LOCUS       NM_007978               2490 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus factor 8-associated gene A (F8a), mRNA.
ACCESSION   NM_007978
VERSION     NM_007978.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Chen,L., Qin,Y., Guo,T., Zhu,W., Lin,J., Xing,T., Duan,X.,
            Zhang,Y., Ruan,E., Li,X., Yin,P., Li,S., Li,X.J. and Yang,S.
  TITLE     HAP40 modulates mutant Huntingtin aggregation and toxicity in
            Huntington's disease mice
  JOURNAL   Cell Death Dis 15 (5), 337 (2024)
   PUBMED   38744826
  REMARK    GeneRIF: HAP40 modulates mutant Huntingtin aggregation and toxicity
            in Huntington's disease mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Milman,P. and Woulfe,J.
  TITLE     Novel variant of neuronal intranuclear rodlet immunoreactive for 40
            kDa huntingtin associated protein and ubiquitin in the mouse brain
  JOURNAL   J Comp Neurol 521 (16), 3832-3846 (2013)
   PUBMED   23749422
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Singh,U., Sun,T., Shi,W., Schulz,R., Nuber,U.A., Varanou,A.,
            Hemberger,M.C., Elliott,R.W., Ohta,H., Wakayama,T. and Fundele,R.
  TITLE     Expression and functional analysis of genes deregulated in mouse
            placental overgrowth models: Car2 and Ncam1
  JOURNAL   Dev Dyn 234 (4), 1034-1045 (2005)
   PUBMED   16247769
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Raefski,A.S. and O'Neill,M.J.
  TITLE     Identification of a cluster of X-linked imprinted genes in mice
  JOURNAL   Nat Genet 37 (6), 620-624 (2005)
   PUBMED   15908953
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Davies,W., Isles,A., Smith,R., Karunadasa,D., Burrmann,D.,
            Humby,T., Ojarikre,O., Biggin,C., Skuse,D., Burgoyne,P. and
            Wilkinson,L.
  TITLE     Xlr3b is a new imprinted candidate for X-linked parent-of-origin
            effects on cognitive function in mice
  JOURNAL   Nat Genet 37 (6), 625-629 (2005)
   PUBMED   15908950
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Chatterjee,A., Faust,C.J., Molinari-Storey,L., Kiochis,P.,
            Poustka,A. and Herman,G.E.
  TITLE     A 2.3-Mb yeast artificial chromosome contig spanning from Gabra3 to
            G6pd on the mouse X chromosome
  JOURNAL   Genomics 21 (1), 49-57 (1994)
   PUBMED   8088815
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Angel,T.A., Faust,C.J., Gonzales,J.C., Kenwrick,S., Lewis,R.A. and
            Herman,G.E.
  TITLE     Genetic mapping of the X-linked dominant mutations striated (Str)
            and bare patches (Bpa) to a 600-kb region of the mouse X
            chromosome: implications for mapping human disorders in Xq28
  JOURNAL   Mamm Genome 4 (3), 171-176 (1993)
   PUBMED   8439729
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Faust,C.J., Levinson,B., Gitschier,J. and Herman,G.E.
  TITLE     Extension of the physical map in the region of the mouse X
            chromosome homologous to human Xq28 and identification of an
            exception to conserved linkage
  JOURNAL   Genomics 13 (4), 1289-1295 (1992)
   PUBMED   1354645
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Levinson,B., Bermingham,J.R. Jr., Metzenberg,A., Kenwrick,S.,
            Chapman,V. and Gitschier,J.
  TITLE     Sequence of the human factor VIII-associated gene is conserved in
            mouse
  JOURNAL   Genomics 13 (3), 862-865 (1992)
   PUBMED   1639415
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Levinson,B., Kenwrick,S., Lakich,D., Hammonds,G. Jr. and
            Gitschier,J.
  TITLE     A transcribed gene in an intron of the human factor VIII gene
  JOURNAL   Genomics 7 (1), 1-11 (1990)
   PUBMED   2110545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054140.1.
            
            On Apr 5, 2007 this sequence version replaced NM_007978.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK054140.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2490              AK054140.1         2-2491
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.29 cM"
     gene            1..2490
                     /gene="F8a"
                     /gene_synonym="DXUcsf1; F8a1"
                     /note="factor 8-associated gene A"
                     /db_xref="GeneID:14070"
                     /db_xref="MGI:MGI:95474"
     exon            1..2490
                     /gene="F8a"
                     /gene_synonym="DXUcsf1; F8a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1156
                     /gene="F8a"
                     /gene_synonym="DXUcsf1; F8a1"
                     /note="factor VIII intron 22 protein; Factor VIII
                     associated protein; cpG island protein"
                     /codon_start=1
                     /product="40-kDa huntingtin-associated protein"
                     /protein_id="NP_032004.2"
                     /db_xref="CCDS:CCDS41011.1"
                     /db_xref="GeneID:14070"
                     /db_xref="MGI:MGI:95474"
                     /translation="MAAGSASSLGGGAWPGSEAGDFLARYRQVSNKLKKRFLRKPNVA
                     EAGEQFAQLARELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQEC
                     DARQRLGCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRAVGQPAA
                     AAGHFQRAAQLHLPLMPLAALQALGDAASCQLLARDYTGALALFTRMQRLAREHGGHP
                     VQQLELLPQPPSGPQPPLSGPQPRPVLGSTLPLPQPPDHAPGSVAPSPGTLGAFADVL
                     VRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDGHGQDTSGQLPEELFLLLQS
                     LVMAAQEKDTEGIKKLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV"
     regulatory      1466..1471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F8a"
                     /gene_synonym="DXUcsf1; F8a1"
                     /note="hexamer: AATAAA"
     polyA_site      1490
                     /gene="F8a"
                     /gene_synonym="DXUcsf1; F8a1"
                     /note="major polyA site"
ORIGIN      
        1 gccggtcaac atggctgcgg gctctgcgtc ctccttgggc ggcggtgcct ggccaggctc
       61 agaggctggg gacttcttgg cacgctatcg gcaggtgtcc aacaagctca agaagcgctt
      121 cttgaggaag ccgaacgtgg ccgaggccgg ggagcagttc gcccagctag cccgggagct
      181 gcgcgcccag gagtgcctgc cttatgctgc ctggtgccag ctggctgtgg cgcgctgcca
      241 gcaggcgctc ttccatgggc ccggggaagc gctggccctc acagaggcgg cccgactttt
      301 cctgcggcag gagtgcgacg cgcgccaacg cttgggctgt cccgccgcct acggggagcc
      361 tctgcaggcg gccgccagcg ccctcggcgc cgctgtgcgc ttgcacctcg agctcggcca
      421 gcctgccgcc gctgctgcac tgtgcctgga actagctgct gcccttcgcg cagtgggcca
      481 gccggccgct gctgccggtc actttcagcg ggctgcccag ctgcacctgc ccctgatgcc
      541 actggccgca ctgcaagcgc ttggtgatgc tgcctcctgc cagctgttgg cgcgcgacta
      601 cacaggcgcc ctggcgctat ttacacgcat gcaacgcctg gcacgggagc atgggggcca
      661 cccggtacag caactcgagc tgctgccgca gccgccttct gggccccagc cacccctgtc
      721 gggaccccag ccgagacctg tcttgggctc gaccttgccc ctcccgcagc ccccggacca
      781 cgccccaggc tctgttgcgc cttcacctgg cacactcggt gcctttgctg acgtcctagt
      841 caggtgtgag gtgtcccgtg tactgctgct gctgctcctg caaccaccac ctgccaagct
      901 gctgcccgag catgcccaga ccctggagaa gtactcctgg gaggctttcg atggccatgg
      961 ccaggatacc agcggccagc ttcctgagga gctgtttctg ttattgcagt ctctggtcat
     1021 ggctgcccaa gaaaaggaca ctgaaggcat caagaagctg caggtggaga tgtggccact
     1081 gctaaccgct gagcagaacc acctcctcca cctcgttctg caggaaacca tctctccctc
     1141 tggacagggt gtctgataag tcaccttctt accaacttgt tttatctttg gggacaggtg
     1201 atgaaacatg tgatctagct tctgtttttt ttgtctgttt ttgtcttgtt tttcttttca
     1261 tttctattgc tgccatgtta atttggcttt gtgtgcctag caagttactt aaattagtgc
     1321 cctccaattc catccattat tgcctcgaat gagaaaactt catccttaag gctggaggag
     1381 attctacgga gtaatctttc tttatgcatc tgtcagttgc tagataatgt tgattcattt
     1441 tcctggctgt tctaggtata gtgccaataa actcaggagg acagatgttc ctttggcgta
     1501 ttgatttcct tttcttttgt tcctggtggg gtgtggcatc accaagaagt atttagaaaa
     1561 gattagaaat atttgtgtct tgaaaattgt gaggatttga caatttgggc ataatctctc
     1621 ttttaataca ttattgcttc gtttctatat aaactagcac agcagtctgg ggagtgggaa
     1681 aagcaccaga tgacataaaa tgtaactgtt gttacataca aatactctgt gtatctgaac
     1741 atgaggacta tgttaataag cagaactgac atgttctgtc atacattcca gatttatttt
     1801 atcttctgta cactctgcta gcccaggttc ttcctgatgg aatgaccaaa acctttctcc
     1861 tgagtagcat ctgtgatctt ttggtgatcc tgcctttatt gggttgcagc aaatttctgt
     1921 tatccagaag tttttggcaa gagatgagtc aaagttttta gaattggtcc tctgtttcca
     1981 aaccagggtt ttgattgctc tcactgtgta ccacaacaca attacccctg tacaatcgag
     2041 atctgtcttc acagccaata cctaagttct attctgcctt tcaggaccat gttctgagaa
     2101 atctaattgc ataaaactgt aatggtattc ccttaaatat tctgaccttg aaaactagag
     2161 gtactaaact atgtaaccca gtgttgctgg ggcaaatagc aaagaaatgt ttctgactga
     2221 gtattaagtg atacaaagcc agttctactt ttctctgtag ttcctggatc aatgcatctt
     2281 tgctttcaga aatatggtgt catatattga atcttggttt aaggcaccca gcacacctgc
     2341 aagggtagca ttccaacttt cctaaatgtt ttcccactac attgtcaccc tatttaaccc
     2401 caagttagaa caccattcta taaggccagc tggtaattgg cctatggggt atatgtacaa
     2461 aaccaatgaa ttccataaat ttaatgcctt
//
