LOCUS       NM_001404941            5953 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exostosin-like glycosyltransferase 3 (Extl3),
            transcript variant 6, mRNA.
ACCESSION   NM_001404941
VERSION     NM_001404941.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5953)
  AUTHORS   Shin,J.H., Bozadjieva-Kramer,N., Shao,Y., Lyons-Abbott,S.,
            Rupp,A.C., Sandoval,D.A. and Seeley,R.J.
  TITLE     The gut peptide Reg3g links the small intestine microbiome to the
            regulation of energy balance, glucose levels, and gut function
  JOURNAL   Cell Metab 34 (11), 1765-1778 (2022)
   PUBMED   36240758
REFERENCE   3  (bases 1 to 5953)
  AUTHORS   Wilson,L.F.L., Dendooven,T., Hardwick,S.W., Echevarria-Poza,A.,
            Tryfona,T., Krogh,K.B.R.M., Chirgadze,D.Y., Luisi,B.F., Logan,D.T.,
            Mani,K. and Dupree,P.
  TITLE     The structure of EXTL3 helps to explain the different roles of
            bi-domain exostosins in heparan sulfate synthesis
  JOURNAL   Nat Commun 13 (1), 3314 (2022)
   PUBMED   35676258
  REMARK    GeneRIF: The structure of EXTL3 helps to explain the different
            roles of bi-domain exostosins in heparan sulfate synthesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5953)
  AUTHORS   Sugisawa,E., Kondo,T., Kumagai,Y., Kato,H., Takayama,Y.,
            Isohashi,K., Shimosegawa,E., Takemura,N., Hayashi,Y., Sasaki,T.,
            Martino,M.M., Tominaga,M. and Maruyama,K.
  TITLE     Nociceptor-derived Reg3gamma prevents endotoxic death by targeting
            kynurenine pathway in microglia
  JOURNAL   Cell Rep 38 (10), 110462 (2022)
   PUBMED   35263589
REFERENCE   5  (bases 1 to 5953)
  AUTHORS   Zhang,H., Corredor,A.L.G., Messina-Pacheco,J., Li,Q.,
            Zogopoulos,G., Kaddour,N., Wang,Y., Shi,B.Y., Gregorieff,A.,
            Liu,J.L. and Gao,Z.H.
  TITLE     REG3A/REG3B promotes acinar to ductal metaplasia through binding to
            EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
  JOURNAL   Commun Biol 4 (1), 688 (2021)
   PUBMED   34099862
  REMARK    GeneRIF: REG3A/REG3B promotes acinar to ductal metaplasia through
            binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5953)
  AUTHORS   Takahashi,I., Noguchi,N., Nata,K., Yamada,S., Kaneiwa,T.,
            Mizumoto,S., Ikeda,T., Sugihara,K., Asano,M., Yoshikawa,T.,
            Yamauchi,A., Shervani,N.J., Uruno,A., Kato,I., Unno,M.,
            Sugahara,K., Takasawa,S., Okamoto,H. and Sugawara,A.
  TITLE     Important role of heparan sulfate in postnatal islet growth and
            insulin secretion
  JOURNAL   Biochem Biophys Res Commun 383 (1), 113-118 (2009)
   PUBMED   19336225
REFERENCE   7  (bases 1 to 5953)
  AUTHORS   Levetan,C.S., Upham,L.V., Deng,S., Laury-Kleintop,L., Kery,V.,
            Nolan,R., Quinlan,J., Torres,C. and El-Hajj,R.J.
  TITLE     Discovery of a human peptide sequence signaling islet neogenesis
  JOURNAL   Endocr Pract 14 (9), 1075-1083 (2008)
   PUBMED   19158046
REFERENCE   8  (bases 1 to 5953)
  AUTHORS   Osman,N.M., Naora,H. and Otani,H.
  TITLE     Glycosyltransferase encoding gene EXTL3 is differentially expressed
            in the developing and adult mouse cerebral cortex
  JOURNAL   Brain Res Dev Brain Res 151 (1-2), 111-117 (2004)
   PUBMED   15246697
  REMARK    GeneRIF: EXTL3 expression at different grades in the central and
            peripheral nervous system components including the neural retina
            and neural crest-derived structures at embryonic days (E) 11.5,
            E12.5, E14.5, and E16.5.
REFERENCE   9  (bases 1 to 5953)
  AUTHORS   Osman,N.M., Kagohashi,Y., Udagawa,J. and Otani,H.
  TITLE     Alpha1,4-N-acetylglucosaminyltransferase encoding gene EXTL3
            expression pattern in mouse adult and developing tissues with
            special attention to the pancreas
  JOURNAL   Anat Embryol (Berl) 207 (4-5), 333-341 (2003)
   PUBMED   14618397
  REMARK    GeneRIF: EXTL3 expression is developmentally regulated, and
            contributes to the regulated production of heparan sulfate in
            different adult and embryonic tissues of mice.
REFERENCE   10 (bases 1 to 5953)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155172.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.1173266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC155172.4         252276-252355       c
            81-181              AC155172.4         234654-234754       c
            182-2787            AC155172.4         229863-232468       c
            2788-2915           AC155172.4         220962-221089       c
            2916-3060           AC155172.4         213264-213408       c
            3061-3189           AC155172.4         211110-211238       c
            3190-5953           AC155172.4         206338-209101       c
FEATURES             Location/Qualifiers
     source          1..5953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.86 cM"
     gene            1..5953
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /note="exostosin-like glycosyltransferase 3"
                     /db_xref="GeneID:54616"
                     /db_xref="MGI:MGI:1860765"
     exon            1..80
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     exon            81..181
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     exon            182..2787
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..3399
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /EC_number="2.4.1.223"
                     /note="isoform 1 is encoded by transcript variant 6;
                     exostosin; exostoses-like 3; exostosin-like 3; exostoses
                     (multiple)-like 3; multiple exostosis-like protein 3;
                     glucuronyl-galactosyl-proteoglycan
                     4-alpha-N-acetylglucosaminyltransferase"
                     /codon_start=1
                     /product="exostosin-like 3 isoform 1"
                     /protein_id="NP_001391870.1"
                     /db_xref="GeneID:54616"
                     /db_xref="MGI:MGI:1860765"
                     /translation="MTGYTMLRNGGVGNGGQTCMLRWSNRIRLTWLSFTLFIILVFFP
                     LIAHYYLTTLDEADEAGKRIFGPRAGSELCEVKHVLDLCRIRESVSEELLQLEAKRQE
                     LNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLL
                     PEKDDAGLPPPKVTRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFAFGSYLDPLVKQAF
                     QATVRANVYVTENAAIACLYVVLVGEMQEPTVLRPADLEKQLFSLPHWRTDGHNHVII
                     NLSRKSDTQNLLYNVSTGRAMVAQSTFYAAQYRAGFDLVVSPLVHAMSEPNFMEIPPQ
                     VPVKRKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLD
                     QVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPHLLISSGCATR
                     LFEALEVGAVPVVLGEQVQLPYHDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAM
                     RRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEVAAEIPHRSGKAAGTDPN
                     MADNGDLDLGPVETEPPYASPKYLRNFTLTVTDCYRGWNSAPGPFHLFPHTPFDPVLP
                     SEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVQREQFTVVMLTYEREEVLMNSLER
                     LNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAI
                     LSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
                     LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWT
                     FRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTK
                     CFKFI"
     exon            2788..2915
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3060
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3189
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..5953
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5928..5933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /note="hexamer: AATAAA"
     polyA_site      5949
                     /gene="Extl3"
                     /gene_synonym="2900009G18Rik; Ext1l; mKIAA0519"
                     /note="major polyA site"
ORIGIN      
        1 gcagccggcg gccagagcgg cttgtgggaa gcggactttc acgcaggcaa cggcggtggc
       61 tcgttactga ctggaagccg atcaggagaa caagctctgg tgtccattag ttcaagaaat
      121 cctgtgttga agcataatgt tgctacataa gccagagaaa ggaagagcgc tgccaggtag
      181 ggcctgatcg ttggtagtgg catggaggac ggggctggca tttcagactg ccagctgttt
      241 ttaccagccg ctgcatcact tgaatagaag ctatgcatat tggctggccg acaaagccaa
      301 gggacaaaag ctatggccgt taaaatggtc cctctgagtc cagggctctt tccctggctt
      361 ttagcaccat ggatctcttc cttttcatcc catcagcaat gtggtacctt cttctacttg
      421 atgatgacag ctgatacttc agatttgcct gactaaggtt agaaacctga attgccgtga
      481 ggaagatgaa atttccattt tacttggtgc cttgtgcagg gagcacactg atccttccag
      541 aaacttgtgt gtgaaaagag gttgcgtttt gtcagacaga ctcatggtta tggcgagcga
      601 tccgacgtga tcagagtggg caagaggcac agcgaactca tgacaggcta taccatgttg
      661 cggaatgggg gagtggggaa cggtggtcag acctgtatgc tgcgctggtc caatcgcatc
      721 cggctgacat ggctgagttt cacgctgttc atcatcctcg tcttcttccc cctcattgct
      781 cactattacc tcaccactct ggacgaggca gacgaggctg gcaagcgcat cttcggccct
      841 cgggctggca gtgagctctg tgaggtaaag cacgtcctcg atctctgtcg gattcgtgag
      901 tctgtgagcg aagagcttct acagctcgaa gccaagcggc aggagctgaa cagcgagatt
      961 gccaagctga acctcaagat tgaagcctgt aagaagagca tagagaatgc caagcaggac
     1021 ctgctgcagc tcaagaatgt cattagccag acagagcact cctacaagga gctgatggcc
     1081 cagaaccagc ccaaactgtc cctgcccatc cgactgctcc ccgagaagga cgatgccggc
     1141 cttccacccc ccaaggtcac tcggggttgc cgccttcaca actgctttga ttactctcgt
     1201 tgtcctctga cgtctggctt tcccgtctac gtctatgaca gtgaccagtt tgcctttggg
     1261 agctacctgg accctttggt caagcaggct tttcaggcta cagtgagagc caacgtttat
     1321 gttacagaaa atgcggccat cgcctgcctg tatgtggtgt tagtgggaga aatgcaagag
     1381 cccactgtgc tgcggcctgc cgaccttgaa aagcagctgt tttctctgcc acactggagg
     1441 acagatgggc acaaccacgt cattatcaac ctgtcccgga agtcagacac acagaatcta
     1501 ctgtacaacg tcagtacagg ccgggccatg gtggcccagt ccaccttcta tgctgcccag
     1561 tacagagctg gctttgacct ggtcgtgtca ccccttgtcc atgctatgtc tgaacccaac
     1621 ttcatggaaa tcccaccgca ggtgccagtt aagcggaaat atctcttcac tttccagggc
     1681 gagaagatcg agtctctgag atctagcctt caggaggccc gttccttcga ggaagagatg
     1741 gagggcgacc ctccggccga ctatgacgat cgcatcattg ccaccctaaa ggccgtacag
     1801 gacagcaagc tggatcaggt gctggtagaa ttcacttgca aaaaccagcc gaagcccagc
     1861 ctgccgactg agtgggcact gtgtggggag cgggaagacc gcctggagtt actgaagctc
     1921 tccaccttcg ccctcatcat cactcccggg gacccgcacc tgctcatttc atctgggtgt
     1981 gccacgcggc tcttcgaggc cctggaggtg ggggccgtgc cggtggtgct cggggagcag
     2041 gtgcagctcc cgtaccacga catgctgcag tggaacgagg ccgccctggt ggtgcccaag
     2101 cctcgcgtca cagaggtcca cttcctgtta cgaagtcttt cagacagtga tctgttggcc
     2161 atgaggcggc aaggccgctt tctctgggag acctacttct ccaccgcaga cagtattttt
     2221 aataccgtgc tggccatgat taggactcga attcagatcc cagctgctcc catccgggaa
     2281 gaggtagcgg ctgagatccc ccatcgttca ggcaaagcag ctggaactga ccccaacatg
     2341 gctgacaatg gggacctgga cctggggccg gtagagacag aaccacccta tgcctcacct
     2401 aaatacctcc gcaatttcac tctgactgtc acagactgtt accgtggctg gaactctgcc
     2461 ccgggaccct tccatctttt tccccacaca ccctttgatc ctgtgttgcc ctctgaggcc
     2521 aaattcctgg gctcagggac tggatttcgg cccatcggtg gcggggctgg gggctctggc
     2581 aaggagttcc aggcagcgct cggaggcaat gtccagcggg agcagttcac agttgtgatg
     2641 ctgacctacg agcgggagga agtgctcatg aactccctgg agagactcaa cggcctcccc
     2701 tacctgaaca aggtagtggt ggtgtggaac tctcccaagc tgccctcgga ggaccttttg
     2761 tggccagaca ttggtgtccc catcatggtc gtccgtactg agaagaacag tttgaacaat
     2821 cggttcttgc cctggaatga gattgagaca gaggccatac tgtccatcga cgatgatgct
     2881 cacctccgcc atgatgaaat catgtttggg tttcgggtgt ggagagaagc acgtgatcgc
     2941 attgtgggtt tccctggccg gtaccatgcg tgggacatac cacaccagtc ctggctctac
     3001 aattccaact actcctgtga gctgtccatg gtgctgacgg gcgctgcctt ctttcacaag
     3061 tattatgcct acctgtattc ttatgtgatg ccccaggcca tccgggacat ggtggacgag
     3121 tacatcaact gtgaggatat cgccatgaac ttccttgtct cccacatcac acggaaaccc
     3181 cccatcaagg tgacatcaag gtggactttt cgatgcccag ggtgccctca ggccctgtcc
     3241 catgatgact ctcattttca cgagcggcac aagtgtatca acttttttgt caaggtgtac
     3301 ggctatatgc ctctcttgta cacacagttc agggtggact ccgtgctctt caagacccgc
     3361 ctgccccatg acaagaccaa gtgcttcaag ttcatctagg gccttgccag ttctgaggag
     3421 acgatgagca gagcgagggg agtcaccctc aaggttccca aggtgtcgaa ggtccttggg
     3481 gacatctgtc gggcagggcc aagacccttt gctgggagag gcagcaggaa gagtggaaag
     3541 ggatagctgt ctttcatttt gaagtcagcc acactgggcc tgggatcctg gtcagcagac
     3601 tcagggcgtc tgcacagggc actgactgat agcgaacact gaggactgtt cataagccca
     3661 ggacagctgc ttcgtggttt ttaaattcag taacagctat tattatttaa agagagaatt
     3721 tcacatctgc cattcaaggc ttatttatat gtgtgcgtat atgtacacac atatgtgtat
     3781 atacgtatat atgcacacac acatacacac acattcatac atacattcat acatacatac
     3841 atacatacac atatatatat tttggtgggt cggggtgcac ctgaaatttc tgccaatctc
     3901 tccaagggag ggtcctaccc agctatgtat ttagtggaga gggccctggc cctgcgttac
     3961 ctggacattc atttgcggtc ccccccgtcc cagggacact ggctgcagaa ataagcagga
     4021 tgggcctgac ctaggcaggg tctcctgacc tctcctggcc ccgttccaat gccacagtgc
     4081 tgctcccaca gcttgccccg ctgtaggctg cacagtgggg acgacacacc ccggacgctt
     4141 tgaagggttg ggccaggccg cactcaggca tcacctggct ttccattctt tcttgtgttt
     4201 gagagagaag gaggcggcag acagtgaggc agagatgaga cctgtacgta gctccccccc
     4261 tccccccccc cccggggtga cactggtgca gggtgctggt ggccagttcc gtggtacttg
     4321 tttctcacag aggagacaac aggaacttgg caggctggct gggagctcgg cgggtgtaga
     4381 gccagcctgg gtccttccgg gattctgtag tcttactgca aggctttgga aggaacaccg
     4441 aagtgaaatt caccttccct cttgtgtcta gaagtccatc ctgtagctgt gggctttaga
     4501 cccctgatgc cacgttggct gtacgagccc cccctccccc caaccttcaa agtctagggt
     4561 gggctagaac ccggaggctg tgatttgcta ggtaagtcct agtcttgtcg tagacgttaa
     4621 caggaattca ccccacgtta ccactttcca tgtcctgttg atggttttct tcccagggct
     4681 gaaaatgaaa taaactaact tggggtatgg tggcagtggg aaacttaggt cagggatttg
     4741 gcctgtgact tgtctcccca gccccagcag ctgacgcaga gctcagtctg tcttggtcat
     4801 gcacctgcct taagccagtt ccgtcttcct aggccctgac acgtgtgctg ctgcttgctg
     4861 tcctctgcct gctgtcctga cttctctcta gatccctcct gccgtagggc tggcatggcc
     4921 cccgggagac cctcaggcca gcaggaccag gctgctgcag aacttcactg ggtcttctgg
     4981 aacctgacac caagggctgc ctgggacatc tggttcttgg caactcagtg aaggggtcaa
     5041 gactgtttcc caaccttctg tcctctcatc agcccttgta gcagtagccc tcttcccccg
     5101 ggggagccaa agagtgtggt gttttgcgct aaatatgtgg ctgctatttt atcttttttt
     5161 tttcctctcc cagtattggg gatggacgcc agagctgtgg gtggacatcc cgacaatcgc
     5221 tctgccctga gccctgtccc tattgtctcg tttcttttca ttgagaggtt gtaaatggtg
     5281 ctgtggtacc tgataagaaa gtcagtctct gtggtaggac cccctctgtg ggtcactcat
     5341 gggtatcatt gatctgtgtt tgagggatag tgatgtcaag agtgtcctag gggatagccc
     5401 tctgggcctg gtgggaacgc tcactgaagg accccagcag caaacattgg cagtgactgt
     5461 acctgaggga ctcttgtcag aggcaagagg cagagacaaa gcagttggac cctgcttgtg
     5521 atttgggttt tggggttagg gacatgcttg gaaatgattg tgccactaca cgtccgtgga
     5581 gcctgcctgg tgtttgacgt tgtttaccat gggtcacctc ctagagcaga ttgctaacac
     5641 aggtcacact cagctaccta gtctcagctc cagggccagg acagctttgt tttccagttg
     5701 ctcttcatct taaggtcaaa ggccacccac agagtgacag ccccccggga tgcctcaggc
     5761 caccacctaa tgctcctgtc aggggtggcc ttgttagtga acatggagct ggagggtggg
     5821 gccgcctggg gtggctttga tgacttgtcc atctgtctgc ccctttcaaa ccatgagcac
     5881 aaaggtctta cgttggattt ttgtaaaaaa caaaaaacaa aaaacaaaat aaatggagac
     5941 tttaactcat gca
//
