LOCUS       NM_172456               3816 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus exo/endonuclease G (Exog), transcript variant 2, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_172456
VERSION     NM_172456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3816)
  AUTHORS   Szczesny,B., Brunyanszki,A., Olah,G., Mitra,S. and Szabo,C.
  TITLE     Opposing roles of mitochondrial and nuclear PARP1 in the regulation
            of mitochondrial and nuclear DNA integrity: implications for the
            regulation of mitochondrial function
  JOURNAL   Nucleic Acids Res 42 (21), 13161-13173 (2014)
   PUBMED   25378300
REFERENCE   3  (bases 1 to 3816)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166052.5 and AC121922.3.
            
            On Jan 12, 2018 this sequence version replaced NM_172456.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162566.1, AK028887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC166052.5         3278-3468           c
            192-341             AC166052.5         1330-1479           c
            342-380             AC166052.5         1-39                c
            381-481             AC121922.3         124962-125062       c
            482-558             AC121922.3         123636-123712       c
            559-673             AC121922.3         121148-121262       c
            674-3816            AC121922.3         107972-111114       c
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..3816
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="exo/endonuclease G"
                     /db_xref="GeneID:208194"
                     /db_xref="MGI:MGI:2143333"
     exon            1..191
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1135
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /EC_number="3.1.30.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; endonuclease G-like 1; nuclease EXOG,
                     mitochondrial; endo G-like 1; endo/exonuclease (5'-3'),
                     endonuclease G-like"
                     /codon_start=1
                     /product="nuclease EXOG, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_766044.1"
                     /db_xref="CCDS:CCDS23616.1"
                     /db_xref="GeneID:208194"
                     /db_xref="MGI:MGI:2143333"
                     /translation="MAAKSFASRLRDSRRFLNGFLAGAVVGAAGAGLTALQFFRRPDA
                     ESAKLARQPHESAEEAVLEQFGFPLAGTETRRYTNHALSYDQAKRVPRWVLEHISKDK
                     IIGDADRKHCKFKPDPSVPSAFSALNEDYIGSGWSRGHMAPAGNNKFSSEAMAETFYL
                     SNIVPQNFDNNSGYWNRIEMYCRELTERFEDVWIVSGPLTLPHTRNDGTKTVSYQVIG
                     EDNVAVPSHLYKVILARRSPESTEPLALGAFVVPNKAIGFQSQLSEFQVSLHDLEKMS
                     GLVFFPRLDRSRDIRNICSVDTCKLLGFQEFTLYLSTRKIDGARSVARLEKVLEALKS
                     SGVEPDDYFLSRYEKKLEELKAKEQKDAQLEKQS"
     exon            192..341
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            342..481
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            482..558
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            559..673
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            674..3816
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="major polyA site"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="hexamer: AATAAG"
     polyA_site      2540
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="major polyA site"
     regulatory      2861..2866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="hexamer: AACAAA"
     polyA_site      2879
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="major polyA site"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="hexamer: AATAAA"
     polyA_site      3816
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
ORIGIN      
        1 agagacaaag tgctggcgcc cgcgagtcat ggctgcaaag agcttcgctt cccgtctcag
       61 ggactcgcgg cgatttctga atggcttctt ggccggggct gtagtgggcg ccgcgggagc
      121 ggggctgacg gcgctgcagt ttttccggcg tccggacgcg gaatccgcga agctggcgag
      181 gcagccacac gaatctgcag aagaagctgt cttggaacag tttgggtttc ctttagctgg
      241 aacagagacg aggcgttaca ctaaccacgc cctgtcttac gatcaggcaa aacgggtgcc
      301 cagatgggtt cttgagcata tatccaagga caagatcatc ggtgacgctg acagaaagca
      361 ttgtaaattc aagccggatc cttctgtccc ttcagccttc agcgccctca atgaagacta
      421 tatcgggagt ggctggtcac gaggccacat ggccccggca ggaaataaca agttttccag
      481 tgaagccatg gcagaaacct tttacctttc taatatcgtg cctcagaatt ttgataataa
      541 ctccggctac tggaacagaa tagaaatgta ttgtcgtgag ctgacggaga gatttgaaga
      601 tgtttggata gtatcaggac ctttaacctt acctcatact aggaatgatg gaacgaaaac
      661 agttagttac caggtgattg gtgaggacaa cgtggccgtc ccctcgcacc tttacaaggt
      721 gatcctggct cgcagaagcc cggaatctac ggagccgctg gcgctggggg cctttgtggt
      781 gccaaataaa gccattgggt tccagtccca gttatccgag ttccaggtga gcctccatga
      841 cctggagaag atgtcaggtc tggtgttttt cccccgtctg gatagaagca gggacatccg
      901 gaatatttgc tctgtggaca cctgcaagct cctgggtttc caggaattca ctctgtacct
      961 gagcacgagg aagattgatg gagcccggtc tgtggccaga ctggagaagg ttctggaagc
     1021 tttgaagagc tcaggggtgg aacctgacga ttacttcctg agtcgctatg agaaaaagct
     1081 ggaggaactg aaggctaagg agcaaaagga cgcccagctg gaaaagcagt cctagtgtct
     1141 gtctcggtgt gcactgagca cctgtgacca acaggtttat tttcaagaaa tgatggaatt
     1201 ctgaccaaaa tcctccaaag actcggggct caaaactcag tgtcgtcctt ctctgggatc
     1261 cgaggtggct gagatggttt taaaactctg ctctcacgtg ctccttccct catgaccctg
     1321 aagtcctccc atctgtctgt gttggagaat ccagtgactg ttcttcctct gtgcaaaccc
     1381 tgctgtccca tcttacctgt gggcaagatg aggctcagag aactctgtat ctttaccatt
     1441 ggtattcaac agaagtcatc cagggtgcct cagagtcaag acagagttag atggatgtaa
     1501 ctcagtccgt acctgcatcc acggctgttt ctggcactac agccctcctg gtgagaaggg
     1561 tgtgtctctt ctcgcatcat ttctgtggga aaaaacagtg ggtcttggaa agatggagat
     1621 gttttgtggg tttaaccaga gactgtggtt ccctccaggg atcacatggt gccagataag
     1681 tatgtttctt gcctcattgg ggcctttcta aaggagccca agaaaggtgt ttgccaagag
     1741 tcgccgggta cctctggtcc tgctgtctgc tggaccagca caccacaggt aggtatagcc
     1801 tgggcccaag gtccgaacca gctcattgcc tggggaaaga gcagctgctg tctgtgctga
     1861 cctccagact ggtttataca gatcttgagc tgtcctgagt ccatgcgcac agcccagaag
     1921 cttctgggca aaaggactcg tctgaatctg ccactctgcc actgtcctcc aagcaatacg
     1981 agagtgatct ttgtggcatt gtgtttgcct ccgatagaaa tgcatgactt tacaataaag
     2041 acaagaaggc tctggctgac cctcttctgc tccttcattt ggagaaaaag aaactgtcag
     2101 gtgtaggaca cagtgacgga ttagctccgt tctgcggtac cttcctcttc cccattaact
     2161 tgtgccagtc cttctgagga tagaaagcca aaatgtcacc atgaccgaaa aaaaaatctg
     2221 ttactttctc tcctcagaaa agaggtgatg gcggggcctg agtgtttctc cagcagccct
     2281 gggaaggagg ctgaggctcc tcctgcctgt gccccaggtt cccaccatgt gtttatgcag
     2341 ccgagctcct cctcctgttg ccgtgctctc ctctgctggc ctggcttgct gctggctttg
     2401 gagttgcttc ccacactctc cctactcagg aagaatcttg tctgtatcag aaagtttctg
     2461 tagcctggga ttttatttct tatggcagat gctacctggc cattgtaaga cagaaataag
     2521 agcaaaccaa aaagacagca cgcctgactg catatttatt tatttattta ttgaatctgt
     2581 atttcttatg agtgttttgc ctgtttgcat ctgtgcatac cacacgagtg cctgttgccc
     2641 acagaggtta gaagagctca ttggataccc tggaaatgga atcccagatg gttctgagcc
     2701 accgtgtgaa tgctggattc tctgcagttg aatcggggtt ctctgcaaga gcagccagtg
     2761 ctcttgagcc ccgatctcag attttatgtg tgaaatatct attgacatat aacactgatc
     2821 cttgaattgt cctgtgaaca tttgcattaa gaggacccaa aacaaacact taaaatggcc
     2881 cctcagtgtg actgtccgtt tttctggatt gcagtgcagc agattcctgg gccatacttg
     2941 agtatcaaat gtgtcagagg cagacgttgt agccagtcaa acctgagtgg ggtcactgtc
     3001 tgttcgtcac ctcagtgggc tccctcaggt tcttgggctg agccttctgg gccattcacc
     3061 cttccagttc ctggtctgaa gaaatgacca ggctgggttg gctctgctgt gggaagtccc
     3121 tgtctcgggg agggagattt aattcttaat ctttcatcat ttctagtgat gtcttcaagt
     3181 tctttggtct ttggactaag gctgttggcc aaagctgaat acagcaaaag ccttactgga
     3241 agttagagag gttagggaga gggatgcgag cccctgaact gcgctgccat ttctgctctt
     3301 acatcttaac cagcagagac ctctaccctt ctcttcggcc tttgacgagt gcccagcagg
     3361 agaggcagtc tgctcttgag ggaatggctt cctgcagagc tgtgctcagt ttgcagcctg
     3421 acactggcat gatcctgtgt gcctccatgt cacctgtgcg ccctgcctca tctgagaggg
     3481 tattgttgag ctcactccgt ttgtggcaga cttcctgtta acggcttgtg aggggtagga
     3541 tgtgccctgc caactgcacc cacagcctgt gcacctgtga aagccctgca gttcttggga
     3601 gaggaggcct gactggtgga agtgggtcag tagaagcagg ctttgaaggt taaccccctc
     3661 tcgcttcggg cctgtgtgct ttgctttctg tctgccgcca tagaaacata taaacctctg
     3721 gagactgctg ttcctgttgc cctgcctccc ataccatagt ggactggaat cccagcgctg
     3781 tcggatcaaa taaatccttc ccgaagttgc ttctga
//
