LOCUS       NM_001320232            1571 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exosome component 1 (Exosc1), transcript variant 4,
            mRNA.
ACCESSION   NM_001320232 XM_006527257
VERSION     NM_001320232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Liu,Q., Xiao,Q., Sun,Z., Wang,B., Wang,L., Wang,N., Wang,K.,
            Song,C. and Yang,Q.
  TITLE     Exosome component 1 cleaves single-stranded DNA and sensitizes
            human kidney renal clear cell carcinoma cells to poly(ADP-ribose)
            polymerase inhibitor
  JOURNAL   Elife 10, e69454 (2021)
   PUBMED   34159897
  REMARK    GeneRIF: Exosome component 1 cleaves single-stranded DNA and
            sensitizes human kidney renal clear cell carcinoma cells to
            poly(ADP-ribose) polymerase inhibitor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Wolf,I., Bouquet,C. and Melchers,F.
  TITLE     cDNA-library testing identifies transforming genes cooperating with
            c-myc in mouse pre-B cells
  JOURNAL   Eur J Immunol 46 (11), 2555-2565 (2016)
   PUBMED   27538750
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Cotney,J., Leng,J., Oh,S., DeMare,L.E., Reilly,S.K., Gerstein,M.B.
            and Noonan,J.P.
  TITLE     Chromatin state signatures associated with tissue-specific gene
            expression and enhancer activity in the embryonic limb
  JOURNAL   Genome Res 22 (6), 1069-1080 (2012)
   PUBMED   22421546
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Kooistra,M.K., Leduc,R.Y., Dawe,C.E., Fairbridge,N.A.,
            Rasmussen,J., Man,J.H., Bujold,M., Juriloff,D., King-Jones,K. and
            McDermid,H.E.
  TITLE     Strain-specific modifier genes of Cecr2-associated exencephaly in
            mice: genetic analysis and identification of differentially
            expressed candidate genes
  JOURNAL   Physiol Genomics 44 (1), 35-46 (2012)
   PUBMED   22045912
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002930.1, AK006018.1 and BY361617.1.
            
            On Feb 17, 2016 this sequence version replaced XM_006527257.1.
            
            Transcript Variant: This variant (4) lacks an in-frame exon in the
            3' coding region compared to variant 1. The resulting isoform (4)
            is shorter, missing an internal protein segment compared to isoform
            1. Like variant 1, this variant also uses the downstream AUG.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI991254.1, ERR3363658.1355360.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK002930.1         1-12
            13-377              AK006018.1         1-365
            378-624             AK006018.1         417-663
            625-1037            AK002930.1         553-965
            1038-1038           BY361617.1         125-125
            1039-1571           AK002930.1         967-1499
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.46 cM"
     gene            1..1571
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="exosome component 1"
                     /db_xref="GeneID:66583"
                     /db_xref="MGI:MGI:1913833"
     exon            1..63
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..569
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="isoform 4 is encoded by transcript variant 4; 3'-5'
                     exoribonuclease CSL4 homolog; exosome complex component
                     CSL4"
                     /codon_start=1
                     /product="exosome complex component CSL4 isoform 4"
                     /protein_id="NP_001307161.1"
                     /db_xref="GeneID:66583"
                     /db_xref="MGI:MGI:1913833"
                     /translation="MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKT
                     SENGAVPVVSVMRETESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGT
                     IRKEDIRATEKDKISLGDAQSNYLLTTAENELGVVVAHSESGVQMVPISWCEMQCPKT
                     HTKEFRKVARVQPEFLQT"
     exon            64..179
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            180..254
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            255..343
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..377
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..462
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1571
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      959..964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="hexamer: TATAAA"
     polyA_site      978
                     /gene="Exosc1"
                     /gene_synonym="2610035C18Rik; 2610104C07Rik;
                     2610312F07Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttctcatc cgggttgtgg atggtggcaa gcatggcacc accggtgagg tactgcatcc
       61 ccggcgaacg tctgtgtaac ttggaggaag gcagccccgg cagcggcacc tacacccggc
      121 atggctacat cttttcgtcg ctggctggct gcctgatgaa gaccagcgag aatggcgcgg
      181 ttcccgtggt gtcagtgatg agagaaacag agtcccagtt gcttccagat gtgggagctg
      241 tcgtcacctg taaggtctct agcatcaact cacggtttgc caaagtacac atcctgtatg
      301 tgggatccac accactcaaa aatgcttttc gaggaactat ccgcaaagaa gatatccgag
      361 caactgaaaa agacaagatc tccctaggcg atgcacagtc caattacctg ctgactactg
      421 ctgaaaacga gctgggcgtt gtggtggccc acagtgagtc aggtgttcag atggttccca
      481 tcagctggtg tgagatgcag tgccccaaga cccacactaa agaattccga aaagtggccc
      541 gagtacagcc cgagttccta cagacctaag cccacctacc ccaaagagga cttcagcact
      601 tcagctactt ctaaaagtac acatataaaa aaaccatcaa gatgcaatgg tctttattaa
      661 ggtacctgcg gtcagctggc aaccatctct tgaaacaatg tgccggaaat gtattcatgc
      721 tgtaatgaca cccaaggccc ctgccgctgc tgagacaggg agattgttag tgcccaagtt
      781 tgaggccagc ctgggctaca tattaagact ctttcaacca aaagacaaaa aagaaaatgt
      841 acactatcta aaacactatt tttgggaaac taatttttat actctgggct catgaatctc
      901 atttaaaggc actcaacaaa caaaatcatg taatattgaa aataccttat gccttcttta
      961 taaatatgta catatgtatt ttgctatgac tggaaaaaat tcttttcatt tgttagtgat
     1021 atagtctctc tctctcttcc tctctctctc tctctctctc tctgtgtgtt ttgataccag
     1081 gttcactttt ttgtgtgaat gcttgagatt ttcactcagc tgctcatgac tgggtattga
     1141 tttcctttac ccttaagcca tctccacagc ccatgctgtc actattgggt gaacttgcag
     1201 tgatatttct gactccatct ccccaatgca gggattacaa gcatggctaa catgtcttct
     1261 gttgtcttta gcagagagaa gaatctaagt agtagcgtga cttttggatc aggtgtattt
     1321 acctagtggc cctcattaac tatgcccatc accaacccat ccttttgtgt tttatctgat
     1381 gtgtgcctgc ttccctctat gtgagtcgtt gtgtagcgtc tctggaggcc agaagatggc
     1441 attggatccc cggaactgga gtcacaagtt gtgagctcca actactctca gccactggtc
     1501 tcagccactc ttttgttttg tttcttgaga caaggtctga gtactacata ataaacctct
     1561 cactaacatg c
//
