LOCUS       NM_010172               1845 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coagulation factor VII (F7), mRNA.
ACCESSION   NM_010172
VERSION     NM_010172.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Zelaya,H., Grunz,K., Nguyen,T.S., Habibi,A., Witzler,C., Reyda,S.,
            Gonzalez-Menendez,I., Quintanilla-Martinez,L., Bosmann,M.,
            Weiler,H. and Ruf,W.
  TITLE     Nucleic acid sensing promotes inflammatory monocyte migration
            through biased coagulation factor VIIa signaling
  JOURNAL   Blood 143 (10), 845-857 (2024)
   PUBMED   38096370
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Fleischer,M.I., Rohrig,N., Raker,V.K., Springer,J., Becker,D.,
            Ritz,S., Bros,M., Stege,H., Haist,M., Grabbe,S., Haub,J.,
            Becker,C., Reyda,S., Disse,J., Schmidt,T., Mahnke,K., Weiler,H.,
            Ruf,W. and Steinbrink,K.
  TITLE     Protease- and cell type-specific activation of protease-activated
            receptor 2 in cutaneous inflammation
  JOURNAL   J Thromb Haemost 20 (12), 2823-2836 (2022)
   PUBMED   36161697
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Gould,T.W., Dominguez,B., de Winter,F., Yeo,G.W., Liu,P.,
            Sundararaman,B., Stark,T., Vu,A., Degen,J.L., Lin,W. and Lee,K.F.
  TITLE     Glial cells maintain synapses by inhibiting an activity-dependent
            retrograde protease signal
  JOURNAL   PLoS Genet 15 (3), e1007948 (2019)
   PUBMED   30870413
  REMARK    GeneRIF: Trancriptomic analysis shows that expression of the
            antithrombins serpin C1 and D1 is significantly reduced in Schwann
            cell-deficient mice. In the absence of peripheral neuromuscular
            activity, neurodegeneration is completely blocked, and expression
            of prothrombin in muscle is markedly reduced.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Lacombe,J., Rishavy,M.A., Berkner,K.L. and Ferron,M.
  TITLE     VKOR paralog VKORC1L1 supports vitamin K-dependent protein
            carboxylation in vivo
  JOURNAL   JCI Insight 3 (1), 96501 (2018)
   PUBMED   29321368
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Liang,Z., Cooper,A., Rosen,E.D. and Castellino,F.J.
  TITLE     Chromosomal arrangement of the murine coagulation factor VII and
            factor X genes
  JOURNAL   Thromb Haemost 80 (3), 524-525 (1998)
   PUBMED   9759642
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Stauffer,D.R., Chukwumezie,B.N., Wilberding,J.A., Rosen,E.D. and
            Castellino,F.J.
  TITLE     Characterization of transcriptional regulatory elements in the
            promoter region of the murine blood coagulation factor VII gene
  JOURNAL   J Biol Chem 273 (4), 2277-2287 (1998)
   PUBMED   9442072
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Rosen,E.D., Chan,J.C., Idusogie,E., Clotman,F., Vlasuk,G.,
            Luther,T., Jalbert,L.R., Albrecht,S., Zhong,L., Lissens,A.,
            Schoonjans,L., Moons,L., Collen,D., Castellino,F.J. and
            Carmeliet,P.
  TITLE     Mice lacking factor VII develop normally but suffer fatal perinatal
            bleeding
  JOURNAL   Nature 390 (6657), 290-294 (1997)
   PUBMED   9384381
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Idusogie,E., Rosen,E.D., Carmeliet,P., Collen,D. and
            Castellino,F.J.
  TITLE     Nucleotide structure and characterization of the murine blood
            coagulation factor VII gene
  JOURNAL   Thromb Haemost 76 (6), 957-964 (1996)
   PUBMED   8972017
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Idusogie,E., Rosen,E., Geng,J.P., Carmeliet,P., Collen,D. and
            Castellino,F.J.
  TITLE     Characterization of a cDNA encoding murine coagulation factor VII
  JOURNAL   Thromb Haemost 75 (3), 481-487 (1996)
   PUBMED   8701412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127308.3.
            
            On Aug 30, 2022 this sequence version replaced NM_010172.4.
            
            Summary: This gene encodes a vitamin K-dependent serine protease
            that plays a critical role in the extrinsic pathway of blood
            coagulation. Upon contact with tissue factor III (TF III), the
            encoded protein forms an activated complex termed TF-FVIIa that
            initiates the coagulation cascade involving other coagulation
            factors, ultimately resulting in a fibrin clot. Complete lack of
            the encoded protein in mice results in in perinatal lethality due
            to bleeding from normal blood vessels. [provided by RefSeq, Apr
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44795.1, BC061149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC127308.3         154846-154929
            85-245              AC127308.3         157442-157602
            246-270             AC127308.3         159355-159379
            271-384             AC127308.3         159456-159569
            385-525             AC127308.3         160983-161123
            526-635             AC127308.3         162174-162283
            636-759             AC127308.3         162739-162862
            760-1845            AC127308.3         163522-164607
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..1845
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /note="coagulation factor VII"
                     /db_xref="GeneID:14068"
                     /db_xref="MGI:MGI:109325"
     exon            1..84
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1352
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /EC_number="3.4.21.21"
                     /note="serum prothrombin conversion accelerator"
                     /codon_start=1
                     /product="coagulation factor VII preproprotein"
                     /protein_id="NP_034302.2"
                     /db_xref="CCDS:CCDS22104.1"
                     /db_xref="GeneID:14068"
                     /db_xref="MGI:MGI:109325"
                     /translation="MVPQAHGLLLLCFLLQLQGPLGTAVFITQEEAHGVLHRQRRANS
                     LLEELWPGSLERECNEEQCSFEEAREIFKSPERTKQFWIVYSDGDQCASNPCQNGGTC
                     QDHLKSYVCFCLLDFEGRNCEKSKNEQLICANENGDCDQYCRDHVGTKRTCSCHEDYT
                     LQPDEVSCKPKVEYPCGRIPVVEKRNSSSRQGRIVGGNVCPKGECPWQAVLKINGLLL
                     CGAVLLDARWIVTAAHCFDNIRYWGNITVVMGEHDFSEKDGDEQVRRVTQVIMPDKYI
                     RGKINHDIALLRLHRPVTFTDYVVPLCLPEKSFSENTLARIRFSRVSGWGQLLDRGAT
                     ALELMSIEVPRLMTQDCLEHAKHSSNTPKITENMFCAGYMDGTKDACKGDSGGPHATH
                     YHGTWYLTGVVSWGEGCAAIGHIGVYTRVSQYIDWLVRHMDSKLQVGVFRLPLL"
     exon            85..245
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            246..270
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            271..384
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            385..525
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            526..635
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            636..759
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1845
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /note="hexamer: ATTAAA"
     polyA_site      1845
                     /gene="F7"
                     /gene_synonym="Cf7; FVII"
                     /note="major polyA site"
ORIGIN      
        1 acagtctcat catggttcca caggcgcatg ggctgctgct tctctgcttt ctgctccagc
       61 tccagggacc tctagggact gcagttttca taacccagga ggaagcacat ggtgtcctac
      121 acaggcaaag gcgtgccaac tcactcctgg aggagctttg gcccggctct ctggagagag
      181 agtgcaatga ggaacagtgc tcctttgagg aggcccggga gatcttcaag agccctgaga
      241 ggaccaagca gttctggatt gtttacagtg atggggacca gtgtgcctcg aatccatgtc
      301 agaacggagg tacctgccag gatcatctca agtcttacgt ctgcttctgc ctcctagact
      361 ttgagggtcg gaactgtgag aaaagcaaga atgagcagct gatctgtgca aatgaaaatg
      421 gtgactgtga ccagtactgc agggaccatg tagggaccaa gcgtacctgt agctgtcatg
      481 aggactacac gctacagcca gatgaggtgt cctgcaaacc aaaagttgag tacccgtgtg
      541 ggagaatacc tgttgtagaa aaaagaaact ccagcagccg ccaaggccgc attgtgggag
      601 gcaacgtgtg ccccaaaggg gagtgtccat ggcaggctgt gctgaaaatc aatgggttat
      661 tgctgtgtgg ggccgtcctg ctggacgcca gatggatagt gaccgcagcc cactgcttcg
      721 ataatatccg ctactgggga aacatcacag tggtgatggg tgaacatgac ttcagtgaga
      781 aggatgggga tgagcaagta cgacgggtga cacaggtcat catgcccgac aagtacatcc
      841 gcggcaagat caaccacgac attgccctgc tccgccttca ccggcctgtg accttcactg
      901 actacgtggt gcccctgtgt ctgcctgaaa agtccttctc cgagaacacc ctagccagaa
      961 tccgcttctc aagggtcagt ggctggggcc agctactgga ccgtggtgcc acagccctgg
     1021 aactcatgtc catcgaggtg ccccggctga tgacccagga ctgtctggag cacgccaagc
     1081 acagctctaa cacccccaaa atcacagaga acatgttctg cgctggctac atggatggta
     1141 ccaaggacgc ctgcaagggt gacagcggtg gcccacatgc cacgcactac catggcacat
     1201 ggtatctgac aggtgtggtc agctgggggg agggctgtgc agctattggt cacattgggg
     1261 tgtacaccag ggtctcccag tacatagact ggctggtcag acacatggac tccaagctcc
     1321 aggttggggt tttccgactc ccactactgt agctccttgg atagcccaac ccgtcccaag
     1381 aaggaagcta cggcctgtga agctgttcta tggactttcc tgctattctt gtgtaaggga
     1441 agagaatgag ataaagagag agtgaagaaa gcagaggggg aggtaaatga gagaggctgg
     1501 gaaaggggaa acagaaagca gggccggggg aagagtctaa gttagagact cacaaagaaa
     1561 ctcaagaggg gctgggcagt gcagtcacag tcaggcagct gaggggcagg gtgtccctga
     1621 gggaggcgag gctcaggcct tgctcccgtc tccccgtagc tgcctcctgt ctgcatgcat
     1681 tcggtctgca gtactacaca gtaggtatgc acatgagcac gtaggacacg tgaatgtgcc
     1741 gcatgcatgt gcgtgcctgt gtgtccatca ttggcactgt tgctcacttg tgcttcctgt
     1801 gagcaccctg tcttggtttc aattaaatga gaaacatggt ctcca
//
