LOCUS       NP_062266                438 aa            linear   ROD 09-FEB-2025
DEFINITION  exosome complex component RRP45 [Mus musculus].
ACCESSION   NP_062266
VERSION     NP_062266.1
DBSOURCE    REFSEQ: accession NM_019393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 438)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 438)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (residues 1 to 438)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 438)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 438)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (residues 1 to 438)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   7  (residues 1 to 438)
  AUTHORS   Hao,L., Vassena,R., Wu,G., Han,Z., Cheng,Y., Latham,K.E. and
            Sapienza,C.
  TITLE     The unfolded protein response contributes to preimplantation mouse
            embryo death in the DDK syndrome
  JOURNAL   Biol Reprod 80 (5), 944-953 (2009)
   PUBMED   19129515
REFERENCE   8  (residues 1 to 438)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 438)
  AUTHORS   Bliskovsky,V., Ramsay,E.S., Scott,J., DuBois,W., Shi,W., Zhang,S.,
            Qian,X., Lowy,D.R. and Mock,B.A.
  TITLE     Frap, FKBP12 rapamycin-associated protein, is a candidate gene for
            the plasmacytoma resistance locus Pctr2 and can act as a tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14982-14987 (2003)
   PUBMED   14634209
REFERENCE   10 (residues 1 to 438)
  AUTHORS   Bliskovski,V., Liddell,R., Ramsay,E.S., Miller,M.J. and Mock,B.A.
  TITLE     Structure and localization of mouse Pmscl1 and Pmscl2 genes
  JOURNAL   Genomics 64 (1), 106-110 (2000)
   PUBMED   10708524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY078098.1, AK011636.1 and BE634487.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005622.1, AK010253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.6 cM"
     Protein         1..438
                     /product="exosome complex component RRP45"
                     /note="polymyositis/scleroderma autoantigen 1; exosome
                     complex exonuclease RRP45; autoantigen PM/Scl 1;
                     polymyositis/scleroderma autoantigen 75 kDa; P75
                     polymyositis-scleroderma overlap syndrome-associated
                     autoantigen"
                     /calculated_mol_wt=48806
     Region          6..264
                     /region_name="RNase_PH_RRP45"
                     /note="RRP45 subunit of eukaryotic exosome; cd11368"
                     /db_xref="CDD:206773"
     Site            order(7..9,12..13,17,20,22)
                     /site_type="other"
                     /note="Rrp40 interface [polypeptide binding]"
                     /db_xref="CDD:206773"
     Site            order(41,43,58,60..62,77,79,84,101,104,108,130,135,140,
                     158..160,190,231..242,247,251)
                     /site_type="other"
                     /note="hexamer interface [polypeptide binding]"
                     /db_xref="CDD:206773"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06265; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Site            297
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q06265; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Site            306
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06265; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Region          337..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Site            346
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06265; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Region          377..438
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHI7.1)"
     CDS             1..438
                     /gene="Exosc9"
                     /gene_synonym="p5; p6; PM/Scl-75; Pmscl1; RRP45"
                     /coded_by="NM_019393.2:81..1397"
                     /db_xref="CCDS:CCDS17312.1"
                     /db_xref="GeneID:50911"
                     /db_xref="MGI:MGI:1355319"
ORIGIN      
        1 mketplsnce rrfllraiee kkrldgrqty dyrnirisfg tdygccivel gktrvlgqvs
       61 celvspklnr ategilffnl elsqmaapaf epgrqsdllv klnrllercl rnskcidtes
      121 lcvvagekvw qirvdlhlln hdgniidaas iaaivalchf rrpdvsvqge evtlytpeer
      181 dpvplsihhm picvsfaffq qgtyllvdpn ereervmdgl lviamnkhre ictiqssggi
      241 mllkdqvfrc skiagvkvae iteliqkale ndqrvrkegg kfgfaesian qritafkmet
      301 apidtsniee raeeiiaeae pppevvsqpv lwtpgtaqig dgienswgdl edsekeeeee
      361 eggideavil ddtkmdtgev sdigsqgapi vlsdseeeem iilepeknpk kiraqtsanq
      421 kapskgqgkr kkkkrtan
//
