LOCUS       NM_172647               2482 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus F11 receptor (F11r), mRNA.
ACCESSION   NM_172647
VERSION     NM_172647.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Berve,K., Michel,J., Tietz,S., Blatti,C., Ivan,D., Enzmann,G.,
            Lyck,R., Deutsch,U., Locatelli,G. and Engelhardt,B.
  TITLE     Junctional adhesion molecule-A deficient mice are protected from
            severe experimental autoimmune encephalomyelitis
  JOURNAL   Eur J Immunol 54 (6), e2350761 (2024)
   PUBMED   38566526
  REMARK    GeneRIF: Junctional adhesion molecule-A deficient mice are
            protected from severe experimental autoimmune encephalomyelitis.
REFERENCE   2  (bases 1 to 2482)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2482)
  AUTHORS   Kiss,M., Lebegge,E., Murgaski,A., Van Damme,H., Kancheva,D.,
            Brughmans,J., Scheyltjens,I., Talebi,A., Awad,R.M., Elkrim,Y.,
            Bardet,P.M.R., Arnouk,S.M., Goyvaerts,C., Swinnen,J., Nana,F.A.,
            Van Ginderachter,J.A. and Laoui,D.
  TITLE     Junctional adhesion molecule-A is dispensable for myeloid cell
            recruitment and diversification in the tumor microenvironment
  JOURNAL   Front Immunol 13, 1003975 (2022)
   PUBMED   36531986
  REMARK    GeneRIF: Junctional adhesion molecule-A is dispensable for myeloid
            cell recruitment and diversification in the tumor microenvironment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2482)
  AUTHORS   Klingensmith,N.J., Fay,K.T., Swift,D.A., Bazzano,J.M., Lyons,J.D.,
            Chen,C.W., Meng,M., Ramonell,K.M., Liang,Z., Burd,E.M.,
            Parkos,C.A., Ford,M.L. and Coopersmith,C.M.
  TITLE     Junctional adhesion molecule-A deletion increases phagocytosis and
            improves survival in a murine model of sepsis
  JOURNAL   JCI Insight 7 (16), e156255 (2022)
   PUBMED   35819838
  REMARK    GeneRIF: Junctional adhesion molecule-A deletion increases
            phagocytosis and improves survival in a murine model of sepsis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2482)
  AUTHORS   Fan,S., Smith,M.S., Keeney,J., O'Leary,M.N., Nusrat,A. and
            Parkos,C.A.
  TITLE     JAM-A signals through the Hippo pathway to regulate intestinal
            epithelial proliferation
  JOURNAL   iScience 25 (5), 104316 (2022)
   PUBMED   35602956
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2482)
  AUTHORS   Williams,L.A., Martin-Padura,I., Dejana,E., Hogg,N. and
            Simmons,D.L.
  TITLE     Identification and characterisation of human Junctional Adhesion
            Molecule (JAM)
  JOURNAL   Mol Immunol 36 (17), 1175-1188 (1999)
   PUBMED   10698320
REFERENCE   7  (bases 1 to 2482)
  AUTHORS   Carmeliet,P., Lampugnani,M.G., Moons,L., Breviario,F.,
            Compernolle,V., Bono,F., Balconi,G., Spagnuolo,R., Oosthuyse,B.,
            Dewerchin,M., Zanetti,A., Angellilo,A., Mattot,V., Nuyens,D.,
            Lutgens,E., Clotman,F., de Ruiter,M.C., Gittenberger-de Groot,A.,
            Poelmann,R., Lupu,F., Herbert,J.M., Collen,D. and Dejana,E.
  TITLE     Targeted deficiency or cytosolic truncation of the VE-cadherin gene
            in mice impairs VEGF-mediated endothelial survival and angiogenesis
  JOURNAL   Cell 98 (2), 147-157 (1999)
   PUBMED   10428027
REFERENCE   8  (bases 1 to 2482)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   9  (bases 1 to 2482)
  AUTHORS   Malergue,F., Galland,F., Martin,F., Mansuelle,P., Aurrand-Lions,M.
            and Naquet,P.
  TITLE     A novel immunoglobulin superfamily junctional molecule expressed by
            antigen presenting cells, endothelial cells and platelets
  JOURNAL   Mol Immunol 35 (17), 1111-1119 (1998)
   PUBMED   10395200
REFERENCE   10 (bases 1 to 2482)
  AUTHORS   Martin-Padura,I., Lostaglio,S., Schneemann,M., Williams,L.,
            Romano,M., Fruscella,P., Panzeri,C., Stoppacciaro,A., Ruco,L.,
            Villa,A., Simmons,D. and Dejana,E.
  TITLE     Junctional adhesion molecule, a novel member of the immunoglobulin
            superfamily that distributes at intercellular junctions and
            modulates monocyte transmigration
  JOURNAL   J Cell Biol 142 (1), 117-127 (1998)
   PUBMED   9660867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033574.1 and CJ317566.1.
            
            On Feb 10, 2006 this sequence version replaced NM_172647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021876.1, AK033574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1708              AK033574.1         2-1709
            1709-1738           CJ317566.1         236-265
            1739-2482           AK033574.1         1710-2453
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.43 cM"
     gene            1..2482
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /note="F11 receptor"
                     /db_xref="GeneID:16456"
                     /db_xref="MGI:MGI:1321398"
     exon            1..141
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..983
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /note="junction cell adhesion molecule A; junctional
                     adhesion molecule A; junctional adhesion molecule 1; BV11
                     antigen; F11 receptor/F11R; junction cell adhesion
                     molecule1"
                     /codon_start=1
                     /product="junctional adhesion molecule A precursor"
                     /protein_id="NP_766235.1"
                     /db_xref="CCDS:CCDS15496.1"
                     /db_xref="GeneID:16456"
                     /db_xref="MGI:MGI:1321398"
                     /translation="MGTEGKAGRKLLFLFTSMILGSLVQGKGSVYTAQSDVQVPENES
                     IKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKD
                     NGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPP
                     SEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGY
                     GTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPG
                     KKVIYSQPSTRSEGEFKQTSSFLV"
     exon            142..210
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            211..318
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            319..465
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            466..671
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            672..774
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            775..882
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            883..895
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            896..947
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     exon            948..2482
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /note="hexamer: AATAAA"
     polyA_site      1899
                     /gene="F11r"
                     /gene_synonym="9130004G24; ESTM33; JAM; JAM-1; JAM-A;
                     Jcam; Jcam1; Ly106"
                     /note="major polyA site"
ORIGIN      
        1 agagtccagc ccagggcagt ggatcgcgag gctgttccca ttggagttgc tgtgcccgtc
       61 gcgtcgggat tgtaactgta atgggcaccg aggggaaagc cgggaggaaa ctgttgtttc
      121 tcttcacgtc tatgatcctg ggctctttgg tacaaggcaa gggttcggtg tacactgctc
      181 aatctgacgt ccaggttccc gagaacgagt ccatcaaatt gacctgcacc tactctggct
      241 tctcctctcc ccgagtggag tggaagttcg tccaaggcag cacaactgca cttgtgtgtt
      301 ataacagcca gatcacagct ccctatgcgg accgagtcac cttctcatcc agtggcatca
      361 cgttcagttc tgtgacccgg aaggacaatg gagagtatac ttgcatggtc tccgaggaag
      421 gtggccagaa ctacggggag gtcagcatcc acctcactgt gcttgtacct ccatccaagc
      481 cgacgatcag tgtcccctcc tctgtcacca ttgggaacag ggcagtgctg acctgctcag
      541 agcatgatgg ttccccaccc tctgaatatt cctggttcaa ggacgggata tccatgctta
      601 cagcagatgc caagaaaacc cgggccttca tgaattcttc attcactatt gatccaaagt
      661 cgggggatct gatctttgac cccgtgacag cctttgatag tggtgaatac tactgccagg
      721 cccagaatgg atatgggaca gccatgaggt cagaggctgc acacatggat gctgtggagc
      781 tgaatgtggg gggcatcgtg gcagctgtcc tggtaacact gattctcctt ggactcttga
      841 tttttggcgt ctggtttgcc tatagccgtg gatactttga aagaacaaag aaagggactg
      901 caccgggtaa gaaggtcatt tacagccagc ccagtactcg aagtgagggg gaattcaaac
      961 agacctcgtc gttcctggtg tgacctgctg cggctcctcc gttgtccatt tgccttactc
     1021 aggtgctaca ggttccagcc ccctgctggc tgtagctgca caggatgcct tcaatgtctt
     1081 ctaggtccca caggacccct tgcttttatt ctagctaggg tataaattta aaaacatcat
     1141 ctacttcccc ctcctctttc ccaccctccc tcctttcctt accaccattg ggtggcccga
     1201 gactaattac aaagttttcg ttccccattc ctatgtggga ttgggcaaga gtcctagact
     1261 agacagtaat agtggctggg ctgacaggaa cccaaaccaa tacctggctg taaaggcctc
     1321 tgaataagga ctttaagcct agctccctgc tttctcctcc ccggatgggg tgccagctac
     1381 tctagagggg gagctgcaga aaggaggggc tgaggatggt gacctcaggt ctctagtctt
     1441 cggagcctct cttctgtctc cacaaaatgt gccactggga ttctcctgga ttcaaagtaa
     1501 actgacatgg tgtccgtacg aggtgggaga gctctgttag ctcccaagag acttggagta
     1561 agaaagattt aaagtgatct aaagaaaagg ctggaactgg tggccattag tcactcttca
     1621 tttggctgga actaccgcat ggaccctttg aagatatgtg tggatggaga agatacgagc
     1681 tttatagtct tggctctttg gtggcctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1741 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gagagagaga gagagagttg taaattgata
     1801 ttgttatata gaagggcttt ctagctcttt ggcaaggttg tgtttctgtg tgtttatatt
     1861 tgacagatgt tgctggaaat aaaaacttca tttgacagac ttcttttttg ttgaacatgg
     1921 aatattttag ggattgtgag ctactttgta taaacaagaa aagacacaaa agttctgctt
     1981 cccagcaacc catggctgat tcccaggact atattcttaa ctcaaggcaa agcttccggg
     2041 catcagagct gttccgtagc ctcctgctgc tgcgtgggcg aggaaggtgc tgctgtgctg
     2101 gagggggatt tcgtgaagtg ggcggaggaa gtgtctgtgc actctcctgc ctggccttca
     2161 tggtggacct ccccaagtcg tcctctaagg gagagttcct ccatcatcaa atgtttgaga
     2221 aagcagcaat tagcaagata ggtctgatgg tcattgctct cttaccattt gggcccttct
     2281 atagagaaga agaataatga acgaggctct cataactacg ctgcgcttca gacgtctcaa
     2341 acttcaacca actcggctgt tttttatttt ggcaggatct gtgaagtaag gaccgattgg
     2401 ttggaaaagg ggttcggttg ggaatgaagt gacagttttc ctcagggtgc atggggacag
     2461 tttaattaaa ctattccatt cc
//
