LOCUS       NM_027148                955 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Mus musculus exosome component 8 (Exosc8), transcript variant 2,
            mRNA.
ACCESSION   NM_027148
VERSION     NM_027148.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 955)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 955)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 955)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   4  (bases 1 to 955)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 955)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 955)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 955)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 955)
  AUTHORS   Collin,G.B., Marshall,J.D., King,B.L., Milan,G., Maffei,P.,
            Jagger,D.J. and Naggert,J.K.
  TITLE     The Alstrom syndrome protein, ALMS1, interacts with alpha-actinin
            and components of the endosome recycling pathway
  JOURNAL   PLoS One 7 (5), e37925 (2012)
   PUBMED   22693585
REFERENCE   9  (bases 1 to 955)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   10 (bases 1 to 955)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100927.11.
            
            On Jan 5, 2022 this sequence version replaced NM_027148.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220227.1, BC059089.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC100927.11        99776-99816         c
            42-78               AC100927.11        99064-99100         c
            79-142              AC100927.11        98871-98934         c
            143-216             AC100927.11        98426-98499         c
            217-262             AC100927.11        97468-97513         c
            263-368             AC100927.11        96880-96985         c
            369-414             AC100927.11        96749-96794         c
            415-511             AC100927.11        95843-95939         c
            512-632             AC100927.11        94533-94653         c
            633-739             AC100927.11        93962-94068         c
            740-955             AC100927.11        93446-93661         c
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.6 cM"
     gene            1..955
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /note="exosome component 8"
                     /db_xref="GeneID:69639"
                     /db_xref="MGI:MGI:1916889"
     exon            1..41
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..855
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /note="isoform 2 is encoded by transcript variant 2;
                     exosome complex exonuclease RRP43; exosome complex
                     component RRP43; ribosomal RNA-processing protein 43"
                     /codon_start=1
                     /product="exosome complex component RRP43 isoform 2"
                     /protein_id="NP_081424.3"
                     /db_xref="CCDS:CCDS17352.1"
                     /db_xref="GeneID:69639"
                     /db_xref="MGI:MGI:1916889"
                     /translation="MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRATTVNIGSIST
                     ADGSALVKLGNTTVICGVKAEFAAPPVDAPDRGYVVPNVDLPPLCSSRFRTGPPGEEA
                     QVTSQFIADVVDNSQVIKKEDLCISPGKLAWVLYCDLICLDYDGNILDACTFALLAAL
                     KNVQLPEVTINEETALAEVNLKKKSYLNVRTNPVATSFAVFDDTLLIVDPTGEEEHLS
                     TGTLTVVTDEDGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMRHK
                     "
     exon            42..78
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            79..142
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            143..216
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            217..262
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            263..368
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            369..414
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            415..511
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            512..632
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            633..739
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     exon            740..955
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /inference="alignment:Splign:2.1.0"
     regulatory      924..929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /note="hexamer: AATAAA"
     polyA_site      955
                     /gene="Exosc8"
                     /gene_synonym="2310032N20Rik; CIP3; mKIAA4013"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcgcag agcgggccgg aaaaatggcg gctgggttca aaactgtgga gccgctggag
       61 tattacagga gatttctgaa ggaaaactgc cgtcctgatg gaagagaact tggtgaattc
      121 agagccacaa ctgtcaacat aggttcaatc agtacagcgg atggctctgc tctcgtgaag
      181 ctggggaata ccacggtcat ttgtggcgtt aaagcagaat ttgcagcacc accagtagat
      241 gcccccgata gaggatatgt cgtccctaat gtggatctac caccgctgtg ttcttcgagg
      301 ttccggacag gacctcctgg ggaagaggct caagtaacca gccagttcat tgcagatgtc
      361 gttgacaact cacaggtgat taagaaagag gatttatgca tttctccagg caagcttgct
      421 tgggttctat actgtgacct catttgtcta gactacgatg ggaacatttt ggatgcctgc
      481 acatttgctt tgttagcagc tttaaagaat gtacagttgc ctgaagttac tataaacgaa
      541 gagactgctt tagccgaagt caatttaaag aagaaaagtt atttgaatgt tagaacaaac
      601 ccagttgcta cttcctttgc tgtgtttgat gacactctac tgatagtcga tcctaccggc
      661 gaggaggagc acctgtccac aggaacccta accgtagtca cggacgagga cggcaagctg
      721 tgctgtcttc acaagccagg tgggagtggg ctgactggag ctaaacttca ggactgcatg
      781 agtcgagcgg taacgagaca caaagaagtg agcaagctac tggatgaagt aattcagagc
      841 atgagacaca aatgaacaga caccacgact gcaaaacagc tgtaaaaatt gtatttgtta
      901 cactgcacag gctttttata ctaaataaat acctaattcc attctttgaa agata
//
