LOCUS       NM_007971               2665 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus enhancer of zeste 2 polycomb repressive complex 2
            subunit (Ezh2), transcript variant 1, mRNA.
ACCESSION   NM_007971
VERSION     NM_007971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Isshiki,Y., Chen,X., Teater,M., Karagiannidis,I., Nam,H., Cai,W.,
            Meydan,C., Xia,M., Shen,H., Gutierrez,J., Easwar Kumar,V.,
            Carrasco,S.E., Ouseph,M.M., Yamshon,S., Martin,P., Griess,O.,
            Shema,E., Porazzi,P., Ruella,M., Brentjens,R.J., Inghirami,G.,
            Zappasodi,R., Chadburn,A., Melnick,A.M. and Beguelin,W.
  TITLE     EZH2 inhibition enhances T cell immunotherapies by inducing
            lymphoma immunogenicity and improving T cell function
  JOURNAL   Cancer Cell 43 (1), 49-68 (2025)
   PUBMED   39642889
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Zheng,X., Dozmorov,M.G., Espinoza,L., Bowes,M.M., Bastacky,S. and
            Sawalha,A.H.
  TITLE     Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell
            infiltration and prevents interstitial nephritis in MRL/lpr
            lupus-prone mice
  JOURNAL   iScience 27 (11), 111114 (2024)
   PUBMED   39498302
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157853.1, AK220174.1 and BC079538.1.
            
            On Apr 9, 2009 this sequence version replaced NM_007971.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This isoform is also
            known as ENX-1A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157853.1, BC003772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK157853.1         2-46
            46-2645             AK220174.1         1-2600
            2646-2665           BC079538.1         2585-2604
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     gene            1..2665
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /note="enhancer of zeste 2 polycomb repressive complex 2
                     subunit"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
     exon            1..137
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            138..261
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2385
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /EC_number="2.1.1.356"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase EZH2; enhancer of zeste
                     homolog 2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     1"
                     /protein_id="NP_031997.2"
                     /db_xref="CCDS:CCDS20096.1"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
                     /translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSS
                     NRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLN
                     AVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGD
                     RECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKF
                     PADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQ
                     SLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEF
                     AAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGEN
                     NDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDN
                     FCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQL
                     KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQC
                     NTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGW
                     GIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGN
                     KIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIE
                     REMEIP"
     exon            262..390
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            391..507
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            508..628
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            629..769
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            770..872
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1036
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1128
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1369
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1539
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1634
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1675
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1801
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1980
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2076
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2158
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2239
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2324
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2652
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /note="hexamer: AATAAA"
     polyA_site      2652
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /note="major polyA site"
ORIGIN      
        1 gcgtttggcg ctcggtccgg tcgcgtccga cacccagtgg gacatcgaag gcagtggagt
       61 cccggcggcg gcggtggcgg tggcggcggg ttgggggcga cgcgcgggag aggcgcgggc
      121 tggcgcgcgg gacgaagaat aatcatgggc cagactggga agaaatctga gaagggaccg
      181 gtttgttggc ggaagcgtgt aaaatcagag tacatgagac tgagacagct caagaggttc
      241 agaagagctg atgaagtaaa gactatgttt agttccaatc gtcagaaaat tttggaaaga
      301 actgaaacct taaaccaaga gtggaagcag cggaggatac agcctgtgca catcatgact
      361 tctgtgagct cattgcgcgg gactagggag tgttcagtca ccagtgactt ggattttcca
      421 gcacaagtca tcccgttaaa gaccctgaat gcagtcgcct cggtgcctat aatgtactct
      481 tggtcgccct tacaacagaa ttttatggtg gaagacgaaa ctgttttaca taacattcct
      541 tatatggggg atgaagttct ggatcaggat ggcactttca ttgaagaact aataaaaaat
      601 tatgatggaa aagtgcatgg tgacagagaa tgtggattta taaatgatga aatttttgtg
      661 gagttggtaa atgctcttgg tcaatataat gatgatgatg atgacgatga tggagatgat
      721 ccagatgaaa gagaagaaaa acagaaagat ctagaggata atcgagatga taaagaaact
      781 tgcccacctc ggaaatttcc tgctgataaa atatttgaag ccatttcctc aatgtttcca
      841 gataagggca ccgcagaaga actgaaagaa aaatataaag aactcacgga gcagcagctc
      901 ccaggtgctc tgcctcctga atgtactcca aacatcgatg gaccaaatgc caaatctgtt
      961 cagagggagc aaagcttgca ttcatttcat acgctcttct gtcgacgatg ttttaagtat
     1021 gactgcttcc tacatccctt ccatgcaaca cccaacacat ataagaggaa gaacacagaa
     1081 acagctttgg acaacaagcc ttgtggacca cagtgttacc agcatctgga gggagctaag
     1141 gagtttgctg ctgctcttac tgctgagcgt ataaagacac cacctaaacg cccagggggc
     1201 cgcagaagag gaagacttcc gaataacagt agcagaccca gcacccccac catcagtgtg
     1261 ctggagtcaa aggatacaga cagtgacaga gaagcaggga ctgaaactgg gggagagaac
     1321 aatgataaag aagaagaaga gaaaaaagat gagacgtcca gctcctctga agcaaattct
     1381 cggtgtcaaa caccaataaa gatgaagcca aatattgaac ctcctgagaa tgtggagtgg
     1441 agtggtgctg aagcctccat gtttagagtc ctcattggta cttactacga taacttttgt
     1501 gccattgcta ggctaattgg gaccaaaaca tgtagacagg tgtatgagtt tagagtcaag
     1561 gagtccagta tcatagcacc tgttcccact gaggatgtag acactcctcc aagaaagaag
     1621 aaaaggaaac atcggttgtg ggctgcacac tgcagaaaga tacaactgaa aaaggacggc
     1681 tcctctaacc atgtttacaa ctatcaaccc tgtgaccatc cacggcagcc ttgtgacagt
     1741 tcgtgccctt gtgtgatagc acaaaatttt tgtgaaaagt tttgtcaatg tagttcagag
     1801 tgtcaaaacc gctttcctgg atgtcggtgc aaagcacaat gcaacaccaa acagtgtcca
     1861 tgctacctgg ctgtccgaga gtgtgaccct gacctctgtc tcacgtgtgg agctgctgac
     1921 cattgggaca gtaaaaatgt atcctgtaag aactgtagca ttcagcgggg ctctaaaaag
     1981 cacttactgc tggcaccgtc tgatgtggca ggctggggca tctttatcaa agatcctgta
     2041 cagaaaaatg aattcatctc agaatactgt ggggagatta tttctcagga tgaagcagac
     2101 agaagaggaa aagtgtatga caaatacatg tgcagctttc tgttcaactt gaacaatgat
     2161 tttgtggtgg atgcaacccg aaagggcaac aaaattcgtt ttgctaatca ttcagtaaat
     2221 ccaaactgct atgcaaaagt tatgatggtt aatggtgacc acaggatagg catctttgct
     2281 aagagggcta tccagactgg tgaagagttg ttttttgatt acagatacag ccaggctgat
     2341 gccctgaagt atgtgggcat cgaacgagaa atggaaatcc cttgacatct actacctctt
     2401 ccccttctct ctgaaacagc tgccttagct tcaggaacct tgagtactgt gggcaattta
     2461 gaaaacggaa atgcagtttg aaattctgaa tttgcaaagt actgtaacag taatttatag
     2521 taatgtttta aaatcaactt tttattgcct tctcaccagc tgcaaagtgt tttgtaccag
     2581 tgagtttttg caataatgca gtatggtaca tttttcaaat ttgaataaag aatacttgaa
     2641 cttgttgttg aaaaaaaaaa aaaaa
//
