LOCUS       NM_019393               1622 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus exosome component 9 (Exosc9), mRNA.
ACCESSION   NM_019393
VERSION     NM_019393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   7  (bases 1 to 1622)
  AUTHORS   Hao,L., Vassena,R., Wu,G., Han,Z., Cheng,Y., Latham,K.E. and
            Sapienza,C.
  TITLE     The unfolded protein response contributes to preimplantation mouse
            embryo death in the DDK syndrome
  JOURNAL   Biol Reprod 80 (5), 944-953 (2009)
   PUBMED   19129515
REFERENCE   8  (bases 1 to 1622)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1622)
  AUTHORS   Bliskovsky,V., Ramsay,E.S., Scott,J., DuBois,W., Shi,W., Zhang,S.,
            Qian,X., Lowy,D.R. and Mock,B.A.
  TITLE     Frap, FKBP12 rapamycin-associated protein, is a candidate gene for
            the plasmacytoma resistance locus Pctr2 and can act as a tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14982-14987 (2003)
   PUBMED   14634209
REFERENCE   10 (bases 1 to 1622)
  AUTHORS   Bliskovski,V., Liddell,R., Ramsay,E.S., Miller,M.J. and Mock,B.A.
  TITLE     Structure and localization of mouse Pmscl1 and Pmscl2 genes
  JOURNAL   Genomics 64 (1), 106-110 (2000)
   PUBMED   10708524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY078098.1, AK011636.1 and BE634487.1.
            
            On Mar 24, 2007 this sequence version replaced NM_019393.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005622.1, AK010253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY078098.1         2-52
            52-1264             AK011636.1         3-1215
            1265-1622           BE634487.1         1-358               c
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.6 cM"
     gene            1..1622
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /note="exosome component 9"
                     /db_xref="GeneID:50911"
                     /db_xref="MGI:MGI:1355319"
     exon            1..146
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1397
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /note="polymyositis/scleroderma autoantigen 1; exosome
                     complex exonuclease RRP45; autoantigen PM/Scl 1;
                     polymyositis/scleroderma autoantigen 75 kDa; P75
                     polymyositis-scleroderma overlap syndrome-associated
                     autoantigen"
                     /codon_start=1
                     /product="exosome complex component RRP45"
                     /protein_id="NP_062266.1"
                     /db_xref="CCDS:CCDS17312.1"
                     /db_xref="GeneID:50911"
                     /db_xref="MGI:MGI:1355319"
                     /translation="MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYG
                     CCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKL
                     NRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHF
                     RRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMD
                     GLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVR
                     KEGGKFGFAESIANQRITAFKMETAPIDTSNIEERAEEIIAEAEPPPEVVSQPVLWTP
                     GTAQIGDGIENSWGDLEDSEKEEEEEEGGIDEAVILDDTKMDTGEVSDIGSQGAPIVL
                     SDSEEEEMIILEPEKNPKKIRAQTSANQKAPSKGQGKRKKKKRTAN"
     exon            147..241
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            242..361
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            465..602
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            603..685
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            686..818
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            819..907
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1054
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1239
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1318
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1617
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /note="hexamer: AATAAA"
     polyA_site      1617
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcggtt ttccgcgccg ggaagaagcc ggtgtgcgga cttgtctcgg tgccgttcat
       61 cctttgcgtg gcccgccact atgaaggaga cgccgctttc caactgtgag cgccgcttcc
      121 tgctccgcgc aattgaggag aagaagcgcc tggacggcag acagacctat gattacagga
      181 acatcaggat ctcattcgga acggattatg gatgctgtat tgtggaactg ggaaaaacaa
      241 gagtccttgg acaggtttcc tgtgaacttg tttctccgaa actcaatagg gcaacggaag
      301 gtatcctctt ttttaacctt gagctttctc agatggctgc tccagctttt gagcctggca
      361 ggcagtcaga tctcttggtg aagctgaatc gactcttaga aaggtgtcta cgaaattcaa
      421 agtgtataga cactgaatct ctctgtgttg tcgctggtga aaaggtttgg cagatccgtg
      481 tagacctaca tttattaaat catgatggga atattattga tgctgctagc attgctgcaa
      541 ttgtagcctt gtgtcacttc cgaagacctg atgtctctgt ccaaggagag gaagtaacac
      601 tgtatacccc tgaagagcgt gatcccgtgc cattgagcat ccaccatatg cccatttgtg
      661 tcagttttgc tttctttcag caaggaacat acttattggt ggaccccaat gaacgtgaag
      721 aacgagtaat ggatggcttg ctggtgattg ccatgaataa gcatcgagaa atttgtacta
      781 ttcagtctag tggtgggata atgctgctta aagaccaggt tttcagatgc agtaaaatag
      841 ctggtgtgaa agtagcagaa atcacagagc taatacagaa agctttggaa aatgaccaga
      901 gagtcaggaa agaaggtgga aaatttggct ttgcagagtc tatagcaaac caaagaatca
      961 cagcgtttaa aatggagacg gcccctattg atacctccaa catagaggag agagcagaag
     1021 aaattattgc tgaagctgaa cctcccccag aagttgtttc tcaacctgtg ctgtggactc
     1081 ctggaactgc ccagattgga gacggaatag aaaactcctg gggtgacctt gaagattctg
     1141 agaaggaaga ggaagaggag gaaggtggca ttgatgaagc tgtcattctt gatgatacaa
     1201 agatggacac tggagaagtt tctgatattg ggagtcaagg tgcccctata gtgctatcag
     1261 atagtgaaga agaagaaatg attattttgg agccagagaa gaacccaaag aaaataagag
     1321 ctcagaccag tgcaaaccag aaggcaccaa gtaaaggcca agggaaaagg aagaagaaga
     1381 agagaactgc taactaagct aaagtggtgg atctctgtgt gtgtgtgtgt gtatacatac
     1441 tcagtgctaa cagctctggg tatcttacaa gctgaacttc ttgatacact gtttgtcttt
     1501 aacattatgc tttgaataaa ctttctggaa aacttttctg ttgcacaagc ttcccaactc
     1561 atgtaagacc ttatttgtta aagttgataa ataaaatgtc tccataaact actgtaaaaa
     1621 aa
//
