LOCUS       NM_031164               2378 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus coagulation factor XIII, beta subunit (F13b), mRNA.
ACCESSION   NM_031164
VERSION     NM_031164.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Byrnes,J.R., Lee,T., Sharaby,S., Campbell,R.A., Dobson,D.A.,
            Holle,L.A., Luo,M., Kangro,K., Homeister,J.W., Aleman,M.M.,
            Luyendyk,J.P., Kerlin,B.A., Dumond,J.B. and Wolberg,A.S.
  TITLE     Reciprocal stabilization of coagulation factor XIII-A and -B
            subunits is a determinant of plasma FXIII concentration
  JOURNAL   Blood 143 (5), 444-455 (2024)
   PUBMED   37883802
  REMARK    GeneRIF: Reciprocal stabilization of coagulation factor XIII-A and
            -B subunits is a determinant of plasma FXIII concentration.
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Strilchuk,A.W., Meixner,S.C., Leung,J., Safikhan,N.S.,
            Kulkarni,J.A., Russell,H.M., van der Meel,R., Sutherland,M.R.,
            Owens,A.P., Palumbo,J.S., Conway,E.M., Pryzdial,E.L.G., Cullis,P.R.
            and Kastrup,C.J.
  TITLE     Sustained depletion of FXIII-A by inducing acquired FXIII-B
            deficiency
  JOURNAL   Blood 136 (25), 2946-2954 (2020)
   PUBMED   32678423
  REMARK    GeneRIF: Sustained depletion of FXIII-A by inducing acquired
            FXIII-B deficiency.
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   Silva,L.M., Lum,A.G., Tran,C., Shaw,M.W., Gao,Z., Flick,M.J.,
            Moutsopoulos,N.M., Bugge,T.H. and Mullins,E.S.
  TITLE     Plasmin-mediated fibrinolysis enables macrophage migration in a
            murine model of inflammation
  JOURNAL   Blood 134 (3), 291-303 (2019)
   PUBMED   31101623
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Byrnes,J.R., Wilson,C., Boutelle,A.M., Brandner,C.B., Flick,M.J.,
            Philippou,H. and Wolberg,A.S.
  TITLE     The interaction between fibrinogen and zymogen FXIII-A2B2 is
            mediated by fibrinogen residues gamma390-396 and the FXIII-B
            subunits
  JOURNAL   Blood 128 (15), 1969-1978 (2016)
   PUBMED   27561317
  REMARK    GeneRIF: These findings provide insight into assembly of the
            fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic
            situations.
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Watanabe,K., Tsunoda,K., Itoh,M., Fukui,M., Mori,H. and Hitomi,K.
  TITLE     Transglutaminase 2 and Factor XIII catalyze distinct substrates in
            differentiating osteoblastic cell line: utility of highly reactive
            substrate peptides
  JOURNAL   Amino Acids 44 (1), 209-214 (2013)
   PUBMED   22045386
  REMARK    GeneRIF: Physiological significance of mouse TG2 and Factor XIII
            through identification of substrate proteins in MC3T3-E1 cells.
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Souri,M., Koseki-Kuno,S., Takeda,N., Degen,J.L. and Ichinose,A.
  TITLE     Administration of factor XIII B subunit increased plasma factor
            XIII A subunit levels in factor XIII B subunit knock-out mice
  JOURNAL   Int J Hematol 87 (1), 60-68 (2008)
   PUBMED   18224415
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Bernhard,O.K., Kapp,E.A. and Simpson,R.J.
  TITLE     Enhanced analysis of the mouse plasma proteome using
            cysteine-containing tryptic glycopeptides
  JOURNAL   J Proteome Res 6 (3), 987-995 (2007)
   PUBMED   17330941
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Ong,K., Horsfall,W., Conway,E.M. and Schuh,A.C.
  TITLE     Early embryonic expression of murine coagulation system components
  JOURNAL   Thromb Haemost 84 (6), 1023-1030 (2000)
   PUBMED   11154109
REFERENCE   10 (bases 1 to 2378)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of the b subunit of mouse coagulation factor XIII
            and assignment of the gene to chromosome 1: close evolutionary
            relationship to complement factor H
  JOURNAL   Genomics 15 (3), 535-542 (1993)
   PUBMED   8468048
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW213546.1, AI527143.1,
            AK149397.1, AI115049.1 and BB718926.1.
            
            On Mar 13, 2009 this sequence version replaced NM_031164.1.
            
            Summary: This gene encodes subunit B of the coagulation factor XIII
            that catalyzes the final step of the blood coagulation pathway. The
            encoded protein associates with subunit A to form a
            heterotetrameric protein that circulates in the plasma. During the
            blood coagulation process, thrombin-mediated proteolytic cleavage
            of the subunit A results in the dissociation of the encoded protein
            from the heterotetramer. Male mice lacking the encoded protein
            exhibit mild fibrosis together with hemosiderin deposits in the
            heart. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10071.1, AK149397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AW213546.1         1-9
            10-14               AI527143.1         6-10
            15-619              AK149397.1         2-606
            620-711             AI115049.1         610-701
            712-2372            AK149397.1         699-2359
            2373-2378           BB718926.1         274-279
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 61.57 cM"
     gene            1..2378
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /note="coagulation factor XIII, beta subunit"
                     /db_xref="GeneID:14060"
                     /db_xref="MGI:MGI:88379"
     exon            1..106
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2049
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /EC_number="2.3.2.13"
                     /note="coagulation factor XIII B chain; transglutaminase B
                     chain; protein-glutamine gamma-glutamyltransferase B
                     chain"
                     /codon_start=1
                     /product="coagulation factor XIII B chain precursor"
                     /protein_id="NP_112441.2"
                     /db_xref="CCDS:CCDS48386.1"
                     /db_xref="GeneID:14060"
                     /db_xref="MGI:MGI:88379"
                     /translation="MMTLRHLPFILLLILSGELYAEEKQCDFPTVENGRIAQYYYTFK
                     SFYFPMSVDKKLSFFCLAGYATESGKQEEQIRCTAEGWSPNPRCYKKCLKPDLRNGYV
                     SNDKVLYKLQERMSYGCSSGYKTTGGKDEEVVHCLSAGWSSQPSCRKEQETCLAPELE
                     HGNYSTTQRTFKVKDIVAYTCTAGYYTTTGKQTGEAECQANGWSLTPQCNKLMCSSLR
                     LIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPICEGRRNRCP
                     PPPVPLNSKIQPHSTTYRHGERVHIECELNFVIQGSEELLCENGKWTEPPKCIEEKEK
                     VACEQPPSVENGVAHPHSEIYYSGDKVTYRCGGGYSLRGSSTITCNRGRWTLPPECVE
                     NIENCKPPPDIANGVVVDGLLASYTTGSSVEYRCNEYYLLKGSETSRCEQGAWSSPPV
                     CLEPCTIDVDHMNRNNIQLKWKYEGKILHGDLIDFVCKQGYNLSPSIPLSEISAQCNR
                     GDVRYPMCIRKESKGMCASPPVIRNGDIVSSAARTYENGSSVEYRCFDNHFLQGSQNV
                     YCVDGVWTTPPSCLEPCTLSFVEMDKNYLQLKWNFDNRPLILHGEYIEFMCKRDAYIS
                     ETSIAGSVLRVQCDRGRLKYPKCTPRDRRLSFQEALRTRRQMEKR"
     exon            107..307
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            308..493
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            494..670
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            671..847
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1027
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1213
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1396
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1597
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1780
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1994
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2378
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
     polyA_site      2378
                     /gene="F13b"
                     /gene_synonym="Cf-13b; Cf13b"
ORIGIN      
        1 ggtgctttag agctgtaaaa atcttcatga gacacactga tgatgacgct gagacacttg
       61 ccatttattc ttttattaat cctctcagga gaactctatg cagaagagaa acagtgtgat
      121 tttcctaccg tggaaaatgg aaggattgcc caatattatt atacgtttaa aagcttttac
      181 ttccccatga gcgtagacaa aaaactatca ttcttctgtt tggctggcta tgcaaccgaa
      241 agtgggaagc aagaagagca aatcaggtgc acagcagaag gctggtctcc aaacccaagg
      301 tgctacaaga aatgtctgaa gcctgaccta aggaatggct acgtctccaa tgacaaagta
      361 ctgtacaaac ttcaagagag gatgagctac ggttgctctt caggatacaa aaccactggg
      421 ggaaaggacg aggaggtggt ccactgtctt tctgcagggt ggtcttctca accgtcctgc
      481 aggaaagaac aagagacatg tttggcccct gagttggaac atggaaatta ctccacgacg
      541 cagagaacat tcaaagtgaa ggacatagtg gcttacacat gcactgcagg ctactacacc
      601 actacaggga agcagactgg ggaagcagag tgccaggcta atggctggtc cctcacacca
      661 cagtgcaaca aattaatgtg ctcttctttg agattaatag aaaatggcta ttttcatcct
      721 gtaaagcaaa catatgaaga aggagatgta gttcaatttt tctgtcatga aaattattat
      781 ctaagtggat ctgatttaat tcagtgctat aactttggct ggtatccaga atctcccata
      841 tgtgaaggaa gaagaaatcg atgtcctcct ccacctgtgc ctctaaattc taaaattcaa
      901 ccacattcaa caacttaccg tcacggagaa agagtgcata tagaatgtga acttaatttt
      961 gtgattcagg gttcagaaga actgctctgt gaaaatggga agtggacaga acctccaaaa
     1021 tgtattgagg aaaaggagaa ggtagcctgc gagcaaccac cctccgttga gaatggtgtt
     1081 gcacacccac actctgagat ttactacagt ggggataaag tgacatacag gtgtggaggg
     1141 ggctacagtc tcagaggatc aagtacgata acttgcaatc gtggccgatg gacactgccc
     1201 cctgagtgtg ttgaaaatat tgagaattgt aagcctcctc ctgacatagc aaacggtgtg
     1261 gttgttgatg ggttactggc aagttacaca acaggatctt ctgtggagta ccgatgcaat
     1321 gagtattact tattgaaggg gtcggaaaca tctcgctgtg aacaaggagc gtggtcatct
     1381 ccacctgtct gcttggagcc ctgcactatt gatgtggatc acatgaacag gaataacata
     1441 cagttgaagt ggaaatatga gggcaagatt ttacatggag acctaataga ttttgtgtgt
     1501 aagcagggat ataacttgtc accatcaatc ccactgtcgg agatatctgc gcagtgcaat
     1561 agaggcgatg tgaggtaccc catgtgcatt agaaaagaat ctaaagggat gtgtgcatct
     1621 cctccagtga taagaaatgg agatattgtt agttcagcag cccgcaccta tgaaaacggc
     1681 tcctcagtag aataccggtg ttttgataat catttcctac aagggtccca gaatgtctat
     1741 tgtgtcgatg gagtgtggac tacaccacca tcgtgtctag agccttgcac attatcattt
     1801 gttgaaatgg ataagaatta tttacagctg aaatggaatt ttgacaacag accactcatt
     1861 ttacatggag agtatattga gtttatgtgt aagagagatg catatataag tgagacatct
     1921 attgctgggt ctgtacttcg ggtgcagtgt gacaggggaa ggctgaaata ccctaagtgt
     1981 actccaagag acaggaggct gtcctttcag gaagcattac ggacccgaag acaaatggaa
     2041 aaaagataaa gaatattcta acatatgaat ctcgcataaa acaattttag gaagactcca
     2101 ctaagttcag tgttctgagc ctttactttt gcataaaatt gtactcaata ctttccttat
     2161 ttatcaatca aagcacaaat gtatcttatt ttagtttgct taattttaca tttaatctaa
     2221 tctttattgt tgtctttcac ctgtttaatt tgatttattc atcaaatcac ccctgttttc
     2281 aatcgatcgc tgtcagacta tattgtttcc ttgagtatgt atggaaaaca catttgtgtt
     2341 tattatattc attaaaatta agattttctg ttaatttt
//
