LOCUS       NM_007979               2735 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus coagulation factor IX (F9), transcript variant 1,
            mRNA.
ACCESSION   NM_007979 XM_135893
VERSION     NM_007979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Hino,T., Omura,S.N., Nakagawa,R., Togashi,T., Takeda,S.N.,
            Hiramoto,T., Tasaka,S., Hirano,H., Tokuyama,T., Uosaki,H.,
            Ishiguro,S., Kagieva,M., Yamano,H., Ozaki,Y., Motooka,D., Mori,H.,
            Kirita,Y., Kise,Y., Itoh,Y., Matoba,S., Aburatani,H., Yachie,N.,
            Karvelis,T., Siksnys,V., Ohmori,T., Hoshino,A. and Nureki,O.
  TITLE     An AsCas12f-based compact genome-editing tool derived by deep
            mutational scanning and structural analysis
  JOURNAL   Cell 186 (22), 4920-4935 (2023)
   PUBMED   37776859
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Han,W., Huang,R., Li,B., Liu,L., Xu,W. and Zhang,G.
  TITLE     Characteristics of FXa-storing platelets in hemophilia B mice and
            the influence of alcohol on the platelets
  JOURNAL   Sci Rep 13 (1), 16488 (2023)
   PUBMED   37779119
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Cao,Y., Wang,Y., Zhou,Z., Pan,C., Jiang,L., Zhou,Z., Meng,Y.,
            Charugundla,S., Li,T., Allayee,H., Seldin,M.M. and Lusis,A.J.
  TITLE     Liver-heart cross-talk mediated by coagulation factor XI protects
            against heart failure
  JOURNAL   Science 377 (6613), 1399-1406 (2022)
   PUBMED   36137043
  REMARK    GeneRIF: Liver-heart cross-talk mediated by coagulation factor XI
            protects against heart failure.
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Bertolini,T.B., Shirley,J.L., Zolotukhin,I., Li,X., Kaisho,T.,
            Xiao,W., Kumar,S.R.P. and Herzog,R.W.
  TITLE     Effect of CpG Depletion of Vector Genome on CD8+ T Cell Responses
            in AAV Gene Therapy
  JOURNAL   Front Immunol 12, 672449 (2021)
   PUBMED   34135899
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Mann,D.M., Stafford,K.A., Poon,M.C., Matino,D. and Stafford,D.W.
  TITLE     The Function of extravascular coagulation factor IX in haemostasis
  JOURNAL   Haemophilia 27 (3), 332-339 (2021)
   PUBMED   33780107
  REMARK    GeneRIF: The Function of extravascular coagulation factor IX in
            haemostasis.
            Review article
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Levinson,B., Bermingham,J.R. Jr., Metzenberg,A., Kenwrick,S.,
            Chapman,V. and Gitschier,J.
  TITLE     Sequence of the human factor VIII-associated gene is conserved in
            mouse
  JOURNAL   Genomics 13 (3), 862-865 (1992)
   PUBMED   1639415
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Laval,S.H., Blair,H.J., Hirst,M.C., Davies,K.E. and Boyd,Y.
  TITLE     Mapping of FMR1, the gene implicated in fragile X-linked mental
            retardation, on the mouse X chromosome
  JOURNAL   Genomics 12 (4), 818-821 (1992)
   PUBMED   1572655
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Faust,C.J. and Herman,G.E.
  TITLE     Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a
            region of the mouse X chromosome homologous to human Xq28
  JOURNAL   Genomics 11 (1), 154-164 (1991)
   PUBMED   1684949
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Herman,G.E., Faust,C.J., Darlison,M.G. and Barnard,E.A.
  TITLE     Genetic mapping of the mouse X chromosome in the region homologous
            to human Xq27-Xq28
  JOURNAL   Genomics 9 (4), 670-677 (1991)
   PUBMED   1674728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK149372.1 and AA239875.1.
            
            On Apr 3, 2015 this sequence version replaced NM_007979.1.
            
            Summary: This gene encodes a vitamin K-dependent serine protease
            that plays a critical role in the intrinsic pathway of blood
            coagulation. The encoded protein is an inactive zymogen that is
            activated by coagulation factor XIa to generate factor IXa, a
            heterodimer containing heavy and light chains. In association with
            factor VIII, membrane phospholipids and calcium ions, factor IXa
            cleaves the inactive zymogen factor X to generate active factor Xa.
            Genetic deletion of this gene in mice results in a severe bleeding
            phenotype. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149372.1, M23109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2734              AK149372.1         2-2735
            2735-2735           AA239875.1         527-527
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.5 cM"
     gene            1..2735
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /note="coagulation factor IX"
                     /db_xref="GeneID:14071"
                     /db_xref="MGI:MGI:88384"
     exon            1..88
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            89..252
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            253..277
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            278..391
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            392..520
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            521..753
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            754..868
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     exon            869..2735
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
     polyA_site      2735
                     /gene="F9"
                     /gene_synonym="Cf-9; Cf9"
ORIGIN      
        1 atgaagcacc tgaacaccgt catggcagaa tccccggctc tcatcaccat cttcctttta
       61 ggatatctac tcagtaccga atgtgcagtt ttccttgatc gtgaaaatgc caccaaaatt
      121 cttacccgtc caaagagata taattcagga aaactagaag agtttgttcg aggaaacctt
      181 gaaagagagt gtatagaaga aagatgtagt tttgaagaag cacgagaagt ttttgaaaac
      241 actgaaaaaa ctactgaatt ttggaagcag tatgttgatg gagatcagtg tgaatcaaat
      301 ccttgtttaa atggtggaat atgcaaggat gatattagtt cctatgaatg ctggtgccaa
      361 gttggatttg aaggaaggaa ctgtgaatta gatgcaacgt gtaacattaa aaatggcagg
      421 tgcaagcagt tttgtaaaaa cagtcctgat aacaaggtaa tttgttcctg cactgaggga
      481 taccaacttg cagaagacca gaagtcctgt gaaccaacag ttccatttcc atgtgggaga
      541 gcttctattt catacagttc taaaaagatc acgagagctg agactgtttt ctctaatatg
      601 gactatgaaa attctactga agctgtattc attcaagatg acatcactga tggtgccatt
      661 cttaataacg tcactgaaag tagtgaatca cttaatgact tcactcgagt tgttggtgga
      721 gaaaacgcaa aaccgggtca aatcccttgg caggtcattt taaatggtga aattgaggca
      781 ttctgtggag gtgccatcat taatgaaaaa tggattgtaa ctgctgccca ctgtcttaaa
      841 cctggtgata aaattgaggt tgttgctggt gaatataaca ttgataagaa ggaagacaca
      901 gaacaaagga gaaatgtgat tcgaactatc cctcatcacc agtacaatgc aactattaat
      961 aagtatagtc atgacattgc cttgctggaa ctggataaac ctttaatact aaacagctat
     1021 gtaacaccta tctgtgttgc caatagggaa tatacaaata tcttcctcaa gtttggttct
     1081 ggctatgtca gtggctgggg aaaagtcttc aacaaaggga gacaggcttc cattcttcag
     1141 taccttagag ttccactggt ggatagagcc acatgcctta ggtccacaac attcactatc
     1201 tataacaaca tgttctgtgc aggctaccgt gaaggaggca aagattcgtg tgaaggagat
     1261 agtgggggac cccatgttac tgaagtagaa gggacaagtt tcttaactgg cattattagc
     1321 tggggtgaag aatgtgcaat gaaaggcaaa tatggaatat atactaaggt ttcccggtac
     1381 gtcaactgga ttaaggaaaa aacaaagcta acttaatgaa aaacctattt ccaaagacaa
     1441 ttcagtggaa ttgaaaatgg gtgatgccct ttacagacta gtctttctac cttttgttaa
     1501 atttaaatat ataagttcta caaacactga tttttctctg tgcataagac aagcccatct
     1561 aggatctata ttgttctaga gtaagtaggt tagcaaatat aatcactaga gaaatagttt
     1621 agtaagagat tcaccatttc tgtaagtcca gcccttgtta aaattagaaa gtaaagcttt
     1681 ccgtgttgcc cataaggcgt gatggttctt gatacagaga tgtacccaat tctccctcct
     1741 tggcagcaat tcatgtttta gctcttcctt gctactctca attttattag ttttctatcc
     1801 agaatcttta acccatttat ggccagaaga atacaagagc agctgaaaaa ttaaaactca
     1861 tcaaaagcat gacttcctct cctgattttt ctgaatcttg tatcttttac aactcccaaa
     1921 ccacaaatca ctgacctctc cgtcattctc accttccctt tctccatcac cactgaagga
     1981 ggaagctata tgagttccag gacagcctag gtacacagag aaacccggtc ttgaaagaaa
     2041 agagagagtg gggagagaga gagagagaga gagagagaga gagaggagaa agaaatgatt
     2101 aatttaatca tattggtaat atatatatat tatatctcta aaaaaaagtc actaaacctt
     2161 acttgtaaca actgcctatt tctatggtgt aaatatcctt actttggtag atttcaagct
     2221 attaacatga agttactgga aaaggagttg agaaaacata tggaaaatta ctcttaaaac
     2281 tgtttcaggc agtttttaac ctagaagcag ctgaactttc taggaatact tcaacagtgc
     2341 atcttcagcc ttctccagtt ccaacctacc taagggtcat gtctctcaca gcaggctcaa
     2401 ggctgcaaga gtcattgcaa atggccaact gacttgccca tttatggttt tcttctcacc
     2461 ggtaaactgt tattgtaatt aacactgtca tattgaattt tctagaggga tgctgaccat
     2521 ccgacccatt tctcatctga gacttggtga actggcattt taatacttat ctggaccttt
     2581 gtagtgatgc ataattggtt tgaacccctt gtcactgcca cctgccccca ccaacacaaa
     2641 atcctacttc attactgctg actctgctaa cgttccacta cttgttgcct cttttgtctt
     2701 gcaagaagta tcaataaaca tctttccaga tttcc
//
