LOCUS       NM_001418863            1125 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exosome component 7 (Exosc7), transcript variant 4,
            mRNA.
ACCESSION   NM_001418863
VERSION     NM_001418863.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Butler,J.S.
  TITLE     The yin and yang of the exosome
  JOURNAL   Trends Cell Biol 12 (2), 90-96 (2002)
   PUBMED   11849973
  REMARK    Review article
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134248.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.3483610.1,
                                           SRR17253013.4096262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC134248.3         54064-54243
            181-282             AC134248.3         59710-59811
            283-377             AC134248.3         60060-60154
            378-543             AC134248.3         68625-68790
            544-614             AC134248.3         71343-71413
            615-738             AC134248.3         71646-71769
            739-894             AC134248.3         72704-72859
            895-1125            AC134248.3         76718-76948
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.8 cM"
     gene            1..1125
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /note="exosome component 7"
                     /db_xref="GeneID:66446"
                     /db_xref="MGI:MGI:1913696"
     exon            1..180
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..999
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /note="isoform 4 is encoded by transcript variant 4;
                     exosome complex exonuclease RRP42; ribosomal
                     RNA-processing protein 42"
                     /codon_start=1
                     /product="exosome complex exonuclease RRP42 isoform 4"
                     /protein_id="NP_001405792.1"
                     /db_xref="GeneID:66446"
                     /db_xref="MGI:MGI:1913696"
                     /translation="MASVALSEAEKVYIVHGVQVAVAAASAGHIAQGGGAGRPRGQDG
                     RPRLSAAASEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGT
                     PKLEKPNEGYLEFFVDCSANATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLRSLCI
                     SPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGAKDIELSD
                     DPYDCIRLSVENVPCIVTLCKIGCRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKV
                     GKGSLDPESIFEMMESSKRVGKVLHVSLQSLLHKEESLGPKRPRVGFLG"
     exon            181..282
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            283..377
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            378..543
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            544..614
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            615..738
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            739..894
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1125
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1101..1106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /note="hexamer: AATAAA"
     polyA_site      1125
                     /gene="Exosc7"
                     /gene_synonym="2610002K22Rik; mKIAA0116"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcggtg agctgagcag catggcgtcg gtggcgctaa gcgaggccga gaaggtctac
       61 atcgttcatg gagtgcaggt agcggtggcg gccgcgagtg caggccatat tgcgcaggga
      121 ggaggtgcgg ggcggccacg tggtcaggac ggacgcccga ggcttagtgc tgcagcgagt
      181 gaagaccttc gggtggatgg ccgtggctgt gaggactacc gatgtgttga agtagagact
      241 gatgtggtgt ctaacaccag tgggtctgcc agagtcaagc tgggtcacac agacatcttg
      301 gtgggagtga aagcagaaat ggggacaccg aagctggaga aaccgaatga aggctacctg
      361 gagttctttg ttgactgttc agccaatgct accccagaat tcgaagggcg aggaggtgat
      421 gaccttggca cagagattgc taacaccctc taccggatat ttaacaacaa gagcagcgta
      481 gacctgaggt ccctctgcat cagtcctcga gagcactgct gggttctata tgtggatgtg
      541 ctgctgctgg aatgtggtgg gaatttgttt gatgctattt ccattgctgt aaaagctgct
      601 ctcttcaaca caaggatacc aagggttcgt gttctggagg atgaagaggg ggcaaaggac
      661 attgagctgt ctgacgatcc ttatgactgc atccgactga gtgtagagaa tgtcccctgc
      721 attgtcaccc tgtgcaagat tggctgccgg catgtggtag atgccacact tcaagaggag
      781 gcctgttccc tggccagctt gctggtgtca gtgaccagca agggagtagt gacatgcatg
      841 aggaaagtgg ggaaaggaag cctggatcct gagagcatct tcgagatgat ggagagcagc
      901 aagcgagtgg gcaaggtgct gcacgtgtcc ttgcagagcc ttctgcacaa ggaagaaagc
      961 ctggggccca agaggccgag agtcgggttc ctggggtgat ttctctccac tgcacgttgg
     1021 ttgcctcact tttcattgac actggtttgt atatatttct cttaattgtc aaaatttaat
     1081 tccacatttg taaatgtaaa aataaagtct attttttttg gtcca
//
