LOCUS       NM_175399               1789 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus exosome component 4 (Exosc4), mRNA.
ACCESSION   NM_175399
VERSION     NM_175399.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC155074.12.
            
            On May 2, 2007 this sequence version replaced NM_175399.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089890.1, AK144062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC155074.12        120555-120821       c
            268-474             AC155074.12        118982-119188       c
            475-1789            AC155074.12        117548-118862       c
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.72 cM"
     gene            1..1789
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /note="exosome component 4"
                     /db_xref="GeneID:109075"
                     /db_xref="MGI:MGI:1923576"
     exon            1..267
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..834
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /note="exosome complex exonuclease RRP41; ribosomal
                     RNA-processing protein 41"
                     /codon_start=1
                     /product="exosome complex component RRP41"
                     /protein_id="NP_780608.1"
                     /db_xref="CCDS:CCDS37119.1"
                     /db_xref="GeneID:109075"
                     /db_xref="MGI:MGI:1923576"
                     /translation="MAGLELLSDQGYRIDGRRAGELRKIQARMGVFAQADGSAYIEQG
                     NTKALAVVYGPHEIRGSRSRALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQ
                     LRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVMDAGIPMRDFVCAC
                     SAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDSRLHEDHLEQVLEAAA
                     QAARGVHTLLDLVVRQHVQEASVSLGD"
     exon            268..474
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1789
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      856..861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /note="hexamer: AATAAA"
     polyA_site      882
                     /gene="Exosc4"
                     /gene_synonym="1110039I09Rik; 1500001N04Rik; Rrp41"
                     /note="major polyA site"
ORIGIN      
        1 atagttcacc gagactgaaa aggaaacgta ccgacggaag tcgtagtcct gaaggtccag
       61 gtcgagctgt cggaggcgga gtcaggactg tacatcatgg ccgggctgga gctcctgtcc
      121 gatcagggtt accggataga cggtcgccgc gcgggggagc tgcgcaagat ccaggcgcgg
      181 atgggcgtgt ttgcgcaggc cgatggctcg gcttacatcg agcagggcaa caccaaggca
      241 ctggcggtgg tctacgggcc gcacgagatc cggggctccc ggtctcgagc cctgcctgac
      301 cgggctctag tgaactgtca gtacagttca gccaccttca gcacaggtga gcgcaagcga
      361 aggcctcatg gagaccggaa gtcttgtgag atggggctgc agctacgaca gaccttcgag
      421 gcagccatcc tcacacagct gcacccccgc tctcagatcg acatctacgt gcaggtgctg
      481 caagcagatg gtgggaccta cgcagcatgt gtgaatgcag ccacgctagc agtgatggat
      541 gctgggatac ctatgcggga ctttgtatgc gcatgttcag ctggctttgt ggatggcaca
      601 gcactagcgg acctcagcca cgtggaggaa gcagctggag ggccccagct cgccctggcc
      661 ctgctgcccg cctccggcca gatcgcactg cttgagatgg actcgaggct gcacgaagac
      721 cacttggagc aggtgctaga ggctgctgcc caggcggccc gaggtgtgca cactctgctg
      781 gaccttgtcg tccgacagca cgtgcaggag gcctctgtct cactggggga ctgagtggca
      841 accacccctt tccagaataa aggcctgttc ttctcccgag tacaccttac tgtacagcac
      901 ttaaaagctg ctcagggccc tacagcgcag tttatagtgc agtccctaag tggagagagc
      961 acttgtgcta ggaagagcaa gggtgcacct gttgtgcctg cccagatatt agggtccgca
     1021 aagacccctg ggagtatgaa tctgcatgcg aattcagact ttcttcaccc ttaagcttgg
     1081 acctcagact cctccaacac accagatttg tgctgagagc cctgagcctc aattaggcag
     1141 ggtttttata ctagtttgat cagggagcag gggtctcctg cctgtcagtt gccttatttc
     1201 gcaaagttat cttttttttt ttcctgtttt tttgagacag ggtttctctg tgtagccctg
     1261 gctgtcctgg aactcactct gtagaccagg cctgcctctg cctcctgagt gctgggatta
     1321 aaggcgtgtg ccaccaccgc ccggcacaaa gaggtatctc gatgcacagg gtttggtcag
     1381 tgatgagcaa tttatctgta accgttgcaa tggtaggcac tttccctcta tttccctgat
     1441 tggctctggc ccagggcagt ttcttcttgg acttgtcggt ggtatttcta ttaaccacag
     1501 ttcaaaccgg ggaccaacaa actcaagttg gaatcagctt acaaattgga gtttccccct
     1561 tcgcctatgt tggtcactca agtcctccag ctaaggagtg tgccatgctt acacagccca
     1621 tcagggacag gagcacaagg ccgaggttgc actcagctgg ctatgggtgt ccatcattaa
     1681 gagatgacat tatgacgtaa cggcaaaatt agctattcag aatcagccaa ataattttat
     1741 gtttgaggat catcacaaca tgaggaacgg tattaaaggt cagaatgtt
//
