LOCUS       NM_001403821            4342 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus enhancer of zeste 1 polycomb repressive complex 2
            subunit (Ezh1), transcript variant 12, mRNA.
ACCESSION   NM_001403821
VERSION     NM_001403821.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
  REMARK    GeneRIF: Maternal Ezh1/2 deficiency impairs the function of
            mitochondria in mouse oocytes and early embryos.
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Rhodes,C.T., Asokumar,D., Sohn,M., Naskar,S., Elisha,L.,
            Stevenson,P., Lee,D.R., Zhang,Y., Rocha,P.P., Dale,R.K., Lee,S. and
            Petros,T.J.
  TITLE     Loss of Ezh2 in the medial ganglionic eminence alters interneuron
            fate, cell morphology and gene expression profiles
  JOURNAL   Front Cell Neurosci 18, 1334244 (2024)
   PUBMED   38419656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Sun,B., Reynolds,K., Saha,S.K., Zhang,S., McMahon,M. and Zhou,C.J.
  TITLE     Ezh2-dependent methylation in oral epithelia promotes secondary
            palatogenesis
  JOURNAL   Birth Defects Res 115 (19), 1851-1865 (2023)
   PUBMED   37435868
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Feng,X., Wang,A.H., Juan,A.H., Ko,K.D., Jiang,K., Riparini,G.,
            Ciuffoli,V., Kaba,A., Lopez,C., Naz,F., Jarnik,M., Aliberti,E.,
            Hu,S., Segales,J., Khateb,M., Acevedo-Luna,N., Randazzo,D.,
            Cheung,T.H., Munoz-Canoves,P., Dell'Orso,S. and Sartorelli,V.
  TITLE     Polycomb Ezh1 maintains murine muscle stem cell quiescence through
            non-canonical regulation of Notch signaling
  JOURNAL   Dev Cell 58 (12), 1052-1070 (2023)
   PUBMED   37105173
  REMARK    GeneRIF: Polycomb Ezh1 maintains murine muscle stem cell quiescence
            through non-canonical regulation of Notch signaling.
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Laible,G., Haynes,A.R., Lebersorger,A., O'Carroll,D., Mattei,M.G.,
            Denny,P., Brown,S.D. and Jenuwein,T.
  TITLE     The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene
            clusters on mouse chromosomes 11 and 6
  JOURNAL   Mamm Genome 10 (3), 311-314 (1999)
   PUBMED   10051331
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   van Lohuizen,M., Tijms,M., Voncken,J.W., Schumacher,A., Magnuson,T.
            and Wientjens,E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590969.12.
            
            Summary: This gene encodes a member of the Polycomb-group (PcG)
            family. The encoded protein is interchangeable with the related
            Enhancer of zeste 2 (Ezh2) protein as a core component of the
            polycomb repressive complex 2 (PRC2), which methylates histone H3
            at lysine 27 and results in the transcriptional repression of
            affected target genes. This complex is involved in carrying out
            cell-fate decisions during embryonic stem cell differentiation.
            [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.90065.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AL590969.12        163084-163286
            204-270             AL590969.12        170806-170872
            271-391             AL590969.12        172163-172283
            392-520             AL590969.12        172403-172531
            521-640             AL590969.12        174224-174343
            641-761             AL590969.12        175682-175802
            762-938             AL590969.12        178803-178979
            939-1041            AL590969.12        180044-180146
            1042-1205           AL590969.12        181241-181404
            1206-1297           AL590969.12        182097-182188
            1298-1478           AL590969.12        185585-185765
            1479-1675           AL590969.12        186075-186271
            1676-1767           AL590969.12        188599-188690
            1768-1808           AL590969.12        189540-189580
            1809-1934           AL590969.12        190143-190268
            1935-2113           AL590969.12        193829-194007
            2114-2209           AL590969.12        194545-194640
            2210-2291           AL590969.12        194977-195058
            2292-2372           AL590969.12        195720-195800
            2373-2457           AL590969.12        196223-196307
            2458-4342           AL590969.12        196527-198411
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.37 cM"
     gene            1..4342
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /note="enhancer of zeste 1 polycomb repressive complex 2
                     subunit"
                     /db_xref="GeneID:14055"
                     /db_xref="MGI:MGI:1097695"
     exon            1..203
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..270
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2518
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /EC_number="2.1.1.356"
                     /note="isoform 1 is encoded by transcript variant 12;
                     histone-lysine N-methyltransferase EZH1; enhancer of zeste
                     homolog 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH1 isoform
                     1"
                     /protein_id="NP_001390750.1"
                     /db_xref="GeneID:14055"
                     /db_xref="MGI:MGI:1097695"
                     /translation="MRKMDIASPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKAL
                     YVANFAKVQEKTQILNEEWKKLRVQPVQPMKPVSGHPFLKKCTIESIFPGFDSQDMLM
                     RSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGK
                     VHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEDGHNDPSDGKQDDSKEDLPVTRKR
                     KRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQC
                     TPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPE
                     PCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSD
                     RDTGNDWASSSSEANSRCQTPTKQKASPAPAQLCVVEAPSEPVEWTGAEESLFRVFHG
                     TYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPAQKKKRKHRLWAAHCR
                     KIQLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRC
                     KTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSD
                     VAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDAT
                     RKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKY
                     VGIERETDVF"
     exon            271..391
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..520
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..640
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..761
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..938
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1041
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1205
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1297
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1478
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1675
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1767
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1808
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1934
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2113
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2209
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2291
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2372
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2457
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..4342
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /note="hexamer: AATAAA"
     polyA_site      4342
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcagg cgtcctagtg gcgggtggct gcgtctcagg atggagggtg agtgagtaaa
       61 caagacgggg ctgggcggtg gggccgggcc tgggcttggc gtgacgcttg aacctcaggg
      121 ctggggaggc gaagaaatga ggaaactgag ggccacacca ttgcctgacc cggggtagcg
      181 cgaagcctgt cgtcccgagt gtgatcttgc cattcgtctg cagaacagag gtacattata
      241 aagtcaacac ttcccgctgc attccatgag gaaaatggat atagcaagtc ccccaacttc
      301 caaatgcatc acatactgga aaagaaaagt gaaatctgag tatatgcggc ttcgacagct
      361 caaacggctc caggcaaata tgggagcaaa ggctctgtat gtggcaaatt ttgcaaaggt
      421 tcaagaaaaa acccaaatcc tcaatgaaga gtggaagaaa cttcgtgtcc agcctgttca
      481 gccaatgaag cccgtgagtg ggcacccttt tctgaaaaag tgtaccatag agagcatttt
      541 cccagggttc gacagccagg atatgttgat gcggtctctg aacactgttg cactggttcc
      601 catcatgtat tcctggtccc ctctccagca gaatttcatg gtggaagatg agacggtttt
      661 gtgcaatatt ccatacatgg gtgacgaggt gaaggaagaa gatgagactt tcatcgaaga
      721 gctgatcaat aactatgatg gcaaagtcca cggtgaagaa gagatgatcc ctggatctgt
      781 gctgatcagc gatgctgtgt ttctggagct ggtggatgcc ctcaaccagt actctgatga
      841 ggaggaggac gggcacaacg acccctccga tggaaagcaa gacgacagca aagaggacct
      901 gccggtaaca agaaaacgga agcgccatgc tatcgaaggc aacaaaaaga gttccaagaa
      961 acagtttcca aatgacatga tcttcagcgc cattgcgtcc atgtttcctg agaatggtgt
     1021 ccctgacgac atgaaggaga ggtatcgaga gctgacagag atgtcagacc ccaatgcact
     1081 tccccctcag tgcacaccca acatcgatgg ccccaacgcc aagtcagtgc agcgggagca
     1141 gtctctgcac tctttccaca cccttttctg ccggcgctgt tttaaatatg actgcttcct
     1201 tcaccctttc cacgccaccc caaatgtata taagcgcaag aacaaggaaa tcaagattga
     1261 gccagaaccg tgtggcacag actgcttcct tttgctggaa ggagcaaagg agtacgccat
     1321 gctgcacaac cctcggtcca agtgctctgg gcgccgccgc cgaaggcacc cagtggtcag
     1381 tgcttcctgc tccaatgcat cagcttctgc tatggctgaa actaaagaag gagacagtga
     1441 tagagacact ggcaatgact gggcctccag ttcttcagag gctaactctc gctgtcagac
     1501 ccccacgaaa cagaaagcca gtccagcccc agctcagctc tgtgttgtgg aagccccctc
     1561 agagccggtg gaatggaccg gagccgaaga atctcttttc cgagtcttcc acggcaccta
     1621 tttcaacaac ttctgctcaa tagccaggct tctggggaca aagacatgca agcaggtctt
     1681 tcagtttgca gtcaaagaat cacttatcct aaagctgcca acagatgagc tcatgaaccc
     1741 tgcacagaag aagaaaagaa aacacaggtt gtgggccgca cactgcagga aaattcagct
     1801 gaagaaagat aacaattcta cacaagtgta taactaccaa ccctgtgacc acccagaccg
     1861 tccgtgtgac agcacatgcc cctgcatcat gacccagaac ttttgtgaaa agttctgcca
     1921 gtgcagccca gactgccaga atcgctttcc tggttgtcgc tgtaagactc agtgcaatac
     1981 caagcaatgt ccatgctact tggcagttcg tgagtgtgac cctgacttgt gcctcacctg
     2041 tggggcctca gagcactggg actgtaaggt ggtgtcttgc aaaaactgca gcatccagcg
     2101 tggcctcaaa aagcacctgc tgctggcccc ttccgatgtg gccggatggg gcaccttcat
     2161 caaggagtct gtgcagaaga atgaattcat ttctgaatat tgtggtgagc tcatctctca
     2221 ggatgaggct gatcgtcgag ggaaggtcta tgataaatac atgtccagct tcctcttcaa
     2281 cctcaacaat gattttgtag tggatgctac ccggaaagga aacaaaattc gctttgcaaa
     2341 ccattcagtg aaccccaact gttatgccaa agtggttatg gtgaatggag atcaccgcat
     2401 tgggatcttt gccaagagag caattcaggc tggcgaagag ctcttctttg attataggta
     2461 cagccaagct gatgccctca agtatgtggg catcgagagg gaaacggacg tcttctagcc
     2521 ctctgggccc cgtgccagtg ctgtggtggc agcactgtca tggcttcagg cacacaccac
     2581 tgctgctcca gctcctgcaa tgtcttccat gctgagaaac ccacccaccc tgcataacta
     2641 ggcctccact ttattccaag gggacacact gcctcaggag aggggaaaca gaggcggtga
     2701 agacctggtc tcccaggaga gttcagatgt aagaagctgc gctcccatgc caggaggagg
     2761 agatggtggg tgtgggataa tgccagggct tgagttttcc tcagctgcca agccggggac
     2821 cctcaggaac caaccagtgc taccatttta gctttctcga tcaagagttc catgtcactg
     2881 actgtgctca gggttaaagg tgagcctggc aagcattgca gacagaactc aaagggagac
     2941 atgtctccat gccatcaaag caggaattta aggatacagg aaggaaaact taagttcttt
     3001 catcctgtga acatagagcc agctagaccc ttgggaaaag cctaccctat aggttacagg
     3061 ggtggcaggg tggttttcag gctcccagga catgtgccag tgacccactc cttccaaagt
     3121 tctggctcag tggcaacatg cctaagctgc ggctatgcct ggttgggagt gagtactcgg
     3181 ggtcagtgaa gctgcagctg tccctaccct ccattcctca gcggcttgtc catggagcag
     3241 cttgctgctt tcttcagggt agctgggcct aatctaggct agaggaagat gttgctggtc
     3301 tggtttactc cctgtctgta gtacctgctg ttggttgtgt ttgtgggtgt gtggggtgcc
     3361 attgcacatt taggagtgtg tcacagtgca gggtagactg ccaggcagac caccattctc
     3421 tgggattcat agagaacaaa gcactttaac tctcttttag aaggtttata gattggagtg
     3481 gagtttgagc caagtctctg cccgaatccc acttctgaag gaggaagagg agagtggaag
     3541 atcctgcagt ttaatatcat tttctgagag gcaggaggag ctgacttgac acaaaaacaa
     3601 aaactagtca gcatagctac cttgtgtctg gtgtgctgag aataggggct tgtgctggaa
     3661 ggggcgtggg tggatacaga ctgccctaga gtgttagaat ggggcacaag ctccttgctt
     3721 cctgaagaac cagagctcct gtggcccttg ctaaccattc ccttctccca cactgcctct
     3781 tagagatttg catgggacgt gcatgcttgt gcacatactc cttcactaca ctggcaggtc
     3841 cgtgtgtgcc tcacactcag cacactctac agctcctctc cccacaccca gttctgaaac
     3901 tgacatctgc tggggggtta tgtctattgt gtgtatcagg gataccctcc agcctaacga
     3961 taggctctga attactcagt ctctgggaaa ccagagactg gtggaggagg ggctggtcat
     4021 gaggaatgct ttaaaacatg tcggttctag actgagctca gccttccctc agcaggcatc
     4081 actggcagcc cctccctccg cagttcaggc caataatact catgcgctcc agccgcccac
     4141 tcttggttcc tgctgtcctc tatttttaat gacgggtttc acccctcctc tccacttctg
     4201 ccccacgtca cgtggtagat aaagtgaggt gctgtggact ggtggggaac tggcgtacct
     4261 gcggcttaat tgccagtaaa tttcttgcac tttaaagtcc tgtggcttgt gacctcttat
     4321 ctaataaagt gttaagactc ca
//
