacc catgaggaga
     2101 tgcccagcac gggaagaggc aaccacctgc cctcccctgg actcctacag aaacccagga
     2161 catgccctcc ataaccaagt ctggaccttg ctcccctttc tggtctactt tccatcctga
     2221 ccccctactc tatgtgacag cccagcagga acgacacggg ccaaggacca ccaacagtca
     2281 aaaaaagcaa tgtgtttctg tatttttctg ggtatttttc tattaggacc ttggaaccag
     2341 agcctgctga gagggctgtg ctgtccctcc agagctggct gtaatcatgt cactctcctg
     2401 ctccaaagcc tccctaggcc atcacccaca aggtagacac agggacatgt ccttggcact
     2461 tggctcctgc ccttccttcc ttgttcagat tggccccagc tttgatggac accgcccggg
     2521 tcttcctccc tcattccacc tctctctctt ctgacttggc ctttttactt ctctagctgt
     2581 tgtagagaac aaggtttctc tgtgtagccc tggctgtcca ggatctcact ctgtagatca
     2641 ggctggcttt cagctcacaa ggctgcctgc ctgggtgctg ggattaaagg cgtgtgttac
     2701 cagagtctgg ctggctggga tatcttttag ggtcatctct gtaacccatt ttctacttac
     2761 atatccacaa gtcagaacac tggactgagg aaggactatg tcaccctgga tacctgtcag
     2821 ggaacactta cagagatacc agtgtcatca atttgagctt cccagccaaa taagtctcct
     2881 ccagtctgtg tttggttagc ttgccagtat tgacctggct cctgacggct cctccatgta
     2941 ggttgtactg gcgacctagg ataccccttg tggtgagtga gtgagaccac ttgtggtctg
     3001 ggctctgtaa ggtttatcat cacatgccta gcacccagca tgttacctgg cacttagtag
     3061 atagccagtc aggcttgttg gagggatggc agatttattt ctagcgaatc cattttggca
     3121 cctcccgatt acttcctatg ccatccataa tagggaattt tcagtttgcc tctgacctgc
     3181 tacctttatc taatctactt aattcacttt gattcatgac cacagggaca aatatctctt
     3241 tgtctgtgat caacgtagag cttcctcctg gtcaagaagg ctgcatgcat caacttctac
     3301 caaccctcag ctcctccata cttcttccac ccagcccaca agcacattga attcctccca
     3361 ctatgctcag gataagcaaa cagaaacagc ccctgcttga atggtttctc attctaccag
     3421 caactgtgta tttacactgt aggtcacaca aatgctataa agcagaagtc cctgggtatg
     3481 atgacatcaa gcaggctacc tggcccgcag gtcatgtgtg caagagtagg agtatcaggg
     3541 agtgctctct gtgtgaagtg acatgtaagc tggaaagctc acagttaatg ggagccaagg
     3601 aacaagtatt tcaagaagag tggagtcgac ttaaacgctg ctgatgtaac tggataagga
     3661 caagtgaagg gagggatgga gaactccacc tgccatcatt gaatcgagtg cctactgttt
     3721 gccagacact ttaccaaagg ctgccaaggt ccttgctctt agggaactcg ttttctagag
     3781 agagggcatg caaataagat cataaataaa ataatttatg ctgatg
//
