LOCUS       NM_028784               3879 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coagulation factor XIII, A1 subunit (F13a1),
            transcript variant 1, mRNA.
ACCESSION   NM_028784 XM_974371
VERSION     NM_028784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Byrnes,J.R., Lee,T., Sharaby,S., Campbell,R.A., Dobson,D.A.,
            Holle,L.A., Luo,M., Kangro,K., Homeister,J.W., Aleman,M.M.,
            Luyendyk,J.P., Kerlin,B.A., Dumond,J.B. and Wolberg,A.S.
  TITLE     Reciprocal stabilization of coagulation factor XIII-A and -B
            subunits is a determinant of plasma FXIII concentration
  JOURNAL   Blood 143 (5), 444-455 (2024)
   PUBMED   37883802
  REMARK    GeneRIF: Reciprocal stabilization of coagulation factor XIII-A and
            -B subunits is a determinant of plasma FXIII concentration.
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
            Ackerman,S.L.
  TITLE     RREB1 regulates neuronal proteostasis and the microtubule network
  JOURNAL   Sci Adv 10 (2), eadh3929 (2024)
   PUBMED   38198538
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   Piliponsky,A.M., Sharma,K., Quach,P., Brokaw,A., Nguyen,S.,
            Orvis,A., Saha,S.S., Samanas,N.B., Seepersaud,R., Tang,Y.P.,
            Mackey,E., Bhise,G., Gendrin,C., Furuta,A., Seo,A.J., Guga,E.,
            Miralda,I., Coleman,M., Sweeney,E.L., Bauml,C.A., Imhof,D.,
            Snyder,J.M., Moeser,A.J. and Rajagopal,L.
  TITLE     Mast cell-derived factor XIIIA contributes to sexual dimorphic
            defense against group B streptococcal infections
  JOURNAL   J Clin Invest 132 (20), e157999 (2022)
   PUBMED   36006736
  REMARK    GeneRIF: Mast cell-derived factor XIIIA contributes to sexual
            dimorphic defense against group B streptococcal infections.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Negron,O., Hur,W.S., Prasad,J., Paul,D.S., Rowe,S.E., Degen,J.L.,
            Abrahams,S.R., Antoniak,S., Conlon,B.P., Bergmeier,W., Hk,M. and
            Flick,M.J.
  TITLE     Fibrin(ogen) engagement of S. aureus promotes the host
            antimicrobial response and suppression of microbe dissemination
            following peritoneal infection
  JOURNAL   PLoS Pathog 18 (1), e1010227 (2022)
   PUBMED   35041705
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   AbdAlla,S., Lother,H., Langer,A., el Faramawy,Y. and Quitterer,U.
  TITLE     Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of
            monocytes at the onset of atherosclerosis
  JOURNAL   Cell 119 (3), 343-354 (2004)
   PUBMED   15507206
REFERENCE   7  (bases 1 to 3879)
  AUTHORS   Kulkarni,S. and Jackson,S.P.
  TITLE     Platelet factor XIII and calpain negatively regulate integrin
            alphaIIbbeta3 adhesive function and thrombus growth
  JOURNAL   J Biol Chem 279 (29), 30697-30706 (2004)
   PUBMED   15131115
  REMARK    GeneRIF: platelet FXIII and calpain have roles in regulating
            integrin alpha(IIb)beta3 adhesive function
REFERENCE   8  (bases 1 to 3879)
  AUTHORS   Koseki-Kuno,S., Yamakawa,M., Dickneite,G. and Ichinose,A.
  TITLE     Factor XIII A subunit-deficient mice developed severe uterine
            bleeding events and subsequent spontaneous miscarriages
  JOURNAL   Blood 102 (13), 4410-4412 (2003)
   PUBMED   12933578
  REMARK    GeneRIF: Maternal FXIII plays a critical role in uterine hemostasis
            and maintenance of the placenta during gestation.
REFERENCE   9  (bases 1 to 3879)
  AUTHORS   Lauer,P., Metzner,H.J., Zettlmeissl,G., Li,M., Smith,A.G., Lathe,R.
            and Dickneite,G.
  TITLE     Targeted inactivation of the mouse locus encoding coagulation
            factor XIII-A: hemostatic abnormalities in mutant mice and
            characterization of the coagulation deficit
  JOURNAL   Thromb Haemost 88 (6), 967-974 (2002)
   PUBMED   12529747
  REMARK    GeneRIF: impaired clot stabilization in FXIII-A mutant mice
REFERENCE   10 (bases 1 to 3879)
  AUTHORS   Nurminskaya,M.V. and Linsenmayer,T.F.
  TITLE     Immunohistological analysis of transglutaminase factor XIIIA
            expression in mouse embryonic growth plate
  JOURNAL   J Orthop Res 20 (3), 575-578 (2002)
   PUBMED   12038633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK049092.1, BM239113.2 and
            AV249730.1.
            
            On Oct 22, 2009 this sequence version replaced NM_028784.2.
            
            Summary: This gene encodes subunit A of the coagulation factor XIII
            that catalyzes the final step of the blood coagulation pathway. The
            encoded protein associates with subunit B to form a
            heterotetrameric proenzyme that undergoes thrombin-mediated
            proteolysis to generate active factor XIIIa. The transglutaminase
            activity of factor XIIIa is required for the calcium-dependent
            crosslinking of fibrin, leading to the formation of a clot. Mice
            lacking the encoded protein display impaired reproduction and
            reduced survival due to bleeding episodes, hematothorax,
            hematoperitoneum and subcutaneous hemorrhage. Additionally, mice
            lacking the encoded protein exhibit impaired wound healing and
            inadequate healing of myocardial infarction. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040274.1, AK049092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3389              AK049092.1         2-3390
            3390-3874           BM239113.2         1-485               c
            3875-3879           AV249730.1         237-241
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.44 cM"
     gene            1..3879
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /note="coagulation factor XIII, A1 subunit"
                     /db_xref="GeneID:74145"
                     /db_xref="MGI:MGI:1921395"
     exon            1..75
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            76..223
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            224..412
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            413..664
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            665..783
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            784..891
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1066
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1205
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1309
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1398
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1552
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1840
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2001
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2138
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..3879
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3850..3855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /note="hexamer: AATAAA"
     polyA_site      3874
                     /gene="F13a1"
                     /gene_synonym="1200014I03Rik; F13a"
                     /note="major polyA site"
ORIGIN      
        1 gcccgagtcc ttttgaggaa gtacccagag gcacacagag agactaccag agcaccctct
       61 caggagcaca agcaggatcc agtaaagctg agaatgtcag atactccagc aagcaccttt
      121 ggggggaggc gagcagtccc gcccaataac tccaatgctg cagaagtgga cctcccaact
      181 gaggagctac aaggcctggt gccaaggggt gtcaacctga aagattacct gaatgtcaca
      241 gctgttcacc tgttcaagga gagatgggac agtaacaaga ttgatcacca cacagacaaa
      301 tatgacaaca ataagttgat tgtccgcaga gggcagacct tctacatcca gattgacttc
      361 aaccgtccct atgaccccag gaaggatctc ttcagagtgg aatatgtcat tggtcgctac
      421 cctcaggaga acaagggcac ctacatccct gtgcctgtag tgaaagagct gcaaagcgga
      481 aagtggggag ccaaggttat catgaatgag gaccggtcgg tgcgactttc cgttcagtct
      541 tctccggaat gcattgtggg gaaattccgc atgtatgttg cagtctggac tccctatggc
      601 atcctgcgta ctcgaagaga cccagaaaca gacacatata ttctcttcaa cccttggtgt
      661 gaagaggacg ctgtgtatct ggatgatgag aaggaaagag aagagtacgt cctgaatgac
      721 attggagtga tattttatgg ggacttcaaa gacatcaaga gcagaagctg gagctatggc
      781 cagttcgaag acggcatcct ggatacttgc ttgtatgtga tggacaaagc tgagatggac
      841 ctttctggca gaggcaaccc catcaaagtc agccgagttg gatcagcaat ggtgaatgcc
      901 aaggatgatg aaggtgttct tgttggatca tgggacaatg tctatgccta cggcatccct
      961 ccatcagcct ggacaggaag tgttgacatt ctactagaat acagaagctc ggaaacacca
     1021 gtccgatatg gccagtgttg ggtttttgct ggtgtcttta acacattttt aagatgcctt
     1081 ggaatccctg cacgagtcat taccaattac ttctcggccc acgacaatga tgccaatctg
     1141 caaatggaca tcttcctgga agaagatggg aatgtgagct ccaaactcac caaggattcg
     1201 gtgtggaact accactgctg gaacgaagcg tggatgacaa ggcctgatct tcctgttgga
     1261 tttggaggct ggcaagctgt ggacagcaca ccccaggaaa acagtgatgg catgtaccgc
     1321 tgtggccctg cctctgtcca agccgttaag catggccatg tctgcttcca gtttgatgcc
     1381 ccgtttgttt ttgcagaggt caacagtgat cttgtttaca tcacagctaa gcaagatggc
     1441 actcacgtgg tggaagccgt ggatgccacc catatcggga agctaattgt gaccaagcaa
     1501 attggaggag atggcatgca ggatatcacg gatacttaca aatttcaaga aggccaagaa
     1561 gaagagagac tagcccttga aactgctctg atgtatggag ccaagaagac cctcaacact
     1621 gaaggtgttg tcaaatcaag gtctgatgtg accatgaact ttgatgtgga aaatgctgtg
     1681 ctgggaaagg acttcaaagt gactatcacc ttccagaaca atagctccaa tctgtacacc
     1741 atcctggcct atctttctgg caacatcacc ttctacactg gggtatccaa gaaagagttc
     1801 aagaaggagt cctttgaaga gacgctggat cccttttcct ccaagaaaaa ggaggtgctg
     1861 gtcagagcgg gcgagtacat gagccacctt ctagaacagg gcttcttgca cttcttcgtc
     1921 acggcacgca tcaacgagtc cagggatgtc ctggccaaac aaaagtccat aatactgact
     1981 atccccaaga tcaccatcaa ggtccgaggt gctgccatgg ttggctctga tatggttgtg
     2041 actgttgagt tcactaatcc tttaaaagaa acactacaaa atgtctggat tcatttggat
     2101 ggtcctggag tgatgagacc caagagaaag gtgttccgtg aaatccggcc caacaccacg
     2161 gtgcagtggg aagaagtctg tcggccttgg gtctctggcc atcggaagct gattgccagc
     2221 atgaccagtg actccctgag acatgtgtat ggagagctgg atcttcagat tcaaagacga
     2281 cctactatgt aaattcccag aaggctcaag tgggctgggg cacatggcct cttgcagtct
     2341 tggctatgga gattctaatg caaaacatag ctagctcttg ctttaatttg ggtgtgaaga
     2401 ctgagaccga ttccagcata gagatgctat gtatttcata ggcacacctt tccaaccaag
     2461 ctattggaca agggagttag atttgagttg ttccaccttc caatggatct gaacgttagc
     2521 tttaattatg ctataattaa gccttcgtag ctcataagag tgaaagtcat catttatcat
     2581 tgcaaatggc tgtagctcca cagatcagag ggcttccctt gagcaggagg gatgtgccca
     2641 gtacctggcc tcaattaaga attctgattc cccactcagt catttaaggg taacatactc
     2701 tccaaagaaa agggtgttca caattgaatc cttataattc tattcccctt tcttggaatc
     2761 aggctgaaca ctctgtgtta aaatattttt tccaggaatt aagcaagaca tcatttttct
     2821 tcttggcaaa gccagagaaa ggtctttcat cttgcacctg cagccaagga actgcctgcc
     2881 aaatttcaca gattaccttg tgagaagatg tggccccaca ttaacaaatt gcatttgtgg
     2941 ggaacttaat cacctaagag gagataagaa agcaggtgcg gtgctcagat ctattaaata
     3001 atgtagttta tggtgcattt tataggtgtc acactgtgtc ctgatcagca aaatgaataa
     3061 ccttacttta accctttctc gggaagagaa ctagaaagta agggcactga tttgggattg
     3121 gagacctaag gaattagcac ccttgcttgg tgattatact tcacctgttt ctctgaggtc
     3181 atcacattca cccaatgcca ctgtcaaaaa gaaaaacagc ttgagaaact tgcagattca
     3241 gtagacagtt gaagatcaaa cagattctga ttttcctttt tcttcatatt tcctatacca
     3301 agcccttgtc taaacccttg agtgctgaga gctaaggcag attcagcctt gcaaaaggcc
     3361 agcgttactc ttgactgaag gacagagggc acccaaatcc tttaccttat gtgccaaggc
     3421 tccaacagac aagattattg gtacctcttt gtagggcaga tttatagtta taattcccca
     3481 tttaaatgcc ttgggagtga cttaggtcag gtgactatga agaaaaaaaa gaacaaaaag
     3541 aaaggaaagg aagaaggaag gaaagaagga aggaaaggag ggagggaggg agactgtaag
     3601 agggaagtta tggaagagaa gataacagaa tgttctagtc tgtagctatg ctctggttta
     3661 cttctaagtc attgataggt tcctgggaac ttagtactaa cccccgaggt tcagcagatt
     3721 ctataagcaa aactccatga agtcatctct cagcattagc atctaattcc aaatgaaatg
     3781 cattttgcta gactttaaaa cagcttaact tagtatgttg ttattaatga gagtataatc
     3841 aatgcctata ataaagttaa tctgattaca tgtgcccag
//
