LOCUS       NM_010169               3338 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus coagulation factor II thrombin receptor (F2r), mRNA.
ACCESSION   NM_010169
VERSION     NM_010169.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Roh,W.S., Yoo,J.H., Dravid,S.M., Mannaioni,G., Krizman,E.N.,
            Wahl,P., Robinson,M.B., Traynelis,S.F., Lee,C.J. and Han,K.S.
  TITLE     Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course
            at hippocampal CA1 synapses
  JOURNAL   Glia 72 (9), 1707-1724 (2024)
   PUBMED   38864289
  REMARK    GeneRIF: Astrocytic PAR1 and mGluR2/3 control synaptic glutamate
            time course at hippocampal CA1 synapses.
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Julovi,S.M., McKelvey,K., Minhas,N., Chan,Y.A., Xue,M. and
            Jackson,C.J.
  TITLE     Involvement of PAR-2 in the Induction of Cell-Specific Matrix
            Metalloproteinase-2 by Activated Protein C in Cutaneous Wound
            Healing
  JOURNAL   Int J Mol Sci 25 (1), 370 (2023)
   PUBMED   38203540
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Deng,L., Costa,F., Blake,K.J., Choi,S., Chandrabalan,A.,
            Yousuf,M.S., Shiers,S., Dubreuil,D., Vega-Mendoza,D., Rolland,C.,
            Deraison,C., Voisin,T., Bagood,M.D., Wesemann,L., Frey,A.M.,
            Palumbo,J.S., Wainger,B.J., Gallo,R.L., Leyva-Castillo,J.M.,
            Vergnolle,N., Price,T.J., Ramachandran,R., Horswill,A.R. and
            Chiu,I.M.
  TITLE     S. aureus drives itch and scratch-induced skin damage through a V8
            protease-PAR1 axis
  JOURNAL   Cell 186 (24), 5375-5393 (2023)
   PUBMED   37995657
  REMARK    GeneRIF: S. aureus drives itch and scratch-induced skin damage
            through a V8 protease-PAR1 axis.
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Zhao,L., Hu,J., Zheng,P., Mi,B., Chen,Z., Zhao,X., Wu,J. and
            Wang,Y.
  TITLE     PAR1 regulates sepsis-induced vascular endothelial barrier
            dysfunction by mediating ERM phosphorylation via the RhoA/ROCK
            signaling pathway
  JOURNAL   Int Immunopharmacol 124 (Pt B), 110992 (2023)
   PUBMED   37806106
  REMARK    GeneRIF: PAR1 regulates sepsis-induced vascular endothelial barrier
            dysfunction by mediating ERM phosphorylation via the RhoA/ROCK
            signaling pathway.
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Zoungrana,L.I., Krause-Hauch,M., Wang,H., Fatmi,M.K., Li,Z.,
            Slotabec,L., James,A.S., Didik,S. and Li,J.
  TITLE     Activated protein C signaling mediates neuroinflammation in seizure
            induced by pilocarpine
  JOURNAL   Biochem Biophys Rep 35, 101550 (2023)
   PUBMED   37823005
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Xue,J., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Sadler,J.E.
  TITLE     Structure and localization of the thrombin receptor gene on mouse
            chromosome 13
  JOURNAL   Mamm Genome 7 (8), 625-626 (1996)
   PUBMED   8678993
REFERENCE   7  (bases 1 to 3338)
  AUTHORS   Connolly,A.J., Ishihara,H., Kahn,M.L., Farese,R.V. Jr. and
            Coughlin,S.R.
  TITLE     Role of the thrombin receptor in development and evidence for a
            second receptor
  JOURNAL   Nature 381 (6582), 516-519 (1996)
   PUBMED   8632823
REFERENCE   8  (bases 1 to 3338)
  AUTHORS   Schmidt,V.A., Vitale,E. and Bahou,W.F.
  TITLE     Genomic cloning and characterization of the human thrombin receptor
            gene. Structural similarity to the proteinase activated receptor-2
            gene
  JOURNAL   J Biol Chem 271 (16), 9307-9312 (1996)
   PUBMED   8621593
REFERENCE   9  (bases 1 to 3338)
  AUTHORS   Poirier,C., O'Brien,E.P., Bueno Brunialti,A.L., Chambard,J.,
            Swank,R.T. and Guenet,J.
  TITLE     The gene encoding the thrombin receptor (Cf2r) maps to mouse
            chromosome 13
  JOURNAL   Mamm Genome 7 (4), 322 (1996)
   PUBMED   8661713
REFERENCE   10 (bases 1 to 3338)
  AUTHORS   Soifer,S.J., Peters,K.G., O'Keefe,J. and Coughlin,S.R.
  TITLE     Disparate temporal expression of the prothrombin and thrombin
            receptor genes during mouse development
  JOURNAL   Am J Pathol 144 (1), 60-69 (1994)
   PUBMED   8291612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164547.4 and AC159263.3.
            
            On Apr 13, 2018 this sequence version replaced NM_010169.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085990.1, BC031516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC164547.4         144736-144847       c
            113-180             AC159263.3         223671-223738       c
            181-3338            AC159263.3         207164-210321       c
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.21 cM"
     gene            1..3338
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="coagulation factor II thrombin receptor"
                     /db_xref="GeneID:14062"
                     /db_xref="MGI:MGI:101802"
     exon            1..180
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1385
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="proteinase-activated receptor 1; protease-activated
                     receptor 1"
                     /codon_start=1
                     /product="proteinase-activated receptor 1 precursor"
                     /protein_id="NP_034299.2"
                     /db_xref="CCDS:CCDS26701.1"
                     /db_xref="GeneID:14062"
                     /db_xref="MGI:MGI:101802"
                     /translation="MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPRSFF
                     LRNPSENTFELVPLGDEEEEEKNESVLLEGRAVYLNISLPPHTPPPPFISEDASGYLT
                     SPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVL
                     PFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPIQSLSW
                     RTLGRANFTCVVIWVMAIMGVVPLLLKEQTTRVPGLNITTCHDVLSENLMQGFYSYYF
                     SAFSAIFFLVPLIVSTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPT
                     NVLLIVHYLFLSDSPGTEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILC
                     CKESSDPNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA"
     exon            181..3338
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="hexamer: AATAAA"
     regulatory      3313..3318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="hexamer: ACTAAA"
     polyA_site      3324
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="major polyA site"
     polyA_site      3338
                     /gene="F2r"
                     /gene_synonym="Cf2r; Par1; ThrR"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcctct agtcacccgc aggctccgac cgagctactc agaaagaagt aggcgacggc
       61 gggcgccggg ccgcgcgggc agccttggga caatggggcc ccggcgcttg ctgatcgtcg
      121 ccctcggcct cagcctgtgc ggtcccttgc tgtcttcccg cgtccctatg agccagccag
      181 aatcagagag gacagatgct acggtgaacc cccgctcatt ctttctaagg aatcccagtg
      241 aaaatacatt tgaactggtc cccctggggg atgaggagga ggaggagaaa aatgaaagcg
      301 tcctgctgga gggtagggca gtctacttaa atataagcct ccctcctcac acgccgcctc
      361 ctcccttcat ctccgaggac gcctccggat atctgaccag cccctggctg acgctcttca
      421 tgccctccgt gtacacgatt gtgttcattg tcagccttcc tctgaacgtc ctggccatcg
      481 cagtgttcgt cttgaggatg aaggtcaaga agccggccgt ggtgtacatg ctgcacctgg
      541 ccatggccga cgtgctcttc gtgtcggtgc tccccttcaa gatcagctac tacttctccg
      601 gcactgattg gcagttcggg tctggaatgt gccgcttcgc caccgcagcg ttttacggga
      661 acatgtacgc ctccatcatg ctcatgacgg tcataagcat tgaccggttc ctggcggtgg
      721 tgtatccgat ccagtccctg tcctggcgca ctctgggccg agccaacttc acttgcgtgg
      781 tcatttgggt gatggccatc atgggggtgg tgccccttct cctcaaggag cagaccaccc
      841 gagttccggg actcaacatc accacctgcc acgacgtcct cagtgagaac ctgatgcaag
      901 gcttttactc gtactacttc tcggccttct ccgccatctt ctttcttgtg ccgttgatcg
      961 tttccacggt ctgctacacg tccatcatcc ggtgcctgag ctcctccgcg gttgccaacc
     1021 ggagcaagaa gtcgcgggct ttgttcctgt ctgccgcggt gttctgcatc ttcatcgtct
     1081 gctttgggcc caccaacgtc ctcctgattg tgcactacct tttcctctcc gacagtcctg
     1141 gtacagaggc agcctacttt gcttacctcc tctgcgtctg tgtgagcagc gtgagctgct
     1201 gcatcgatcc gttgatttac tactacgcct cctccgagtg ccagaggcac ctctacagca
     1261 tcttgtgctg caaagaaagc tctgatccca acagttgcaa cagcaccggc cagctgatgc
     1321 cgagtaaaat ggatacctgc tctagtcacc tgaataacag catatacaaa aagctattag
     1381 cttagggaaa gggttgctgg aaggttccat gagaaaaggt tggaaagcca acagcgggga
     1441 atcccattag tccctgcaaa gaactgtatt tacttcgaaa cctaaaaaac aaccaatatc
     1501 cgatatgcac gaatacttct gctatcaaga gtctagattg gataattacc agcaaggtga
     1561 cgggaacgga aataaaggtg tccagtgttg ctagtgctat gatagtaact ggatgtcact
     1621 tcttatatat ctaggtgact ttaatatata gatggtatgc acacactcat ttgtcatgca
     1681 ggagggaatc tgcactttga cacatttttg tttattccct ggccgttact atggaaataa
     1741 tctgattctc tgacttaata aacaaagtct gagttggtgg gtgttagcac tgggcagctg
     1801 gagatcctaa tgatagggga ggagtccgta gtttagactt aacacagctt ttgcctatat
     1861 tttttttcaa attatttgat aataatggtt agtgatggaa ggatgagaca gtattacctg
     1921 tgtaggggaa gctctaatac ttttcatctt gaacataccg tagttttaag aattatcaag
     1981 gctgttggaa aacccgtttt gatatgggta gcattttttt tttaacttgc aatttactta
     2041 ctgaatacat ggaccaagac tgagcataag actcaccagg actgtaataa accttacaaa
     2101 gcagccaagc ctagacacag ccatctgcat ggaggcctct gagcaccagg tacatcacac
     2161 cccttcggct atgcctccca gagagcagag atggatggga agcaccaggc ccaccccatc
     2221 ctgctaggat tctcattagc tgtgagctga ctgtgtcttt tagaaattgg caaggtaagg
     2281 tatgccatct tgggaggcag taactatgaa agactgacga gaggagaaag gtgtgtttac
     2341 atccagtagc tgtcctgcaa ggctggccct tgcacagaca gacacaccca catgccctgg
     2401 tcacactgtt ggatagtggg ccatagactg actataggag aataaccgag tcctgtcctt
     2461 actcaggcaa cgcagagagc tggcatgtgg tcagctatga tgcacataga acttgtcttc
     2521 agctggatgt gaccaagtgt atttcacata agcaaggcct atcagctaaa ctgctttgca
     2581 tatctgagtt tctgcttcca gtagctatag attaggataa aaacacagta taagatgtat
     2641 atttttaata catatgccct tcagcctaca aaattacaca ctatttattt acaaatgttt
     2701 tttcaaaaat tactcaaatc agccaggcat tatggtatac acctttaatc ccagaacttg
     2761 ggaggcagag gcaggcagat cttaaacaat ttttttttta agaaacaagc aaacacaaaa
     2821 agttttactt aagtccaatt ttaagaaata tataggtcag tttggttaaa aataatagta
     2881 atgaaaggaa atttcattga ttgaaattta ttctgtattt ttcttgagtt attgagatta
     2941 tttgtaaagc atttttaatg ccacagtgac taacaagcat ataaaatctt catacctttg
     3001 acaaaataat ttgaaaatta atttaaaaca tatccttttt ctgatgaaaa aatatgttgg
     3061 cattttaagc aaataagagt agaaaggttg tttatttaag agaacaaagt atttccaaat
     3121 actgtagagt cgcttccacg aaagtcctat ggttgtatgg ttaacttggt tccggtgttg
     3181 gctgatctca attactgact ccctgtcccg tgttctgtct gtgacttaat gtaactgtta
     3241 tcaccgcgct tgtgaccttt tacgtcattg ttttgtgttc accctctttt ttaaaaaaaa
     3301 atatattaat aaactaaaac catgcttggt gtctggaa
//
