LOCUS       NM_009510               3070 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ezrin (Ezr), mRNA.
ACCESSION   NM_009510 XR_105821 XR_106894
VERSION     NM_009510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   2  (bases 1 to 3070)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3070)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3070)
  AUTHORS   Bondarenko,V., Nikolaev,M., Kromm,D., Belousov,R., Wolny,A.,
            Blotenburg,M., Zeller,P., Rezakhani,S., Hugger,J., Uhlmann,V.,
            Hufnagel,L., Kreshuk,A., Ellenberg,J., van Oudenaarden,A.,
            Erzberger,A., Lutolf,M.P. and Hiiragi,T.
  TITLE     Embryo-uterine interaction coordinates mouse embryogenesis during
            implantation
  JOURNAL   EMBO J 42 (17), e113280 (2023)
   PUBMED   37522872
REFERENCE   5  (bases 1 to 3070)
  AUTHORS   Han,Y., Srinivasan,S. and Yun,C.C.
  TITLE     Inhibition of protein kinase C-alpha and activation of ezrin by
            Lactobacillus acidophilus restore Na+/H+ exchange activity and
            fluid absorption in db/db mice
  JOURNAL   Am J Physiol Endocrinol Metab 325 (3), E214-E226 (2023)
   PUBMED   37467022
  REMARK    GeneRIF: Inhibition of protein kinase C-alpha and activation of
            ezrin by Lactobacillus acidophilus restore Na[+]/H[+] exchange
            activity and fluid absorption in db/db mice.
REFERENCE   6  (bases 1 to 3070)
  AUTHORS   Bretscher,A., Reczek,D. and Berryman,M.
  TITLE     Ezrin: a protein requiring conformational activation to link
            microfilaments to the plasma membrane in the assembly of cell
            surface structures
  JOURNAL   J Cell Sci 110 (Pt 24), 3011-3018 (1997)
   PUBMED   9365271
  REMARK    Review article
REFERENCE   7  (bases 1 to 3070)
  AUTHORS   Takeuchi,K., Kawashima,A., Nagafuchi,A. and Tsukita,S.
  TITLE     Structural diversity of band 4.1 superfamily members
  JOURNAL   J Cell Sci 107 (Pt 7), 1921-1928 (1994)
   PUBMED   7983158
REFERENCE   8  (bases 1 to 3070)
  AUTHORS   Fazioli,F., Wong,W.T., Ullrich,S.J., Sakaguchi,K., Appella,E. and
            Di Fiore,P.P.
  TITLE     The ezrin-like family of tyrosine kinase substrates:
            receptor-specific pattern of tyrosine phosphorylation and
            relationship to malignant transformation
  JOURNAL   Oncogene 8 (5), 1335-1345 (1993)
   PUBMED   8479753
REFERENCE   9  (bases 1 to 3070)
  AUTHORS   Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,S. and
            Tsukita,S.
  TITLE     A gene family consisting of ezrin, radixin and moesin. Its specific
            localization at actin filament/plasma membrane association sites
  JOURNAL   J Cell Sci 103 (Pt 1), 131-143 (1992)
   PUBMED   1429901
REFERENCE   10 (bases 1 to 3070)
  AUTHORS   Funayama,N., Nagafuchi,A., Sato,N., Tsukita,S. and Tsukita,S.
  TITLE     Radixin is a novel member of the band 4.1 family
  JOURNAL   J Cell Biol 115 (4), 1039-1048 (1991)
   PUBMED   1955455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145707.1, BC098502.1 and AK035271.1.
            
            On or before Dec 14, 2010 this sequence version replaced
            XR_105821.1, XR_106894.1, NM_009510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145707.1, AK004588.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AK145707.1         2-141
            141-2745            BC098502.1         93-2697
            2746-2926           AK145707.1         2747-2927
            2927-3070           AK035271.1         2295-2438
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.38 cM"
     gene            1..3070
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="ezrin"
                     /db_xref="GeneID:22350"
                     /db_xref="MGI:MGI:98931"
     exon            1..149
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1898
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="cytovillin; villin-2"
                     /codon_start=1
                     /product="ezrin"
                     /protein_id="NP_033536.2"
                     /db_xref="CCDS:CCDS37428.1"
                     /db_xref="GeneID:22350"
                     /db_xref="MGI:MGI:98931"
                     /translation="MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWY
                     FGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVAEELIQDITQKLF
                     FLQVKDGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQ
                     HKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWL
                     GVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVE
                     REKEQMLREKEELMLRLQDYEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEAD
                     RMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAK
                     EAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGI
                     LDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYK
                     TLRQIRQGNTKQRIDEFEAM"
     exon            150..233
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..329
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..604
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..688
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..835
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..932
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1096
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1227
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1388
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1481
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1733
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..3070
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="hexamer: AATAAA"
     polyA_site      2592
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="major polyA site"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Ezr"
                     /gene_synonym="p81; Vil2"
                     /note="major polyA site"
ORIGIN      
        1 atactcggga ctgcggagcg cgcgcagggc ttccctccgc ctgcaggtcc cgacgcgtct
       61 ccgccgtcgc cgtcgccgtc gcctccgccg tacagccgaa tagccgagga cccacgcaga
      121 gccaccaacc agccaagatg cccaagccaa tcaacgtccg ggtgaccacc atggatgccg
      181 agctggagtt tgccatccag ccaaacacca ccgggaagca gctctttgat caggtggtaa
      241 agacgattgg cctccgggaa gtgtggtact tcggcctcca gtatgtagac aataaaggat
      301 ttcctacctg gctgaaactt gataaaaagg tctccgcaca ggaggtccga aaggagaacc
      361 ctgtccagtt taaattccgg gccaagttct accccgaaga cgtggccgag gaactcatcc
      421 aggacatcac acagaagctc ttcttcctgc aagtcaagga cgggatcctc agcgacgaga
      481 tctactgccc cccagagaca gccgtgctcc tgggctccta tgccgttcag gccaagttcg
      541 gagattataa caaggaaatg cacaagtctg ggtacctcag ctcggagcgg ctgatccccc
      601 agagagtcat ggaccaacac aagctcagca gggaccagtg ggaggaccgg atccaggtgt
      661 ggcacgcgga acaccgaggg atgctcaagg acagtgctat gctagaatac ctgaagattg
      721 cccaggacct ggaaatgtat gggatcaact atttcgagat caaaaacaag aaaggaacag
      781 acctttggct tggagtcgat gcccttggac ttaacattta tgagaaagat gacaagttga
      841 ccccaaagat cggcttccct tggagtgaga tcaggaacat ctctttcaac gacaagaagt
      901 ttgtcattaa gcccatcgac aagaaggcac ctgactttgt gttctacgcc ccgcgcctga
      961 gaattaacaa gcggatcctg cagctctgca tggggaacca tgagctgtac atgcgccgca
     1021 ggaagcccga caccatcgag gtgcagcaga tgaaggccca ggctcgggag gagaagcacc
     1081 agaagcagct agagcgacag cagttggaaa ccgagaagaa gaggcgagag acggtggaga
     1141 gagaaaagga gcagatgctc cgggagaagg aggagctgat gcttcggctg caggactacg
     1201 agcagaagac caagagggcg gagaaagagc tctccgagca gattgagaag gccctccaac
     1261 tggaggaaga gaggaggcga gcccaggagg aggctgaacg tctggaggcc gaccgcatgg
     1321 ccgccctgcg ggccaaggaa gaactcgaga gacaggcgca ggatcagata aagagccagg
     1381 agcagctggc tgcagagctg gcagagtaca cggccaagat cgcactgctg gaggaggcgc
     1441 ggaggcgcaa ggaggacgag gtagaagagt ggcagcaccg ggctaaagaa gcccaggacg
     1501 acctggtgaa gaccaaagag gagctgcacc tggtgatgac ggccccaccg cccccaccgc
     1561 ccccagtgta tgagcctgtg aattaccacg tgcaggaggg actgcaggac gagggagcag
     1621 agcctatggg ctacagtgcc gagctctcca gtgagggcat cctggatgac cgcaacgagg
     1681 agaagcggat cacagaggca gagaagaatg agcgcgtgca gcggcagctg ctgaccctga
     1741 gcaatgagtt gtcccaggcc cgggatgaga acaagaggac ccacaatgac atcatccaca
     1801 acgagaacat gcggcaaggc agggacaagt ataagacgct gcggcaaatc aggcagggca
     1861 acaccaagca acgcattgac gagttcgagg ccatgtagag gccaggctgg gaccaagggc
     1921 agagggcacc tcactgcagg caggtgtcac acttggctct ttagttctct taagtttaga
     1981 cacccccttg ctgtgttcca gtcccttaaa gagcagttac ggggcctgca ttctgccccg
     2041 agacccagtg ggctcctcct tggttccttc taattgtatc acatagtgcc aaacaggtca
     2101 gatttaatga cagttaccga atcacttcct gtttggagca gggattcgga gggctggccc
     2161 tcatgaagca agattcattg tcactgggac agcactgtgg ctcacgggtg ccatactttt
     2221 ctctagtttt acaatgagct caaatcgatt ttgttcttga tttttatgaa ggatccatct
     2281 ctgtgtattg aggggtaaaa atgattttga aatttgagtc taaagcatgc ccccacagag
     2341 tctccttcct ccagaccgct ggcagagtct ccaggggtcc ttcagagtgt acggtacagg
     2401 actctccgat acaaaattct catgcttatc tgttagcata cattgttgga cttatatatc
     2461 taatgatctg ctatagagga tagtatttat atataagcga taatatgggt ttgtaacatt
     2521 agttttaaaa aagggaaagt tttgttctgt atattttgtt accttttaca gaataaaaga
     2581 attcaacatt aagaaccatg taaccgagac acttgatctg acacaggggc agtcgggaaa
     2641 ccgatgactg cagtaatcac cactgtacaa aaatgttagt gggttttgtg cacgtaaaat
     2701 gcacacttcc atttcctgtc agtttcttat ttgaaaaaaa aaaaatacac accgagagca
     2761 tccagactcc agccctgaag ggacgccggc ctctttattg tgagcaactt gttcccgttt
     2821 tcagtttgtc ttccttcctt tcgcggacta gcctccttgg ttgtgatgtc tgtcctgtgc
     2881 gggtgactcc gcaccagatt tacacacaat aaaagctctc caaggccttg tgtctgattg
     2941 catggggggg gttggggtgg gagtgggggg tctctcagac ttgtcctcgg gattcaggaa
     3001 gcatgctaat cagagagggg tcttccccag ctcccctgca ctgggaggtt tgccacccga
     3061 gaggagcaca
//
