LOCUS       NM_144886               1689 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exosome component 2 (Exosc2), mRNA.
ACCESSION   NM_144886 XM_979843
VERSION     NM_144886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929275.8 and AK166881.1.
            
            On Sep 13, 2016 this sequence version replaced NM_144886.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021807.1, AK144234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL929275.8         9642-9654
            14-1642             AK166881.1         2-1630
            1643-1689           AL929275.8         20233-20279
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.86 cM"
     gene            1..1689
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /note="exosome component 2"
                     /db_xref="GeneID:227715"
                     /db_xref="MGI:MGI:2385133"
     exon            1..147
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..907
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /note="homolog of Yeast RRP4 (ribosomal RNA processing 4),
                     3'-5'-exoribonuclease; exosome complex exonuclease RRP4"
                     /codon_start=1
                     /product="exosome complex component RRP4"
                     /protein_id="NP_659135.1"
                     /db_xref="CCDS:CCDS15900.1"
                     /db_xref="GeneID:227715"
                     /db_xref="MGI:MGI:2385133"
                     /translation="MALEMRLPKARKPLSESLGRDSKKHLVVPGDTITTDTGFMRGHG
                     TYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNS
                     RLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRS
                     LKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKDEDAGG
                     FIANLEPVALSDREVISRLRNCVVLLVTQRMMLFDTSILYCYEASLAHQIKDILKPEV
                     MEEIMLETRQRLLDQEG"
     exon            148..249
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            250..295
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..385
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            386..451
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..520
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..697
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            698..826
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1689
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /note="hexamer: AATAAA"
     polyA_site      1687
                     /gene="Exosc2"
                     /gene_synonym="Rrp4"
                     /note="major polyA site"
ORIGIN      
        1 gcctgcgcaa gtcattggcg ccaagatggc gttggagatg aggctcccta aagctcgcaa
       61 acctctcagt gagagcttgg gccgcgactc taagaaacac ttggtggtgc cgggggacac
      121 gatcaccacg gacacaggct tcatgcgggg ccatgggaca tacatggggg aagagaagct
      181 cattgcgtct gtggccggct ctgtggagag agtgaacaaa ctgatctgtg tcaaagcctt
      241 gaaaaccaga tacaatggag aggtcggaga cattgtagtg gggagaatca cagaggttca
      301 acagaagagg tggaaggtag agaccaattc caggctggac tccgtcttgc tcctctcatc
      361 catgaaccta cctgggggag agctgaggag aaggtctgcg gaggatgagc tggccatgag
      421 aggcttcttg caggaaggcg acctcatcag tgcggaggtc caggctgtgt tctcggatgg
      481 agctgtttct ctgcacacga ggagcctgaa atatgggaag ctaggtcagg gagttttagt
      541 ccaggtctcg ccttccctgg tgaaaagaca gaagactcat ttccatgact tgccatgtgg
      601 tgcctcagtg attctgggta acaacggttt catctggatc tacccaacac ctgagcacaa
      661 ggatgaggat gctgggggct tcattgctaa cttggagccc gtagctctta gtgatcgaga
      721 ggtgatctcc cggcttcgga actgtgtagt cttgctggta actcagagaa tgatgctgtt
      781 cgacaccagc atcctgtact gctatgaggc ctcccttgcg catcagatca aggatatctt
      841 aaaaccggaa gtaatggagg agatcatgct ggaaacacgc cagaggcttt tggaccagga
      901 gggatgaggc cgagagctga aggatgggac tgggcacccc ctgggccagt tttgggagtg
      961 aaaactctgc catgtggtcc ccaaggagca tctgacaaac acattcctca cctgcagtgg
     1021 ggctgcagag ccaggcctgt ctttctgttc tgagagaaaa ctagggggag gtaatggtgg
     1081 gttgggctct tgggtcccag tagttttagg tctttcagag cacagtgtcc cggcctgatg
     1141 ctgacttacc ttggaataac ttggagaatt tatgacttcc aatcacccca cacaatgtaa
     1201 tgccccatga aactgtcctg gtagaaaaca tggtgacctg gggatgtatc tcaggagtgg
     1261 accacttcct aaaatgtgca agttcccaag ttccatttcc agccttaccc taaccccaga
     1321 aaaaagaaaa ccaaagacaa agacatggca gtgccatcga gaatggtctc tttccacttc
     1381 cgctctgtct cctttaatgc acaagtgtgt ggttggagag aaggtggtgg agtcaggcca
     1441 gagtcaagtg gatatgagaa taaagggagg gctggtgaga tggctcagtg ggtaagagca
     1501 cccgactgct cttccgaagg tcaggagttc aaatcccagc aaccacatgg tggctcacaa
     1561 ccatccgtta cgagatctgg cgccctcttc tggagtgtct gaagacagct tcagtgtact
     1621 tacatataat aaataaatct ttaaaaaaaa aaaaaaaaaa aagagaataa agggaggtag
     1681 cagcctttg
//
