LOCUS       NM_028066               2710 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus coagulation factor XI (F11), transcript variant 1,
            mRNA.
ACCESSION   NM_028066
VERSION     NM_028066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Parunov,L.A., Liang,Y., Lu,Q., Shibeko,A.M., Tucker,E.I., Lee,T.K.,
            Ataullakhanov,F.I., Scott,D.E. and Ovanesov,M.V.
  TITLE     Thrombogenic potential of picomolar coagulation factor XIa is
            mediated by thrombin wave propagation
  JOURNAL   Blood Adv 7 (11), 2622-2631 (2023)
   PUBMED   36724509
  REMARK    GeneRIF: Thrombogenic potential of picomolar coagulation factor XIa
            is mediated by thrombin wave propagation.
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Mohammed,B.M., Cheng,Q., Matafonov,A., Verhamme,I.M., Emsley,J.,
            McCrae,K.R., McCarty,O.J.T., Gruber,A. and Gailani,D.
  TITLE     A non-circulating pool of factor XI associated with
            glycosaminoglycans in mice
  JOURNAL   J Thromb Haemost 17 (9), 1449-1460 (2019)
   PUBMED   31125187
  REMARK    GeneRIF: A non-circulating pool of factor XI associated with
            glycosaminoglycans in mice.
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Heestermans,M., Salloum-Asfar,S., Streef,T., Laghmani,E.H.,
            Salvatori,D., Luken,B.M., Zeerleder,S.S., Spronk,H.M.H.,
            Korporaal,S.J., Kirchhofer,D., Wagenaar,G.T.M., Versteeg,H.H.,
            Reitsma,P.H., Renne,T. and van Vlijmen,B.J.M.
  TITLE     Mouse venous thrombosis upon silencing of anticoagulants depends on
            tissue factor and platelets, not FXII or neutrophils
  JOURNAL   Blood 133 (19), 2090-2099 (2019)
   PUBMED   30898865
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Ivanov,I., Matafonov,A., Sun,M.F., Mohammed,B.M., Cheng,Q.,
            Dickeson,S.K., Kundu,S., Verhamme,I.M., Gruber,A., McCrae,K. and
            Gailani,D.
  TITLE     A mechanism for hereditary angioedema with normal C1 inhibitor: an
            inhibitory regulatory role for the factor XII heavy chain
  JOURNAL   Blood 133 (10), 1152-1163 (2019)
   PUBMED   30591525
REFERENCE   5  (bases 1 to 2710)
  AUTHORS   Lorentz,C.U., Verbout,N.G., Cao,Z., Liu,L., Hinds,M.T.,
            McCarty,O.J.T., Ivanov,I., Tucker,E.I., Gailani,D. and Gruber,A.
  TITLE     Factor XI contributes to myocardial ischemia-reperfusion injury in
            mice
  JOURNAL   Blood Adv 2 (2), 85-88 (2018)
   PUBMED   29365314
  REMARK    GeneRIF: interfering with the FXIIa-FXI interaction could inhibit
            thromboinflammatory processes without compromising hemostasis.
            Inhibiting FXI activation with anti-FXI antibody 14E11 reduces
            myocardial ischemia-reperfusion injury.
REFERENCE   6  (bases 1 to 2710)
  AUTHORS   Aasrum,M. and Prydz,H.
  TITLE     Gene targeting of tissue factor, factor X, and factor VII in mice:
            their involvement in embryonic development
  JOURNAL   Biochemistry (Mosc) 67 (1), 25-32 (2002)
   PUBMED   11841337
  REMARK    GeneRIF: Gene targeting of tissue factor, factor X, and factor VII
            in mice: their involvement in embryonic development
            Review article
REFERENCE   7  (bases 1 to 2710)
  AUTHORS   Chan,J.C., Ganopolsky,J.G., Cornelissen,I., Suckow,M.A.,
            Sandoval-Cooper,M.J., Brown,E.C., Noria,F., Gailani,D., Rosen,E.D.,
            Ploplis,V.A. and Castellino,F.J.
  TITLE     The characterization of mice with a targeted combined deficiency of
            protein c and factor XI
  JOURNAL   Am J Pathol 158 (2), 469-479 (2001)
   PUBMED   11159184
REFERENCE   8  (bases 1 to 2710)
  AUTHORS   Gailani,D., Sun,M.F. and Sun,Y.
  TITLE     A comparison of murine and human factor XI
  JOURNAL   Blood 90 (3), 1055-1064 (1997)
   PUBMED   9242536
REFERENCE   9  (bases 1 to 2710)
  AUTHORS   Gailani,D., Lasky,N.M. and Broze,G.J. Jr.
  TITLE     A murine model of factor XI deficiency
  JOURNAL   Blood Coagul Fibrinolysis 8 (2), 134-144 (1997)
   PUBMED   9518045
REFERENCE   10 (bases 1 to 2710)
  AUTHORS   Mills,K.A., Mathews,K.D., Scherpbier-Heddema,T., Schelper,R.L.,
            Schmalzel,R., Bailey,H.L., Nadeau,J.H., Buetow,K.H. and Murray,J.C.
  TITLE     Genetic mapping near the myd locus on mouse chromosome 8
  JOURNAL   Mamm Genome 6 (4), 278-280 (1995)
   PUBMED   7613034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120003.6.
            
            On Aug 31, 2022 this sequence version replaced NM_028066.2.
            
            Summary: This gene encodes a glycoprotein coagulation factor that
            plays an important role in intrinsic pathway of blood coagulation
            and hemostasis. The encoded protein is an inactive zymogen that can
            be activated by coagulation factor XIIa, thrombin or factor XIa to
            generate active factor XIa protease. Mice lacking the encoded
            protein display a survival advantage during peritoneal sepsis and
            resist inflammation and bacterial accumulation upon infection with
            Listeria. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019485.1, AK005546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC120003.6         73090-73134         c
            46-101              AC120003.6         72174-72229         c
            102-264             AC120003.6         66352-66514         c
            265-371             AC120003.6         64170-64276         c
            372-531             AC120003.6         63166-63325         c
            532-641             AC120003.6         61205-61314         c
            642-801             AC120003.6         60653-60812         c
            802-911             AC120003.6         60159-60268         c
            912-1074            AC120003.6         59892-60054         c
            1075-1187           AC120003.6         59702-59814         c
            1188-1347           AC120003.6         57895-58054         c
            1348-1523           AC120003.6         56777-56952         c
            1524-1619           AC120003.6         54014-54109         c
            1620-1759           AC120003.6         53365-53504         c
            1760-2710           AC120003.6         51807-52757         c
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.14 cM"
     gene            1..2710
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /note="coagulation factor XI"
                     /db_xref="GeneID:109821"
                     /db_xref="MGI:MGI:99481"
     exon            1..45
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            46..101
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1921
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /EC_number="3.4.21.27"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; plasma thromboplastin antecedent"
                     /codon_start=1
                     /product="coagulation factor XI isoform 1 preproprotein"
                     /protein_id="NP_082342.1"
                     /db_xref="CCDS:CCDS22274.1"
                     /db_xref="GeneID:109821"
                     /db_xref="MGI:MGI:99481"
                     /translation="MTSLHQVLYFIFFASVSSECVTKVFKDISFQGGDLSTVFTPSAT
                     YCRLVCTHHPRCLLFTFMAESSSDDPTKWFACILKDSVTEILPMVNMTGAISGYSFKQ
                     CPQQLSTCSKDVYVNLDMKGMNYNSSVVKNARECQERCTDDAHCQFFTYATGYFPSVD
                     HRKMCLLKYTRTGTPTTITKLNGVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSV
                     VAPDAFVCRRICTHHPTCLFFTFFSQAWPKESQRHLCLLKTSESGLPSTRITKSHALS
                     GFSLQHCRHSVPVFCHPSFYNDTDFLGEELDIVDVKGQETCQKTCTNNARCQFFTYYP
                     SHRLCNERNRRGRCYLKLSSNGSPTRILHGRGGISGYSLRLCKMDNVCTTKINPRVVG
                     GAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIETPKKLRVYGGIVNQ
                     SEINEGTAFFRVQEMIIHDQYTTAESGYDIALLKLESAMNYTDFQRPICLPSKGDRNA
                     VHTECWVTGWGYTALRGEVQSTLQKAKVPLVSNEECQTRYRRHKITNKMICAGYKEGG
                     KDTCKGDSGGPLSCKYNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQTV
                     "
     exon            102..264
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            265..371
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            372..531
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            532..641
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            642..801
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            802..911
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1074
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1187
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1347
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1523
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1619
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1759
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2710
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /note="hexamer: TATAAA"
     polyA_site      2710
                     /gene="F11"
                     /gene_synonym="1600027G01Rik; Cf11; FXI; PTA"
                     /note="major polyA site"
ORIGIN      
        1 aaacactccg ccgaggacta cagcaaagac agaaagtatc tgcaggatga cctcattaca
       61 tcaggtgtta tattttatct tttttgcctc agtttctagt gaatgcgtta ctaaggtctt
      121 caaagacatc agctttcaag gaggtgacct gagtactgtt ttcacaccga gcgccacata
      181 ctgccgcttg gtctgcactc accacccacg gtgcttgctc ttcacgttca tggctgagtc
      241 atcttcggat gatcctacca aatggtttgc ctgcatcctg aaggacagcg tcacagaaat
      301 attgccaatg gtaaacatga caggcgcgat ctctggatat tccttcaagc aatgccctca
      361 gcaattaagt acttgcagca aagatgtgta cgtgaaccta gacatgaagg gcatgaacta
      421 taacagctct gtcgtgaaga atgctcgaga atgccaggag agatgcacag acgatgccca
      481 ctgccagttt ttcacatacg caacagggta ttttcccagt gtggaccatc gtaaaatgtg
      541 tcttttgaag tacacccgaa cggggacgcc aaccacaata acgaagctca atggcgtggt
      601 atctggattt tcactgaagt cctgtggact ttcaaacttg gcttgtatca gggacatttt
      661 ccctaacacg gtgctggcag accttaacat tgacagcgtg gtggccccag atgcttttgt
      721 ctgtcgtcgc atctgcacgc atcaccccac ttgtttgttc ttcacattct tttcccaagc
      781 atggccgaaa gaatctcaga gacatctttg tctccttaaa acctctgaaa gtggattacc
      841 aagcacacgc attacaaaga gccacgccct ttcgggcttc agtctccagc actgcaggca
      901 cagtgtccca gtattctgcc atccgtcctt ttacaacgac actgatttct tgggagaaga
      961 gctggacatc gtcgatgtga aaggccaaga aacctgtcag aaaacgtgta ccaataacgc
     1021 ccgctgccag ttctttacct actatccatc gcacagactg tgcaatgaga ggaaccgcag
     1081 gggcagatgt tacctaaagc tttcctccaa tggatctcca acgagaatac ttcatgggag
     1141 gggaggcatc tctggatact cactgaggct gtgcaaaatg gataatgtgt gcacaactaa
     1201 aatcaacccc agagtggtag gaggagctgc gtctgttcac ggtgagtggc catggcaggt
     1261 gactctgcac atcagccagg gacacctgtg tggaggctcc atcattggaa accaatggat
     1321 actgacagca gctcattgtt tctctgggat agagacacct aaaaagctgc gtgtctacgg
     1381 tggcattgta aatcaatcag aaataaatga agggactgct ttcttcaggg ttcaagaaat
     1441 gataattcat gatcagtata cgacagcaga aagtgggtat gatattgccc tgttaaaact
     1501 ggaatcagcc atgaattaca cagattttca gcggccaata tgcctgcctt ccaaaggaga
     1561 tagaaacgca gtgcacacag aatgctgggt gactggatgg gggtacacag cactaagagg
     1621 tgaagtacaa agtactcttc agaaagccaa ggttccattg gtgtcaaatg aagaatgtca
     1681 gacaagatac agaagacaca aaataaccaa taagatgatc tgtgcaggct acaaagaagg
     1741 agggaaggat acgtgcaagg gagattctgg agggcccctg tcctgcaaat acaatggggt
     1801 ctggcacttg gtgggcatca caagctgggg tgaaggctgt ggtcagaagg agagaccggg
     1861 ggtctacacg aacgtggcca agtacgtgga ctggattctg gagaaaactc aaacagtctg
     1921 aaagagttca actggtatca ctttgtggcc ctggaagatt attccataga aatgagcttg
     1981 acgtctctga tgaagacact gggatactga ctcttccact gtaaccaatt gaatggcctt
     2041 gatgtacgta agaacaccca gaaagaaaac tattattttc agaattcctg atctgggaga
     2101 accactggtt gttttctgca tccagctact actcaaggaa acaaatacag caaggagatt
     2161 ttaaaaataa aaacacatca gatatataag gaaaatatca agtaagggtg ctgtctgcct
     2221 ttttagtctc tgtgacaaat acctaaagta gttcacaaaa ggaaaaattt cttttgcaca
     2281 cctttcctca ggtttcagcc tacgatctgg ttggctggcc ccattgcttt agcctgaggt
     2341 gaggcagaac catatatcca taggaggctg tggagaagga gtctgctcag ttcatggtag
     2401 gcaggaagca aatggaaaca ggaatgtatt ggggacacga atggtccttc aagaatatac
     2461 tgtcaatcat ttacttcttc cagagacatc ctgctcccta acctcccttt ccttcccaga
     2521 taacacctct gtcctagctg gccccaagag atcaggtaga aaggcagagg aaaccatata
     2581 aagagttgtt aagtgcaaaa tcaaaaccag aaggaatgca gacaggagct caaaatgtcc
     2641 atttataaga atcttttttt ttctctgcct atatgaatcc ccctcctgta taaaggactg
     2701 actcaattca
//
