LOCUS       NM_021489               1971 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus coagulation factor XII (Hageman factor) (F12), mRNA.
ACCESSION   NM_021489
VERSION     NM_021489.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Elwakiel,A., Gupta,D., Rana,R., Manoharan,J., Al-Dabet,M.M.,
            Ambreen,S., Fatima,S., Zimmermann,S., Mathew,A., Li,Z., Singh,K.,
            Gupta,A., Pal,S., Sulaj,A., Kopf,S., Schwab,C., Baber,R.,
            Geffers,R., Gotze,T., Alo,B., Lamers,C., Kluge,P., Kuenze,G.,
            Kohli,S., Renne,T., Shahzad,K. and Isermann,B.
  TITLE     Factor XII signaling via uPAR-integrin beta1 axis promotes tubular
            senescence in diabetic kidney disease
  JOURNAL   Nat Commun 15 (1), 7963 (2024)
   PUBMED   39261453
  REMARK    GeneRIF: Factor XII signaling via uPAR-integrin beta1 axis promotes
            tubular senescence in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Ballard-Kordeliski,A., Lee,R.H., O'Shaughnessy,E.C., Kim,P.Y.,
            Jones,S.R., Pawlinski,R., Flick,M.J., Paul,D.S., Mackman,N.,
            Adalsteinsson,D.A. and Bergmeier,W.
  TITLE     4D intravital imaging studies identify platelets as the predominant
            cellular procoagulant surface in a mouse hemostasis model
  JOURNAL   Blood 144 (10), 1116-1126 (2024)
   PUBMED   38820498
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Clermont,A.C., Murugesan,N., Edwards,H.J., Lee,D.K., Bayliss,N.P.,
            Duckworth,E.J., Pethen,S.J., Hampton,S.L., Gailani,D. and
            Feener,E.P.
  TITLE     Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain
            FXII mediated kallikrein kinin system activation
  JOURNAL   Front Pharmacol 14, 1287487 (2023)
   PUBMED   38178859
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Sparkenbaugh,E.M., Henderson,M.W., Miller-Awe,M., Abrams,C.,
            Ilich,A., Trebak,F., Ramadas,N., Vital,S., Bohinc,D., Bane,K.L.,
            Chen,C., Patel,M., Wallisch,M., Renne,T., Gruber,A., Cooley,B.,
            Gailani,D., Kasztan,M., Vercellotti,G.M., Belcher,J.D.,
            Gavins,F.E., Stavrou,E.X., Key,N.S. and Pawlinski,R.
  TITLE     Factor XII contributes to thrombotic complications and
            vaso-occlusion in sickle cell disease
  JOURNAL   Blood 141 (15), 1871-1883 (2023)
   PUBMED   36706361
  REMARK    GeneRIF: Factor XII contributes to thrombotic complications and
            vaso-occlusion in sickle cell disease.
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Stetter,C., Lopez-Caperuchipi,S., Hopp-Kramer,S., Bieber,M.,
            Kleinschnitz,C., Siren,A.L. and Albert-Weissenberger,C.
  TITLE     Amelioration of Cognitive and Behavioral Deficits after Traumatic
            Brain Injury in Coagulation Factor XII Deficient Mice
  JOURNAL   Int J Mol Sci 22 (9), 4855 (2021)
   PUBMED   34063730
  REMARK    GeneRIF: Amelioration of Cognitive and Behavioral Deficits after
            Traumatic Brain Injury in Coagulation Factor XII Deficient Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Rosen,E.D., Xu,H., Liang,Z., Martin,J.A., Suckow,M. and
            Castellino,F.J.
  TITLE     Generation of genetically-altered mice producing very low levels of
            coagulation factorVII
  JOURNAL   Thromb Haemost 94 (3), 493-497 (2005)
   PUBMED   16268461
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Renne,T., Pozgajova,M., Gruner,S., Schuh,K., Pauer,H.U.,
            Burfeind,P., Gailani,D. and Nieswandt,B.
  TITLE     Defective thrombus formation in mice lacking coagulation factor XII
  JOURNAL   J Exp Med 202 (2), 271-281 (2005)
   PUBMED   16009717
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Pauer,H.U., Renne,T., Hemmerlein,B., Legler,T., Fritzlar,S.,
            Adham,I., Muller-Esterl,W., Emons,G., Sancken,U., Engel,W. and
            Burfeind,P.
  TITLE     Targeted deletion of murine coagulation factor XII gene-a model for
            contact phase activation in vivo
  JOURNAL   Thromb Haemost 92 (3), 503-508 (2004)
   PUBMED   15351846
  REMARK    GeneRIF: F12 KNOCKOUT MICE, generated to elucidate the biological
            role(s) of FXII, had a markedly prolonged APTT. Deficiency of
            murine FXII does not cause thrombophilia or impaired fibrinolysis
            or affect hemostasis.
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Bouzin,C., Clotman,F., Renauld,J.C., Lemaigre,F.P. and
            Rousseau,G.G.
  TITLE     The onecut transcription factor hepatocyte nuclear factor-6
            controls B lymphopoiesis in fetal liver
  JOURNAL   J Immunol 171 (3), 1297-1303 (2003)
   PUBMED   12874218
REFERENCE   10 (bases 1 to 1971)
  AUTHORS   Ong,K., Horsfall,W., Conway,E.M. and Schuh,A.C.
  TITLE     Early embryonic expression of murine coagulation system components
  JOURNAL   Thromb Haemost 84 (6), 1023-1030 (2000)
   PUBMED   11154109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT009762.8.
            
            On Apr 7, 2015 this sequence version replaced NM_021489.2.
            
            Summary: This gene encodes a glycoprotein coagulation factor that
            plays an important role in the intrinsic pathway of blood
            coagulation and hemostasis. The encoded protein is an inactive
            zymogen that is autoactivated upon contact with negatively charged
            surfaces or misfolded protein aggregates. Mice lacking the encoded
            protein have a severe defect in forming stable fibrin clots.
            [provided by RefSeq, Apr 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037085.1, X99571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                CT009762.8         105986-106078
            94-151              CT009762.8         106430-106487
            152-251             CT009762.8         110018-110117
            252-322             CT009762.8         110314-110384
            323-433             CT009762.8         110713-110823
            434-565             CT009762.8         110906-111037
            566-670             CT009762.8         111161-111265
            671-836             CT009762.8         111382-111547
            837-1009            CT009762.8         111643-111815
            1010-1232           CT009762.8         111919-112141
            1233-1369           CT009762.8         112307-112443
            1370-1513           CT009762.8         112530-112673
            1514-1662           CT009762.8         114290-114438
            1663-1971           CT009762.8         114524-114832
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..1971
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /note="coagulation factor XII (Hageman factor)"
                     /db_xref="GeneID:58992"
                     /db_xref="MGI:MGI:1891012"
     exon            1..93
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1830
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /EC_number="3.4.21.38"
                     /note="factor XII; hageman factor"
                     /codon_start=1
                     /product="coagulation factor XII preproprotein"
                     /protein_id="NP_067464.2"
                     /db_xref="CCDS:CCDS36675.1"
                     /db_xref="GeneID:58992"
                     /db_xref="MGI:MGI:1891012"
                     /translation="MTALLFLGSLLMSLDLTLSAPPWKDSKKFKDAPDGPTVVLTVDG
                     RLCHFPFQYHRQLHHKCIHKRRPGSRPWCATTPNFDEDQQWGYCLEPKKVKDHCSKHN
                     PCHKGGTCINTPNGPHCLCPEHLTGKHCQKEKCFEPQLLKFFHENELWFRTGPGGVAR
                     CECKGSEAHCKPVASQACSINPCLNGGSCLLVEDHPLCRCPTGYTGYFCDLDLWATCY
                     EGRGLSYRGQAGTTQSGAPCQRWTVEATYRNMTEKQALSWGLGHHAFCRNPDNDTRPW
                     CFVWSGDRLSWDYCGLEQCQTPTFAPLVVPESQEESPSQAPSLSHAPNDSTDHQTSLS
                     KTNTMGCGQRFRKGLSSFMRVVGGLVALPGSHPYIAALYWGNNFCAGSLIAPCWVLTA
                     AHCLQNRPAPEELTVVLGQDRHNQSCEWCQTLAVRSYRLHEGFSSITYQHDLALLRLQ
                     ESKTNSCAILSPHVQPVCLPSGAAPPSETVLCEVAGWGHQFEGAEEYSTFLQEAQVPF
                     IALDRCSNSNVHGDAILPGMLCAGFLEGGTDACQGDSGGPLVCEEGTAEHQLTLRGVI
                     SWGSGCGDRNKPGVYTDVANYLAWIQKHIAS"
     exon            94..151
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            152..251
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            252..322
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            323..433
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            434..565
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            566..670
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            671..836
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1009
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1232
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1369
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1513
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1662
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1971
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /note="hexamer: AATAAA"
     polyA_site      1963
                     /gene="F12"
                     /gene_synonym="FXII; HAF"
                     /note="major polyA site"
ORIGIN      
        1 actcctgggc aggcagcggg gccatcggca gacgccatga cggctctgtt gttcctgggg
       61 tctctgctga tgagtctgga tctgacactt tcggctccac catggaaaga ctccaagaaa
      121 tttaaggacg cacctgatgg gcccacagtg gttctcactg tggatgggag gctctgccat
      181 tttccctttc agtaccaccg tcagctacac cacaaatgca tccacaaaag gcggccaggc
      241 tcccgcccct ggtgtgctac cacccccaac tttgatgaag atcagcaatg gggatactgc
      301 ttggagccca agaaagtgaa agaccattgc agcaaacaca acccgtgcca caaaggaggg
      361 acatgtatca acacccccaa tgggccacac tgtctctgcc ctgaacacct cactgggaaa
      421 cattgccaga aagagaaatg ctttgagcct cagcttctca agttcttcca cgagaatgag
      481 ctatggttta gaacggggcc aggaggtgtg gccaggtgcg agtgcaaagg ttctgaggct
      541 cactgcaagc cggtggccag ccaggcctgc agcatcaatc cgtgccttaa tgggggcagc
      601 tgcctcctcg tggaggacca cccactgtgc cgttgcccta caggctacac tggatatttt
      661 tgcgacttgg acctttgggc gacctgctat gaaggcaggg ggctcagcta ccggggccag
      721 gctggaacta cgcaatcggg tgcgccatgt cagcggtgga ccgtggaggc cacctaccgg
      781 aacatgactg agaagcaagc gctaagctgg ggcctgggcc accacgcatt ttgccggaac
      841 ccagataatg acacacgtcc atggtgcttc gtctggagtg gcgacaggct gagctgggac
      901 tattgcggcc tggagcagtg ccagacgcca acgtttgcac ctctagttgt ccctgagagt
      961 caggaggagt ccccgtccca ggcaccatct ctgtcccatg caccaaatga ctcgaccgat
     1021 catcagactt ctctgtccaa gaccaacacg atgggctgcg gacagaggtt ccgcaaggga
     1081 ctgtcctcgt tcatgcgcgt ggtgggcgga ctagtggctc tgcctgggtc gcacccctac
     1141 atcgctgcac tgtactgggg taacaacttc tgcgcgggca gtctcatcgc cccctgttgg
     1201 gtgctgaccg cggctcactg cctgcagaat cggccagcgc ccgaggaact gacagtggta
     1261 cttggtcaag atcgccacaa ccagagctgc gagtggtgcc agactctggc tgtgcgctcc
     1321 taccgccttc acgagggctt ctcctccatc acctaccagc acgacttggc tctgctgcgc
     1381 ctgcaggaaa gcaaaaccaa cagttgcgcg atcctgtcac ctcacgttca gcctgtgtgt
     1441 ctacccagcg gcgcggcccc accctctgag acagtgctct gcgaggtggc cggctggggt
     1501 caccagttcg agggggctga agaatactcc accttcctgc aggaggcaca ggttcccttt
     1561 atcgccctgg atcgctgctc caactctaac gtgcacggag acgccattct ccctgggatg
     1621 ctttgcgctg gcttcttgga gggaggcacc gatgcctgcc agggtgactc cgggggccct
     1681 ctggtgtgtg aggaaggaac tgcagaacat cagctcaccc tgcgcggagt catcagctgg
     1741 ggctccggct gtggtgaccg caacaagccc ggagtctaca cagacgtggc caactacctg
     1801 gcttggatcc agaagcatat tgcttcataa ctaaccaggc tttatccttc cctccttgtg
     1861 tgctccttgg gatgggacga tgaatgtggc atgctgggtc acagtgaagc tagtgccccg
     1921 acactggggg cacagaaact caataaagtg ctttgaaaac gttcctcaga a
//
