LOCUS       NM_007976               8134 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus coagulation factor V (F5), mRNA.
ACCESSION   NM_007976
VERSION     NM_007976.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8134)
  AUTHORS   Marar,T.T., Matzko,C.N., Wu,J., Esmon,C.T., Sinno,T., Brass,L.F.,
            Stalker,T.J. and Tomaiuolo,M.
  TITLE     Thrombin spatial distribution determines protein C activation
            during hemostasis and thrombosis
  JOURNAL   Blood 139 (12), 1892-1902 (2022)
   PUBMED   34890454
REFERENCE   2  (bases 1 to 8134)
  AUTHORS   Wilhelm,A.R., Parsons,N.A., Samelson-Jones,B.J., Davidson,R.J.,
            Esmon,C.T., Camire,R.M. and George,L.A.
  TITLE     Activated protein C has a regulatory role in factor VIII function
  JOURNAL   Blood 137 (18), 2532-2543 (2021)
   PUBMED   33512448
REFERENCE   3  (bases 1 to 8134)
  AUTHORS   Maroney,S.A., Westrick,R.J., Cleuren,A.C., Martinez,N.D.,
            Siebert,A.E., Zogg,M., Ginsburg,D., Weiler,H. and Mast,A.E.
  TITLE     Tissue factor pathway inhibitor is required for cerebrovascular
            development in mice
  JOURNAL   Blood 137 (2), 258-268 (2021)
   PUBMED   32735640
REFERENCE   4  (bases 1 to 8134)
  AUTHORS   Zhang,N., Czepielewski,R.S., Jarjour,N.N., Erlich,E.C.,
            Esaulova,E., Saunders,B.T., Grover,S.P., Cleuren,A.C., Broze,G.J.,
            Edelson,B.T., Mackman,N., Zinselmeyer,B.H. and Randolph,G.J.
  TITLE     Expression of factor V by resident macrophages boosts host defense
            in the peritoneal cavity
  JOURNAL   J Exp Med 216 (6), 1291-1300 (2019)
   PUBMED   31048328
  REMARK    GeneRIF: selective expression of coagulation factor V (FV) by
            resident peritoneal macrophages in mice promotes bacterial
            clearance in the peritoneal cavity.
REFERENCE   5  (bases 1 to 8134)
  AUTHORS   Tomberg,K., Westrick,R.J., Kotnik,E.N., Cleuren,A.C.,
            Siemieniak,D.R., Zhu,G., Saunders,T.L. and Ginsburg,D.
  TITLE     Whole exome sequencing of ENU-induced thrombosis modifier mutations
            in the mouse
  JOURNAL   PLoS Genet 14 (9), e1007658 (2018)
   PUBMED   30188893
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8134)
  AUTHORS   Yin,Z.F., Huang,Z.F., Cui,J., Fiehler,R., Lasky,N., Ginsburg,D. and
            Broze,G.J. Jr.
  TITLE     Prothrombotic phenotype of protein Z deficiency
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6734-6738 (2000)
   PUBMED   10829076
REFERENCE   7  (bases 1 to 8134)
  AUTHORS   Yang,T.L., Cui,J., Taylor,J.M., Yang,A., Gruber,S.B. and
            Ginsburg,D.
  TITLE     Rescue of fatal neonatal hemorrhage in factor V deficient mice by
            low level transgene expression
  JOURNAL   Thromb Haemost 83 (1), 70-77 (2000)
   PUBMED   10669158
REFERENCE   8  (bases 1 to 8134)
  AUTHORS   Yang,T.L., Cui,J., Rehumtulla,A., Yang,A., Moussalli,M.,
            Kaufman,R.J. and Ginsburg,D.
  TITLE     The structure and function of murine factor V and its inactivation
            by protein C
  JOURNAL   Blood 91 (12), 4593-4599 (1998)
   PUBMED   9616155
REFERENCE   9  (bases 1 to 8134)
  AUTHORS   Cui,J., O'Shea,K.S., Purkayastha,A., Saunders,T.L. and Ginsburg,D.
  TITLE     Fatal haemorrhage and incomplete block to embryogenesis in mice
            lacking coagulation factor V
  JOURNAL   Nature 384 (6604), 66-68 (1996)
   PUBMED   8900278
REFERENCE   10 (bases 1 to 8134)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110499.19, AC157771.8 and
            AC105161.10.
            
            On Mar 27, 2023 this sequence version replaced NM_007976.3.
            
            Summary: This gene encodes a glycoprotein coagulation factor that
            plays a critical role in the process of blood coagulation and
            hemostasis. The encoded protein is activated by thrombin, to
            generate a heterodimer containing heavy and light chains held
            together by calcium ions. About half of the mice lacking the
            encoded protein die at an embryonic stage possible due to abnormal
            yolk-sac vasculature while the remaining animals succumbed to
            massive hemorrhage immediately after birth. A point mutation in
            this gene has been shown to cause disseminated intravascular
            thrombosis in the perinatal period, resulting in frequent deaths of
            newborn mice. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137537.1, U52925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC110499.19        13622-13915         c
            295-383             AC110499.19        11328-11416         c
            384-506             AC110499.19        3842-3964           c
            507-719             AC157771.8         31111-31323         c
            720-863             AC157771.8         29059-29202         c
            864-1085            AC157771.8         25846-26067         c
            1086-1251           AC157771.8         23646-23811         c
            1252-1429           AC157771.8         22429-22606         c
            1430-1529           AC157771.8         20816-20915         c
            1530-1741           AC157771.8         20300-20511         c
            1742-1892           AC157771.8         18506-18656         c
            1893-2105           AC157771.8         15099-15311         c
            2106-4812           AC157771.8         10790-13496         c
            4813-4987           AC157771.8         9698-9872           c
            4988-5224           AC157771.8         6475-6711           c
            5225-5432           AC157771.8         3694-3901           c
            5433-5612           AC157771.8         462-641             c
            5613-5729           AC105161.10        21815-21931
            5730-5801           AC105161.10        22657-22728
            5802-5905           AC105161.10        23742-23845
            5906-6061           AC105161.10        24268-24423
            6062-6206           AC105161.10        26553-26697
            6207-6358           AC105161.10        29180-29331
            6359-6541           AC105161.10        32172-32354
            6542-8134           AC105161.10        34183-35775
FEATURES             Location/Qualifiers
     source          1..8134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.46 cM"
     gene            1..8134
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /note="coagulation factor V"
                     /db_xref="GeneID:14067"
                     /db_xref="MGI:MGI:88382"
     exon            1..294
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            295..383
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            384..506
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            507..719
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            720..863
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1085
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1251
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1429
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1529
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1741
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1892
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2105
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..4812
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..4987
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            4988..5224
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5432
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5433..5612
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5613..5729
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5730..5801
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5802..5905
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            5906..6061
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            6062..6206
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            6207..6358
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..6541
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     exon            6542..8134
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7420..7425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /note="hexamer: AATAAA"
     polyA_site      7441
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /note="major polyA site"
     regulatory      8108..8113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /note="hexamer: AATAAA"
     polyA_site      8134
                     /gene="F5"
                     /gene_synonym="Cf-5; Cf5"
                     /note="major polyA site"
ORIGIN      
        1 agacagccac cacaggggac agggacactc actgtgccct gcagcttctt agtcctccag
       61 ggagacagat cagcgcgcaa cagggacaga gcactgagca ctgtcggtgg tggcagcgcg
      121 cggcaggaca agggccatgc tcctagtctg cccgtgcttc ttcctcctgg tggttctggg
      181 aacccgctgg gcgggctggg gcagccacca ggcagaggcc gcgcaactaa ggcagttcta
      241 tgtggcagct caggggatcc tctggaacta tcatcctgag cccacagatc caagtttgaa
      301 ttctatacct tccttcaaga aaattgtcta cagagagtat gaacagtatt ttaagaaaga
      361 aaagccacga tctagcaact caggacttct tggacctact ttatacgctg aagttgggga
      421 cgtcattaaa gttcacttta gaaacaaagc agacaaacca ctaagcatcc atcctcaagg
      481 gattaaatac agtaaatttt cagaaggggc ttcttacgca gaccacacgt tccctgccga
      541 gaggaaggat gatgccgtgg ctcctggaga agaatacacc tatgaatgga tcgtcagtga
      601 ggacagcggg cccacacctg atgacccacc atgcctcacc cacatctact attcctatga
      661 aaacctgacc caggatttca actcgggtct gattgggcct ctgcttatct gcaagaaagg
      721 caccctgacc gaggatggga ctcagaagat gtttgacaag cagcatgtgc tcctatttgc
      781 tgtgtttgat gaaagcaaga gccggagcca gtcaccatcc ctaatgtaca caattaatgg
      841 ctttgtgaat aagacgatgc cagatataac agtctgtgcc catgaccacg tcagctggca
      901 tctgatcggg atgagctcgg ggccagaatt gttttctatt cacttcaacg gccaagtcct
      961 agagcagaac cagcataaag tgtccaccgt caccctggtc agcgcaacat ctacgactgc
     1021 aaacatgact atgagcccag aaggaagatg gattgtttct tctctcatcc caaagcatta
     1081 tcaagctggg atgcaggctt acattgacat taaaaactgc ccaaagaaaa cgaggagccc
     1141 caagaccctc actcgggagc agaggcggta catgaagaga tgggagtatt tcatagccgc
     1201 agaggaggtc atttggaact atgcacccgt gatacctgcg aatatggaca aaatttacag
     1261 gtctcagcac ttggataatt tctcaaacca aattggaaaa cattacaaga aagttatcta
     1321 caggcaatat gaagaagaga ccttcaccaa acgcactgac aaccccagca tcaaacaaag
     1381 tgggattctg ggccctgtta tcagagccca ggtcagagac acactcaaga tcgtgttcaa
     1441 aaatatggcg agccgaccct acagcattta ccctcacggg gtgaccttct ctccttacga
     1501 agatggaatc aattcttcct ccacctcagg cagtcacacc acgatcagac cagttcaacc
     1561 gggggaaacc ttcacttaca aatggaacat tctagagttt gatgaaccca cggaaaacga
     1621 tgcccagtgc ctaacaaggc catactacag tgatgtggac gttacaaggg atattgcctc
     1681 tgggctgata gggctgcttc taatttgtaa gagcaggtcc ctggaccaga ggggtgtaca
     1741 gagggtggca gacatcgagc agcaggccgt gtttgctgtg tttgacgaga acaagagctg
     1801 gtacattgag gacaacatca acaagttctg tgagaatcct gatgaggtga agcgtgatga
     1861 tcccaagttt tacgaatcaa acatcatgag cactatcaac ggctacgtgc ccgagagcat
     1921 ttccactctg ggattctgtt ttgatgacac tgtccagtgg cacttctgca gtgtgggaac
     1981 tcatgatgat attttgacca tccacttcac tgggcactcg ttcatctatg ggaggaggca
     2041 cgaggacacc ttgaccctgt tccccatgcg tggtgaatct gtgacagtta caatggataa
     2101 tgttggaact tggatgttga ccaccatgaa ttccaatcca aaacgcagaa acctaagact
     2161 gagattcaga gatgttaagt gtaatcggga ttatgacaat gaggactcat atgagattta
     2221 tgaacctcct gcacctacat ccatgacaac tcggagaatt catgattcct tagaaaatga
     2281 atttggcata gacaacgaag atgatgatta ccagtactta ctggcgtcat cattaggaat
     2341 taggtcattc aaaaactcat cattgaatcc agaggaaaat gagttcaatc tcactgctct
     2401 cgctctggag aacagctctg agttcatatc tccaagcaca gacagagttg ttgactcaaa
     2461 ctcttcacga atccttagta aaatcatcaa taataacctc aaagactttc aaagaacact
     2521 tcctggctca ggagccaccg tggctggtac cctccttaga aacctcattg gcttagatga
     2581 gaacttcgtc ctcaactctt ctacagaaca tcgttccagc tcatatcatg aaaatgatat
     2641 ggaaaatcca cagtcaaaca tcacaatggt atacctactt cctcttggtc caaaaggatc
     2701 tgggaatcga gaacaagata aacctaaaac catcaagaca ggaagacccc acatgatgaa
     2761 gcacaggttc tcctggatga aagcgccagc tggtaaaact gggaggcatt caaacccaaa
     2821 gaattcgtat tctggaatga agtctgagga ggacattcct agcgagttga tacccttaaa
     2881 gcaaaagatc acttccaaat ttctgaatag acgatggcgt gtggcttctg aaaagggtag
     2941 ttatgaaata atagcagcaa atggtgaaga cacagatgtg gataagctga ccaacagtcc
     3001 tcaaaatcag aatatcacag tacctcgggg agagagcacc tctcacacaa acacaacaag
     3061 aaagccaagt gacctcccaa cattttctgg agttggacat aaatctccac atgtaagaca
     3121 ggaggaagaa aacagtggtt ttcagaaaag acagttattc atcaggacac ggaagaagaa
     3181 gaaaaataag aagcttgcac tacacagtcc tctatctcca aggggctttg accctttgag
     3241 aggacataac cattccccat ttccagacag gagactactt aatcactcac tgttactcca
     3301 caagtccaat gaaacagctc tttctccaga cctgaaccag acctctcctt caatgagtac
     3361 ggacaggtca cttcctgact ataatcagta ctcgaaaaat gacactgagc agatgagctc
     3421 ttctttagat ctttatcagt cagtgcccgc agaggaacac tctccaacat ttcctgccca
     3481 agatcctgat caaacacact ctaccacaga tcctagctac agatcctctc cgccagagct
     3541 cagccagggg cttgattatg acctaagtca tgacttttac cctgatgaca ttggtctaac
     3601 atctttcttt ccagaccaaa gtcaaaagtc atctttctct tcagatgatg accaagcaat
     3661 cccttcctca gacttaagcc tctttaccat ctctccagaa ttggatcaga caattattta
     3721 cccagacctg gatcagttgc tcctttctcc agaagacaat cagaagacct cctccccaga
     3781 cctgggccag gtgccccttt ctccagatga caaccagaag acctcctccc cagacctggg
     3841 tcaggtgtcc ctttctccag atgataacca gaagacctcc tccccagacc tgggtcaggt
     3901 gcccctttct ctagatgaca accagaagac gacctcccca gacctgggtc aggtgcccct
     3961 ttctccagat gacaaccaga tgatcacctc cccagacctg ggtcaggtgc ccctttcttc
     4021 tgataaccag aagacctctt ccccagatct gggtcaggtg cctctttttc ctgaagacaa
     4081 ccagaattac ttcctagacc tgagtcaggt acctctctcc tcagaccaaa accaggagac
     4141 ctcctccaca gacctactga ctctctctcc tgattttggt cagacagtcc tttccccaga
     4201 cttggatcag ctgccactcc cttcagacaa tagtcaggtg accgtttccc cagacctcag
     4261 cctcttgacc ctctcaccag attttaatga gataatccta gccccagacc ttggtcaagt
     4321 gaccctctct ccagacctca tccagacaaa ccctgctctt aatcatggac acaaagcatc
     4381 ctctgcagac cctgatcaag catcctaccc tccagattct ggtcaggctt catcgcttcc
     4441 agaactgaat cggactcttc ctcatccaga tctcactcac ataccacctc cttcaccatc
     4501 tcccacactc aataacactt ctttgtcaag gaaatttaac cctcttgttg tagtaggtct
     4561 cagtagagta gatggagacg acgttgagat tgttccaagt gaggagccag agagaataga
     4621 tgaagattat gccgaggatg actttgtaac ctataatgac ccctacagaa cagacactag
     4681 gacagatgtc aattcctcca gaaatcctga cactatcgca gcatggtacc tccgaggcca
     4741 cggtggacac aaaaaattct actatattgc agctgaagaa ataacctgga attacgcaga
     4801 gtttgcacaa agtgaaatgg accatgaaga cacaggccac actccaaagg acaccacata
     4861 caagaaagtc gttttcagaa aataccttga tagcacgttt acaagtcgtg atcctcgggc
     4921 agaatatgag gagcaccttg gcattctcgg tcctgtgatc cgggctgaag tggatgatgt
     4981 gatccaagtt cgatttaaaa atttggcatc cagaccgtat tctcttcatg ctcacggact
     5041 ttcctatgaa aaatcctcag aggggaagac ttatgaagat gaatctcctg aatggtttca
     5101 ggaagatgat gctgtccagc ccaatagcag ttacacctat gtatggcatg ccaccaagcg
     5161 ctcagggcca gagaaccctg gttctgcctg ccgggcttgg gcctactatt ctgcagtgaa
     5221 tgtggagagg gacatccact caggcttgat cggccccctt ctgatctgcc ggaaaggaac
     5281 acttcacatg gagcgcaacc tgcctatgga catgagagag tttgtcttac tcttcatggt
     5341 ctttgatgag aagaagagct ggtactatga aaagtccaag gggtcacgga gaattgaatc
     5401 cccagaagag aaaaatgccc acaagtttta cgcaattaat gggatgatct acaacctgcc
     5461 cggcctgaga atgtacgagc aagagtgggt gaggctacac ctgctgaaca tgggcggctc
     5521 ccgagatatt cacgtggttc acttccatgg ccagaccctg ctggataata ggaccaaaca
     5581 gcaccagtta ggcgtctggc cccttctgcc tggttcattt aaaactcttg aaatgaaggc
     5641 atccaagcct ggctggtggc tcctagacac agaggttgga gaaaaccagg tagctggcat
     5701 gcaaacgcca tttctcatca tagacaaaga gtgtaagatg ccaatgggac taagcactgg
     5761 tgtcatatct gattcacaga tcaaggcttc ggaatatctg acttattggg agcccagatt
     5821 agcacgatta aacaatgctg gttcatacaa tgcttggagt atagaaaaaa ctgcattaga
     5881 ttttcccatt aaaccttgga tccaggtgga catgcagaag gaagttgtag tcaccgggat
     5941 acaaacccaa ggtgctaaac actacctaaa gtcctgcttt accacggagt tccaagtggc
     6001 ttacagctct gaccaaacca actggcagat cttcagaggg aagagcggga agagcgtgat
     6061 gtattttact ggtaattcag atggctctac aataaaagag aatcgacttg acccacccat
     6121 tgtggctaga tacattagga tacacccaac aaaatcctat aatagaccca cccttcggct
     6181 ggagctgcag ggctgtgagg tgaacggatg ttccacacca ctgggcctgg aagatggacg
     6241 gattcaagac aagcaaatta ctgcatcttc atttaaaaag tcgtggtggg gagactactg
     6301 ggagccctcc cttgcccgcc tgaacgccca gggccgcgtg aacgcctggc aagccaaggc
     6361 aaacaacaac aagcagtggt tacaagtcga tctgctcaaa atcaagaagg taacggccat
     6421 cgtaacgcag ggctgtaagt ctctgtcctc tgagatgtac gtgaagagct acagcatcca
     6481 gtacagtgac cagggtgtgg catggaaacc ttaccgacag aaatcctcca tggtggacaa
     6541 gatttttgaa ggaaacagca ataccaaggg gcacatgaag aactttttca acccgcccat
     6601 tatttccaga tttatccgca tcattcctaa aacatggaac cagagcatcg cccttcgcct
     6661 agagctcttc ggctgtgaca tttattagaa ttaaattcca aaaagagaaa aaaaaaggaa
     6721 aagagagaat aaaagctgaa gaaactcctt caagcctaaa ccatttagag caggccctat
     6781 agcatgggta ttttaaatgt taacagaagt tctgctattt ttttctagtt gagaataagc
     6841 tttatgtgag aagcttttaa tactccttca tcgctgccac taagtgagat ggcagctatt
     6901 atttcttcac tgatttgaat ataaatgggg aaatattaag acctggcaag aatatgactg
     6961 tttttcactc tgattaaaga cattgtataa tataatagtt atataatgga atgatatgat
     7021 tcactgtggc tctttgaaat cctgtagaca ttagcaaaag ataatacttt tggaaatttt
     7081 tcatggacct agaaagcctt tctttctata tttttctttt aaaagcaaac tgtaatttgt
     7141 aaacaataga aacaaaagta gttgaggttt tttttttatc atagagaaaa atatatcttg
     7201 ttgtaattaa gtgagaactt aaaaataccc agtgttgggc tggctcagtg ggcaaaagtg
     7261 cttgctgcca aaacaaaaca acaacagcaa cacaacacaa aacaaacctt atggcttgag
     7321 ttcaagtcct ggaacccaca gtgaaaggag agagcatatt ccagaaagcc gtcccctggt
     7381 ttctgcatga cccacgacca tgtacaagca ctaacggtaa ataaaagatt tttaaagctt
     7441 gccttctcaa gcgttctgat tctccattag gaaagaaaca attgagcgtg tttctcatgt
     7501 cccagttgga cttgtgaatc tgtcttgttt ggggcagata gcacatatcg ataccctagt
     7561 gtagcagcca tcagacatta aaagagatgt cagtgatgac cttgggagaa ctggtcatgt
     7621 gccttggctt gactgaaaag ctggcacggt gtggcatact gtttcaaaac ttgggttcat
     7681 ctaagggaag acacttacct gtaaaggaga atatgggact gttggctcaa agcttttaac
     7741 agttcctgtt agaactgctc caggccaaat tgacaagtga atgaaaagtt ctttctgtgt
     7801 ctttctttct gcctctcctc actcagcagc ttctcctgtt agcatgtttt tctctgaaaa
     7861 cttggaatct catggcacca catcacttgc cagtctgtgg agcctttcaa cacacgcaaa
     7921 gtcacttggg gtggacgctt tatacacaca gaatggtcat tcaaatagaa agttgaaacc
     7981 atctggtttt gtgaaataaa ccatcccaat gcttaagtaa gaattgtgca aaatataact
     8041 gatgtgataa gatagatggt aattttgtac agtgtacata tatcaaaaca tgcttatatg
     8101 taccataaat aaaattttct ggttaaaatt ttaa
//
