LOCUS       NM_007974               2773 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus F2R like trypsin receptor 1 (F2rl1), mRNA.
ACCESSION   NM_007974
VERSION     NM_007974.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Ha,S., Kim,H.W., Kim,K.M., Kim,B.M., Kim,J., Son,M., Kim,D.,
            Kim,M.J., Yoo,J., Yu,H.S., Jung,Y.S., Lee,J., Chung,H.Y. and
            Chung,K.W.
  TITLE     PAR2-mediated cellular senescence promotes inflammation and
            fibrosis in aging and chronic kidney disease
  JOURNAL   Aging Cell 23 (8), e14184 (2024)
   PUBMED   38687090
  REMARK    GeneRIF: PAR2-mediated cellular senescence promotes inflammation
            and fibrosis in aging and chronic kidney disease.
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Reches,G., Khoon,L., Ghanayiem,N., Malka,A. and Piran,R.
  TITLE     Controlling autoimmune diabetes onset by targeting
            Protease-Activated Receptor 2
  JOURNAL   Biomed Pharmacother 175, 116622 (2024)
   PUBMED   38653114
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Nakazawa,M., Tochinai,R., Fujii,W., Komori,M., Yonezawa,T.,
            Momoi,Y. and Maeda,S.
  TITLE     Protective role of protease-activated receptor-2 in anaphylaxis
            model mice
  JOURNAL   PLoS One 19 (4), e0283915 (2024)
   PUBMED   38635782
  REMARK    GeneRIF: Protective role of protease-activated receptor-2 in
            anaphylaxis model mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Rondeau,L.E., Da Luz,B.B., Santiago,A., Bermudez-Brito,M., Hann,A.,
            De Palma,G., Jury,J., Wang,X., Verdu,E.F., Galipeau,H.J.,
            Rolland,C., Deraison,C., Ruf,W., Bercik,P., Vergnolle,N. and
            Caminero,A.
  TITLE     Proteolytic bacteria expansion during colitis amplifies
            inflammation through cleavage of the external domain of PAR2
  JOURNAL   Gut Microbes 16 (1), 2387857 (2024)
   PUBMED   39171684
  REMARK    GeneRIF: Proteolytic bacteria expansion during colitis amplifies
            inflammation through cleavage of the external domain of PAR2.
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Damiano,B.P., Cheung,W.M., Santulli,R.J., Fung-Leung,W.P., Ngo,K.,
            Ye,R.D., Darrow,A.L., Derian,C.K., de Garavilla,L. and
            Andrade-Gordon,P.
  TITLE     Cardiovascular responses mediated by protease-activated receptor-2
            (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice
            deficient in PAR-2 or PAR-1
  JOURNAL   J Pharmacol Exp Ther 288 (2), 671-678 (1999)
   PUBMED   9918574
REFERENCE   7  (bases 1 to 2773)
  AUTHORS   Kahn,M.L., Hammes,S.R., Botka,C. and Coughlin,S.R.
  TITLE     Gene and locus structure and chromosomal localization of the
            protease-activated receptor gene family
  JOURNAL   J Biol Chem 273 (36), 23290-23296 (1998)
   PUBMED   9722561
REFERENCE   8  (bases 1 to 2773)
  AUTHORS   Nystedt,S., Emilsson,K., Larsson,A.K., Strombeck,B. and Sundelin,J.
  TITLE     Molecular cloning and functional expression of the gene encoding
            the human proteinase-activated receptor 2
  JOURNAL   Eur J Biochem 232 (1), 84-89 (1995)
   PUBMED   7556175
REFERENCE   9  (bases 1 to 2773)
  AUTHORS   Nystedt,S., Larsson,A.K., Aberg,H. and Sundelin,J.
  TITLE     The mouse proteinase-activated receptor-2 cDNA and gene. Molecular
            cloning and functional expression
  JOURNAL   J Biol Chem 270 (11), 5950-5955 (1995)
   PUBMED   7890726
REFERENCE   10 (bases 1 to 2773)
  AUTHORS   Nystedt,S., Emilsson,K., Wahlestedt,C. and Sundelin,J.
  TITLE     Molecular cloning of a potential proteinase activated receptor
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9208-9212 (1994)
   PUBMED   7937743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY029876.1, AK160916.1 and DV551864.1.
            
            On Apr 1, 2008 this sequence version replaced NM_007974.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY029876.1, AK160916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY029876.1         1-13
            14-2753             AK160916.1         2-2741
            2754-2773           DV551864.1         271-290
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.53 cM"
     gene            1..2773
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /note="F2R like trypsin receptor 1"
                     /db_xref="GeneID:14063"
                     /db_xref="MGI:MGI:101910"
     exon            1..204
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1313
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /note="proteinase-activated receptor 2; thrombin
                     receptor-like 1; G-protein coupled receptor 11;
                     coagulation factor II receptor-like 1; Protease-activated
                     receptor-2; coagulation factor II (thrombin) receptor-like
                     1"
                     /codon_start=1
                     /product="proteinase-activated receptor 2 precursor"
                     /protein_id="NP_032000.3"
                     /db_xref="CCDS:CCDS26700.1"
                     /db_xref="GeneID:14063"
                     /db_xref="MGI:MGI:101910"
                     /translation="MRSLSLAWLLGGITLLAASVSCSRTENLAPGRNNSKGRSLIGRL
                     ETQPPITGKGVPVEPGFSIDEFSASILTGKLTTVFLPVVYIIVFVIGLPSNGMALWIF
                     LFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNNWVYGEALCKVLIGFFYGN
                     MYCSILFMTCLSVQRYWVIVNPMGHPRKKANIAVGVSLAIWLLIFLVTIPLYVMKQTI
                     YIPALNITTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAM
                     DEHSEKKRQRAIRLIITVLAMYFICFAPSNLLLVVHYFLIKTQRQSHVYALYLVALCL
                     STLNSCIDPFVYYFVSKDFRDHARNALLCRSVRTVNRMQISLSSNKFSRKSGSYSSSS
                     TSVKTSY"
     exon            205..2768
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /note="hexamer: AATAAA"
     polyA_site      2289
                     /gene="F2rl1"
                     /gene_synonym="Gpcr11; PAR-2; Par2"
                     /note="major polyA site"
ORIGIN      
        1 gccccaggaa ggctcagtga agctcgtgtt aagggaaggg accctgtgct cagagtaggg
       61 ctccgagttt cgaaccactg gtggcggatt gcccgcccgc cccacgtccg gggatgcgaa
      121 gtctcagcct ggcgtggctg ctgggaggta tcacccttct ggcggcctcg gtctcctgca
      181 gccggaccga gaaccttgca ccgggacgca acaacagtaa aggaagaagt cttattggca
      241 gattagaaac ccagcctcca atcactggga aaggggttcc ggtagaacca ggcttttcca
      301 tcgatgagtt ctctgcgtcc atcctcaccg ggaagctgac cacggtcttt cttccggtcg
      361 tctacattat tgtgtttgtg attggtttgc ccagtaatgg catggccctc tggatcttcc
      421 ttttccgaac gaagaagaaa caccccgccg tgatttacat ggccaacctg gccttggccg
      481 acctcctctc tgtcatctgg ttccccctga agatctccta ccacctacat ggcaacaact
      541 gggtctacgg ggaggccctg tgcaaggtgc tcattggctt tttctatggt aacatgtatt
      601 gctccatcct cttcatgacc tgcctcagcg tgcagaggta ctgggtgatc gtgaacccca
      661 tgggacaccc caggaagaag gcaaacatcg ccgttggcgt ctccttggca atctggctcc
      721 tgatttttct ggtcaccatc cctttgtatg tcatgaagca gaccatctac attccagcat
      781 tgaacatcac cacctgtcac gatgtgctgc ctgaggaggt attggtgggg gacatgttca
      841 attacttcct ctcactggcc attggagtct tcctgttccc ggccctcctt actgcatctg
      901 cctacgtgct catgatcaag acgctccgct cttctgctat ggatgaacac tcagagaaga
      961 aaaggcagag ggctatccga ctcatcatca ccgtgctggc catgtacttc atctgctttg
     1021 ctcctagcaa ccttctgctc gtagtgcatt atttcctaat caaaacccag aggcagagcc
     1081 acgtctacgc cctctacctt gtcgccctct gcctgtcgac cctcaacagc tgcatagacc
     1141 cctttgtcta ttactttgtc tcaaaagatt tcagggatca cgccagaaac gcgctcctct
     1201 gccgaagtgt ccgcactgtg aatcgcatgc aaatctcgct cagctccaac aagttctcca
     1261 ggaagtccgg ctcctactct tcaagctcaa ccagtgttaa aacctcctac tgagctgtac
     1321 ctgaggatgt caagcctgct tgatgatgat gatgatgatg gtgtgtgtgt gtgtgtgtgt
     1381 gtgtgtgtgt gtgtgtgtgt gcacccgtgt gtgagtgcgt ggtagggatg caccaacatg
     1441 catggggctg tcatttccta tccaagctgc ctgtctctgc accaatcaca agcatgcagc
     1501 tctccccagg attgccagaa gcctcctcct ttgcatgaga acagtcttcc actctgatga
     1561 aaagcatcag tatcagaaac tgaaacgaac tgagaggagc ttgttttgtg aaagtgaaga
     1621 gaagatggag ggtcagtgac ttgcaaaaaa aaccaaccaa acaaaaacta cacctggcaa
     1681 gaaggctaag actctctgaa atgcttcctt ttccatctgg agttcgtctc ggccttgttc
     1741 aggacctgag gccctggtag agcttcagtc cagttgattg actttacaga cttgagagag
     1801 gagtgaatga ggagtgaatg aggctcctgg cggcatccta accggctaac agtggccttg
     1861 ctggacaata ggattcagat ggctggagtt acattctcac accatttcat cagaactatt
     1921 ggggatcttg atcaatgtgc aggtccctta gcgtcagtaa ccctgggagc tcagacacga
     1981 tgggggtgag ggtgggggtg ggggtggggg tgaggctcta caaaccttag tgatgactgc
     2041 agacacagaa ccatggagct gagcctgctt ctgcttgcca gggcaccact gtaatgttgg
     2101 caaagaaaaa ccaacagcag tgttttgagc ctcttttttt ggtcagttta tgatgaattt
     2161 gcctattggt ttattgggat tttcagttcc tttattactt tgttgtaatt ttgtgtgttt
     2221 attagtcaag aaaaagaaga tgaggctctt aaaaatgtaa ataaaatttt tggttttttg
     2281 gttttttaac ttgggccaac tacaaatact gcttaggttt ttttctaact taattgttaa
     2341 ctacatcatg tgaacttaag acattttcat gataaagcat tactgtagtg tcagttttcc
     2401 ctcatcctcg atcatagtcc ttcccgtgaa gcagggccct tcccctcccc cccctttgcc
     2461 gtttccctcc ccaccagata gtcccctgtc tgctttaacc taccagttag tattttataa
     2521 aaacagatca ttggaatatt tattatcagt tttgttcact gttatcagtt ttgttcacta
     2581 atttgtccaa taatggaatt aacgtcttct catctgtttg aggaagatct gaaacaaggg
     2641 gccattgcag gagtacatgg ctccaggctt actttatata ctgcctgtat ttgtggcttt
     2701 aaaaaaatga ccttgttata tgaatgcttt ataaataaat aatgcatgaa ctttaaaaaa
     2761 aaaaaaaaaa aaa
//
