LOCUS       NM_016699               2811 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus exosome component 10 (Exosc10), transcript variant 1,
            mRNA.
ACCESSION   NM_016699
VERSION     NM_016699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Demini L, Kervarrec C, Guillot L, Com E, Lavigne R, Kernanec PY,
            Primig M, Pineau C, Petit FG and Jamin SP.
  TITLE     Inactivation of Exosc10 in the oocyte impairs oocyte development
            and maturation, leading to a depletion of the ovarian reserve in
            mice
  JOURNAL   Int J Biol Sci 19 (4), 1080-1093 (2023)
   PUBMED   36923944
  REMARK    GeneRIF: Inactivation of Exosc10 in the oocyte impairs oocyte
            development and maturation, leading to a depletion of the ovarian
            reserve in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Petit FG, Jamin SP, Kernanec PY, Becker E, Halet G and Primig M.
  TITLE     EXOSC10/Rrp6 is essential for the eight-cell embryo/morula
            transition
  JOURNAL   Dev Biol 483, 58-65 (2022)
   PUBMED   34965385
  REMARK    GeneRIF: EXOSC10/Rrp6 is essential for the eight-cell embryo/morula
            transition.
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T,
            Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF and Tuoc T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Wu D and Dean J.
  TITLE     EXOSC10 sculpts the transcriptome during the growth-to-maturation
            transition in mouse oocytes
  JOURNAL   Nucleic Acids Res 48 (10), 5349-5365 (2020)
   PUBMED   32313933
  REMARK    GeneRIF: EXOSC10 promotes normal growth-to-maturation transition in
            mouse oocytes by sculpting the transcriptome to degrade RNAs
            encoding growth-phase factors and, thus, support the maturation
            phase of oogenesis.
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   Jamin SP, Petit FG, Kervarrec C, Smagulova F, Illner D, Scherthan H
            and Primig M.
  TITLE     EXOSC10/Rrp6 is post-translationally regulated in male germ cells
            and controls the onset of spermatogenesis
  JOURNAL   Sci Rep 7 (1), 15065 (2017)
   PUBMED   29118343
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Ciaudo C, Bourdet A, Cohen-Tannoudji M, Dietz HC, Rougeulle C and
            Avner P.
  TITLE     Nuclear mRNA degradation pathway(s) are implicated in Xist
            regulation and X chromosome inactivation
  JOURNAL   PLoS Genet 2 (6), e94 (2006)
   PUBMED   16789828
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Bliskovsky V, Ramsay ES, Scott J, DuBois W, Shi W, Zhang S, Qian X,
            Lowy DR and Mock BA.
  TITLE     Frap, FKBP12 rapamycin-associated protein, is a candidate gene for
            the plasmacytoma resistance locus Pctr2 and can act as a tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14982-14987 (2003)
   PUBMED   14634209
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Bliskovski V, Liddell R, Ramsay ES, Miller MJ and Mock BA.
  TITLE     Structure and localization of mouse Pmscl1 and Pmscl2 genes
  JOURNAL   Genomics 64 (1), 106-110 (2000)
   PUBMED   10708524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277385.1, AK162887.1, AK168700.1, AK081014.1 and AW494502.1.
            
            [WARNING] On Oct 19, 2023 this sequence was replaced by
            NM_016699.4.
            
            On Sep 18, 2017 this sequence version replaced NM_016699.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027326.1, AF091392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY277385.1         1-39
            40-1541             AK162887.1         1-1502
            1542-1799           AK168700.1         1507-1764
            1800-1928           AK081014.1         1789-1917
            1929-2792           AK168700.1         1954-2817
            2793-2811           AW494502.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     gene            1..2811
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /note="exosome component 10"
                     /db_xref="GeneID:50912"
                     /db_xref="MGI:MGI:1355322"
     exon            1..160
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2713
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     autoantigen PM/Scl 2 homolog; polymyositis/scleroderma
                     autoantigen 2 homolog; P100 polymyositis-scleroderma
                     overlap syndrome associated autoantigen homolog"
                     /codon_start=1
                     /product="exosome component 10 isoform 1"
                     /protein_id="NP_057908.2"
                     /db_xref="CCDS:CCDS18939.1"
                     /db_xref="GeneID:50912"
                     /db_xref="MGI:MGI:1355322"
                     /translation="MAPPSPREHQSAPATSATKPDAEMVLPGFPDADSFVKFALGSVV
                     AVTKASGGLPQFGDEYDFYRSFPAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSK
                     VTELEDKFDLLVDTNDVILERVGMLLDEASGVNKHQQPVLPAGLQVPKTIVSSWNRKA
                     GEYGKKAKSETFRLLHAKNIVRPQLRFREKIDNSNTPFLPKIFVKPNARKPLPLALSK
                     ERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELDHFTPPQSVLQRPK
                     PQLYRAVGETPCHLVSSLDELVELNEKLLGCQEFAVDLEHHSYRSFLGLTCLMQISTR
                     TEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQA
                     ARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDR
                     MRLELWERGNHQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLNSQQLT
                     AFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQI
                     NEMHLLIQQAREMPLLKSENAAGVRKSGPLPSAERLENDLFGPHDCSHAPPDNYQNTS
                     TDGTLPLQKQPSLFTEGKEETSVDAGCLLATAVITLFSEPNTEEGGKTPLTVAQKKAQ
                     NIMQSFENPFRMFLPSLEHKAHISQAAKFDPSSKIYEISNRWKLASQVQVQKEPKEAT
                     KKKVAEQTAAREEAKEEAAAGVLEQAIPVRQQAALENATKKRERATSDLRTIEQKQEK
                     KRLKSSKKAKDPDPPGKDFSPYDYSQSDFRAFAGDSKSKPSSQFDPNKLAPSGKKGVG
                     AKKCKQSVGNKSMSFAVGKSDRGFRHNWPKR"
     exon            161..297
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            298..421
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            422..526
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            527..692
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..807
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            808..883
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            884..994
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1138
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1329
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1486
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1635
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1686
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1798
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1849
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1928
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2035
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2131
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2206
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2294
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2371
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2543
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2605
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2682
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2800
                     /gene="Exosc10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2;
                     RRP6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgggcagcc ggaacaatct cgcgagaaga gccgccctag gacggaaaaa tggcgcctcc
       61 cagtccccgg gagcatcagt ccgcgccggc gaccagtgcg accaagcctg acgcggagat
      121 ggtactgcct ggcttccccg atgcagacag cttcgtaaag tttgcacttg ggtcggtagt
      181 ggcagttacc aaggcatccg ggggcctgcc acagttcggt gacgagtatg atttttacag
      241 aagtttccct gccttccagg cattctgtga gacacaagga gacaggttac tgcagtgcat
      301 gagtcgggta atgcagtacc atggctgtcg cagcaacatc aaagaccgaa gtaaagtgac
      361 tgaattggag gacaagtttg atttattagt cgataccaat gacgtgatat tggagagagt
      421 gggcatgtta ctggatgaag cctccggtgt gaacaagcat cagcagcctg tccttcctgc
      481 agggctgcag gtccccaaaa caatagtatc cagctggaat cggaaggcag gagagtatgg
      541 caaaaaggca aaatcggaga ctttccgact gctgcatgca aaaaacatcg tgcgacctca
      601 gctcaggttt cgagagaaga tcgacaattc taacacacca tttctcccga agatctttgt
      661 caaacccaat gcccggaagc cactccctct ggctctctca aaagaaaggc gggaacgccc
      721 gcaggaccgt ccggaggacc tggatgtccc cccagccctg gcagatttca tccatcagca
      781 gcgaacccag caggtggagc aggacatgtt tgcacaccct taccagtatg aactggatca
      841 ctttactccg cctcagtcgg tgctgcagag gccgaagccc cagttgtacc gagctgtggg
      901 agagactccc tgccacttgg tgtcgtccct ggatgagctg gtggagctca acgagaagct
      961 cctgggctgt caggagtttg ccgtggactt agagcatcac tcttacagaa gcttcctagg
     1021 actcacctgc ctcatgcaga tctccacccg gacagaagac ttcattgtcg acaccctcga
     1081 gcttcgcagt gacatgtaca ttctcaacga gagcctcacg gacccagcca tcgttaaggt
     1141 cttccatggt gccgactctg acattgagtg gctgcagaaa gacttcggac tctatgtggt
     1201 gaacatgttt gacacacacc aggcagcacg gcttctcaac ctggctcggc actcactcga
     1261 ccatctgctg agactctact gcggtgtgga atcaaacaag caatatcagc tggcagactg
     1321 gaggatacgt cctctgccag aggaaatgct gagctacgcc cgggatgaca cccattacct
     1381 gctctacatc tatgaccgaa tgaggctgga actgtgggaa agaggcaacc accagcctgt
     1441 ccagttgcag gtggtttggc agcggagcag ggacatctgc ctcaagaaat ttgtcaagcc
     1501 tatctttacg gacgagtcct acctggagct ctatcgaaag caaaagaagc acctgaactc
     1561 gcagcagctg accgccttcc agctgctgtt tgcttggagg gataagacag ctcgcaggga
     1621 ggatgagagc tacggatatg ttctaccaaa tcacatgatg ctaaagatag ctgaggaact
     1681 gcctaaggag cctcaaggca tcatagcttg ctgtaaccca gtaccacctc ttgtccggca
     1741 gcagatcaat gagatgcatc tcctaatcca gcaggctcga gagatgcccc tgctcaagtc
     1801 tgaaaatgca gctggagtga ggaagagcgg accactgcct agcgccgaga gattggagaa
     1861 tgatctcttt ggaccccatg actgttccca cgcccctcca gataactacc agaacacctc
     1921 aactgatggg accctgccac ttcagaagca gccaagccta ttcactgagg gcaaagaaga
     1981 gacctctgtg gatgccggat gcctccttgc cacagccgtc atcactctgt tcagtgaacc
     2041 taacactgag gaaggtggaa agactccatt gacggtggcc cagaaaaaag cccagaacat
     2101 aatgcagtcc tttgaaaacc catttcggat gttcctgcct tctctggaac acaaggccca
     2161 catctctcaa gcagcaaagt ttgatccttc ttcgaaaatc tatgaaatca gcaaccgctg
     2221 gaagctggcc agccaggtcc aggtccagaa agaacctaaa gaagcaacca agaagaaggt
     2281 agctgagcaa acagctgccc gggaggaggc gaaggaggag gctgcagccg gtgtgctgga
     2341 acaggctatc cctgtgcggc agcaggccgc gctagaaaat gctactaaga agagagaacg
     2401 agccaccagt gacctgagga ctatagagca aaaacaggag aagaaacgac taaaaagctc
     2461 caagaaagcc aaggaccctg atcccccagg gaaagacttc agtccctatg actacagcca
     2521 gtcagacttc agggcctttg ctggggacag taaatccaag ccttcctccc agttcgaccc
     2581 caataagctg gcaccttccg gcaagaaagg tgttggagcc aaaaaatgta aacagtcggt
     2641 gggaaacaaa agcatgtcat ttgctgttgg aaagtcggac agaggcttcc gccacaactg
     2701 gccaaagaga tagtgctgga gggactcctg gggctgccga cagcgctgct ttgtacacac
     2761 ccattttaaa accattaaaa tgtattccta ccagaagaaa aaaaaaaaaa a
//
