LOCUS       NM_010165               2512 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus EYA transcriptional coactivator and phosphatase 2
            (Eya2), transcript variant 1, mRNA.
ACCESSION   NM_010165
VERSION     NM_010165.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Zhang,T. and Xu,P.X.
  TITLE     The role of Eya1 and Eya2 in the taste system of mice from
            embryonic stage to adulthood
  JOURNAL   Front Cell Dev Biol 11, 1126968 (2023)
   PUBMED   37181748
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Zhang,T., Xu,J. and Xu,P.X.
  TITLE     Eya2 expression during mouse embryonic development revealed by
            Eya2lacZ knockin reporter and homozygous mice show mild hearing
            loss
  JOURNAL   Dev Dyn 250 (10), 1450-1462 (2021)
   PUBMED   33715274
  REMARK    GeneRIF: Eya2 expression during mouse embryonic development
            revealed by Eya2(lacZ) knockin reporter and homozygous mice show
            mild hearing loss.
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   Furuta,Y. and Hogan,B.L.
  TITLE     BMP4 is essential for lens induction in the mouse embryo
  JOURNAL   Genes Dev 12 (23), 3764-3775 (1998)
   PUBMED   9851982
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Xu,P.X., Cheng,J., Epstein,J.A. and Maas,R.L.
  TITLE     Mouse Eya genes are expressed during limb tendon development and
            encode a transcriptional activation function
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11974-11979 (1997)
   PUBMED   9342347
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Duncan,M.K., Kos,L., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Tomarev,S.I.
  TITLE     Eyes absent: a gene family found in several metazoan phyla
  JOURNAL   Mamm Genome 8 (7), 479-485 (1997)
   PUBMED   9195991
  REMARK    Erratum:[Mamm Genome 1997;8(11):877]
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Zimmerman,J.E., Bui,Q.T., Steingrimsson,E., Nagle,D.L., Fu,W.,
            Genin,A., Spinner,N.B., Copeland,N.G., Jenkins,N.A., Bucan,M. and
            Bonini,N.M.
  TITLE     Cloning and characterization of two vertebrate homologs of the
            Drosophila eyes absent gene
  JOURNAL   Genome Res 7 (2), 128-141 (1997)
   PUBMED   9049631
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Xu,P.X., Woo,I., Her,H., Beier,D.R. and Maas,R.L.
  TITLE     Mouse Eya homologues of the Drosophila eyes absent gene require
            Pax6 for expression in lens and nasal placode
  JOURNAL   Development 124 (1), 219-231 (1997)
   PUBMED   9006082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591712.18.
            
            On Oct 27, 2022 this sequence version replaced NM_010165.3.
            
            Summary: This gene encodes a member of the eyes absent protein
            family. The encoded protein is a tyrosine phosphatase which acts as
            a transcriptional activator during development. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2012].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003755.1, SRR13861890.207211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AL591712.18        14213-14504
            293-393             AL591712.18        23755-23855
            394-439             AL591712.18        41806-41851
            440-582             AL591712.18        44518-44660
            583-699             AL591712.18        46588-46704
            700-767             AL591712.18        72474-72541
            768-945             AL591712.18        74920-75097
            946-1088            AL591712.18        83643-83785
            1089-1172           AL591712.18        90522-90605
            1173-1262           AL591712.18        113410-113499
            1263-1321           AL591712.18        120873-120931
            1322-1482           AL591712.18        122666-122826
            1483-1597           AL591712.18        125184-125298
            1598-1719           AL591712.18        126006-126127
            1720-1820           AL591712.18        128194-128294
            1821-2512           AL591712.18        130003-130694
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.83 cM"
     gene            1..2512
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /note="EYA transcriptional coactivator and phosphatase 2"
                     /db_xref="GeneID:14049"
                     /db_xref="MGI:MGI:109341"
     exon            1..292
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..393
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..439
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..582
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..699
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..767
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..945
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1088
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1172
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1262
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1321
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1482
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1597
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1719
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1820
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2512
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /note="hexamer: AATAAA"
     polyA_site      2418
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /note="major polyA site"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /note="hexamer: AATAAA"
     polyA_site      2512
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /note="major polyA site"
ORIGIN      
        1 cctagtagga atgactcaca agctgccagt gccagggctt ggctcagacc tgaacctggg
       61 tatagtcacc tattgggaga cacggatccg ggactctctc tcattccacg ggctcactgg
      121 gaacactgga ggaaacagat ccaggcaatt gcctggaatg taatggcgct ctccatgaaa
      181 gagctgtgac tcgaatgtta ggttttttct gactttgcaa attctcagag ctcatggtga
      241 aggtcaaccc cttctgcaca ggagcccgga gctagaacaa gcagcaggaa aggtacaagg
      301 caatgttaga agtggtgacc tcacccagcc tcgcaacaag cagtgactgg agcgagcacg
      361 gtgctgccgt ggggacgctg agtgacaggg aaggcatcgc caaatcagcg gctctgagtg
      421 tgcctcagct ctttgtgaag tctcatccac gtgtccctcc tggtcagtcc tccacagcca
      481 tggcggccta tggccagaca cagtacagca caggcattca gcaggcacca ccctatacag
      541 cgtacccaac tccggcgcaa gcctatggaa tcccccctta cagcatcaag acagaagaca
      601 gtttgaatca ctcccccagc cagagcgggt tcctgagcta tggaccgagc ttcagcaccg
      661 cgcctgctgg acagagcccc tacacctacc ccgtgcacag caccgctggg ctctatcaag
      721 gcgccaacgg actgaccaac accgctggat ttgggagcgt gcaccaggat tatccgtcct
      781 accccagctt ttcacagaac cagtaccccc agtatttcag cccatcatac aacccgccct
      841 acgtccctgc cagcagcctc tgctcctcgc ccctctccac gtccacctac gtcctccagg
      901 aggctcctca caatgtcccc agccagagtt ctgagtccct ggccggagac tacaacacac
      961 acaacggacc ctccacacca gcaaaggagg gtgacacaga gaggccacat cgagcctcgg
     1021 atgggaagct acggggccgg tcaaagagaa atagtgaccc ttccccagca ggagacaatg
     1081 aaatcgagcg cgtgttcgtc tgggacctgg acgagacaat cattatcttc cactccctgc
     1141 tcacagggac gtttgcatcc agatacggga aggacaccac gacgtctgtg cgcattggcc
     1201 tgatgatgga ggagatgatc ttcaaccttg ctgacacaca cctgttcttc aatgacctgg
     1261 aggactgtga ccaaatccac gtggatgatg tctcatccga tgacaatggt caggatttaa
     1321 gcacatacaa cttctccact gatggcttcc acagcacggc gccaggagcc agcttgtgcc
     1381 tgggtacagg tgttcatggc ggtgtggact ggatgaggaa actggccttc cgctaccgtc
     1441 gtgtgaagga gatgtacaac acctaccgca acaacgtggg tggcttgata ggtgctccca
     1501 aaagagagac ctggctgcag ctgcgcgccg agctggaggc cctgactgac ctctggctca
     1561 cccactccct gaaagccctc aatctcatca actctcgacc caactgtgtc aatgtgttgg
     1621 tcaccaccac gcaactgatc cctgcattgg ccaaggtcct gctgtacggt ctgggctccg
     1681 tgttccccat cgagaacatc tacagtgcga ccaagacagg caaggagagc tgcttcgaaa
     1741 gaatcatgca gaggtttggc cgcaaagctg tctacattgt gataggcgac ggggtagagg
     1801 aagagcaagg agccaaaaag cacaacatgc ctttctggag gatatcctgt catgctgacc
     1861 tggaggctct aaggcatgcc ctggaactgg agtatctata gcagtgcggg acgcagccac
     1921 cgcctgccac ccaccagcca ggcccctgtc atctcatacc atgagggccc tagacaccag
     1981 aaactagcta ggggccctat acctagggga catgttccac agccatttca gaagtgtctt
     2041 cttcccttgg ggacggagag tcggactctg atatgaaacc cagagaccca aatgagggcg
     2101 ccccagctcg tcttgttctc ctttttaatt tatggactgc acccgttact cccattaccc
     2161 acgggtccct gtgttgtcgt ttctcggctg taggtctggt ttcgggtggt gagtacccag
     2221 tttgtgtttc agagacaatc attctctggg cattggcaag ggaggtggtg tggggctgtg
     2281 gggaagcccg atgtcatgtg gacagtgtgc gtgccttatg ccgccatctt gtgttgtagg
     2341 agagggggac tctgggaagg caagggtact cggccatgat ggataaaggc attcaataaa
     2401 aaccacgttt acattttact tcggaagagt gtggtgacct ttgcccgttg tttaggcttc
     2461 cacgtgctag cttttcaagt tgcaaaaata ataaaaatcc attttgaact tg
//
