LOCUS       NM_001402659            4200 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus EYA transcriptional coactivator and phosphatase 1
            (Eya1), transcript variant 4, mRNA.
ACCESSION   NM_001402659 XM_011238344
VERSION     NM_001402659.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Huang,B., Zeng,Z., Kim,S., Fausto,C.C., Koppitch,K., Li,H., Li,Z.,
            Chen,X., Guo,J., Zhang,C.C., Ma,T., Medina,P., Schreiber,M.E.,
            Xia,M.W., Vonk,A.C., Xiang,T., Patel,T., Li,Y., Parvez,R.K.,
            Der,B., Chen,J.H., Liu,Z., Thornton,M.E., Grubbs,B.H., Diao,Y.,
            Dou,Y., Gnedeva,K., Ying,Q., Pastor-Soler,N.M., Fei,T.,
            Hallows,K.R., Lindstrom,N.O., McMahon,A.P. and Li,Z.
  TITLE     Long-term expandable mouse and human-induced nephron progenitor
            cells enable kidney organoid maturation and modeling of plasticity
            and disease
  JOURNAL   Cell Stem Cell 31 (6), 921-939 (2024)
   PUBMED   38692273
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Xu,M., Li,S., Xie,X., Guo,L., Yu,D., Zhuo,J., Lin,J., Kol,L. and
            Gan,L.
  TITLE     ISL1 and POU4F1 Directly Interact to Regulate the Differentiation
            and Survival of Inner Ear Sensory Neurons
  JOURNAL   J Neurosci 44 (8), e1718232024 (2024)
   PUBMED   38267260
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4200)
  AUTHORS   Zhang,T. and Xu,P.X.
  TITLE     The role of Eya1 and Eya2 in the taste system of mice from
            embryonic stage to adulthood
  JOURNAL   Front Cell Dev Biol 11, 1126968 (2023)
   PUBMED   37181748
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4200)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   6  (bases 1 to 4200)
  AUTHORS   Bulfone,A., Gattuso,C., Marchitiello,A., Pardini,C., Boncinelli,E.,
            Borsani,G., Banfi,S. and Ballabio,A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
REFERENCE   7  (bases 1 to 4200)
  AUTHORS   Xu,P.X., Cheng,J., Epstein,J.A. and Maas,R.L.
  TITLE     Mouse Eya genes are expressed during limb tendon development and
            encode a transcriptional activation function
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11974-11979 (1997)
   PUBMED   9342347
REFERENCE   8  (bases 1 to 4200)
  AUTHORS   Duncan,M.K., Kos,L., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Tomarev,S.I.
  TITLE     Eyes absent: a gene family found in several metazoan phyla
  JOURNAL   Mamm Genome 8 (7), 479-485 (1997)
   PUBMED   9195991
  REMARK    Erratum:[Mamm Genome 1997;8(11):877]
REFERENCE   9  (bases 1 to 4200)
  AUTHORS   Abdelhak,S., Kalatzis,V., Heilig,R., Compain,S., Samson,D.,
            Vincent,C., Weil,D., Cruaud,C., Sahly,I., Leibovici,M.,
            Bitner-Glindzicz,M., Francis,M., Lacombe,D., Vigneron,J.,
            Charachon,R., Boven,K., Bedbeder,P., Van Regemorter,N.,
            Weissenbach,J. and Petit,C.
  TITLE     A human homologue of the Drosophila eyes absent gene underlies
            branchio-oto-renal (BOR) syndrome and identifies a novel gene
            family
  JOURNAL   Nat Genet 15 (2), 157-164 (1997)
   PUBMED   9020840
REFERENCE   10 (bases 1 to 4200)
  AUTHORS   Xu,P.X., Woo,I., Her,H., Beier,D.R. and Maas,R.L.
  TITLE     Mouse Eya homologues of the Drosophila eyes absent gene require
            Pax6 for expression in lens and nasal placode
  JOURNAL   Development 124 (1), 219-231 (1997)
   PUBMED   9006082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119875.7 and AC156988.6.
            
            On Mar 21, 2022 this sequence version replaced XM_011238344.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1844383.1,
                                           SRR7345562.1858328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AC119875.7         16467-16870
            405-454             AC119875.7         22042-22091
            455-582             AC119875.7         23619-23746
            583-660             AC119875.7         43318-43395
            661-730             AC119875.7         51913-51982
            731-876             AC119875.7         52306-52451
            877-1014            AC119875.7         55674-55811
            1015-1097           AC119875.7         73414-73496
            1098-1284           AC119875.7         73902-74088
            1285-1424           AC156988.6         132711-132850       c
            1425-1508           AC156988.6         130791-130874       c
            1509-1598           AC156988.6         110193-110282       c
            1599-1657           AC156988.6         85924-85982         c
            1658-1818           AC156988.6         85647-85807         c
            1819-1933           AC156988.6         84679-84793         c
            1934-2055           AC156988.6         84455-84576         c
            2056-2156           AC156988.6         80778-80878         c
            2157-4200           AC156988.6         70251-72294         c
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.31 cM"
     gene            1..4200
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /note="EYA transcriptional coactivator and phosphatase 1"
                     /db_xref="GeneID:14048"
                     /db_xref="MGI:MGI:109344"
     exon            1..404
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            405..454
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            455..582
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..2237
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 4 is encoded by transcript variant 4; eyes
                     absent homolog 1; eyes absent 1 homolog; protein
                     phosphatase EYA1"
                     /codon_start=1
                     /product="protein phosphatase EYA1 isoform 4"
                     /protein_id="NP_001389588.1"
                     /db_xref="GeneID:14048"
                     /db_xref="MGI:MGI:109344"
                     /translation="MEMQDLTSPHSRLSGSSESPSGPKLDSSHINSTSMTPNGTEVKT
                     EPMSSSEIASTAADGSLDSFSGSALGSSSFSPRPAHPFSPPQIYPSNRSYPHILPTPS
                     SQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGALWAGIKTESGLSQSQSPGQ
                     TGFLSYGTSFGTPQPGQAPYSYQMQGSSFTTSSGLYSGNNSLTNSSGFNSSQQDYPSY
                     PGFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGVTSQAVTDPTAE
                     YSTIHSPSTPIKETDSERLRRGSDGKSRGRGRRNNNPSPPPDSDLERVFIWDLDETII
                     VFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSS
                     DDNGQDLSTYNFGTDGFPAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKN
                     NVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPA
                     LAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKK
                     HAMPFWRVSSHSDLMALHHALELEYL"
     exon            583..660
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            661..730
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            731..876
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1014
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1097
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1284
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1424
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1508
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1598
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1657
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1818
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1933
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2055
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2156
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..4200
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4174..4179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="Eya1"
                     /gene_synonym="bor"
                     /note="major polyA site"
ORIGIN      
        1 agatgctatc tgccgctgcc gttcgctggg gcgcaaagcc gttcccaaac agaccgcggc
       61 gagctgatgg ctccgagctt gcggcgaggt agcgagtgtg cagggccact tccgactgga
      121 agccttcctg tggcggtgcg cggtggcggg gtccttcctg gggaaggcga tcgcgctcag
      181 tcgctccaca gcccgagcct gcagcagcgc ccgggcgcag tccccgggag ccgggcaatc
      241 cccggcctct gcgctccgct gccagccgcg tcacagcgcc tctgagagct cccgggtccc
      301 cgtgttcctg cacagcagcc aaactatgtc aggaatggag gtctgctaac acagaaaact
      361 ccaaggagca cactaaaccg gtggaggcag cagatgtgag cgctgtgcga acgtctcaca
      421 gcagttccga tgttgctctt tcctcaagtt gcaggtctat ggaaatgcag gatctaacca
      481 gcccgcatag ccgactgagt ggtagtagcg aatcccccag tggtcccaaa ctcgatagct
      541 ctcatataaa tagtacttcc atgactccca atggcaccga agttaaaaca gagccaatga
      601 gcagcagtga aatagcttca acagcagcag acgggtcttt agacagtttc tcaggttcag
      661 ctctcggaag cagcagcttt agtccaagac cagctcaccc gttctctcca ccacagattt
      721 atccttccaa cagatcatac ccacatattc tccctacccc ttcctcacaa actatggctg
      781 catatgggca aacacagttt accacaggaa tgcaacaagc cacagcctac gccacgtacc
      841 cacagcctgg acagccctat ggaatttcct cctatggtgc attgtgggca ggcatcaaga
      901 cggaaagtgg attgtcacag tctcagtcac ctggacagac gggatttctt agctatggca
      961 caagctttgg tacccctcaa cctggacagg caccgtacag ctaccagatg caaggtagca
     1021 gctttaccac gtcatcagga ttatattcag gaaataattc actcaccaac tcctccggat
     1081 tcaacagttc acagcaggac tatccgtctt atcccggctt tggccagggt cagtacgcac
     1141 agtattataa cagctcgccg tatccagcac actacatgac gagcagtaac accagcccga
     1201 ccacaccgtc caccaatgcc acttaccaac tccaggaacc accttctggc gtcacaagtc
     1261 aggcggtcac agaccccaca gcagagtaca gtacaatcca cagtccttcc acacccatta
     1321 aagagactga ctccgagcgg ctgcgtcgag gttcagatgg gaagtcacgt ggccgaggca
     1381 gaagaaacaa taatccctcc cctcccccgg attctgacct tgagagagtg ttcatctggg
     1441 acctggacga gaccatcatt gttttccact ccttgctcac ggggtcctac gccaacagat
     1501 acgggaggga tccacctact tctgtttccc tgggactacg aatggaagag atgattttca
     1561 acttggcaga cacacatcta tttttcaatg acctagaaga gtgtgaccaa gtccatatag
     1621 atgatgtttc atcagacgac aacggccagg acctgagcac atacaacttt ggaacagatg
     1681 gctttcctgc tgcagccacc agtgctaatt tatgcctggc aactggtgtc cgaggtggtg
     1741 tggactggat gcggaaactg gccttccgct acagacgagt aaaagagatc tacaacacct
     1801 acaaaaacaa cgtgggaggt ctgcttggcc cagctaagag ggaagcctgg ctccagctga
     1861 gggctgagat tgaggcactc acagactcct ggctgaccct ggccctgaag gccctctccc
     1921 tcatccactc ccggacgaac tgtgtgaata ttttagtaac aactacgcag ctcatcccag
     1981 cattggcaaa agtcctgcta tatggattag gaattgtgtt tccaatagaa aatatttaca
     2041 gtgcaactaa aataggaaag gaaagctgtt ttgagaggat aatccaaagg tttggaagga
     2101 aagtggtata cgttgtcata ggagatggtg tggaagaaga gcaaggggca aaaaagcatg
     2161 ctatgccctt ctggagggtc tccagtcact cggacctcat ggcactgcat catgccttgg
     2221 aattagagta cctgtaacag cttcctgcca acttgacact gcacaactgc cctgtggcca
     2281 gagataaccc agcaggcttg tcttcttgtg tcagtgctgg acttcaggat gtaccaattt
     2341 cagcatatgg atgcatagct gctgcgggct tgactgctac cctcggggtt aatggaggac
     2401 catgtgtatt cttcagaaca gctgttgact ctagtactgt gaatccagtg aaagtaagcc
     2461 atgagaatgt tctcacacag tgtggtgtgt cttggctaca ttaactacat ggttcaaacc
     2521 tgtgaagaaa agacctacag acactttggt tttcggcaaa tgtgatacaa acagcgtctg
     2581 tgatccagca aacttgatcc cacaacaaag actcccacgc gtcacctgga caaccatgga
     2641 gctattttat tttctcagag gttcactttt tggtgtcccc cacccagggc aatctgtact
     2701 tcgctactta tttatgaaaa aagactttga aaaaacagat ttgctgaggt ataattcata
     2761 taccatatga ttcaccaaga cagacttctc ggcttcaaat agttgaaggg acaatagcat
     2821 aagaaataat caataaaagg ccttggcctg acagtacagc aagtactttg aattttagca
     2881 cattgcaaaa gtagtttaaa gtatgtctaa tttaaatgtg taaaatgtac atcactgaga
     2941 caatcgtgta cagaaggaat ttttggtgta aatttgtaat aatggatgat tcttacacat
     3001 tctgtttagg gaatgctatt atgaggtaga aatgctttcc taggaagctt gggcacaaac
     3061 tcctgcagtg ccttatctaa ggattgggta taaatattgt agataatgga tctttttgat
     3121 aatgttatct aagaccaaaa gcatgaatgt caagtgtcaa caaggatttt attttcttag
     3181 tcttttatcc cattcatttt tctaatttgt gtacgtgagt gtgtgtgtgt gtgtgtgtgt
     3241 gtgtgtgtgt gtgtgtgtat tggttagtta gaagggactt gataaaaata acagtggctc
     3301 acaacttaaa agttttgaag tcttcctgac cacctccccg actttctcat ttcaacacta
     3361 atgtattata tgtaactact tggaaaagaa tgactattca aacacttcat cccacagaaa
     3421 gaatatagat gatagatata ttttattaat aaaattaact ggagcctagc agagtctcca
     3481 tgcactcaga atgattaccg tgtctgggat tcttgtttat atcaacgagg actttactac
     3541 ataactgggt cagcagcact tctcatccca tctcttactc tttccttccc acccagacaa
     3601 ggttcattgc ccgatggtgg gttggtctgg ccatcatcag aaacactaat gttgctctct
     3661 acgtatgaca agacagacat aaacctagag ggtgatggga gaaacacaaa aatgatcatg
     3721 tttgtcatgt tataaaaaag attcttccaa actgatgaat ttgtatacgg tcaggagtct
     3781 ttctcattgt ggtctttgtg ttgccataaa attacccttt ggatcaattt tagtttatat
     3841 tattaagtta ttaataatat tatttaatac tgggggcagc aggtttgacc cagagtagca
     3901 gaaaaaccac cctacttttt tctattctaa aagtccatgt tgctgctaaa attagtcgtt
     3961 ataaattctc taaattgtta aaaatgaata atggaattag tttctcccct gatgcagaca
     4021 gaaatggcca gtgttgagac ctcttcattt gatgctgttg tattctgcag actgaaaaga
     4081 cagccttgac cttggcctta ctgtaaacag gtgtgctgtg tccacgattg tgtacagaac
     4141 tttttttttc ttcattaatg ttgtgtttaa attaataaac ttgatttgtg cagtactgta
//
