LOCUS       NM_001347372            5292 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus EYA transcriptional coactivator and phosphatase 4
            (Eya4), transcript variant 2, mRNA.
ACCESSION   NM_001347372 XM_006512522
VERSION     NM_001347372.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5292)
  AUTHORS   Cesario,J., Ha,S., Kim,J., Kataria,N. and Jeong,J.
  TITLE     Candidate positive targets of LHX6 and LHX8 transcription factors
            in the developing upper jaw
  JOURNAL   Gene Expr Patterns 43, 119227 (2022)
   PUBMED   34861428
REFERENCE   2  (bases 1 to 5292)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   3  (bases 1 to 5292)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5292)
  AUTHORS   Wan,Y., Rogers,M.B. and Szabo-Rogers,H.L.
  TITLE     A six-gene expression toolbox for the glands, epithelium and
            chondrocytes in the mouse nasal cavity
  JOURNAL   Gene Expr Patterns 27, 46-55 (2018)
   PUBMED   29122676
REFERENCE   5  (bases 1 to 5292)
  AUTHORS   Siletti,K., Tarchini,B. and Hudspeth,A.J.
  TITLE     Daple coordinates organ-wide and cell-intrinsic polarity to pattern
            inner-ear hair bundles
  JOURNAL   Proc Natl Acad Sci U S A 114 (52), E11170-E11179 (2017)
   PUBMED   29229865
REFERENCE   6  (bases 1 to 5292)
  AUTHORS   Okabe,Y., Sano,T. and Nagata,S.
  TITLE     Regulation of the innate immune response by threonine-phosphatase
            of Eyes absent
  JOURNAL   Nature 460 (7254), 520-524 (2009)
   PUBMED   19561593
  REMARK    GeneRIF: that Eyes absent 4 (EYA4), originally identified as a
            co-transcription factor, stimulates the expression of IFN-beta and
            CXCL10 in response to the undigested DNA of apoptotic cells
REFERENCE   7  (bases 1 to 5292)
  AUTHORS   Depreux,F.F., Darrow,K., Conner,D.A., Eavey,R.D., Liberman,M.C.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Eya4-deficient mice are a model for heritable otitis media
  JOURNAL   J Clin Invest 118 (2), 651-658 (2008)
   PUBMED   18219393
  REMARK    GeneRIF: Eya4(-/-) mice developed otitis media with effusion;
            anatomic studies revealed abnormal middle ear cavity and eustachian
            tube dysmorphology.
REFERENCE   8  (bases 1 to 5292)
  AUTHORS   Zhang,Y., Knosp,B.M., Maconochie,M., Friedman,R.A. and Smith,R.J.
  TITLE     A comparative study of Eya1 and Eya4 protein function and its
            implication in branchio-oto-renal syndrome and DFNA10
  JOURNAL   J Assoc Res Otolaryngol 5 (3), 295-304 (2004)
   PUBMED   15492887
  REMARK    GeneRIF: constructs of the homologous region ( Eya1HR and Eya4HR)
            interact with Six1 prey constructs, although no interaction with
            Dach1 prey was demonstrable
REFERENCE   9  (bases 1 to 5292)
  AUTHORS   Komada,M., McLean,D.J., Griswold,M.D., Russell,L.D. and Soriano,P.
  TITLE     E-MAP-115, encoding a microtubule-associated protein, is a retinoic
            acid-inducible gene required for spermatogenesis
  JOURNAL   Genes Dev 14 (11), 1332-1342 (2000)
   PUBMED   10837026
REFERENCE   10 (bases 1 to 5292)
  AUTHORS   Borsani,G., DeGrandi,A., Ballabio,A., Bulfone,A., Bernard,L.,
            Banfi,S., Gattuso,C., Mariani,M., Dixon,M., Donnai,D., Metcalfe,K.,
            Winter,R., Robertson,M., Axton,R., Brown,A., van Heyningen,V. and
            Hanson,I.
  TITLE     EYA4, a novel vertebrate gene related to Drosophila eyes absent
  JOURNAL   Hum Mol Genet 8 (1), 11-23 (1999)
   PUBMED   9887327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041625.1, CD348600.1, AA738596.1, AC113497.6 and AK045060.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_001347372.2.
            
            On Nov 24, 2016 this sequence version replaced XM_006512522.3.
            
            Transcript Variant: This variant (2) contains a shorter 5' UTR and
            uses an alternate in-frame exon in the 3' coding region compared to
            variant 1. The encoded isoform (2) is the same length, but contains
            a distinct internal segment compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120899.1, SRR17253013.3071569.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1268              AK041625.1         15-1282
            1269-1925           CD348600.1         1-657
            1926-2068           AA738596.1         305-447
            2069-2567           AK041625.1         2083-2581
            2568-2568           AC113497.6         96786-96786
            2569-3137           AK041625.1         2583-3151
            3138-3138           AC113497.6         97356-97356
            3139-4086           AK041625.1         3153-4100
            4087-4750           AC113497.6         98305-98968
            4751-5291           AK045060.1         155-695
            5292-5292           AC113497.6         99510-99510
FEATURES             Location/Qualifiers
     source          1..5292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 10.44 cM"
     gene            1..5292
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /note="EYA transcriptional coactivator and phosphatase 4"
                     /db_xref="GeneID:14051"
                     /db_xref="MGI:MGI:1337104"
     exon            1..129
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..228
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2046
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2; eyes
                     absent homolog 4; eyes absent 4 homolog"
                     /codon_start=1
                     /product="eyes absent homolog 4 isoform 2"
                     /protein_id="NP_001334301.1"
                     /db_xref="CCDS:CCDS83687.1"
                     /db_xref="GeneID:14051"
                     /db_xref="MGI:MGI:1337104"
                     /translation="MEDTQDLNEQSVKKTCPEADVSEPQNSRSMEMQDLASPHALVGG
                     SDTPGSSKLDKSGLSSTSVTTNGTGVSLLAVKTEPLHSSESTTTTGDGALDTFTGSVI
                     TSSGYSPRSAQQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQ
                     TGQPYSLPAYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMP
                     GSSFAPSSTIYANNSVSNSTNFSSSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNT
                     ADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRK
                     NNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFN
                     LADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRG
                     GVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALK
                     SLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIV
                     SRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEYL"
     exon            229..278
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..403
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            404..496
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..563
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            564..706
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            707..850
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            851..930
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1096
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1233
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1317
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1407
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1466
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1627
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1742
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1864
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1965
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..5292
                     /gene="Eya4"
                     /gene_synonym="B130023L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacagcg cgaagggaaa acttagacac tggaaggaaa gcgagtaaat acgtagatcg
       61 gacccgcaga tcactggctg ggacagacaa ttgaacttcg ggagtccaag gcggtccggg
      121 ccgccagaga tagtcaagtt tgaatccaag gaagctgctt ctgcgtggca gtggcaagag
      181 aagttagaga accacatgga agacacccag gacctaaatg agcaatctgt aaagaaaacg
      241 tgcccagaag cagatgtttc ggaacctcag aattccaggt ctatggaaat gcaagaccta
      301 gcaagtcccc atgccttggt tggaggcagt gatacacctg ggagctccaa gctggataaa
      361 tctggtctca gcagcacttc agtcacaaca aatgggacag gagtgtctct tcttgcagtc
      421 aaaacagagc ccttgcacag cagtgagtcc actaccacga ctggagatgg agcgcttgac
      481 acttttactg ggtcagtaat aacaagcagc ggctacagcc ccaggtcggc gcagcagtac
      541 tctccacagc tgtacccctc caagccctat ccacacattc tttctacacc agcagctcaa
      601 acaatgtcgg cctatgcagg ccagactcag tactctggga tgcagcagcc ggccgtctac
      661 acagcctact cgcagacagg acagccctac agcctgcctg cctacgatct tggtgtgatg
      721 ttgccagcca tcaagacgga aagtgggctt tcccaaactc agtccccgtt acagagtggc
      781 tgcctgagct acagccctgg gttttctacc ccacagccag gccagacgcc ttactcttac
      841 caaatgccag gttccagctt tgcaccatcg tctactattt atgcaaataa ttccgtttct
      901 aattcaacaa acttcagcag ctcacagcag gattacccat cctacacagc ctttggccaa
      961 aaccaatatg ctcagtatta ctcagcatca acctatgggg catacatgac atcaaacaac
     1021 acagctgacg gcacatcatc gtcaacatca acttatcagc tgcaggaatc tctccaagga
     1081 ctgactagcc aaccaggaga gtttgataca gtgcagagtc cctccacacc aatcaaagat
     1141 ctcgatgaca gaacatgtag aagttctggg tcaaagtctc gaggaagagg ccggaaaaat
     1201 aatccctccc cacctccgga cagtgaccta gagcgtgtgt ttgtctggga cttggatgaa
     1261 accatcatcg tcttccactc tctcctcacg ggctcttatg cacagaagta tggcaaggat
     1321 cccccaatgg ctgtgactct cgggctccgg atggaagaaa tgatctttaa tcttgcagat
     1381 acacatttgt tttttaatga cttagaggag tgtgatcaag ttcatataga tgatgtttcc
     1441 tccgacgaca atggtcagga cttaagtacc tacagttttg caactgatgg cttccatgca
     1501 gctgcaagta gtgcgaacct ttgtttgcca acaggtgtga gaggaggagt ggactggatg
     1561 aggaagctgg cttttcgtta cagaagagta aaggaattat ataacaccta caagaacaat
     1621 gttggaggac tccttggccc tgctaagagg gatgcatggc tgcagttaag ggcagagatc
     1681 gaaggcctaa cagattcctg gctaacgaat gcacttaagt ctttatcaat tattagtact
     1741 aggagtaact gtgtaaatgt cttggtaacg acaacccagc tgattcctgc tcttgcaaaa
     1801 gtcctgctct acagcctagg aggtgctttc cccattgaga acatttacag cgcaacgaaa
     1861 ataggcaagg aaagctgttt tgagcgtata gtgtccagat ttggcactaa cataacttat
     1921 gttgtgattg gagatggccg ggatgaggag cacgctgcta accagcacaa catgcccttt
     1981 tggaggatat caagccactc ggacctcttg gctctacatc aagcactgga attagagtat
     2041 ttgtaactgt attctctagc tggggatcca ttgtttttat atttcaagta cactgtattt
     2101 ttatgtgtga tccaatgccg ctggcttctt ctacacatat taatggtctt aacggatgaa
     2161 atcatactcg gaatgaaaac tccagagtga agaattcagg ttgctgaatg gaattaaact
     2221 ttagtgctac agaaaggaag ctctatggtc ttattatctt tacaatactt tcatggttta
     2281 aaacataata ataacaaaaa tctgtggcag ttgctgacat gtatcgagtg agtcctaaca
     2341 agaattaaca gctttagtac agaactcgaa ccctcccgag ccacagcatc tgctctgcct
     2401 ctgacaaggt ggttgaaaac attcctcaaa atgggagctc ttctcaaccc tgaggtttga
     2461 atctgactta tagcctacct agcccagaaa atctgaatcg gaatgcactc agactgtata
     2521 acgacagtcc tatctagacc tataatttgt gtaaattatt gatggaaata atttactgtg
     2581 actttattag cagctgactc tgaaagtgga tgcaattttt cttttatttg tcagggtggg
     2641 aaaagggctg gggaaatggg aatataatat tgtctctttt ataagtttgg caaagagaat
     2701 gttcatactg atgtgttgtg ccttaaagac aagacagcat ttgtgtgtta caatgtaact
     2761 ttgactaaag tctctgtagt taatgaaata caaaatcaaa caaacaaaac aaacaagcaa
     2821 acaaaaacct ttgtgataat tcttcacatg accaaattta aaattcaaga tattagttta
     2881 acgtggaaac atcaacaaac tgaatatttg ttaaaaggag aaaccagtaa caataataat
     2941 acaagaaagc ttgcatttta attgggttct aaacgattcc agtattcagt atatgccaat
     3001 tatctgaaca ctcaatcata agcagatttg ggagactatg ggttctttat ttagagagtg
     3061 aaatatatat atattctcaa gtgtcctctc ttacagtttt ctgggaggaa attaagagcc
     3121 atgttcatat caacataccc aattttagtt taagactgga tatgtgccag ttgctaaggg
     3181 gacaatatca tggtgcacat ttagcaaata tcatcaaagt catttttaga acatgctatg
     3241 gaatgaatgt agcttaaaac acacattgag taggcacagc agattgcatt tgtctttcat
     3301 gctgttgcaa aagcaaatat catcagtgat agaaggcagg tatactagat agctctcaag
     3361 aaaaaaatca gaatctatga atattttata taatatcatc ttaagttaat tatcaaacaa
     3421 gctctatgtt gacaacatca ccatatcaca acagtaaaag ggtattcgct ctccttgaac
     3481 acaccagccc agggtcttcc cgttacagac aggaatacat tggtttcttc ctgtatggtt
     3541 gctgaacaat tgcctgcatt cattcctggg agagcctggc tgcattgtgt ctgcctgtct
     3601 ttttgtcttg ttggtgtata gcccatactg gtaacacaat acagattctc ctgtcgtttc
     3661 ttatgacatg gtttgccttg tggaaattta agacttcaag aaggaaaata ttctaatggt
     3721 gtgagtgcct gaatctctct gcattctgaa tgacatgaaa tggacccacg agtccagctc
     3781 ttaatctcat ctgaggctgc ttcataagag gtcatcatct gaggcttttg caacttaaat
     3841 aaggccaaca ttttgctcaa agatcacaga gaatactctg gagggatgta tttctttaga
     3901 gaatgctgtg gccctgttta caaatgggta gattgaagat aattctgcat aagataggga
     3961 ctccttatct aagtccttac tttttaaatg tgtcttttgg ttaccctttc cccaatgcta
     4021 tggtggcaaa atatggttgg aatattttaa tactaatatc attaataata aattttatac
     4081 tcctctggtc ttcagcttga aagtaattaa aaggtcaaag attttccttt ttattactgg
     4141 aactcattcg tatttagtac tactactaaa accaagttag tttggcacac agccaatttc
     4201 tttcattgat agacttcatg tctctacatc aaaagttaaa actcttcttg aaatctgatg
     4261 aacagggctt cttagagtgc tccacttgag ggacagagag gcacactctt tccaaatgcc
     4321 caaggactgg ctgttggcct cctccttgct ccagtttatc catccccctt ttccggccct
     4381 gcatatctgt taagggaagg cagccagtgt aatacctaca agtgaggctg atggaaaaca
     4441 gattgttcag cacaacaatg gtgacagcca gaaagccatg gcccagccta gtcatgtcac
     4501 ctgagcaggg tcaaactaca actcttctct tcccacctta ggacaggaaa atgctctatc
     4561 tttctaaaaa cacatcagac aaacagcaat aaaaaataaa taaaataaaa ataaaaaacc
     4621 agccctgcgg gcagttccta ccttctattt ttatgtagaa tatcgtgcct tattataaat
     4681 gagtttgaaa actgctctcc aaccagatgg ggtttgggct attactattc aagcttggta
     4741 tgatattaga aaaaaaaata actgccttat attgcacctt aaaaatatca agaccctatc
     4801 acttgagtaa gaaactaggt ggcctaacta caacattata gcatacatct aagatgatta
     4861 aaaaccccga agaaatgtgc aaatccaatt cagaggtaaa aataagattt taagattata
     4921 tggtctgtgt acaaaaatag gtactaactg tctggcgagc taagatcaaa atagcttcaa
     4981 cagcacaccc tactgtgaag tttgttttgt aaagcctact cgttggtgac aagcctacat
     5041 tctctgtgaa tatggcgttt agtatttctt ttcaacacaa acctaagcct catgagccaa
     5101 agttgcattt tgactcccag ctatggtggc gttttaggga atctcacagt caaagtcaaa
     5161 ggtttctgtt atgtattagt aaagtataga ttattggggc ctacataatt taaagaaatg
     5221 taaattaata ttaaaagctt gtaaaaatat gtacatcttt actatttctc aataaatacc
     5281 tttgcaactg ta
//
