LOCUS       NM_025644               1622 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exosome component 1 (Exosc1), transcript variant 1,
            mRNA.
ACCESSION   NM_025644
VERSION     NM_025644.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Liu,Q., Xiao,Q., Sun,Z., Wang,B., Wang,L., Wang,N., Wang,K.,
            Song,C. and Yang,Q.
  TITLE     Exosome component 1 cleaves single-stranded DNA and sensitizes
            human kidney renal clear cell carcinoma cells to poly(ADP-ribose)
            polymerase inhibitor
  JOURNAL   Elife 10, e69454 (2021)
   PUBMED   34159897
  REMARK    GeneRIF: Exosome component 1 cleaves single-stranded DNA and
            sensitizes human kidney renal clear cell carcinoma cells to
            poly(ADP-ribose) polymerase inhibitor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Wolf,I., Bouquet,C. and Melchers,F.
  TITLE     cDNA-library testing identifies transforming genes cooperating with
            c-myc in mouse pre-B cells
  JOURNAL   Eur J Immunol 46 (11), 2555-2565 (2016)
   PUBMED   27538750
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   Cotney,J., Leng,J., Oh,S., DeMare,L.E., Reilly,S.K., Gerstein,M.B.
            and Noonan,J.P.
  TITLE     Chromatin state signatures associated with tissue-specific gene
            expression and enhancer activity in the embryonic limb
  JOURNAL   Genome Res 22 (6), 1069-1080 (2012)
   PUBMED   22421546
REFERENCE   7  (bases 1 to 1622)
  AUTHORS   Kooistra,M.K., Leduc,R.Y., Dawe,C.E., Fairbridge,N.A.,
            Rasmussen,J., Man,J.H., Bujold,M., Juriloff,D., King-Jones,K. and
            McDermid,H.E.
  TITLE     Strain-specific modifier genes of Cecr2-associated exencephaly in
            mice: genetic analysis and identification of differentially
            expressed candidate genes
  JOURNAL   Physiol Genomics 44 (1), 35-46 (2012)
   PUBMED   22045912
REFERENCE   8  (bases 1 to 1622)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
REFERENCE   9  (bases 1 to 1622)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   10 (bases 1 to 1622)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002930.1, AK006018.1 and BY361617.1.
            
            On Sep 2, 2009 this sequence version replaced NM_025644.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longest isoform (1). It contains an
            in-frame AUG four codons upstream from the currently annotated
            translation start site; however, Kozak signal strength and
            conservation data support the use of the annotated downstream AUG.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011817.1, BC024423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK002930.1         1-12
            13-675              AK006018.1         1-663
            676-1088            AK002930.1         553-965
            1089-1280           BY361617.1         125-316
            1281-1622           AK002930.1         1158-1499
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.46 cM"
     gene            1..1622
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="exosome component 1"
                     /db_xref="GeneID:66583"
                     /db_xref="MGI:MGI:1913833"
     exon            1..63
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..620
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="isoform 1 is encoded by transcript variant 1; 3'-5'
                     exoribonuclease CSL4 homolog; exosome complex component
                     CSL4"
                     /codon_start=1
                     /product="exosome complex component CSL4 isoform 1"
                     /protein_id="NP_079920.1"
                     /db_xref="CCDS:CCDS29816.1"
                     /db_xref="GeneID:66583"
                     /db_xref="MGI:MGI:1913833"
                     /translation="MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKT
                     SENGAVPVVSVMRETESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGT
                     IRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSES
                     GVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT"
     exon            64..179
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            180..254
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            255..343
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..377
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..428
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..513
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1622
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1010..1015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1029
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttctcatc cgggttgtgg atggtggcaa gcatggcacc accggtgagg tactgcatcc
       61 ccggcgaacg tctgtgtaac ttggaggaag gcagccccgg cagcggcacc tacacccggc
      121 atggctacat cttttcgtcg ctggctggct gcctgatgaa gaccagcgag aatggcgcgg
      181 ttcccgtggt gtcagtgatg agagaaacag agtcccagtt gcttccagat gtgggagctg
      241 tcgtcacctg taaggtctct agcatcaact cacggtttgc caaagtacac atcctgtatg
      301 tgggatccac accactcaaa aatgcttttc gaggaactat ccgcaaagaa gatatccgag
      361 caactgaaaa agacaaggta gaaatttaca agagttttcg gccaggtgac atagttttgg
      421 ccaaagttat ctccctaggc gatgcacagt ccaattacct gctgactact gctgaaaacg
      481 agctgggcgt tgtggtggcc cacagtgagt caggtgttca gatggttccc atcagctggt
      541 gtgagatgca gtgccccaag acccacacta aagaattccg aaaagtggcc cgagtacagc
      601 ccgagttcct acagacctaa gcccacctac cccaaagagg acttcagcac ttcagctact
      661 tctaaaagta cacatataaa aaaaccatca agatgcaatg gtctttatta aggtacctgc
      721 ggtcagctgg caaccatctc ttgaaacaat gtgccggaaa tgtattcatg ctgtaatgac
      781 acccaaggcc cctgccgctg ctgagacagg gagattgtta gtgcccaagt ttgaggccag
      841 cctgggctac atattaagac tctttcaacc aaaagacaaa aaagaaaatg tacactatct
      901 aaaacactat ttttgggaaa ctaattttta tactctgggc tcatgaatct catttaaagg
      961 cactcaacaa acaaaatcat gtaatattga aaatacctta tgccttcttt ataaatatgt
     1021 acatatgtat tttgctatga ctggaaaaaa ttcttttcat ttgttagtga tatagtctct
     1081 ctctctcttc ctctctctct ctctctctct ctctgtgtgt tttgatacca ggttcacttt
     1141 tttgtgtgaa tgcttgagat tttcactcag ctgctcatga ctgggtattg atttccttta
     1201 cccttaagcc atctccacag cccatgctgt cactattggg tgaacttgca gtgatatttc
     1261 tgactccatc tccccaatgc agggattaca agcatggcta acatgtcttc tgttgtcttt
     1321 agcagagaga agaatctaag tagtagcgtg acttttggat caggtgtatt tacctagtgg
     1381 ccctcattaa ctatgcccat caccaaccca tccttttgtg ttttatctga tgtgtgcctg
     1441 cttccctcta tgtgagtcgt tgtgtagcgt ctctggaggc cagaagatgg cattggatcc
     1501 ccggaactgg agtcacaagt tgtgagctcc aactactctc agccactggt ctcagccact
     1561 cttttgtttt gtttcttgag acaaggtctg agtactacat aataaacctc tcactaacat
     1621 gc
//
