LOCUS       NM_028274               1346 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus exosome component 6 (Exosc6), mRNA.
ACCESSION   NM_028274
VERSION     NM_028274.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC116985.1 and BM941848.1.
            
            On Feb 28, 2013 this sequence version replaced NM_028274.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               BC116985.1         2-789
            789-1346            BM941848.1         17-574              c
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.92 cM"
     gene            1..1346
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
                     /note="exosome component 6"
                     /db_xref="GeneID:72544"
                     /db_xref="MGI:MGI:1919794"
     exon            1..1326
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..854
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
                     /EC_number="3.1.13.-"
                     /note="exosome complex exonuclease MTR3; Mtr3 (mRNA
                     transport regulator 3)-homolog"
                     /codon_start=1
                     /product="exosome complex component MTR3"
                     /protein_id="NP_082550.1"
                     /db_xref="CCDS:CCDS85611.1"
                     /db_xref="GeneID:72544"
                     /db_xref="MGI:MGI:1919794"
                     /translation="MPGDHRRIRGPEESQPPQLYAAEDDETPAARDPTRLRPVYARAG
                     LLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGSGPAGAGGEAPAALRGRLLCDFRR
                     APFSGRRRRAPQGGGGEDRELGLALQEALEPAVRLGRYPRAQLEVSALLLEDGGCALA
                     AALTAAALALADAGVEMYDLVVGCGLSLTPGPSPTWLLDPTRLEEEHSAAGLTVALMP
                     VLNQVAGLLGSGEGGQTESWTDAVRLGLEGCQRLYPVLQQCLVRAARRRGAAAPP"
     regulatory      1242..1247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
                     /note="hexamer: CATAAA"
     polyA_site      1267
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
                     /note="major polyA site"
     polyA_site      1326
                     /gene="Exosc6"
                     /gene_synonym="2610510N21Rik; C76919; Mtr3"
ORIGIN      
        1 aggcggaagt agctcgcacg ccggtagccg ccatgccggg agaccatcgc cgcatccgcg
       61 ggccggagga gtctcagccg ccgcagctgt acgcggccga agacgacgag acgcccgctg
      121 ctcgcgaccc gacgcggctc cgcccggtgt acgcgcgcgc cgggctgctg agccaggcca
      181 agggctccgc ctacctggag gcgggcggga ccaaggtgct gtgcgccgtg tccggtccgc
      241 ggcaggccga gggcggcgag cgcggcagcg gccctgcggg agcgggcggg gaagctcccg
      301 ctgccctccg gggtcgcctg ctctgcgatt tccgccgcgc tcccttctcc ggtcgccggc
      361 gtcgcgcgcc ccagggcggc ggcggggagg atcgcgagct gggactggcg ctacaggagg
      421 ctctggagcc cgccgtgcgc ctggggcgct acccgcgtgc tcagctcgag gtgtcggcgc
      481 tgctgctgga ggacggcggc tgtgcgctgg ccgcggcgct caccgcggcc gcgctcgccc
      541 tggccgacgc gggagtggag atgtacgatc tggtggtggg ctgcggcctg agcctcaccc
      601 cgggaccctc cccgacctgg ctgctggacc ccacgcggct ggaggaggag cactccgcgg
      661 ccggtctcac ggtggccctc atgcctgtgc tcaatcaggt ggccgggtta ctgggcagtg
      721 gggaaggcgg gcagactgag agttggaccg atgctgtgcg cctgggcctg gagggctgcc
      781 agcgcctcta cccagtgctg cagcagtgtt tggtgcgggc tgcccgccgg aggggtgccg
      841 ccgccccacc ctgattggaa aaaaccggag cgacgaggat tcgaggactg ctatcgccct
      901 tctctcccta aaggaccaag cgctgatggt cgcctgactc cgcagagctg agaaacgaag
      961 agtggggcag ttgggcgcac agaaccaaag cactggacag ctctgttgga aaggtttaaa
     1021 aggccgttgg aaacacgatc cagttggaga gatttgaaag cagccatact cccaagttgg
     1081 aaaggacttg ggctggattt acctagtaaa tgagataagg ggctatggtc ttgtaggaga
     1141 tggacccagt gcaggccagc cattggctcc aatacataat aaactgattc ttttgagagg
     1201 atggaccagg ggactttgcc ttctcactac tcagagtaaa acataaaaac tattttatga
     1261 ctggaaatac atctgttgtg ttttttcttg atactagagt tagaaacaat gctgttctga
     1321 actgggaaaa aaaaaaaaaa aaaaaa
//
