LOCUS       NP_001390750             750 aa            linear   ROD 30-APR-2025
DEFINITION  histone-lysine N-methyltransferase EZH1 isoform 1 [Mus musculus].
ACCESSION   NP_001390750
VERSION     NP_001390750.1
DBSOURCE    REFSEQ: accession NM_001403821.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
  REMARK    GeneRIF: Maternal Ezh1/2 deficiency impairs the function of
            mitochondria in mouse oocytes and early embryos.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Rhodes,C.T., Asokumar,D., Sohn,M., Naskar,S., Elisha,L.,
            Stevenson,P., Lee,D.R., Zhang,Y., Rocha,P.P., Dale,R.K., Lee,S. and
            Petros,T.J.
  TITLE     Loss of Ezh2 in the medial ganglionic eminence alters interneuron
            fate, cell morphology and gene expression profiles
  JOURNAL   Front Cell Neurosci 18, 1334244 (2024)
   PUBMED   38419656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Sun,B., Reynolds,K., Saha,S.K., Zhang,S., McMahon,M. and Zhou,C.J.
  TITLE     Ezh2-dependent methylation in oral epithelia promotes secondary
            palatogenesis
  JOURNAL   Birth Defects Res 115 (19), 1851-1865 (2023)
   PUBMED   37435868
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Feng,X., Wang,A.H., Juan,A.H., Ko,K.D., Jiang,K., Riparini,G.,
            Ciuffoli,V., Kaba,A., Lopez,C., Naz,F., Jarnik,M., Aliberti,E.,
            Hu,S., Segales,J., Khateb,M., Acevedo-Luna,N., Randazzo,D.,
            Cheung,T.H., Munoz-Canoves,P., Dell'Orso,S. and Sartorelli,V.
  TITLE     Polycomb Ezh1 maintains murine muscle stem cell quiescence through
            non-canonical regulation of Notch signaling
  JOURNAL   Dev Cell 58 (12), 1052-1070 (2023)
   PUBMED   37105173
  REMARK    GeneRIF: Polycomb Ezh1 maintains murine muscle stem cell quiescence
            through non-canonical regulation of Notch signaling.
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Laible,G., Haynes,A.R., Lebersorger,A., O'Carroll,D., Mattei,M.G.,
            Denny,P., Brown,S.D. and Jenuwein,T.
  TITLE     The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene
            clusters on mouse chromosomes 11 and 6
  JOURNAL   Mamm Genome 10 (3), 311-314 (1999)
   PUBMED   10051331
REFERENCE   7  (residues 1 to 750)
  AUTHORS   van Lohuizen,M., Tijms,M., Voncken,J.W., Schumacher,A., Magnuson,T.
            and Wientjens,E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590969.12.
            
            Summary: This gene encodes a member of the Polycomb-group (PcG)
            family. The encoded protein is interchangeable with the related
            Enhancer of zeste 2 (Ezh2) protein as a core component of the
            polycomb repressive complex 2 (PRC2), which methylates histone H3
            at lysine 27 and results in the transcriptional repression of
            affected target genes. This complex is involved in carrying out
            cell-fate decisions during embryonic stem cell differentiation.
            [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.90065.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.37 cM"
     Protein         1..750
                     /product="histone-lysine N-methyltransferase EZH1 isoform
                     1"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH1; enhancer
                     of zeste homolog 1"
                     /calculated_mol_wt=85473
     Region          42..71
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          162..265
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          436..477
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(437,466..467,469..470,472..474,476..477)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     Region          563..594
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          611..746
                     /region_name="SET_EZH1"
                     /note="SET domain found in enhancer of zeste homolog 1
                     (EZH1) and similar proteins; cd19217"
                     /db_xref="CDD:380994"
     Site            order(625,627..628,645,652,655..656,659,663,666,668..672,
                     689..693,701,728,730..731)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380994"
     Site            order(627..628,661..662,669,682,689..693,730)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380994"
     Site            order(627..628,661..662,665,669,682,689..690,692)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:380994"
     Site            order(645,655..656,668,670..672,701,728,730,732)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380994"
     Site            730
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:380994"
     CDS             1..750
                     /gene="Ezh1"
                     /gene_synonym="ENX-2"
                     /coded_by="NM_001403821.1:266..2518"
                     /note="isoform 1 is encoded by transcript variant 12"
                     /db_xref="GeneID:14055"
                     /db_xref="MGI:MGI:1097695"
ORIGIN      
        1 mrkmdiaspp tskcitywkr kvkseymrlr qlkrlqanmg akalyvanfa kvqektqiln
       61 eewkklrvqp vqpmkpvsgh pflkkcties ifpgfdsqdm lmrslntval vpimyswspl
      121 qqnfmvedet vlcnipymgd evkeedetfi eelinnydgk vhgeeemipg svlisdavfl
      181 elvdalnqys deeedghndp sdgkqddske dlpvtrkrkr haiegnkkss kkqfpndmif
      241 saiasmfpen gvpddmkery reltemsdpn alppqctpni dgpnaksvqr eqslhsfhtl
      301 fcrrcfkydc flhpfhatpn vykrknkeik iepepcgtdc flllegakey amlhnprskc
      361 sgrrrrrhpv vsascsnasa samaetkegd sdrdtgndwa sssseansrc qtptkqkasp
      421 apaqlcvvea psepvewtga eeslfrvfhg tyfnnfcsia rllgtktckq vfqfavkesl
      481 ilklptdelm npaqkkkrkh rlwaahcrki qlkkdnnstq vynyqpcdhp drpcdstcpc
      541 imtqnfcekf cqcspdcqnr fpgcrcktqc ntkqcpcyla vrecdpdlcl tcgasehwdc
      601 kvvsckncsi qrglkkhlll apsdvagwgt fikesvqkne fiseycgeli sqdeadrrgk
      661 vydkymssfl fnlnndfvvd atrkgnkirf anhsvnpncy akvvmvngdh rigifakrai
      721 qageelffdy rysqadalky vgieretdvf
//
