LOCUS       NM_007975               2026 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus F2R like thrombin or trypsin receptor 3 (F2rl3), mRNA.
ACCESSION   NM_007975
VERSION     NM_007975.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Andrianova,I., Kowalczyk,M. and Denorme,F.
  TITLE     Protease activated receptor-4: ready to be part of the
            antithrombosis spectrum
  JOURNAL   Curr Opin Hematol 31 (5), 238-244 (2024)
   PUBMED   38814792
  REMARK    GeneRIF: Protease activated receptor-4: ready to be part of the
            antithrombosis spectrum.
            Review article
REFERENCE   2  (bases 1 to 2026)
  AUTHORS   Deng,L., Cao,C., Cai,Z., Wang,Z., Leng,B., Chen,Z., Kong,F.,
            Zhou,Z., He,J., Nie,X. and Bian,J.S.
  TITLE     STING Contributes to Pulmonary Hypertension by Targeting IFN and
            BMPR2 Signaling through Regulating of F2RL3
  JOURNAL   Am J Respir Cell Mol Biol 71 (3), 356-371 (2024)
   PUBMED   38864771
  REMARK    GeneRIF: STING Contributes to Pulmonary Hypertension by Targeting
            IFN and BMPR2 Signaling through Regulating of F2RL3.
REFERENCE   3  (bases 1 to 2026)
  AUTHORS   Han,X., Knauss,E.A., Fuente,M., Li,W., Conlon,R.A., LePage,D.F.,
            Jiang,W., Renna,S.A., McKenzie,S.E. and Nieman,M.T.
  TITLE     A mouse model of the protease-activated receptor 4 Pro310Leu
            variant has reduced platelet reactivity
  JOURNAL   J Thromb Haemost 22 (6), 1715-1726 (2024)
   PUBMED   38508397
  REMARK    GeneRIF: A mouse model of the protease-activated receptor 4
            Pro310Leu variant has reduced platelet reactivity.
REFERENCE   4  (bases 1 to 2026)
  AUTHORS   Qu,G., Li,X., Jin,R., Guan,D., Ji,J., Li,S., Shi,H., Tong,P.,
            Gan,W. and Zhang,A.
  TITLE     MicroRNA-26a alleviates tubulointerstitial fibrosis in diabetic
            kidney disease by targeting PAR4
  JOURNAL   J Cell Mol Med 28 (3), e18099 (2024)
   PUBMED   38164021
  REMARK    GeneRIF: MicroRNA-26a alleviates tubulointerstitial fibrosis in
            diabetic kidney disease by targeting PAR4.
REFERENCE   5  (bases 1 to 2026)
  AUTHORS   Ye,S., Agalave,N.M., Ma,F., D Mahmood,D.F., Al-Grety,A.,
            Khoonsari,P.E., Svensson,C.I., Kultima,K. and Vera,P.L.
  TITLE     Lumbosacral spinal proteomic changes during PAR4-induced persistent
            bladder pain
  JOURNAL   Neurosci Lett 818, 137563 (2024)
   PUBMED   38036085
  REMARK    GeneRIF: Lumbosacral spinal proteomic changes during PAR4-induced
            persistent bladder pain.
REFERENCE   6  (bases 1 to 2026)
  AUTHORS   Sambrano,G.R., Weiss,E.J., Zheng,Y.W., Huang,W. and Coughlin,S.R.
  TITLE     Role of thrombin signalling in platelets in haemostasis and
            thrombosis
  JOURNAL   Nature 413 (6851), 74-78 (2001)
   PUBMED   11544528
REFERENCE   7  (bases 1 to 2026)
  AUTHORS   Grewal,P.K., Holzfeind,P.J., Bittner,R.E. and Hewitt,J.E.
  TITLE     Mutant glycosyltransferase and altered glycosylation of
            alpha-dystroglycan in the myodystrophy mouse
  JOURNAL   Nat Genet 28 (2), 151-154 (2001)
   PUBMED   11381262
REFERENCE   8  (bases 1 to 2026)
  AUTHORS   Yoshida,S. and Shiosaka,S.
  TITLE     Plasticity-related serine proteases in the brain (review)
  JOURNAL   Int J Mol Med 3 (4), 405-409 (1999)
   PUBMED   10085414
  REMARK    Review article
REFERENCE   9  (bases 1 to 2026)
  AUTHORS   Kahn,M.L., Hammes,S.R., Botka,C. and Coughlin,S.R.
  TITLE     Gene and locus structure and chromosomal localization of the
            protease-activated receptor gene family
  JOURNAL   J Biol Chem 273 (36), 23290-23296 (1998)
   PUBMED   9722561
REFERENCE   10 (bases 1 to 2026)
  AUTHORS   Kahn,M.L., Zheng,Y.W., Huang,W., Bigornia,V., Zeng,D., Moff,S.,
            Farese,R.V. Jr., Tam,C. and Coughlin,S.R.
  TITLE     A dual thrombin receptor system for platelet activation
  JOURNAL   Nature 394 (6694), 690-694 (1998)
   PUBMED   9716134
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY344718.1, AK036427.1 and
            AI413964.1.
            
            On Sep 24, 2016 this sequence version replaced NM_007975.3.
            
            Summary: This gene encodes a member of the protease-activated
            receptor subfamily, part of the G-protein coupled receptor 1 family
            of proteins. The encoded receptor is proteolytically processed to
            reveal an extracellular N-terminal tethered ligand that binds to
            and activates the receptor. This receptor plays a role in blood
            coagulation, inflammation and response to pain. Mice lacking a
            functional copy of this gene exhibit impaired platelet activation
            and prolonged bleeding times. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036427.1, AK156729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               BY344718.1         3-223
            222-1983            AK036427.1         2-1763
            1984-2026           AI413964.1         8-50                c
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     gene            1..2026
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="F2R like thrombin or trypsin receptor 3"
                     /db_xref="GeneID:14065"
                     /db_xref="MGI:MGI:1298207"
     exon            1..356
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1435
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="proteinase-activated receptor 4; PAR-4; thrombin
                     receptor-like 3; coagulation factor II receptor-like 3;
                     coagulation factor II (thrombin) receptor-like 3"
                     /codon_start=1
                     /product="proteinase-activated receptor 4 preproprotein"
                     /protein_id="NP_032001.2"
                     /db_xref="CCDS:CCDS22419.1"
                     /db_xref="GeneID:14065"
                     /db_xref="MGI:MGI:1298207"
                     /translation="MCWPLLYPLVLGLSISLAEGIQTPSIYDDVESTRGSHEGPLGPT
                     VELKEPKSSDKPNPRGYPGKFCANDSDTLELPASSQALLLGWVPTRLVPALYGLVVAV
                     GLPANGLALWVLATRVPRLPSTILLMNLAVADLLLALVLPPRLAYHLRGQRWPFGEAA
                     CRVATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGQRLTTGLCLVAWLSAAT
                     LALPLTLHRQTFRLAGSDRMLCHDALPLTEQTSHWRPAFICLAVLGCFVPLLAMGLCY
                     GATLRALAANGQRYSHALRLTALVLFSAVASFTPSNVLLVLHYSNPSPEAWGNLYGAY
                     VPSLALSTLNSCVDPFIYYYVSHEFREKVRAMLCRQPEASSSSQASREAGSRGTAICS
                     STLL"
     exon            357..1996
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="hexamer: ATTAAA"
     polyA_site      1982
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="major polyA site"
ORIGIN      
        1 gttctttatg agacattttg gagagagaga cctaggcagg acacccagac ctcctgagtg
       61 cacacaggga ccttcgatgg gctccagggt gagcaagcag atcccaatgg gtctatgggg
      121 gtgggagctc tgctgtctcc ccgaaggtgc agttgctccc cacaaggact ccggaagccg
      181 agggtggagt tgacagggca ggaagtccca ggctgcagcc cagaaagctt ctgatcctgg
      241 cagcatgtgc tggccgctgc tgtatccttt ggtgctgggg ctcagcatca gcctggcaga
      301 gggcatccag acccccagca tctacgatga tgtagagagt accaggggaa gccatgaagg
      361 ccctctgggt cccacagtag aactcaagga gccgaagtcc tcagacaagc ctaatccacg
      421 aggctacccg ggcaaattct gtgccaacga cagtgacacg ctggagctcc cggccagctc
      481 tcaagcactg ctgctggggt gggtccccac gaggctggta cctgccctct atgggcttgt
      541 ggtggctgtg gggctgcctg ccaatgggct ggcgctgtgg gtgctggcca caagggtgcc
      601 acgcctgcca tccaccattc tgctcatgaa cctggcagtg gctgatctgc tgttggccct
      661 ggtgctgcca ccacgactgg cttaccactt gcgtggccag cgctggccat ttggtgaggc
      721 tgcctgccgg gtggccacag ctgccctcta tggccacatg tatggttcag tgttgctgct
      781 ggctgcagtc agcttggaca gatacctggc cctggtgcat cctttgcggg cccgtgcact
      841 gcgtggtcaa cgcctcacta ctggactctg tttggtggcc tggctctctg cagccaccct
      901 ggccttgcct ctcactctgc atcggcagac cttccgatta gctggctccg atcgcatgct
      961 gtgtcatgat gcgctgcccc tgactgagca gacctcccac tggagaccgg ccttcatctg
     1021 cctggctgtc ctgggctgct tcgtgccact gctggccatg ggcctgtgct atggagccac
     1081 ccttcgtgca ctggcggcca atggccagcg ctacagccat gcactcagac tgacagccct
     1141 ggtactgttc tcggcagtgg cctctttcac acctagcaat gtgctgctgg tgctgcacta
     1201 ttcaaacccg agccctgagg cctggggcaa tctctatgga gcctatgtgc ccagcctggc
     1261 actcagcacc ctcaacagct gcgtagaccc tttcatctac tactatgtgt cccatgagtt
     1321 cagggagaag gtacgcgcta tgttgtgtcg ccagccggag gccagcagct cctctcaggc
     1381 ctccagggag gctggaagcc gagggactgc catttgctcc tctacacttc tgtgactggt
     1441 agctgaggtg ggaagggggc attctggctt gactgggtct ccccttaaac tacatccctc
     1501 ttgaaccctc aggacatgac cttatttgga tatgcagttg gtgcgacctt cattagtgga
     1561 gctgaggtcc actggaaatg cttttgtaaa aggtctgggt actatacgtc tgtcactcca
     1621 gcactaggga ggtggagaag aggatcagga gttcaggatt atctttgact gtagtgaatt
     1681 tggagctagg ctgggctatg tgagagtcca gaggcagaaa ggagttatga ggtcactagc
     1741 tagaggatgc tgagaaacca gaatggagtt tcccttagag cttcagggga tccagcccta
     1801 gacaccctga ttttgtcaag gtgcctctta gaacttcaaa cctttgtgct tagcatgtgt
     1861 ctgcacagtg tagatgtgtc tgcacacata tattgtatgt gcctgcgggt acacagagag
     1921 gccaaaggat gatgggtgtc tacctcaatt ccttctctac cattaaattt ttaaaaaaat
     1981 gctatatata tatataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
