LOCUS       NM_007972               2503 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus coagulation factor X (F10), transcript variant 2,
            mRNA.
ACCESSION   NM_007972
VERSION     NM_007972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Cali,B., Troiani,M., Bressan,S., Attanasio,G., Merler,S.,
            Moscarda,V., Mosole,S., Ricci,E., Guo,C., Yuan,W., Gallagher,L.,
            Lundberg,A., Bernett,I., Figueiredo,I., Arzola,R.A., Abreut,E.B.,
            D'Ambrosio,M., Bancaro,N., Brina,D., Zumerle,S., Pasquini,E.,
            Maddalena,M., Lai,P., Colucci,M., Pernigoni,N., Rinaldi,A.,
            Minardi,D., Morlacco,A., Moro,F.D., Sabbadin,M., Galuppini,F.,
            Fassan,M., Ruschoff,J.H., Moch,H., Rescigno,P., Francini,E.,
            Saieva,C., Modesti,M., Theurillat,J.P., Gillessen,S., Wilgenbus,P.,
            Graf,C., Ruf,W., de Bono,J. and Alimonti,A.
  TITLE     Coagulation factor X promotes resistance to androgen-deprivation
            therapy in prostate cancer
  JOURNAL   Cancer Cell 42 (10), 1676-1692 (2024)
   PUBMED   39303726
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Verhenne,S., McCluskey,G., Maynadie,H., Adam,F., Casari,C.,
            Panicot-Dubois,L., Crescence,L., Dubois,C., Denis,C.V.,
            Lenting,P.J. and Christophe,O.D.
  TITLE     Fitusiran reduces bleeding in factor X-deficient mice
  JOURNAL   Blood 144 (2), 227-236 (2024)
   PUBMED   38620079
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Zelaya,H., Grunz,K., Nguyen,T.S., Habibi,A., Witzler,C., Reyda,S.,
            Gonzalez-Menendez,I., Quintanilla-Martinez,L., Bosmann,M.,
            Weiler,H. and Ruf,W.
  TITLE     Nucleic acid sensing promotes inflammatory monocyte migration
            through biased coagulation factor VIIa signaling
  JOURNAL   Blood 143 (10), 845-857 (2024)
   PUBMED   38096370
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Cooper,A., Liang,Z., Castellino,F.J. and Rosen,E.D.
  TITLE     Cloning and characterization of the murine coagulation factor X
            gene
  JOURNAL   Thromb Haemost 83 (5), 732-735 (2000)
   PUBMED   10823271
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   Dewerchin,M., Liang,Z., Moons,L., Carmeliet,P., Castellino,F.J.,
            Collen,D. and Rosen,E.D.
  TITLE     Blood coagulation factor X deficiency causes partial embryonic
            lethality and fatal neonatal bleeding in mice
  JOURNAL   Thromb Haemost 83 (2), 185-190 (2000)
   PUBMED   10739370
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Heidtmann,H.H. and Kontermann,R.E.
  TITLE     Cloning and recombinant expression of mouse coagulation factor X
  JOURNAL   Thromb Res 92 (1), 33-41 (1998)
   PUBMED   9783672
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Liang,Z., Cooper,A., Rosen,E.D. and Castellino,F.J.
  TITLE     Chromosomal arrangement of the murine coagulation factor VII and
            factor X genes
  JOURNAL   Thromb Haemost 80 (3), 524-525 (1998)
   PUBMED   9759642
REFERENCE   9  (bases 1 to 2503)
  AUTHORS   Liang,Z., Cooper,A., DeFord,M.E., Carmeliet,P., Collen,D.,
            Castellino,F.J. and Rosen,E.D.
  TITLE     Cloning and characterization of a cDNA encoding murine coagulation
            factor X
  JOURNAL   Thromb Haemost 80 (1), 87-91 (1998)
   PUBMED   9684791
REFERENCE   10 (bases 1 to 2503)
  AUTHORS   Koizumi,T., Hendel,E., Lalley,P.A., Tchetgen,M.B. and Nadeau,J.H.
  TITLE     Homologs of genes and anonymous loci on human chromosome 13 map to
            mouse chromosomes 8 and 14
  JOURNAL   Mamm Genome 6 (4), 263-268 (1995)
   PUBMED   7613031
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127308.3 and AF087644.1.
            
            On Jun 3, 2011 this sequence version replaced NM_007972.3.
            
            Summary: This gene encodes factor X, a component of both the
            intrinsic and extrinsic blood coagulation pathways. The encoded
            protein is a zymogen that undergoes further processing in a vitamin
            K-dependent manner to generate mature factor X, a heterodimer
            comprised of disulfide-linked heavy and light chains. The mature
            factor X is proteolytically activated either by factor IXa
            (intrinsic pathway) or factor VIIa (extrinsic pathway) to form
            factor Xa serine endopeptidase. Activated factor Xa catalyzes the
            conversion of prothrombin to thrombin. A complete lack of the
            encoded protein is fatal to mice. A severe deficiency of the
            encoded protein in mice causes age-dependent iron deposition and
            cardiac fibrosis. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Aug 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus, compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154100.1, AK171096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC127308.3         166106-166345
            241-263             AC127308.3         166613-166635
            264-1342            AF087644.1         1-1079
            1343-2503           AC127308.3         184314-185474
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..2503
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /note="coagulation factor X"
                     /db_xref="GeneID:14058"
                     /db_xref="MGI:MGI:103107"
     exon            1..240
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            241..333
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1709
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /EC_number="3.4.21.6"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; stuart factor"
                     /codon_start=1
                     /product="coagulation factor X isoform 2 preproprotein"
                     /protein_id="NP_031998.3"
                     /db_xref="CCDS:CCDS40226.1"
                     /db_xref="GeneID:14058"
                     /db_xref="MGI:MGI:103107"
                     /translation="MGSPVQLSLLCVVLASLLLPGKGVFINRERANNVLARTRRANSF
                     FEEFKKGNLERECMEEICSYEEVREIFEDDEKTKEYWTKYKDGDQCESSPCQNQGACR
                     DGIGGYTCTCSEGFEGKNCELFVRKLCRLDNGDCDQFCREEQNSVVCSCASGYFLGND
                     GKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLNLN
                     ETQPERSSDDLVRIVGGRECKDGECPWQALLINEDNEGFCGGTILNEFYILTAAHCLH
                     QARRFKVRVGDRNTEKEEGNEMVHEVDVVIKHNKFQRDTYDYDIAVLRLKTPITFRMN
                     VAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILKMLEVPYVDRNTCKLSTS
                     FSITQNMFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVSWGEGCARKGKYGIYT
                     KVTTFLKWIDRSMKARVGPTAETPRTAGPPN"
     exon            334..494
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            495..519
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            520..633
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            634..765
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1001
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1119
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..2503
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /note="hexamer: ATTAAA"
     polyA_site      1738
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /note="major polyA site"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="F10"
                     /gene_synonym="Cf10; fX"
ORIGIN      
        1 ggttcctgtt ccccaatagc tcagcctgtt tccgtgacta caatatatag ccattgtcca
       61 agagacacat aaacctcaca cctacacctc tgcccgcccg gagtcagcag ggcccagcca
      121 gaagattgag ggcttggatt caaatcccac atctgacctg acacccatgc tttgcctcat
      181 gcctgtttca acttctgttc cttaaaacaa ggagggggga ctgacccctc taccagctgg
      241 ccactgccgt ccttgaccac accatgggga gcccggtgca actcagcctg ctctgtgttg
      301 tcctggccag cctcctgctc cctgggaaag gtgtgtttat taaccgggaa cgtgccaaca
      361 atgtcctggc gaggactcgg agggcaaact cattttttga agagttcaag aaaggaaatc
      421 tggaaagaga gtgtatggaa gaaatttgtt cttatgaaga ggtccgtgaa atcttcgagg
      481 acgacgagaa gacgaaagaa tactggacca aatataaaga cggcgaccag tgtgaaagca
      541 gcccttgcca gaaccaagga gcgtgtcgag atggcatcgg gggttacacg tgcacctgct
      601 cggagggatt tgaaggcaaa aactgtgagc tctttgttcg gaaactctgc cgcctagaca
      661 acggagactg tgaccagttc tgcagagaag agcagaactc agtggtgtgc tcctgcgcca
      721 gcggttactt cctgggtaat gatggcaagt cttgcatctc cacagctccc ttcccctgtg
      781 gaaaaatcac tacaggacgt aggaagaggt ctgtggccct aaacaccagc gacagtgagc
      841 ttgaccttga agacgccctg cttgatgagg atttcctgtc ccctacggag aatcctattg
      901 aactgctcaa cctcaacgag acacagcctg agaggagcag cgatgacctt gttcggattg
      961 tgggtggccg ggaatgcaag gatggagaat gtccctggca ggctctgctc attaacgaag
     1021 acaatgaagg gttctgtggg ggcaccatct tgaatgagtt ctacatcctc actgctgccc
     1081 actgtctcca tcaggccagg cgattcaagg tgagggtagg tgatcggaac acagagaagg
     1141 aagaaggcaa cgagatggtg cacgaggtgg acgtggtcat taagcacaac aagtttcaga
     1201 gggacaccta cgactatgat atcgccgtgc tgaggctgaa gactcccatc acgttccgga
     1261 tgaacgtggc ccctgcctgc ctgcctcaga aagactgggc cgagtccaca ctgatgacac
     1321 agaagacggg catcgtgagc gggtttggac gcacgcatga gaagggccgc cagtcgaaca
     1381 tcctgaagat gctggaggta ccctacgtgg atcgcaacac ctgcaagctc tccaccagct
     1441 tcagcatcac acagaatatg ttctgtgcgg gctatgaggc caagttagag gatgcctgcc
     1501 agggggacag tggtggcccc catgtcacac ggttcaaaaa tacctactat gtgaccggca
     1561 ttgtcagctg gggagagggg tgtgcaagga aagggaaata tggcatctac acaaaggtca
     1621 cgaccttcct caagtggatt gacaggtcca tgaaagccag ggtgggaccc acagccgaga
     1681 ccccaaggac agcaggtccg cccaattaaa gcagtccttc tccagtcctg ctgggtcaca
     1741 tctggtgttg tttaatgttg ccaccttaaa caggaatgtt cttggggcag ctgccccacc
     1801 tgtggtgggg tcttttccct cagtcttatt tcccttgact tcatggtata cgaaacgggc
     1861 tgcagccggg cagtggtggc acacaccttt aatctcagca ctcaggaggc agagacaggc
     1921 agatttctga atttgaggcc agactggtct acagagtgag ttccaggaca gccagggcta
     1981 cacagagaaa ccctgtctca aaaaatgaat gaacgaacaa acgaacgaac aaacaaatga
     2041 acgaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aaggaaggaa ggaaggaagg
     2101 aaggaaggaa gaaagaaaga aagaaagaag ctgcaagtga gcaaaggtct ctcttcctga
     2161 accagactag aagacactca gggagtcgct ggctctaggg ggttcggtgt ctgctcacac
     2221 ttggatggag cccatagaca tagcatatgg ttctgatttt cagtatgtgt gtgtgcgcgc
     2281 gtgcacacac acacacacat acacacagac acagggactt cagcccctgt tttaggttga
     2341 gaggcctaga ctctgctact ccttagcctg gccagagaac cctcactgtc ctctgggaac
     2401 taggcaacat ggaattactg gttccgtgac atccactgaa agtaaagact cctgggaaga
     2461 gaggctaagg tctttgtcta aataaaggaa ccttttaccc gga
//
