LOCUS       NM_138586               1039 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus exosome component 5 (Exosc5), transcript variant 1,
            mRNA.
ACCESSION   NM_138586
VERSION     NM_138586.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1039)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   2  (bases 1 to 1039)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1039)
  AUTHORS   Hildebrandt,M.R., Wang,Y., Li,L., Yasmin,L., Glubrecht,D.D. and
            Godbout,R.
  TITLE     Cytoplasmic aggregation of DDX1 in developing embryos: Early
            embryonic lethality associated with Ddx1 knockout
  JOURNAL   Dev Biol 455 (2), 420-433 (2019)
   PUBMED   31330130
REFERENCE   4  (bases 1 to 1039)
  AUTHORS   Flynn,R.A., Almada,A.E., Zamudio,J.R. and Sharp,P.A.
  TITLE     Antisense RNA polymerase II divergent transcripts are P-TEFb
            dependent and substrates for the RNA exosome
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10460-10465 (2011)
   PUBMED   21670248
REFERENCE   5  (bases 1 to 1039)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   6  (bases 1 to 1039)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1039)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 1039)
  AUTHORS   Jaradat,S.A., Ko,M.S. and Grossman,L.I.
  TITLE     Tissue-specific expression and mapping of the Cox7ah gene in mouse
  JOURNAL   Genomics 49 (3), 363-370 (1998)
   PUBMED   9615220
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856072.1, BY198385.1, AK006475.1 and BE854983.1.
            
            On Jul 28, 2009 this sequence version replaced NM_138586.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007372.1, BY707474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BB856072.1         2-11
            11-119              BY198385.1         9-117
            120-1022            AK006475.1         73-975
            1023-1039           BE854983.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.96 cM"
     gene            1..1039
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /note="exosome component 5"
                     /db_xref="GeneID:27998"
                     /db_xref="MGI:MGI:107889"
     exon            1..231
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..791
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /note="exosome complex exonuclease RRP46; ribosomal
                     RNA-processing protein 46"
                     /codon_start=1
                     /product="exosome complex component RRP46"
                     /protein_id="NP_613052.1"
                     /db_xref="CCDS:CCDS20990.1"
                     /db_xref="GeneID:27998"
                     /db_xref="MGI:MGI:107889"
                     /translation="MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGS
                     ASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTC
                     EAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALD
                     SDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQ
                     HIFRFYRESLQRRYSKS"
     exon            232..345
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     exon            346..467
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     exon            468..608
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     exon            609..698
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1031
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      984..989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /note="hexamer: ATTAAA"
     polyA_site      1031
                     /gene="Exosc5"
                     /gene_synonym="D7Wsu180e"
                     /note="major polyA site"
ORIGIN      
        1 gcaataggta cgcggccggt agaactgcgc gcgccgctaa gcggaagcta cggtgggagc
       61 cgcagcgcgc gtggtcagcg gctatggagg gcgcaaagcg tgcagacgcc aatttactca
      121 ctgacaccgg aacagagtcc agcccccgaa gtccagtctg cagtctccgg cactttgctt
      181 gtgagcaaaa cctgctgtcc cggccggatg gatctgcttc ttttcttcaa ggtgatacct
      241 ctgtcctggc tggagtctat gggccggccg aggtgaaggt cagcaaagaa atcttcaaca
      301 aggccaccct tgaagtgatc ctgaggccga agatcgggct gcctggcgtg gccgagaaga
      361 gccgcgagcg gctggtcagg aatacctgtg aagctgtggt tctaggggcc ctgcaccccc
      421 ggacctcaat caccgtggtg ctgcaggtgg tgagcgacgc tggctctctc ttggcctgtt
      481 gcttgaacgc tgcttgcatg gcattggtgg atgcaggtgt gcccatgcga gccctcttct
      541 gtggggtcac ctgtgccctg gactctgatg gaaatctcgt gctggacccc acaaccaagc
      601 aagaaaagga ggcccgggcc atcctgacct ttgctctgga tagcgccgag cagaagctgc
      661 tcatgtccac caccaagggg ctctattctg acgctgagct ccaacagtgt ctggccgccg
      721 cccaagccgc ctcacagcac atcttccgat tctaccggga atcactgcag aggcgctact
      781 cgaagagctg aggcacgcca gggtagggcg cccctcccac catgcccacc gcctaccacc
      841 gccacgagcc agcactccac tgtgcctctg tctgtgccca tgtagcctct ggtcctgtcg
      901 cagcggaggc tcctgtgcca ggctggggtg ggggcttagg gacattctag gcctgggtat
      961 aaccctccct tcatcaggat accattaaaa agggctcccc cgtgttgggt gagtgagtca
     1021 gtacccactg aaaaaaaaa
//
