LOCUS       NM_010170               2464 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus coagulation factor II thrombin receptor like 2
            (F2rl2), mRNA.
ACCESSION   NM_010170
VERSION     NM_010170.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Mwirigi,J., Kume,M., Hassler,S.N., Ahmad,A., Ray,P.R., Jiang,C.,
            Chamessian,A., Mseeh,N., Ludwig,B.P., Rivera,B.D., Nieman,M.T., Van
            de Ven,T., Ji,R.R., Dussor,G., Boitano,S., Vagner,J. and Price,T.J.
  TITLE     A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception
            Demonstrated Through Development of a Novel Peptide Agonist
  JOURNAL   J Pain 22 (6), 692-706 (2021)
   PUBMED   33429107
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Castillo,M.M., Yang,Q., Sigala,A.S., McKinney,D.T., Zhan,M.,
            Chen,K.L., Jarzembowski,J.A. and Sood,R.
  TITLE     The endothelial protein C receptor plays an essential role in the
            maintenance of pregnancy
  JOURNAL   Sci Adv 6 (45) (2020)
   PUBMED   33158859
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Gould,T.W., Dominguez,B., de Winter,F., Yeo,G.W., Liu,P.,
            Sundararaman,B., Stark,T., Vu,A., Degen,J.L., Lin,W. and Lee,K.F.
  TITLE     Glial cells maintain synapses by inhibiting an activity-dependent
            retrograde protease signal
  JOURNAL   PLoS Genet 15 (3), e1007948 (2019)
   PUBMED   30870413
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Shahzad,K., Gadi,I., Nazir,S., Al-Dabet,M.M., Kohli,S., Bock,F.,
            Breitenstein,L., Ranjan,S., Fuchs,T., Halloul,Z., Nawroth,P.P.,
            Pelicci,P.G., Braun-Dullaeus,R.C., Camerer,E., Esmon,C.T. and
            Isermann,B.
  TITLE     Activated protein C reverses epigenetically sustained p66Shc
            expression in plaque-associated macrophages in diabetes
  JOURNAL   Commun Biol 1, 104 (2018)
   PUBMED   30271984
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   Nazir,S., Gadi,I., Al-Dabet,M.M., Elwakiel,A., Kohli,S., Ghosh,S.,
            Manoharan,J., Ranjan,S., Bock,F., Braun-Dullaeus,R.C., Esmon,C.T.,
            Huber,T.B., Camerer,E., Dockendorff,C., Griffin,J.H., Isermann,B.
            and Shahzad,K.
  TITLE     Cytoprotective activated protein C averts Nlrp3
            inflammasome-induced ischemia-reperfusion injury via mTORC1
            inhibition
  JOURNAL   Blood 130 (24), 2664-2677 (2017)
   PUBMED   28882883
REFERENCE   6  (bases 1 to 2464)
  AUTHORS   Ong,K., Horsfall,W., Conway,E.M. and Schuh,A.C.
  TITLE     Early embryonic expression of murine coagulation system components
  JOURNAL   Thromb Haemost 84 (6), 1023-1030 (2000)
   PUBMED   11154109
REFERENCE   7  (bases 1 to 2464)
  AUTHORS   Yoshida,S. and Shiosaka,S.
  TITLE     Plasticity-related serine proteases in the brain (review)
  JOURNAL   Int J Mol Med 3 (4), 405-409 (1999)
   PUBMED   10085414
  REMARK    Review article
REFERENCE   8  (bases 1 to 2464)
  AUTHORS   Kahn,M.L., Hammes,S.R., Botka,C. and Coughlin,S.R.
  TITLE     Gene and locus structure and chromosomal localization of the
            protease-activated receptor gene family
  JOURNAL   J Biol Chem 273 (36), 23290-23296 (1998)
   PUBMED   9722561
REFERENCE   9  (bases 1 to 2464)
  AUTHORS   Kahn,M.L., Zheng,Y.W., Huang,W., Bigornia,V., Zeng,D., Moff,S.,
            Farese,R.V. Jr., Tam,C. and Coughlin,S.R.
  TITLE     A dual thrombin receptor system for platelet activation
  JOURNAL   Nature 394 (6694), 690-694 (1998)
   PUBMED   9716134
REFERENCE   10 (bases 1 to 2464)
  AUTHORS   Ishihara,H., Connolly,A.J., Zeng,D., Kahn,M.L., Zheng,Y.W.,
            Timmons,C., Tram,T. and Coughlin,S.R.
  TITLE     Protease-activated receptor 3 is a second thrombin receptor in
            humans
  JOURNAL   Nature 386 (6624), 502-506 (1997)
   PUBMED   9087410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171003.2.
            
            On Jul 25, 2007 this sequence version replaced NM_010170.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089444.1, U92972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC171003.2         25849-26056         c
            209-2464            AC171003.2         20208-22463         c
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.38 cM"
     gene            1..2464
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /note="coagulation factor II thrombin receptor like 2"
                     /db_xref="GeneID:14064"
                     /db_xref="MGI:MGI:1298208"
     exon            1..208
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1254
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /note="protease-activated receptor 3; proteinase-activated
                     receptor 3; PAR-3; thrombin receptor-like 2; coagulation
                     factor II receptor-like 2; Proteinase activated receptor 3
                     precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation
                     factor II receptor-like 2)"
                     /codon_start=1
                     /product="proteinase-activated receptor 3 precursor"
                     /protein_id="NP_034300.3"
                     /db_xref="CCDS:CCDS26702.1"
                     /db_xref="GeneID:14064"
                     /db_xref="MGI:MGI:1298208"
                     /translation="MKILILVAAGLLFLPVTVCQSGINVSDNSAKPTLTIKSFNGGPQ
                     NTFEEFPLSDIEGWTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYIL
                     LFVVGVPANIVTLWKLSLRTKSISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVF
                     GEVTCRITTVVFYGNMYCAILILTCMGINRYLATAHPFTYQKLPKRSFSMLMCGMVWV
                     MVFLYMLPFVILKQEYHLVHSEITTCHDVVDACESPSSFRFYYFVSLAFFGFLIPFVI
                     IIFCYTTLIHKLKSKDRIWLGYIKAVLLILVIFTICFAPTNIILVIHHANYYYHNTDS
                     LYFMYLIALCLGSLNSCLDPFLYFVMSKVVDQLNP"
     exon            209..2464
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /note="hexamer: ATTAAA"
     polyA_site      1601
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /note="major polyA site"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
                     /note="hexamer: AATAAA"
     polyA_site      2436
                     /gene="F2rl2"
                     /gene_synonym="F730031A08; PAR3"
ORIGIN      
        1 gcaaggacga gtccctgccc acacagtcca ggctggcaga gttctcagct ttccacttgc
       61 tgctcataca tggagctgag gggaatctac gctgtgactt tgtatactta acaacatcct
      121 gtaaccgggt ctcaggacat caagatgaaa atccttatct tggttgcagc tgggctgctg
      181 tttctgccag tcactgtttg ccaaagtggc ataaatgttt cagacaactc agcaaagcca
      241 accttaacta ttaagagttt taatgggggt ccccaaaata cctttgaaga attcccactt
      301 tctgacatag agggctggac aggagccacc acaactataa aagcggagtg tcccgaggac
      361 agtatttcaa ctctccacgt gaataatgct accataggat acctgagaag ttccttaagt
      421 acccaagtga tacctgccat ctacatcctg ctgtttgtgg ttggtgtacc agccaacatc
      481 gtgaccctgt ggaaactctc cttaaggacc aaatccatca gtctggtcat ctttcacacc
      541 aacctggcca tcgcagatct ccttttctgt gtcacactgc catttaagat cgcctaccat
      601 ctcaatggca acaactgggt atttggcgag gtcacgtgcc ggatcaccac ggttgttttc
      661 tacggcaaca tgtactgcgc tatcctgatc ctcacctgca tgggcatcaa ccgctacctg
      721 gccacggctc accctttcac ataccagaag ctgcccaaac gcagcttctc catgctcatg
      781 tgtggcatgg tgtgggtcat ggttttctta tacatgctgc cctttgtcat cctgaagcag
      841 gagtaccacc tcgtccactc cgagatcacc acctgccacg atgtcgttga cgcgtgcgag
      901 tccccatcat ccttccgatt ctactacttc gtctccttag cattctttgg gttcctcatc
      961 ccgtttgtga tcatcatctt ctgttacacg actctcatcc acaaacttaa atcaaaggat
     1021 cggatatggc tgggctacat caaggccgtc ctcctcatcc ttgtgatttt cacaatttgc
     1081 tttgccccca ccaacatcat actcgtaatc caccatgcca actactacta ccacaatacc
     1141 gacagcttgt actttatgta tcttattgct ctgtgcctgg ggagcctgaa tagctgccta
     1201 gatccattcc tttactttgt catgtcgaaa gttgtagatc agcttaatcc ttagtcagca
     1261 atggcaagac caccttagag accaaggaga gatatctggg aagacgtaca tgcttggctg
     1321 acttgtgcat ggcaccatca gctcaatttt tgatttttta attttaattt aatttaattt
     1381 tatgtttttg agacagagcc tcactgtgta gtcctggctg gcctggctgg ttctctattt
     1441 agaccaggtt agccttgaac tcacagagat ctgcctgctt ctgcctccca agtgctgggt
     1501 tcaaccaggt ctggcaagcg ctccattttt cagctcctct gcaacagtgc tttatacttc
     1561 caatgtgaag tcatgagaat taaaagaata ctttgtattt agagagtgtc ttaattgtaa
     1621 gcaacattag cagtattccg atggcaatgg atgcatttct acttgccttc ctgattctcc
     1681 aagctataca tgtccccttc cctcctgtga gcggtgtcgg cagactggga ggttgtcact
     1741 acccgtggtt ctccctcctc ctcaagcagg tatcctgtct ttgttgtgtc tctcactggg
     1801 gtcccatgtt catgccacct ctgtccaaag atggcagccc tcactgccag ctgagcctca
     1861 tttccacaga ttgggttaac cttccctgaa cagctttctg aatacatcat gcaatacttc
     1921 ccttgaccct gcagtgctcc tgaaatgaca agcccttgca tggctttcct ggtggagctg
     1981 tgcctgcgat tccacacacc ttcacaccga ctgtcttccc tcccatccct gtcgccccac
     2041 tgaaacccct tctagcatct ttgctttagc ctgtccagct tttcaagtcg ttaaaggccc
     2101 gttcttccct tattctcaaa ctagaagcat cattttcttt atctggattt ctaaagcact
     2161 ttcttatctt tatggcactt ctagacaaac aagcctgcta agctcatttg catatagata
     2221 ttacttccat aaggaattaa gttctctgtg tggtcagctc tctgtccctg caagtttcat
     2281 acctgcagat tcaaccaacc acagacccaa aacacttgaa aaaccttgta tgagctgaaa
     2341 acgaacagag ttcattattc attattcaga gtattttcat tactccctaa ataatactga
     2401 taataaataa taataaacaa tactctttgc acagcattca cactgtatta aatatttcta
     2461 agtc
//
