LOCUS       NM_019578               4129 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus exostosin-like glycosyltransferase 1 (Extl1),
            transcript variant 1, mRNA.
ACCESSION   NM_019578 NM_177063
VERSION     NM_019578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Liu,J., Cheng,Y., Zhang,X., Chen,Y., Zhu,H., Chen,K., Liu,S., Li,Z.
            and Cao,X.
  TITLE     Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell
            migration to restrain infection and autoimmunity
  JOURNAL   Cell Rep 42 (1), 111991 (2023)
   PUBMED   36656709
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Mathysen,D., Wuyts,W., Bossuyt,P.J., Wauters,J.G. and Van Hul,W.
  TITLE     Assignment of the mouse Extl1 gene to the distal part of chromosome
            4 by in situ hybridization and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 162-163 (2001)
   PUBMED   11306818
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Stickens,D., Brown,D. and Evans,G.A.
  TITLE     EXT genes are differentially expressed in bone and cartilage during
            mouse embryogenesis
  JOURNAL   Dev Dyn 218 (3), 452-464 (2000)
   PUBMED   10878610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085075.1, AK161915.1 and AF224461.1.
            
            On Apr 4, 2008 this sequence version replaced NM_019578.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF224461.1, AK085075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               AK085075.1         2-651
            651-2525            AK085075.1         653-2527
            2526-3885           AK161915.1         1599-2958
            3886-4109           AK085075.1         3890-4113
            4110-4129           AF224461.1         3351-3370
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.63 cM"
     gene            1..4129
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /note="exostosin-like glycosyltransferase 1"
                     /db_xref="GeneID:56219"
                     /db_xref="MGI:MGI:1888742"
     exon            1..1590
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             830..2839
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /EC_number="2.4.1.224"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple exostoses-like 1; exostosin-L; multiple
                     exostosis-like protein;
                     glucuronosyl-N-acetylglucosaminyl-proteoglycan
                     4-alpha-N-acetylglucosaminyltransferase; exostoses
                     (multiple)-like 1; Exostosin-like 1 (Exostosin-L)
                     (Multiple exostosis-like protein)"
                     /codon_start=1
                     /product="exostosin-like 1 isoform 1"
                     /protein_id="NP_062524.2"
                     /db_xref="CCDS:CCDS18770.1"
                     /db_xref="GeneID:56219"
                     /db_xref="MGI:MGI:1888742"
                     /translation="MLWRRKSFWLALSAFWLLLVLLGVFPLRLAVLPGPLPGRSQGWP
                     RWLDAAFLQSFSQSETNPEDVAQLPRVSRGSSCTWGACFDTSKCRGKVLKIFVHSPAG
                     PTSEAQRRILDSLEGSRYSALSPADACLLLFLPSQDRRGACGPLPPNWNGGRNHLVLS
                     LYPAPCTRLGQAMVAEASPSSDIFRPGFDLALPYLPEAHPLRGGAPGKLQQHSPQPGA
                     TLLAVAEEKGRWRITSTHASACLWDRHCEQDPGPQQTYPGETLPNATFCLIPGHRSAT
                     SCFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIIADERLPLQVLAALREMLPSRVL
                     ALRQQTQFLWTAYFSSVEKVIHTTLEIIQDRIWGASGHPSLMWNSPPGALLALPTFST
                     SLQDFPFYHLQLGSGPGSSFSAVIWVGASGESLLKLIQEVAGSRHCAQILILWNSEKL
                     PPDRWPETAVPLTVIKGHRKVSNRFFPYSNISTNVILSLDAQSTLSTSEVDFAFVVWQ
                     SFPERMVGFLSGSHFWDEAQGGWGYRTGMTNEFSMVLTTAAFYHRYYHTLFTHSLPKA
                     LRTIADETPTCVDVLMNFLVATVTKLPPIKVPYGRQHPEAVPMDSGDPRPVPEPQPLD
                     QDCINRLAAGFGHMPLVSSQVRLDPVLFKDPVSVQRKKYRSLEKP"
     exon            1591..1681
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1789
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1909
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2042
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2149
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2239
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2326
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2487
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2656
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..4114
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3666..3671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3684
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /note="major polyA site"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4114
                     /gene="Extl1"
                     /gene_synonym="D430033M16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gataccttct ggagtgggac ctggagctgc cggctggacc tgtggggcag gaacaggaat
       61 ttggagcgta ggtcttgccc tctgccctgt gacagctcct agccggaggg tgcagagcag
      121 ctgcctgggt taggggccat agccgagggg aagaagacca cactccgaac cttctcattc
      181 cccaggcggc gggcatggga tgcactccgg ctccaacttc agctggctct ggtggcccac
      241 atggacacaa ggtctattta tagttctgcc acagaaggcc agccaccaaa cacaggggta
      301 gccagggttt ttttcaagag cttttggggc agagggaaga gtgggagagg acagtcctgc
      361 ctccttctac atcatccttg gccaccccct cccgataccc actccccatg aacccagaca
      421 gttctccata gatagcctgc ccttgggtca agggtaagat caggggtgca gtcctgagcg
      481 caaatggaca cgatcttgtg gtctggacaa gggttgcatc agcccgagca gtggcccagg
      541 gcagaggtcc cgatgagagg gcaaagggtg gcaaggttgt gtgaaggtag agaaagcagt
      601 cggagagtgg gaatgcaaat ttagaaagcc agagcctcct tggacttccc acgaggggtc
      661 aatcccacag gtggccaatg gttagtcgaa cttagctagg ggacctgcct tcaatggtga
      721 gagcgctgga ccagaaggct gatttccagc tccctcctgc ctggggtcgc ctcctccact
      781 tgctacagaa attcctcact tccttctagt cctagctgtt ggtggccaca tgctgtggag
      841 aagaaagtcc ttctggctgg cgttgtcagc cttctggctc ctcctcgtcc tcctaggagt
      901 cttccccctt cgcctggcag tgttgcccgg tcctcttcca gggcgctccc aaggctggcc
      961 ccgctggctg gatgctgcct tcttacagag tttctcccag tctgagacga acccagaaga
     1021 tgtcgcacag ctccctcggg tctctcgggg aagcagctgc acctggggag cctgctttga
     1081 cacctccaag tgtaggggaa aggtcctcaa gatctttgtg cactccccgg ctggtccgac
     1141 ctctgaggct cagcgcagga tcctggattc cttggaaggc tcccgctact ctgcactcag
     1201 cccagcagac gcttgccttc tcctttttct ccccagccag gatcgtagag gagcctgcgg
     1261 gcccctgcct ccgaactgga acggaggccg gaaccatctg gtgttgagtc tctacccagc
     1321 cccttgcacc aggctgggac aggcgatggt agctgaggcc agcccctcct cggacatctt
     1381 ccgaccgggc ttcgatttag cgctcccgta tctccccgaa gctcacccat tgcgaggtgg
     1441 ggctcccggc aagctgcagc agcacagtcc ccaacctggg gccaccttac tggcggtagc
     1501 agaggagaaa ggcaggtggc gtatcacaag cacccacgcc tcagcctgcc tctgggacag
     1561 gcactgtgag caagaccctg gaccccagca gacctaccca ggagagaccc ttcccaatgc
     1621 caccttctgc ctcatccctg gtcaccgatc tgccacctcc tgctttctcc aagcccttca
     1681 ggccggctgc atccccgtgc tcctcagccc ccgctgggag ctgcctttct ctgaagtcat
     1741 cgactggacc aaggcagcca tcattgctga tgagagactc ccactgcagg tcctggctgc
     1801 cctccgtgaa atgctccctt cgagggtcct cgccctgcgc cagcagaccc agtttctgtg
     1861 gaccgcttac ttctcctcgg tggaaaaagt tatccatacc accctagaga ttattcagga
     1921 ccggatctgg ggtgcatcag gtcacccctc actgatgtgg aatagccccc cgggagcact
     1981 cttggcgctg cccacatttt ccacgagcct tcaagacttc cccttttatc atctgcaact
     2041 gggctctggc cctgggagca gtttcagcgc cgtgatctgg gtgggagcct ctggagagtc
     2101 cctgctgaag ctcatccagg aggtggcagg ttctcggcac tgtgcccaga tcctgattct
     2161 ctggaacagt gagaagctgc cccctgacag gtggcccgag acagcagtgc ccctaacagt
     2221 catcaagggg cacaggaagg tcagcaaccg gttcttcccg tacagcaaca tcagcaccaa
     2281 tgttatcctc agccttgatg ctcagagcac tctttctacc agtgaggtgg actttgcctt
     2341 tgtggtgtgg cagagctttc ctgagcggat ggtgggcttt ctgtctggaa gccacttctg
     2401 ggatgaggcc cagggtggct ggggctaccg tactgggatg accaatgagt tctccatggt
     2461 cctgaccacg gctgccttct accacaggta ctaccacacc ctcttcaccc actccctgcc
     2521 taaggccctg aggaccatag ctgatgagac tcccacctgt gttgacgtcc tgatgaactt
     2581 cctggtagcc accgtcacca aactgccccc tatcaaggtg ccttatggga ggcagcaccc
     2641 ggaggctgtg ccaatggatt ctggggatcc acgaccagtg ccggagcctc agcccctgga
     2701 tcaggactgc atcaaccgtt tagcagcagg gttcggccac atgcctctgg tttcctctca
     2761 agtgcgtctg gatccggtgt tgttcaagga cccggtatcg gtgcaacgca agaagtatcg
     2821 cagtctagag aagccatagg cgaggcactg cacctgtctg ctagacacga gagaaccaac
     2881 agagatggat caaagtcctg tcccggttgg ccaatcgcta cagggatccc tgagggccgg
     2941 ggccttctcc agctgcagtg gggttgcgtt tggcacgttt cgcacaggcc ggtgtacagg
     3001 ctgatcctgt tccctgaaat gcctttctct gcatctctgc ctggtcgacc tatgtctgtc
     3061 agacctgcac tcacctcctt ggtgatctcg aagtcctcgc acgattcacg ccgagtggcc
     3121 ttgagcacat cacgaggccc cagggccggc ctgcaagctc cgtagggcgg agtcctgctc
     3181 tcatctcttt ggtctggcag gtgcactgta aatatttgag caatagctgc aagagtatta
     3241 actggtggca tgcgtggtgg aacacgggca gaatgtgcac aagacataac gctgcccctt
     3301 actctggagt tcctggtccc ggtacaaagc acacaccagg atttccagac tcaatcaagc
     3361 gtgaacaaag aggccaggag tcgaagataa ccagaggatt cggtgtctcg gcagacccgg
     3421 gatcttgggt gactagcagc actgcactac caatcttgac cactagaggt cagctgctgc
     3481 actactctcc cttcaaagga atggagtttg gttttgcttg acattttgtt gtttgtttgt
     3541 ttgtttttgt ttttcaagta agggtttctc tgggtagtcc tggctgtcct ggaactcgca
     3601 ctgtatgcca gactagcctc aaattcacag agatccacct gacttttgct tcccagggtg
     3661 ctgagattaa attcatgcac tacacctggc tgcctcttga acttgggggg ggtcaggagg
     3721 ggaggaggag gcaagacaag gtcccagtct gtaacccagg ctggcttgga actcactgca
     3781 gtcttactgc ctcagtttcc caagtgttag agttacaggt gtgagccaca atgcctgact
     3841 gaatggagtt aaagactacg gataaaatgt cgagctagag ggtcactggt gtgtgcagac
     3901 cccaggatga aaacatgcaa ggaatacgac agaactccac gttggcctgc aaacttgggc
     3961 tgttggcaga tgggctggtc gccaggaaga gggctgtcct cagcatcctg taggtgagag
     4021 tggagtaggg gaggggaggc tgcttttcct gggttcgtcc acctggaact ggaattatcg
     4081 cttccgaaat aaagcacgtg tccttgccca ctcaaaaaaa aaaaaaaaa
//
