LOCUS       NM_010171               1876 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus coagulation factor III, tissue factor (F3), mRNA.
ACCESSION   NM_010171
VERSION     NM_010171.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Ballard-Kordeliski,A., Lee,R.H., O'Shaughnessy,E.C., Kim,P.Y.,
            Jones,S.R., Pawlinski,R., Flick,M.J., Paul,D.S., Mackman,N.,
            Adalsteinsson,D.A. and Bergmeier,W.
  TITLE     4D intravital imaging studies identify platelets as the predominant
            cellular procoagulant surface in a mouse hemostasis model
  JOURNAL   Blood 144 (10), 1116-1126 (2024)
   PUBMED   38820498
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Shi,Q., Xu,J., Chen,C., Hu,X., Wang,B., Zeng,F., Ren,T., Huang,Y.,
            Guo,W., Tang,X. and Ji,T.
  TITLE     Direct contact between tumor cells and platelets initiates a
            FAK-dependent F3/TGF-beta positive feedback loop that promotes
            tumor progression and EMT in osteosarcoma
  JOURNAL   Cancer Lett 591, 216902 (2024)
   PUBMED   38641310
  REMARK    GeneRIF: Direct contact between tumor cells and platelets initiates
            a FAK-dependent F3/TGF-beta positive feedback loop that promotes
            tumor progression and EMT in osteosarcoma.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Manoharan,J., Rana,R., Kuenze,G., Gupta,D., Elwakiel,A.,
            Ambreen,S., Wang,H., Banerjee,K., Zimmermann,S., Singh,K.,
            Gupta,A., Fatima,S., Kretschmer,S., Schaefer,L., Zeng-Brouwers,J.,
            Schwab,C., Al-Dabet,M.M., Gadi,I., Altmann,H., Koch,T., Poitz,D.M.,
            Baber,R., Kohli,S., Shahzad,K., Geffers,R., Lee-Kirsch,M.A.,
            Kalinke,U., Meiler,J., Mackman,N. and Isermann,B.
  TITLE     Tissue factor binds to and inhibits interferon-alpha receptor 1
            signaling
  JOURNAL   Immunity 57 (1), 68-85 (2024)
   PUBMED   38141610
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Zheng,L., Tang,R., Shi,L., Zhou,Z., Song,J. and Lu,Z.
  TITLE     CD142 promotes trophoblast cell migration by inhibiting
            BCL2-related autophagic degradation of IL-8
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (2), 131-141 (2023)
   PUBMED   36847889
  REMARK    GeneRIF: CD142 promotes trophoblast cell migration by inhibiting
            BCL2-related autophagic degradation of IL-8.
            Erratum:[In Vitro Cell Dev Biol Anim. 2023 Dec;59(10):821. doi:
            10.1007/s11626-023-00829-4. PMID: 38030872]
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Felts,S.J., Stoflet,E.S., Eggers,C.T. and Getz,M.J.
  TITLE     Tissue factor gene transcription in serum-stimulated fibroblasts is
            mediated by recruitment of c-Fos into specific AP-1 DNA-binding
            complexes
  JOURNAL   Biochemistry 34 (38), 12355-12362 (1995)
   PUBMED   7547979
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Ito,T., Hiraiwa,J., Nishioka,J., Iino,M. and Suzuki,K.
  TITLE     Characterization of functionally important regions of tissue factor
            by using monoclonal antibodies
  JOURNAL   J Biochem 114 (5), 691-696 (1993)
   PUBMED   8113222
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Johnson,B., Brooks,B.A., Heinzmann,C., Diep,A., Mohandas,T.,
            Sparkes,R.S., Reyes,H., Hoffman,E., Lange,E., Gatti,R.A. et al.
  TITLE     The Ah receptor nuclear translocator gene (ARNT) is located on q21
            of human chromosome 1 and on mouse chromosome 3 near Cf-3
  JOURNAL   Genomics 17 (3), 592-598 (1993)
   PUBMED   8244375
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Mackman,N., Imes,S., Maske,W.H., Taylor,B., Lusis,A.J. and
            Drake,T.A.
  TITLE     Structure of the murine tissue factor gene. Chromosome location and
            conservation of regulatory elements in the promoter
  JOURNAL   Arterioscler Thromb 12 (4), 474-483 (1992)
   PUBMED   1348427
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Ranganathan,G., Blatti,S.P., Subramaniam,M., Fass,D.N., Maihle,N.J.
            and Getz,M.J.
  TITLE     Cloning of murine tissue factor and regulation of gene expression
            by transforming growth factor type beta 1
  JOURNAL   J Biol Chem 266 (1), 496-501 (1991)
   PUBMED   1985911
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Hartzell,S., Ryder,K., Lanahan,A., Lau,L.F. and Nathan,D.
  TITLE     A growth factor-responsive gene of murine BALB/c 3T3 cells encodes
            a protein homologous to human tissue factor
  JOURNAL   Mol Cell Biol 9 (6), 2567-2573 (1989)
   PUBMED   2761539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129311.6, AK137642.1 and
            C86417.1.
            
            On Mar 18, 2008 this sequence version replaced NM_010171.2.
            
            Summary: This gene encodes a membrane-bound glycoprotein that forms
            the primary physiological initiator of the blood coagulation
            process following vascular damage. The encoded protein binds to
            coagulation factor VIIa and the ensuing complex catalyzes the
            proteolytic activation of coagulation factors IX and X. Mice
            lacking encoded protein die in utero resulting from massive
            hemorrhaging in both extraembryonic and embryonic vessels. A severe
            deficiency of the encoded protein in mice results in impaired
            uterine homeostasis, shorter life spans due to spontaneous fatal
            hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024886.1, AK144872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC129311.6         42132-42203
            73-1773             AK137642.1         2-1702
            1774-1876           C86417.1           1-103               c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.94 cM"
     gene            1..1876
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /note="coagulation factor III, tissue factor"
                     /db_xref="GeneID:14066"
                     /db_xref="MGI:MGI:88381"
     exon            1..266
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1063
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /note="tissue factor; coagulation factor III"
                     /codon_start=1
                     /product="tissue factor precursor"
                     /protein_id="NP_034301.3"
                     /db_xref="CCDS:CCDS17805.1"
                     /db_xref="GeneID:14066"
                     /db_xref="MGI:MGI:88381"
                     /translation="MAILVRPRLLAALAPTFLGCLLLQVTAGAGIPEKAFNLTWISTD
                     FKTILEWQPKPTNYTYTVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVL
                     SVPRRNSVHGDGDQLVIHGEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVK
                     DSLTLVRKNGTFLTLRQVFGKDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYC
                     FFVQAMIFSRKTNQNSPGSSTVCTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCK
                     RRKNRAGQKGKNTPSRLA"
     exon            267..372
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     exon            373..590
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     exon            591..769
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     exon            770..929
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1876
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="F3"
                     /gene_synonym="CD142; Cf-3; Cf3; TF"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggcg cggggtggag aggagccggt gtccgcgcgg ccctttataa cgcaccccgc
       61 gccgaccccg gcagcctggg tacagccggt acccatcact cgctccctcc gatcgctcct
      121 gtagcgtagc caacgcgccg ccgctgaagc cccgagacct cgcctccagc ccttggacat
      181 ggcgatcctc gtgcgcccgc gcctcctagc ggctctcgcg cccacgtttc tcggctgcct
      241 cctcctccag gtgaccgcgg gtgcaggcat tccagagaaa gcgtttaatt taacttggat
      301 atcaactgat ttcaagacaa ttttggagtg gcaacccaaa cccaccaact atacctacac
      361 tgtacagata agtgatcgat ctagaaactg gaaaaacaag tgcttctcga ccacagacac
      421 cgagtgcgac ctcacagacg agatcgtgaa ggatgtgacc tgggcctatg aagcaaaggt
      481 cctctctgtc ccacggagga actcagttca tggagacgga gaccaacttg tgattcatgg
      541 ggaggagccg ccatttacaa acgccccaaa gtttttacct taccgagaca caaaccttgg
      601 acagccagta attcagcagt ttgaacaaga tggtagaaaa ctgaacgtgg ttgtaaaaga
      661 ctcacttaca ttagtcagaa agaatggtac attcctcacc ctgcggcaag tctttggcaa
      721 ggacttgggt tatataatta cttatcggaa aggctcaagc acgggaaaga aaacaaacat
      781 tacaaacacc aatgaattct cgattgatgt ggaagaagga gtaagctact gcttttttgt
      841 acaagctatg attttctcca ggaaaactaa ccaaaatagc ccaggaagca gtacagtgtg
      901 caccgagcaa tggaagagtt tcctgggaga aacactcatc attgtgggag cagtggtgct
      961 cctggccacc atctttatca tcctcctgtc catatctctg tgcaagcgca gaaagaaccg
     1021 agcgggacag aaagggaaga acaccccgtc gcgcttggca tagaggaaag gctgaagccg
     1081 ctaacgctca cactgcctgc acggcactgt tgcggagagc tctgatggga actgtgcaac
     1141 atggagcgtg gagcctgccg atcctagctc agagaggctg ccttcatggc ctgttactcc
     1201 agctaacgct ttgattccaa cactagcatt tgtcacgtta ggacgaactg aaacggtaca
     1261 aactggttaa cactacagcg ccttttgcac aaatgcttta gattgtatgg tctacactca
     1321 ggaagacact aggtcaccca ggcaaagcca gtggacagat gcctttcata taacctgggt
     1381 gggcttttgg aaaatctttg agaagttgat ttcataggct gtagaacagt aaagtgggaa
     1441 ctgggcggac ttttctaaca gtcgtacttt tataaagcgg tatttgggtg ttttttccct
     1501 cgaataggta cttttggaag ttcaaagcaa gtggcaaact ttcatataaa catgttaaat
     1561 gcaggatatt tctgcttggg gcatctttgt gatttgtact ttcctacaat ttagcacttt
     1621 aactgacaat gatggggttt aaacatttga cagccaactc tatttttata cgactactat
     1681 acaaagaaac tacatatagt tttatgattt aaggtactta gaaatgttta tggttaacat
     1741 tgtatatatt tacataaaat ttaaaggttt tgtatatggg attttctatt tatatagctt
     1801 ctatttgtat attttgagat aatttattta atatactttt atataaataa aggtgattgg
     1861 gaattgagac aatcgc
//
