LOCUS       NM_001362788             809 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exosome component 3 (Exosc3), transcript variant 2,
            mRNA.
ACCESSION   NM_001362788
VERSION     NM_001362788.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Nair,L., Zhang,W., Laffleur,B., Jha,M.K., Lim,J., Lee,H., Wu,L.,
            Alvarez,N.S., Liu,Z.P., Munteanu,E.L., Swayne,T., Hanna,J.H.,
            Ding,L., Rothschild,G. and Basu,U.
  TITLE     Mechanism of noncoding RNA-associated N6-methyladenosine
            recognition by an RNA processing complex during IgH DNA
            recombination
  JOURNAL   Mol Cell 81 (19), 3949-3964 (2021)
   PUBMED   34450044
REFERENCE   5  (bases 1 to 809)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 809)
  AUTHORS   Pefanis,E., Wang,J., Rothschild,G., Lim,J., Chao,J., Rabadan,R.,
            Economides,A.N. and Basu,U.
  TITLE     Noncoding RNA transcription targets AID to divergently transcribed
            loci in B cells
  JOURNAL   Nature 514 (7522), 389-393 (2014)
   PUBMED   25119026
REFERENCE   7  (bases 1 to 809)
  AUTHORS   Sun,J., Keim,C.D., Wang,J., Kazadi,D., Oliver,P.M., Rabadan,R. and
            Basu,U.
  TITLE     E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA
            polymerase II in B cells
  JOURNAL   Genes Dev 27 (16), 1821-1833 (2013)
   PUBMED   23964096
REFERENCE   8  (bases 1 to 809)
  AUTHORS   Rudnik-Schoneborn,S., Senderek,J., Jen,J.C., Houge,G., Seeman,P.,
            Puchmajerova,A., Graul-Neumann,L., Seidel,U., Korinthenberg,R.,
            Kirschner,J., Seeger,J., Ryan,M.M., Muntoni,F., Steinlin,M.,
            Sztriha,L., Colomer,J., Hubner,C., Brockmann,K., Van Maldergem,L.,
            Schiff,M., Holzinger,A., Barth,P., Reardon,W., Yourshaw,M.,
            Nelson,S.F., Eggermann,T. and Zerres,K.
  TITLE     Pontocerebellar hypoplasia type 1: clinical spectrum and relevance
            of EXOSC3 mutations
  JOURNAL   Neurology 80 (5), 438-446 (2013)
   PUBMED   23284067
  REMARK    GeneRIF: EXOSC3 mutations account for 30%-40% of patients with PCH1
            with variability in survival and clinical severity that is
            correlated with the genotype.
REFERENCE   9  (bases 1 to 809)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   10 (bases 1 to 809)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772285.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV504859.1, SRR11927934.5823792.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL772285.9         117637-117727       c
            92-241              AL772285.9         116661-116810       c
            242-393             AL772285.9         114789-114940       c
            394-809             AL772285.9         113724-114139       c
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.84 cM"
     gene            1..809
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="exosome component 3"
                     /db_xref="GeneID:66362"
                     /db_xref="MGI:MGI:1913612"
     exon            1..91
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..595
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="isoform 2 is encoded by transcript variant 2;
                     exosome complex exonuclease RRP40; exosome complex
                     component RRP40; ribosomal RNA-processing protein 40"
                     /codon_start=1
                     /product="exosome complex component RRP40 isoform 2"
                     /protein_id="NP_001349717.1"
                     /db_xref="GeneID:66362"
                     /db_xref="MGI:MGI:1913612"
                     /translation="MAEVLSAGPESVAGCRARAVHKYVPVKGDHVIGIVIAKSGDIFK
                     VDVGGSEPASLSYLAFEGATKRNRPNVQVGDLIYGQCVVANKDMEPEMVCIDSCGRAN
                     GMGVIGQDGLLFKVTLGLIRKLLAPDCEIVQELGKLYPLEIVFGMNGRIWVKAKTIQQ
                     TLILANVLEACEHMTTEQRKQIFARLAES"
     exon            92..241
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /inference="alignment:Splign:2.1.0"
     exon            242..393
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /inference="alignment:Splign:2.1.0"
     exon            394..809
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      716..721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="hexamer: AATAAA"
     polyA_site      737
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="major polyA site"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="hexamer: AATAAA"
     polyA_site      793
                     /gene="Exosc3"
                     /gene_synonym="2310005D06Rik; Rrp40"
                     /note="major polyA site"
ORIGIN      
        1 ggaagctgcg atggtgacgc ctgccatggc tgaagtactg tccgcgggac cggagtcggt
       61 ggcgggctgc cgagcacggg ccgtgcacaa gtatgtacct gtgaaagggg accacgtgat
      121 tggcatagtg atcgctaaat ctggagatat attcaaagtt gatgttggag ggagtgagcc
      181 agcgtctttg tcttacctgg catttgaagg ggcaactaaa agaaacagac caaatgtgca
      241 ggttggagat ctcatctatg gccagtgtgt ggtcgctaat aaagacatgg aaccagagat
      301 ggtctgcatt gacagctgtg gccgcgccaa tgggatgggt gtgattgggc aggatggcct
      361 gctcttcaaa gtgacgttgg gcttaattag aaagctatta gctccagatt gtgaaattgt
      421 gcaagagctg ggaaaactct atccattgga gattgtgttt ggaatgaatg gaagaatatg
      481 ggtcaaagct aagaccattc agcagacgtt aattttagca aatgtcttag aagcttgtga
      541 acacatgaca acagagcaaa gaaaacagat ctttgccaga ctggcagaga gttgacatat
      601 aaattttctt aatggatatt ttagtcaaga ctgagtttcc tggggaaatt tttttttcca
      661 ggtgaatttc ttcctggcag atctttagaa gaagcatatt attttactag aattgaataa
      721 aatatttttg taagagatac tggttgtcaa tcatgtatag atgagaaaat tataaaaact
      781 tttatataat aaactttgtt ggtagtgtc
//
