LOCUS       NP_034295                532 aa            linear   ROD 25-FEB-2025
DEFINITION  protein phosphatase EYA2 [Mus musculus].
ACCESSION   NP_034295
VERSION     NP_034295.1
DBSOURCE    REFSEQ: accession NM_010165.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 532)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (residues 1 to 532)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 532)
  AUTHORS   Zhang,T. and Xu,P.X.
  TITLE     The role of Eya1 and Eya2 in the taste system of mice from
            embryonic stage to adulthood
  JOURNAL   Front Cell Dev Biol 11, 1126968 (2023)
   PUBMED   37181748
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 532)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   5  (residues 1 to 532)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 532)
  AUTHORS   Furuta,Y. and Hogan,B.L.
  TITLE     BMP4 is essential for lens induction in the mouse embryo
  JOURNAL   Genes Dev 12 (23), 3764-3775 (1998)
   PUBMED   9851982
REFERENCE   7  (residues 1 to 532)
  AUTHORS   Xu,P.X., Cheng,J., Epstein,J.A. and Maas,R.L.
  TITLE     Mouse Eya genes are expressed during limb tendon development and
            encode a transcriptional activation function
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11974-11979 (1997)
   PUBMED   9342347
REFERENCE   8  (residues 1 to 532)
  AUTHORS   Duncan,M.K., Kos,L., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Tomarev,S.I.
  TITLE     Eyes absent: a gene family found in several metazoan phyla
  JOURNAL   Mamm Genome 8 (7), 479-485 (1997)
   PUBMED   9195991
  REMARK    Erratum:[Mamm Genome 1997;8(11):877]
REFERENCE   9  (residues 1 to 532)
  AUTHORS   Zimmerman,J.E., Bui,Q.T., Steingrimsson,E., Nagle,D.L., Fu,W.,
            Genin,A., Spinner,N.B., Copeland,N.G., Jenkins,N.A., Bucan,M. and
            Bonini,N.M.
  TITLE     Cloning and characterization of two vertebrate homologs of the
            Drosophila eyes absent gene
  JOURNAL   Genome Res 7 (2), 128-141 (1997)
   PUBMED   9049631
REFERENCE   10 (residues 1 to 532)
  AUTHORS   Xu,P.X., Woo,I., Her,H., Beier,D.R. and Maas,R.L.
  TITLE     Mouse Eya homologues of the Drosophila eyes absent gene require
            Pax6 for expression in lens and nasal placode
  JOURNAL   Development 124 (1), 219-231 (1997)
   PUBMED   9006082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591712.18.
            
            Summary: This gene encodes a member of the eyes absent protein
            family. The encoded protein is a tyrosine phosphatase which acts as
            a transcriptional activator during development. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2012].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003755.1, SRR13861890.207211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.83 cM"
     Protein         1..532
                     /product="protein phosphatase EYA2"
                     /EC_number="3.1.3.48"
                     /note="eyes absent homolog 2; eyes absent 2 homolog"
                     /calculated_mol_wt=58115
     Region          <54..>262
                     /region_name="PTZ00395"
                     /note="Sec24-related protein; Provisional"
                     /db_xref="CDD:185594"
     Region          202..258
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08575.1)"
     Region          261..532
                     /region_name="HAD_Eya"
                     /note="protein tyrosine phosphatase domain of the nuclear
                     transcription factor of Eyes absent (Eya) and related
                     phosphatase domains; cd02601"
                     /db_xref="CDD:319789"
     Site            order(263,490,492,508,510..513,519,522,525..526,529..532)
                     /site_type="other"
                     /note="SIX1 interface [polypeptide binding]"
                     /db_xref="CDD:319789"
     Site            order(268..272,362..363,471,495..496,500..501)
                     /site_type="active"
                     /db_xref="CDD:319789"
     CDS             1..532
                     /gene="Eya2"
                     /gene_synonym="Eab1"
                     /coded_by="NM_010165.4:303..1901"
                     /db_xref="CCDS:CCDS17084.1"
                     /db_xref="GeneID:14049"
                     /db_xref="MGI:MGI:109341"
ORIGIN      
        1 mlevvtspsl atssdwsehg aavgtlsdre giaksaalsv pqlfvkshpr vppgqsstam
       61 aaygqtqyst giqqappyta yptpaqaygi ppysikteds lnhspsqsgf lsygpsfsta
      121 pagqspytyp vhstaglyqg angltntagf gsvhqdypsy psfsqnqypq yfspsynppy
      181 vpasslcssp lststyvlqe aphnvpsqss eslagdynth ngpstpakeg dterphrasd
      241 gklrgrskrn sdpspagdne iervfvwdld etiiifhsll tgtfasrygk dtttsvrigl
      301 mmeemifnla dthlffndle dcdqihvddv ssddngqdls tynfstdgfh stapgaslcl
      361 gtgvhggvdw mrklafryrr vkemyntyrn nvggligapk retwlqlrae lealtdlwlt
      421 hslkalnlin srpncvnvlv tttqlipala kvllyglgsv fpieniysat ktgkescfer
      481 imqrfgrkav yivigdgvee eqgakkhnmp fwrischadl ealrhalele yl
//
